RSC Advances
·
2016
·Vol. 6
·期 84
·81174-81183
·
IF 3.289
Jie Yu,Xiaoyan Ma,Wenyan Yin,Zhanjun Gu
Polyvinylpyrrolidone (PVP)-modified MoS2 nanoparticles (PVP-MoS2 NPs) with d = 5 nm and in high purity and yield were prepared by a facile one-pot hydrothermal method. Cytotoxicity and hemolysis studies demonstrated that PVP-MoS2 NPs show good biocompatibility. The PVP-MoS2 NPs exhibited remarkable peroxidase-like catalytic activity, which was similar to that of horseradish peroxidase (HRP). Based on this peroxidase-like activity, a platform for colorimetric detection of H2O2 was established. We have found that these NPs have high sensitivity to detect H2O2 with a nearly linear range between 2.0 × 10−6 mol L−1 and 1.5 × 10−4 mol L−1. Furthermore, the PVP-MoS2 NPs were also used for glucose measurement in serum by quantifying the released H2O2 in the presence of glucose oxidase. The linear range for glucose detection was from 1.0 × 10−3 mol L−1 to 1.0 × 10−2 mol L−1. This work will pave a way for the high-throughput synthesis of other ultra-small transition metal dichalcogenide (TMDs) NPs. Such enzyme-mimic nanomaterials could be a useful tool for medical diagnosis.
研究领域:
纳米技术
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生物化学
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分析化学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2020
·
IF 4.939
Zhongyu Qiu,Naibao Huang,Xiaowen Ge,Jiaping Xuan,Pei Wang
In order to reduce the cost of oxygen reduction reaction (ORR) catalyst, a metal-free N-doped carbon nanocage as ORR catalysts is prepared by using Polyethylene oxide-polypropylene oxide-polyethylene oxide (PEO-PPO-PEO) three-block copolymer (F127), polyvinyl pyrrolidone (PVP) and Zn (OH) 2 as a carbon source, nitrogen source and the morphology retaining agent, respectively, via a self-template method. The structure and microstructure of the N-doped carbon nanocage are characterized via physical characterization methods such as X-ray diffraction, Raman spectroscopy , scanning electron microscopy, transmission electron microscopy , Brunauer–Emmett–Teller method, and X-ray photoelectron spectroscopy. Electrochemical properties are evaluated in an O 2 -saturated alkaline solution. The obtained sample pyrolyzed at 800 °C with 10% content of PVP (C–N-800) presents nano-hollow carbon capsule with a diameter of 100 nm and shell thickness of 8 nm, and has the maximum surface area of 978 m 2 ·g −1 . In O 2 -saturated 0.1 M KOH solution, C–N-800's onset potential, limit current density, and half-wave potential, which are 0.87 V, 5.73 mA/cm 2 @0.45 V, and 0.77 V, respectively, are close to those of commercial 20% Pt/C catalysts. Meanwhile, its electrochemical performance only loss 11.75% after 5000 cycles, showing excellent ORR catalytic performance and stability. During self-assembly of F127, the added PVP participated into the process. Pyrolysis at 800 °C would result in the complete decomposition of F127 and PVP's lipophilic. So, the metal-free N-doped carbon nanocage was obtained and behaved excellent ORR catalytic activity and stability.
研究领域:
材料科学
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电化学
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2017
·Vol. 9
·期 37
·5494-5501
·
IF 1.9
Min Zhu,Nuerguli Kari,Yin Yan,Abliz Yimit
A m-Cresol Purple-polyvinylpyrrolidone (m-CP-PVP) composite-film was immobilized on the surface of a potassium ion-exchanged glass optical waveguide using the spin-coating method. The optical properties of the film were probed by UV-visible Spectroscopy and Fourier Transform Infrared Spectroscopy. The transmittance variation and the structural properties of the m-CP-PVP composite film/K+-exchanged glass optical waveguide sensor were studied before and after reaction with an amine and volatile organic gases. When the sensing film was exposed to an amine gas, the color changed from yellow to purple/blue. This simply designed sensor was able to measure trimethylamine (TMA) gas down to a concentration of 0.1 ppb at room temperature, and its response and recovery times were 1.4 s and 5.6 s, respectively.
