ACS Nano
·
2024
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IF 15.8
Yunxia Ji,Libang Chen,Yunqing Wang,Jinjin Zhang,Yue Yu,Meirong Wang,Xiaoyan Wang,Weili Liu,Bing Yan,Liang Xiao,Xiaodong Song,Changjun Lv,Lingxin Chen
The smaller size fraction of plastics may be more substantially existing and detrimental than larger-sized particles. However, reports on nanoplastics (NPs), especially their airborne occurrences and potential health hazards to the respiratory system, are scarce. Previous studies limit the understanding of their real respiratory effects, since sphere-type polystyrene (PS) nanoparticles differ from NPs occurring in nature with respect to their physicochemical properties. Here, we employ a mechanical breakdown method, producing NPs directly from bulk plastic, preserving NP properties in nature. We report that among four relatively high abundance NP materials PS, polyethylene terephthalate (PET), polyvinyl chloride (PVC), and polyethylene (PE) with a size of 100 nm, PVC induced slightly more severe lung toxicity profiles compared to the other plastics. The lung cytotoxicity of NPs is higher than that of commercial PS NPs and comparable to natural particles silicon dioxide (SiO2) and anatase titanium dioxide (TiO2). Mechanistically, BH3-interacting domain death agonist (Bid) transactivation-mediated mitochondrial dysfunction and nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy or ferroptosis are likely common mechanisms of NPs regardless of their chemical composition. This study provides relatively comprehensive data for evaluating the risk of atmospheric NPs to lung health.
研究领域:
环境科学
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毒理学
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材料科学
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呼吸医学
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DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2021
·
IF 7.963
Xiaowei Li,Man Li,Qingqing Mei,Shiyu Niu,Xuan Wang,Huafang Xu,Bin Dong,Xiaohu Dai,John L. Zhou
Despite a wealth of information on removal of the microplastics (MPs) in wastewater treatment plants (WWTPs), little attention has been paid to how wastewater treatment process affect the MP physicochemical and adsorption characteristics. In this study, changes in physicochemical property of three MPs, i.e. polyamide (PA), polyethylene (PE) and polystyrene (PS) through the wastewater pipeline, grit and biological aeration tanks were investigated. The results show that compared with virgin MPs, the treated MPs have higher specific surface area and O content, and lower C and H contents, and glass transition temperature , implying that the three treatments cause the chain scission and oxidation of the MPs. Cd adsorption capacities of the MPs are higher than the corresponding virgin MPs after sulfidation in the pipeline (SWPN) and biological treatment in aeration tank (BTAT). Pearson correlation analysis shows that the increase is mainly resulted from the enhancement of the O-containing groups on the MPs. However, Cd adsorption capacities of the MPs decrease after mechanical abrasion in grit tank (MAGT), corresponding to the decrease in carbonyl index. Two dimensional FTIR correlation spectroscopy demonstrates that the N H bond in the PA plays a more important role than C H bond in the adsorption of Cd, but only change of the C H bond is found in the PE and PS. The findings provide new insights into the effect of WWTPs on the MP aging and physicochemical characteristics.
研究领域:
环境科学
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化学
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污水处理工程
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DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2021
·
IF 5.89
Yang Chen,Liu Yushi,Liu Wan-Qiu,Wu Changzhu,Li Jian
Cell-free systems have been used to synthesize chemicals by reconstitution of in vitro expressed enzymes. However, coexpression of multiple enzymes to reconstitute long enzymatic pathways is often problematic due to resource limitation/competition (e.g., energy) in the one-pot cell-free reactions. To address this limitation, here we aim to design a modular, cell-free platform to construct long biosynthetic pathways for tunable synthesis of value-added aromatic compounds, using (S)-1-phenyl-1,2-ethanediol ((S)-PED) and 2-phenylethanol (2-PE) as models. Initially, all enzymes involved in the biosynthetic pathways were individually expressed by an E. coli-based cell-free protein synthesis (CFPS) system and their catalytic activities were confirmed. Then, three sets of enzymes were coexpressed in three cell-free modules and each with the ability to complete a partial pathway. Finally, the full biosynthetic pathways were reconstituted by mixing two related modules to synthesize (S)-PED and 2-PE, respectively. After optimization, the final conversion rates for (S)-PED and 2-PE reached 100 and 82.5%, respectively, based on the starting substrate of l-phenylalanine. We anticipate that the modular cell-free approach will make a possible efficient and high-yielding biosynthesis of value-added chemicals.
