MICROPOROUS AND MESOPOROUS MATERIALS
·
2022
·
IF 5.876
Yiming Wang,Hong Li,Ze-nan Hu,Xin Chen,Zejun Sun,Yongjian Ai,Wenjuan Xu,Wenhui Zhang,Kelong Ding,Chengrui Li,Tong Jiang,Shuya Zhao,Haipeng Wang,Gang Zhang,Hong-bin Sun
Designing and developing efficient synergistic catalytic systems has always been an exciting topic. In this work, a sandwich-type nanocomposite , UiO-66-NH 2 @Pt@PCN-222, was utilized as a synergistic catalytic system for the selective reduction of nitrobenzaldehydes to nitrobenzyl alcohols. Benefiting from the synergy of PCN-222 and Pt NPs, the catalyst can efficiently promote the formation of 10 nitrobenzyl alcohols under mild conditions within as short as 30 min. Moreover, the PCN-222 provides not only active sites but also protection for metal nanoparticles , so the catalyst remained intact activity in cycles. This work has reference significance for the construction of synergistic catalytic systems.
研究领域:
化学
·
催化科学
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DOI
高影响因子
NPG Asia Materials
·
2019
·Vol. 11
·期 1
·1-15
·
IF 8.052
Cheng Qian,Li Zi-Hao,Sun Yun-Xia,Zhang Xian-Zheng
In this paper, a simple strategy is proposed to prepare a core-shell nanohybrid (PB@PCN) by the controllable coating of zirconium-porphyrin (PCN) shells on Prussian blue (PB) nanoparticles. By adjusting the thickness of the PCN shell, the PB@PCN nanohybrid with the best comprehensive performance was obtained for tumor treatment and imaging. The integrated nanosystem as a tandem catalyst is able to convert H 2 O 2 to O 2 through the PB core, and then the O 2 is directly injected into the PCN framework, leading to a high quantum yield of singlet oxygen to kill tumor cells and attack heat shock proteins (HSPs). The nanohybrid was further camouflaged by a tumor cell membrane (PB@PCN@MEM) with good immune evasion and active targeting ability. Upon accumulation at the tumor site, PN@PCN@MEM showed an enhanced photodynamic therapeutic effect against hypoxic tumor cells. Furthermore, coupled with the photothermal therapy of PB, photothermal/photodynamic synergistic therapy of tumors can be realized. In addition, due to its excellent imaging performance, this core-shell nanohybrid can be employed for the multimodal image-guided therapy of tumors.
研究领域:
纳米技术
·
癌症治疗
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材料科学
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生物医学工程
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DOI
高影响因子
Food Chemistry-X
·
2025
·
IF 8.2
Keyu Du,Jie Shen,Siyao Zhong,Hefei Wang,Yulou Qiu,Xuping Shentu,Xiaoping Yu,Zihong Ye,Haizhi Huang
Nitrofurazone and its metabolite semicarbazide (SEM) residues present in food products pose substantial health hazards to humans. Herein, the colorimetric–fluorescent lateral flow immunoassay (LFIA) for 4[(4-carboxyphenyl)-methylene]-hydrazinecarboxamide (CPSEM) detection was developed using PCN-222@Pectin as a signal tag. Herein, the PCN-222 surface was subsequently modified with pectin to enhance its aqueous solubility and stability. The PCN-222@Pectin-LFIA system exhibited a broad linear range from 0.025 ng/mL to 100 ng/mL. The low limits of detection for the colorimetric and fluorescence-based detection methods were 0.1 and 0.05 ng/mL, respectively. Notably, these values represent a 10- and 20-fold higher sensitivity than that of the traditional colloidal gold nanoparticle-based LFIA. This method was successfully used to detect CPSEM in actual samples, with recovery rates of 89.34 %–120.80 %. This approach fulfills the need for on-site preliminary qualitative assessment during detection and permits subsequent accurate quantitative analysis.