研究领域:
光学传感
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生物医学工程
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分析化学
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纳米材料
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环境监测
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Yutang Kang,Jiahao Chen,Shasha Feng,Huixian Zhou,Fangqi Zhou,Ze-Xian Low,Zhaoxiang Zhong,Weihong Xing
Particulate matters (PMs) emissions from energy consumption contribute the vast majority of PM pollution, which are typically associated with high temperatures (>300 °C) and are difficult to remove directly at high temperatures. Electrospinning nanofiber membranes have irreplaceable advantages of high removal efficiency and low pressure drop for PMs filtration, however, the efficient filtration of PMs at high temperature is challenging for polymer-based nanofiber membranes because of the poor heat resistance and inflammability. Herein, we design a thermally-oxidized polyacrylonitrile/polyvinylpyrrolidone/SnO 2 (OPAN/PVP/SnO 2 ) nanofiber membrane by performing the thermally induced cyclization and oxidation reaction of PAN/PVP/SnCl 2 nanofiber membrane at 350 °C in air. During the thermal oxidization process, Sn 2+ acted as a catalyst and activation, preventing the melting and fusion of PAN nanofibers. The addition of PVP greatly increased the mechanical properties of OPAN/SnO 2 nanofiber membrane. The prepared OPAN/PVP/SnO 2 nanofiber membrane possesses superior PMs filtration performance at room temperature, with the PM 0.3 and PM 2.5 filtration efficiency of 99.53% and 99.98%, respectively. The OPAN/PVP/SnO 2 nanofiber membrane exhibits high temperature tolerance up to 350 °C and wide pH tolerance of 1–14, it remains a high PMs removal efficiency of 98.51% at 350 °C and 98.67% at 300 °C. Moreover, the OPAN/PVP/SnO 2 nanofiber membrane shows excellent fire retarding and self-extinguishing property not shown in pristine PAN nanofiber membrane. This work provides a novel approach for clean use of energy via a cost-effective, heat-resistant, and flame-retardant nanofiber membrane.
研究领域:
环境科学
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材料科学
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纳米技术
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能源工程
✓ 已验证
产品关联
DOI
高影响因子
SOLID STATE IONICS
·
2021
·
IF 3.785
Na Sun,Xuhui Wang,Xufeng Dong,Hao Huang,Min Qi
The application of the SiO 2 anodes for flexible and free-standing lithium-ion batteries (LIBs) is restricted by the weaknesses of SiO 2 nanoparticles , such as agglomeration, huge volume expansion and rapid capacity fading during charge/discharge cycles. Herein, the PVP-grafted-silica@carbon nanofibers (PVP-g-SiO 2 @CNF) flexible free-standing anode with high capacity and long cycle stability is successfully fabricated by PVP-grafted-SiO 2 , electrospinning and subsequent heat treatment . PVP modifies the interface between SiO 2 nanoparticles and electrospinning solution to prevent the nanoparticles from aggregation, which makes them are uniformly encapsulated in nanofibers. The uniform structure is beneficial to enhance the interface contact between SiO 2 and Li + , and alleviate volume expansion during lithiation . Furthermore, PVP introduces mesoporous into carbon nanofibers , facilitating the transports of ions and electrons to attain high-rate performance. As a flexible free-standing anode material for LIBs, PVP-g-SiO 2 @CNF achieves high reversible capacity, high-rate capacity and superior cycle stability (440 mAh g −1 at 0.1 A g −1 after 200 cycles), especially 89% capacity retention after 180° bending deformation . Consequently, enhanced capacity and cycle stability for flexible free-standing anode are available through PVP-grafted interface modification and electrospinning.