研究领域:
合成生物学
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代谢工程
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生物技术
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
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IF 13.3
Jinqi Wang,Xiaolong Su,Qianqin Zhu,Yaling Zhai,Xin Dai,Ning Tang,Wangxiang Pan,Hengxue Xiang,Meifang Zhu
An increasing number of hospital-acquired infections (HNIs) confirms the urgency of medical protective fiber material (MDPF), which possesses high strength, low toxicity and excellent hydrophobicity and is considered as an effective method to deal with HNIs. However, the current performance of MDPF mainly relies on a single physical barrier mechanism, and pathogenic and contagious bacteria or virus attached on the surface barrier layer are one of the important paths for secondary infection. Therefore, research on the fabrication of highly effective antibacterial MDPF is of great significance for preventing contagious infections. Herein, high-strength, environment-friendly and antibacterial PE@PDA@ZnO-Ag (PE@PDAZA) nonwoven fabric was successfully prepared through a simple one-pot coating method. The functional fabric exhibits antibacterial rate up to 99.9 % against Escherichia coli ( E. coli ) and Bacillus subtilis ( B. subtilis ) with low amount of antibacterial agent additions. Moreover, the fabric exhibits tested tensile strength of 35.4 ± 2.9 MPa. This work provides a new strategy for preparing high-strength and automatically-protective MDPF, which can reduce hospital-acquired contagious infections through a simple post-treatment process and has great potential for large-scale production.
研究领域:
材料科学
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生物医学工程
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纺织工程
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高分子科学
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DOI
高影响因子
Energy Storage Materials
·
2022
·
IF 20.831
Denghua Zhang,Xihao Zhang,Chao Luan,Biao Tang,Zhongyu Zhang,Nianwen Pu,Kaiyue Zhang,Jianguo Liu,Chuanwei Yan
Thin membranes with high conductivity are of great importance for high power density vanadium flow batteries (VFBs), however, the trade-off between conductivity and ion selectivity limits their further development. Herein, an ultrathin composite membrane (∼10 μm) enabled by a zwitterionic interface between conductive polybenzimidazole (PBI) and porous polyethylene (PE) substrate is proposed to break the trade-off, and greatly enhance the power density of a VFB. The zwitterionic interface is engineered by the covalent reaction between polydopamine and zwitterionic sulfonated 3-dimethylaminopropylamine (DMAPAPS). The as-fabricated composite membrane features excellent mechanical properties and high dimensional stability. Furthermore, the zwitterionic interface facilitates proton transportation while blocking vanadium-ion permeation . More importantly, the ion selectivity of the ultrathin membrane is nearly three times higher than the pure PBI membrane (i.e., 2.71 × 10 4 vs. 1.09 × 10 4 S min cm −3 ). As a result, a VFB assembled with the ultrathin membrane demonstrates a superior energy efficiency of 78.7% at 300 mA cm −2 , and achieves an excellent cycle stability over 500 cycles at 300 mA cm −2 . Therefore, the engineering of zwitterionic interface provides a promising strategy in the development of ultrathin composite membrane for high power density VFBs.
研究领域:
材料科学
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电化学
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能源存储
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产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Nuanyuan Xu,Pengjia Dou,Hui Wen,Changkun Liu
Membrane-based nanofiltration is a crucial technique for treating dyestuff-salts wastewater, owing to its excellent selectivity towards mono/multivalent ions and organic matter. In this study, a facile and highly practical method was employed to enhance the hydrophilicity of the PE matrix through in-situ growth of poly( m -phenylenediamine) on the PE fibrils via the chemical oxidative polymerization of MPD. The inclusion of the poly( m -phenylenediamine) on PE enables the formation of homogenous and defect-free PA layer showing a unique honeycomb-like Turing morphology with characteristic crater-belt structure. Furthermore, the pendant amine groups from the poly( m -phenylenediamine) chain promotes the formation of a PA layer with a smaller effective mean pore size and a sharper pore size distribution, resulting from the formation of an extra polyamide network (reaction of PMPD with TMC) within the PA layer. The as-prepared PE-based NF membrane exhibits a high pure water permeance of 17.7 LMH bar −1 , exceptional Na 2 SO 4 rejection of 99.3%, and a long-term stability for cross-flow filtration for over 10 days. The PE-based NF membrane exhibits the water flux 2.2 times higher than that of the commercially available DK and DL membranes while maintaining a high salt rejection. Additionally, the PE-based NF membrane demonstrates exceptional selectivity, with a value of 115 for the separation of NaCl/Na 2 SO 4 and 339.8 for Cl - /SO 4 2- in a binary salt mixture. Furthermore, the PE-based NF membrane shows ultra-high selectivity values of 990 for CR/NaCl and 1039 for MB/NaCl in the treatment of dye/salt mixtures, respectively, which are significantly higher than those of the DK and DL membranes. The findings of this study highlight the potential of the in-situ growth of poly( m -phenylenediamine) on PE fibrils as a simple and cost-effective method for the modulation of hydrophilicity to enhance the NF membrane performance.