研究领域:
食品安全
·
分析化学
·
生物传感器
·
环境监测
·
纳米材料
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Tong Li,Pei Hu,Jiawei Li,Pintong Huang,Weijun Tong,Changyou Gao
Inspired by natural hemin structure, the fabrication of metal organic framework (MOF) nanomaterials constructed by metal ions and iron porphyrin for peroxidase mimicking has attracted extensive attention recently due to their high concentration of active sites and great channeling for substrate diffusion. Herein, by using benzoic acid as capping agent, we fabricated uniform PCN-224 nanoparticles (NPs), which were composed of Zr 6 cluster and tetrakis(4-carboxyphenyl)porphyrin (H 2 TCPP). Then Fe(Ⅲ) ions were incorporated into the center of H 2 TCPP producing iron porphyrin unit similar to hemin serving as catalytic active site. The procedure of iron incorporation didn't change the size and morphology of PCN-224 NPs. The newly formed Fe@PCN-224 NPs possessed peroxidase-like activity with much lower K m values and higher K cat values than most of peroxidase-like nanozymes as well as natural horseradish peroxidase (HRP), indicating their enhanced catalytic activity. Taking advantage of the excellent peroxidase-like activity of Fe@PCN-224 NPs, we successfully developed a colorimetric method for simple and sensitive detection of hydrogen peroxide and glucose in combination with glucose oxidase .
研究领域:
生物化学
·
纳米医学
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DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Chao Li,Juan Lu,Yanjia Guo,Yujia Song,Ruidan Li,Hanyue Jiang,Wenzhuo Wang,Pengfei Han,Guangping Ma,Jing Wang,Li Tian
In this paper, a novel dual-potential ratiometric electrochemiluminescence (RECL) sensor was constructed and applied to the ultrasensitive detection of kanamycin (KAN). The RECL sensor was constructed using porous graphite phase carbon nitride (PCN) and luminol, which serve as the luminescent reagents at the cathode and anode, respectively. PCN not only functioned as the luminescent reagent for the cathode but also served as a carrier for the Pt Au NPs. Simultaneously, Ti 3 CN acted as a carrier for the anode luminescent reagent, luminol, thereby enhancing the ECL signals at anode. Under optimal conditions, the ratio of the anode to cathode ECL signals (I luminol /I PCN ) showing excellent linear relationship with the logarithm of KAN concentration (lgC KAN ) within the range of 5.0 × 10 −14 to 5.0 × 10 −8 mol/L, with a detection limit as low as 1.67 × 10 −14 mol/L, making it suitable for detecting KAN in milk samples.
研究领域:
分析化学
·
食品安全检测
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 34
·6811-6817
·
IF 6.331
Xiao Liang,Yingxuan Chen,Kai Wen,Haobo Han,Quanshun Li
In the past two decades, the number of reports on the construction of uric acid (UA) sensors has increased dramatically, as it is a vital factor in the diagnosis of physiological functions and diseases. Among these sensors, cascade colorimetric detection based on peroxidase mimics has received great attention owing to the advantages of easier operation and more intuitive results. Herein, we report a simple UA detection method via the integration of urate oxidase (UOx) and PCN-222(Fe) with peroxidase-like activity, in which UOx is immobilized in PCN-222(Fe) by physical adsorption. UOx could catalyze the UA oxidation to produce H2O2, and then PCN-222(Fe) catalyzed the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H2O2 to generate a blue product with a maximum absorbance at 652 nm. Under optimal conditions, the increasing absorbance at 652 nm was proportional to the UA concentration. The linear range for UA detection was 10–800 μM with a limit of detection of 3.5 μM, and the cascade system has been successfully utilised for the detection of UA in human serum samples to demonstrate the accuracy of the proposed method. In conclusion, the cascade catalytic system based on the immobilization of UOx in PCN-222(Fe) has the potential to be used as a rapid and sensitive sensor for UA detection.