研究领域:
材料科学
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电化学
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纳米技术
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能源存储
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2022
·Vol. 169
·期 6
·060547
·
IF 4.386
Ruixiang Wang,Yanyang Wang,Zheqin Chen,XiaoCong Zhong,Yongmin Xie,Xiaobo Ji,Jiaming Liu,Shubiao Xia,Zhifeng Xu
Transition metal/nitrogen carbon composite (M/NC) is a highly active oxygen reduction reaction (ORR) electrocatalyst, widely used in fuel cells and zinc-air batteries. Herein, a uniform and regular PVP-assisted iron-doped nano dodecahedron (ZP0.1F/NC) is prepared by a simple and efficient one-step in-solution reaction, followed by controlled in situ pyrolysis. The synthesized electrocatalyst showed excellent electrocatalytic ORR activity in an alkaline medium. Compared with standard 20% Pt/C electrocatalyst, ZP0.1F/NC exhibited onset potential (Eonset) (0.974 V vs 0.967 V), half-wave potential (E1/2) (0.861 V vs 0.857 V) and the limiting current density (jd) was 6.373 mA cm−2 vs 5.401 mA cm−2, also better than the Fe doped ZIF-8 nitrogen composite (ZF/NC), PVP auxiliary ZIF-8 (ZP0.1/NC) and pure ZIF-8 nitrogen composite (Z/NC) synthesized by the same procedure. In addition, the zinc-air battery assembled with ZP0.1F/NC also exhibits outstanding discharge capacity, with a specific capacity and energy density of 793.3 mAh g−1 and 974.9 Wh kgZn−1, respectively, much higher than that of commercial 20% Pt/C-based zinc-air battery (719.8 mAh g−1, 842.6 Wh kgZn−1), indicating its great potential in practical energy conversion and storage.
研究领域:
材料科学
·
电化学
·
能源存储与转换
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2023
·
IF 6.7
miaomiao yuan,Rongjun Zhang,Shuxiang Xu,Lihao Guo,Luoyijun Xie,Yingying Liao,Yang Xu,Xuemei Fu
Photothermal therapy (PTT) is an emerging field, and the photothermal agents could convert visible or near-infrared (NIR) radiation into heat to kill tumor cells. However, the low photothermal conversion efficiency of photothermal agents and their limited antitumor activities delay the development of these agents into monotherapies for cancer. Herein, we have fabricated an ultrasmall polyvinylpyrrolidone (PVP)-Fe-Cu-Ni-S (PVP-NP) nano-agent via a simple hot injection method with an excellent photothermal conversion efficiency (~96%). Photothermal therapy with this nano-agent effectively inhibits tumor growth without apparent toxic side effects. Mechanistically, our results demonstrated that, after NIR irradiation, PVP-NPs can induce ROS/singlet oxygen generation, decrease mitochondrial membrane potential, and release extracellular Fe2+ and consume glutathione, triggering autophagy and ferroptosis of cancer cells. Moreover, PVP-NPs exhibit excellent contrast enhancement according to magnetic resonance imaging (MRI) analysis. In summary, PVP-NPs have a high photothermal conversion efficiency and can be applied for MRI-guided synergistic photothermal/photodynamic/chemo-dynamic cancer therapy, solving the bottleneck of existing phototherapeutic agents.
研究领域:
癌症治疗
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纳米技术
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生物医学工程
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材料科学
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医学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Water Process Engineering
·
2025
·
IF 6.7
Mei Dong,Qiguang Cao,Song Li,Kebin Li
Designing stable and efficient heterogeneous catalysts for peroxymonosulfate (PMS) activation remains a critical challenge in advanced oxidation processes. Herein, we prepared a polyvinylpyrrolidone (PVP)-modified MIL-101(Fe)@CoZn-ZIF (PVP-MCZ) core-shell nanocomposite that synergistically combined enhanced catalytic activity with exceptional stability. The PVP-MCZ catalyst achieved complete degradation of 4-nitrophenol (4-NP) (20 mg/L) within 15 min, while suppressing metal leaching (<0.5 mg/L). Comprehensive characterization (XPS, EPR) revealed a dual-pathway mechanism: (i) radical-dominated SO 4 − generation via Co 2+ /Co 3+ and Fe 2+ /Fe 3+ redox cycling, and (ii) non-radical 1 O 2 production from PMS self-decomposition. This work provides a scalable strategy to design MOF-based catalysts for sustainable water remediation.