研究领域:
材料科学
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环境工程
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Yijing Ai,Fan Shi,Xiao Han,Xiaoqing Li,Wanting Fu,Baoli Wang,Xiaoping Zhang,Wei Sun
In this work, a simple one-step pyrolysis process was designed to synthesize Fe-doped graphite carbon nitride (Fe–C 3 N 4 ) nanosheets with FeCl 3 as Fe source. The resulted samples were characterized by various characterization techniques, and the results showed that Fe species might form Fe–N bonds with N atoms of C 3 N 4 , which was similar to the iron (Ⅲ) porphyrin active center of horseradish peroxidase. Then Fe–C 3 N 4 nanosheet was further mixed with carbon nanotube (CNT) to obtain Fe–C 3 N 4 @CNT nanocomposite, which was further modified on the self-made flexible printed electrode (PE) to construct the flexible working electrode. Fe–C 3 N 4 nanosheets show good catalytic activity for H 2 O 2 and the introduction of CNT can effectively improve the electron transfer efficiency at the modified electrode interface. By combining with wireless portable electrochemical workstation, the sensor shows a wider detection range (10.0 μmol/L–20.0 mmol/L) and a lower limit of detection (0.38 μmol/L, S/N = 3) for the H 2 O 2 analysis. Furthermore, the sensor can be applied to the real time and in-situ analysis of H 2 O 2 secreted from live cells. In word, this self-supported sensing electrode shows great potential applications in monitoring the pathological and physiological dynamics of cancer cells.
研究领域:
材料科学
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电化学
·
生物传感器
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纳米技术
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分析化学
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生物医学工程
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产品关联
DOI
高影响因子
Acta Pharmaceutica Sinica B
·
2023
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IF 14.5
Lijuan Xue,Keanqi Liu,Caixia Yan,Junling Dun,Yexin Xu,Linlin Wu,Huizhu Yang,Huafang Liu,Lin Xie,Guangji Wang,Yan Liang
Nonalcoholic steatohepatitis (NASH) is a spectrum of chronic liver disease characterized by hepatic lipid metabolism disorder. Recent reports emphasized the contribution of triglyceride and diglyceride accumulation to NASH, while the other lipids associated with the NASH pathogenesis remained unexplored. The specific purpose of our study was to explore a novel pathogenesis and treatment strategy of NASH via profiling the metabolic characteristics of lipids. Herein, multi-omics techniques based on LC–Q-TOF/MS, LC–MS/MS and MS imaging were developed and used to screen the action targets related to NASH progress and treatment. A methionine and choline deficient (MCD) diet-induced mouse model of NASH was then constructed, and Schisandra lignans extract (SLE) was applied to alleviate hepatic damage by regulating the lipid metabolism-related enzymes CES2A and CYP4A14. Hepatic lipidomics indicated that MCD-diet led to aberrant accumulation of phosphatidylethanolamines (PEs), and SLE could significantly reduce the accumulation of intrahepatic PEs. Notably, exogenous PE (18:0/18:1) was proved to significantly aggravate the mitochondrial damage and hepatocyte apoptosis. Supplementing PE (18:0/18:1) also deteriorated the NASH progress by up regulating intrahepatic proinflammatory and fibrotic factors, while PE synthase inhibitor exerted a prominent hepatoprotective role. The current work provides new insights into the relationship between PE metabolism and the pathogenesis of NASH.
研究领域:
药理学
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肝病学
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脂质组学
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代谢组学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2022
·Vol. 11
·期 4
·1966-1977
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IF 14.511
Zhiheng Ren,Jixiao Li,Minghui Cai,Ruonan Yin,Jianneng Liang,Qianling Zhang,Chuanxin He,Xiantao Jiang,Xiangzhong Ren
Polymer electrolytes (PEs) synthesized from an in situ polymerization strategy are considered as promising candidates to improve interfacial compatibility. However, most in situ formed PEs still suffer from problems such as low lithium-ion transference number (tLi+) and insufficient ionic conductivity at room temperature (RT). Herein, a series of copolymer electrolytes (CPEs) consisting of 1,3-dioxolane (DOL) and 1,3,5-trioxane (TXE) monomers are synthesized. Due to the additive of succinonitrile (SN), and the promoted dissociation of lithium salt, the obtained polymer electrolyte (SN-CPE) exhibits an excellent ionic conductivity (4.06 × 10−4 S cm−1) and a high lithium-ion transference number (tLi+ = 0.881) at RT, as well as a high voltage oxidation window of 5.1 V. Thanks to the in situ formed intimate contacted electrode/electrolyte interface, the symmetric Li/Li cell can achieve long-term cycling stability over 1500 h without a short circuit. A LiF-rich organic–inorganic composite layer is formed on both the solid electrolyte interphase (SEI) and cathode electrolyte interphase (CEI) as demonstrated by XPS, TEM, and SEM analyses. Thereafter, the LiFePO4/Li cell has a high capacity retention of 84.1% after 900 cycles at RT, and it can still work effectively at high temperatures (e.g. 80 °C). Furthermore, SN-CPE exhibits excellent electrochemical performance and safety in the LiCoO2/Li cell and LiFePO4/graphite pouch cell, which again supports the promising application of SN-CPE.
研究领域:
材料科学
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电化学
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能源存储
·
电池技术
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DOI
高影响因子
危险品化学品经营许可证（带存储）