研究领域:
分析化学
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生物传感器
·
医学诊断
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DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2026
·
IF 8.2
JunHui Wei,Tingting Wang,Jin Tao,Xuezhi Wang,Kangning Li,Junnan Kan,Yijie Lv,Kai Qi,Ailing Wang,Xianglin Li,Caixia Yang
Breast cancer remains a major clinical challenge due to its high incidence, tumor heterogeneity, hypoxia, and limited treatment specificity. In this study, we developed PMDH, a six-in-one integrated nanoplatform for targeted multimodal imaging and combined therapy. PMDH was constructed by sequentially coating a MnO 2 shell on PCN–224, loading doxorubicin (DOX), and conjugating hyaluronic acid (HA). The system features complementary tumor microenvironment (TME) responsive imaging modalities, including fluorescence imaging, magnetic resonance imaging, and photoacoustic imaging for precise diagnostics. Therapeutically, PMDH enables controlled DOX release for chemotherapy, self-enhanced photodynamic therapy (PDT) through intratumoral oxygen generation, and PDT-triggered immunotherapy. These integrated capabilities were comprehensively validated through in vitro and in vivo studies, underscoring PMDH’s potential as a versatile and precise platform for oncology treatment.
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DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Zhong Dengjie,Liu Peng,Liu Yi,Xu Yunlan
The Zn/Fe@N-doped porous graphitic carbon catalyst (Zn/Fe@PCN) was successfully produced through one-step pyrolysis of g-C 3 N 4 and Zn/Fe-MOF and was used for the activation of persulfate (PS) for the degradation of RhB. The Zn/Fe@PCN/PS system was able to degrade 95.92% of RhB in 30 min at a rate of 0.6453 min −1 when RhB was concentrated at 50 mg L −1 . The efficient degradation of RhB is primarily realized through the synergistic activation of PS by Zn, Fe, and N to produce reactive oxygen species 1 O 2 , \(\cdot{\mathrm{O}}_2^-\) , \(\cdot \mathrm{SO}_4^-\) , and ·OH. Zn 0 /Fe 0 in Zn/Fe@PCN forms a galvanic cell with carbon to release electrons to join in the activation of PS. The doping of Zn not only provides sufficient electrons for the activation of PS but also promotes the effective reduction of Fe 2+ and thus the Fe 2+ /Fe 3+ cycle. The N doping accelerates the electron transfer during the reaction progress.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Jinhui Wei,Xiangchuan Wu,Chengyuan Wu,Fan Hou,Lina Wu,He Huang
Aflatoxin B 1 (AFB 1 ), a naturally produced toxin existing in major food crops, is highly toxic and carcinogenic to human and animals. In this study, a reusable material, Pd@PCN-222 with great adsorption performance and peroxidase-like activity was synthesized for the removal of AFB 1 . Pd@PCN-222 exhibited great adsorption performance owing to hierarchical porous structure. Pd@PCN-222 also could catalyze the AFB 1 in the presence of H 2 O 2 due to the Fe-tetrakis (4-carboxyphenyl) porphyrin and Pd as effective peroxidase active site, which improved the removal efficiency of AFB 1 . Pd@PCN-222 was applied for the removal of AFB 1 with a removal rate of 96.52% in 2 h. Owing to the advantages of high removal efficiency and reusability, Pd@PCN-222 had great application potential in AFB 1 removal.
研究领域:
材料科学
·
毒理学
·
食品安全
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Jie Tang,Qi Li,Yubing Liu,Naizhang Xu,Kaiqiang Wang,Qitao Zhang,Wenjuan Yang,Yining Fan
In this study, the novel triphenylphosphine-based covalent organic frameworks (P–COF-1) were firstly introduced into polymeric carbon nitride (PCN) to fabricate P–COF-1/PCN heterojunctions via intermolecular π-π interaction. The photocatalytic H 2 production rate over the 9% P–COF-1/PCN heterojunctions is ca. 12 times as much as that of pure PCN. The photoelectrochemical measurements and theoretical calculation results show that due to the well-matched band structure between P–COF-1 and PCN, the photo-generated electrons tend to migrate from P–COF-1 into the conduction band of PCN through the interface of heterostructures. In addition to the π→π∗ electron transition of conjugated tri- s -triazine units in the 9% P–COF-1/PCN with band gap energy of 2.53 eV, the lone pair electrons of P transition to the π∗ orbitals of P–COF-1 (n→π∗) with lower band gap energy of 1.82 eV results in the effective separation of photo-generated carriers and more visible light absorption , and thus enhanced the photocatalytic hydrogen evolution .