研究领域:
环境化学
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纳米技术
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催化
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材料科学
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水处理
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Liying Zhang,Pei Xie,Hang Wu,Jiulong Zhao,Shige Wang
Acute pancreatitis (AP) is a disease with high mortality which could cause an inflammatory responses such as edema and necrosis of the pancreatic tissue. Studies have proved that the excessive produced reactive oxygen species (ROS) and reactive nitrogen species (RNS) play an important role in the pathogenesis of AP. Although progresses have been made for ROS and RNS elimination using artificial enzymes, biocompatible nanomaterials with advanced multi-enzymatic activities have been rarely studied. In this study, we constructed a simple and efficient method to fabricate a two-dimensional (2D) MoSe 2 @PVP nanosheets (NSs) as an artificial enzyme to treat oxidative stress-related diseases. Both in vitro and in vivo experiments proved that MoSe 2 @PVP NSs have good biocompatibility. Interestingly, the MoSe 2 @PVP NSs simultaneously showed the thermal durable peroxidase, catalase, superoxide dismutase, and glutathione peroxidase mimicking capacities, which endowed the material with good ROS and RNS scavenging abilities. The MoSe 2 @PVP NSs were engaged in treating the AP in an animal model, which led to a significant down-regulation of serum levels of amylase, IL-6, IL-1β, and TNF-α. Further H&E staining of pancreatic tissue validated the AP therapeutic effect of MoSe 2 @PVP NSs. We hope that our research will facilitate the development of multifunctional artificial enzymes for the treating of oxidative stress-related diseases.
研究领域:
纳米技术
·
生物医学工程
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药理学
·
病理学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 34
·8216-8227
·
IF 7
Zhipeng Yuan,Jing Zhang,Xinfu Zhao,Sijia Liu,Shimo Yu,Xiaochan Liu,Xinen Zhang,Xibin Yi
Rapid and safe disinfection and exudate management are two major challenges in infected wound care. Therefore, in this work, we developed a novel wound dressing via encapsulating ZIF-8-derived carbon nanoparticles in a hydrophilic nanofiber sponge to address severe wound infection and heavy exudate problems. The dressing can effectively kill bacteria through chemo-photothermal synergistic therapy. Meanwhile, the hydrophilic nanofiber sponge can quickly absorb wound exudate around the wound and accelerate the evaporation rate of liquid through the photothermal effect and its own structure; therefore, it is possible to remove excess liquid and regulate its wetness. In this way, it prevents the problem of wound overhydration often caused by hydrophilic dressings. In our experiment, the dressing showed good antibacterial performance and biocompatibility in vitro and could effectively control wound infection, absorb wound exudate and promote skin wound healing in vivo. Its good therapeutic effect is not only due to effective infection control and wound exudate management, but also because the structure of nanofibers similar to an extracellular matrix provides basic physical support and structural signals conducive to skin tissue regeneration.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
伤口愈合
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Tungsten
·
2025
·
IF 11.2
Shi Xue-Chao,Wang Yi-Mei,Hou Shu-Xian,Yang Guo-Qiang,Liu Xin-Xin,Ge Jun,Gui Lin,Zhang Wei-Wei,Kaoutar Chaldi,Li Shu-Jie,Wang Jun,Ge Fei
Waterborne microbial contamination represents a significant global environmental challenge. Microorganisms can induce water pollution, precipitating infectious disease outbreaks and posing a substantial threat to human health. Currently, the excessive use of conventional antibiotics has resulted in the emergence of bacterial resistance, posing a challenge to the design and development of antimicrobial agents with high antibacterial efficacy in diverse water such as rivers, lakes, and wastewater from microbiology laboratories. Bimetallic nanomaterials, that amalgamate the distinctive characteristics of diverse metals, are garnering attention due to their synergistic properties. In this study, PVP-FeMo 2 S 3 (PVP: Polyvinylpyrrolidone) and PVP-ZnMo 2 S 3 nanocrystals were synthesized by a high-temperature reaction. The prepared nanocrystals exhibited excellent biocompatibility, regular morphology, long-term stability, and remarkable antibacterial effects. The bacterial biofilms could be eradicated by the combination of photothermal (PTT) and photodynamic synergistic effects of PVP-FeMo 2 S 3 and PVP-ZnMo 2 S 3 nanocrystals. PVP-ZnMo 2 S 3 nanocrystals exhibited enhanced PTT conversion efficiency for water treatment. Remarkably, even after 20 cycles of recycling, PVP-ZnMo 2 S 3 retained substantial antibacterial efficacy. The excellent biosafety of PVP-ZnMo 2 S 3 further guarantees the safety of water quality post-treatment. Thus, PVP-ZnMo 2 S 3 bimetallic nanocrystals can serve as a novel antimicrobial agent for the treatment of microbial contamination in water. This study offers a potential strategy to mitigate secondary water pollution and prevent the development of drug resistance among pathogenic microorganisms.
研究领域:
环境科学
·
微生物学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2024
·
IF 9.4
Jinpeng Yao,Yu Chen,Liang Zhang,Yuancun Cheng,Zheng Chen,Yanhui Zhang,Xiaoyi Zheng,Yanwei Lv,Shige Wang,Zhaoshen Li,Jiulong Zhao
The clinical treatment of inflammatory bowel disease (IBD) is challenging. We developed copper sulfate (CuS)/disulfiram (DSF)/methacrylic acid-ethyl acrylate copolymer (EL)/polyvinylpyrrolidone (PVP) nanoplatform (CuS/DSF/EL/PVP) and evaluated its efficiency for treating IBD. After oral administration, the pH-sensitive EL protected the CuS/DSF/EL/PVP against degradation by acidic gastric juices. Once the colon was reached, EL was dissolved, releasing DSF and Cu 2+ . Further, the main in vivo metabolite of DSF can bind to Cu 2+ and form copper (II) N, N-diethyldithiocarbamate (CuET), which significantly alleviated acute colitis in mice. Notably, CuS/DSF/EL/PVP outperformed CuS/EL/PVP and DSF/EL/PVP nanoplatforms in reducing colonic pathology and improving the secretion of inflammation-related cytokines (such as IL-4 and IL-10) in the colonic mucosa. RNA-seq analysis revealed that the nanoplatform reduced colonic inflammation and promoted intestinal mucosal repair by upregulating C-type lectin receptor (CLR)-related genes and signaling pathways. Furthermore, CuS/DSF/EL/PVP showed potential for improving colitis Th1/Th17 cells through innate immunity stimulation, down-regulation of inflammatory cytokines, and upregulation of anti-inflammatory cytokines. Additionally, the intervention with CuS/DSF/EL/PVP led to increased intestinal flora diversity, decreased Escherichia–Shigella abundance, and elevated levels of short-chain fatty acid (SCFA)-producing bacteria Prevotella, Lactobacillus , and Bifidobacterium , indicating their potential to modulate the dysregulated intestinal flora and suppress inflammation. Statement of Significance Our study introduces the CuS/DSF/EL/PVP nanoplatform as a therapeutic strategy for treating inflammatory bowel disease (IBD). This approach demonstrates significant efficacy in targeting the colon and alleviating acute colitis in mice. It uniquely modulates gut immunity and microbiota, exhibiting a notable impact on inflammation-related cytokines and promoting intestinal mucosal repair. The nanoplatform's ability to regulate gut flora diversity, combined with its cost-effective and scalable production, positions it as a potentially transformative treatment for IBD, offering new avenues for personalized medical interventions.
研究领域:
药学
·
纳米技术
·
胃肠病学
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免疫学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）