研究领域:
材料科学
·
化学
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DOI
高影响因子
International Journal of Pharmaceutics-X
·
2026
·
IF 7.9
Xiang Wang,Hengrui Li,Le Wang,Yihan Ma,Miao Qin,Ruonan Sun,Jing Hu
Tumor hypoxia is a major barrier to oxygen-dependent photodynamic therapy (PDT), markedly limiting its therapeutic efficacy in hepatocellular carcinoma (HCC). Herein, a self‑oxygenating and redox-amplifying metal-organic framework (MOF) nanoplatform is constructed by co-loading sorafenib (Sor) and plumbagin (PLB) into a surface galactose functionalized Mn-porphyrinic PCN-224(Mn) (PM) framework to afford SorPLB@Gal-PM for asialoglycoprotein receptor (ASGPR)-mediated HCC targeting. The Mn-porphyrin centers endow SorPLB@Gal-PM with catalase-like activity, enabling in situ decomposition of endogenous H 2 O 2 to generate O 2 and thereby sustaining 1 O 2 -based PDT under irradiation. Meanwhile, Sor/PLB co-delivery, together with PLB-mediated GPX4 suppression, promotes oxidative stress amplification. In hypoxic liver cancer stem cell-like C5WN1 cells, SorPLB@Gal-PM elicits markedly enhanced intracellular ROS upon irradiation, showing approximately 3.4-fold and 2.9-fold higher DCFH-DA signals than SorPLB@Gal-PCN-224 and PM, respectively, accompanied by downregulation of hypoxia-inducible factor-1α (HIF-1α) and glutathione peroxidase 4 (GPX4). In a C5WN1 tumor-bearing nude mouse model, SorPLB@Gal-PM combined with irradiation achieves the most potent tumor suppression with a tumor inhibition rate of 83.70% ± 4.12%. Collectively, SorPLB@Gal-PM provides a hypoxia-adaptive nanoplatform integrating Mn-assisted self‑oxygenation and redox-amplified chemo-PDT for effective HCC therapy.
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DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Jing Zhao,Chaoyi Lyu,Rui Zhang,Yao Han,Yundi Wu,Xilong Wu
The expansion of large-scale nuclear power causes a substantial volume of radioactive wastewater containing uranium to be released into the environment. Because of uranium's toxicity and bioaccumulation, it is critical to develop the efficient and sustainable materials for selective removal of uranium (VI). Herein, a regenerable anti-biofouling nano zero-valent iron doped porphyrinic zirconium metal–organic framework (NZVI@PCN-224) heterojunction system was successfully fabricated. Due to the Schottky-junction effect at the NZVI/MOF interface, the NZVI nanomaterial immobilized on PCN-224 could improve interfacial electron transfer and separation efficiency, and enhance entire reduction of highly soluble U(VI) to less soluble U(IV), involving photocatalytic reduction and chemical reduction. Meanwhile, the photocatalytic effect also prompts the NZVI@PCN-224 to produce more biotoxic reactive oxygen species (ROS), resulting in high anti-microbial and anti-algae activities. Under dark conditions, NZVI@PCN-224 with a large specific surface area could provide sufficient oxo atoms as the uranium binding sites and show the highest uranium-adsorbing capability of 57.94 mg/g at pH 4.0. After eight adsorption-desorption cycles, NZVI@PCN-224 still retained a high uranium adsorption capacity of 47.98 mg/g and elimination efficiency (91.72%). This sorption/reduction/anti-biofouling synergistic strategy of combining chelation, chemical reduction and photocatalytic performance inspires new insights for highly efficient treatment of liquid radioactive waste .
研究领域:
环境科学
·
材料科学
·
核废料处理
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）