COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Shuo Lv,Mingzu Zhang,Jinlin He,Peihong Ni
The separators play a crucial role in ensuring the safety of lithium batteries and greatly affect the electrochemical performance of the battery. However, the weak thermal stability and non-polar surface of commercial polyolefin separators severely restrict the development of the high-performance lithium batteries. In this work, we initially proposed polyamide acid (PAA) nanofiber separator with three monomers through a two-step synthesis method, which was prepared by electrospinning. By controlling different processing temperatures, PAA separators containing different amount of carboxyl groups were obtained. PAA separator had better wettability and thermal stability than PE separator. Meanwhile, the electrospinning method brings ultra-high porosity (95.3 %) to the membrane, resulting a much higher electrolyte absorption and retention rate of PAA (initially 3214 %, 240 % at 50 min) compared to PE separator. In particular, carboxyl groups serve as functional groups to provide an electronegative atmosphere, promoting the transport of lithium ion between the anode and cathode, and playing an important role in improving ionic conductivity. Consequently, batteries with PAA-SOH-50 separator showed the best rate charging/discharging performance, maintaining 87.7 % and 73.6 % of its initial capacity at 2.0 C. Moreover, cells with PAA separator exhibited much higher initial discharge capacity (164.3 mAh g −1 ) than that with PE separator (126.8 mAh g −1 ). After 100 cycles at 0.5 C, the PAA nanofiber separator achieved an ultralow attenuation rate of only 0.04 % per cycle, which was less than half of the commercial PE separator (0.10 % per cycle). This work provides a new vision for the development of separator materials, revealing the great influence of functional groups, such as carboxyl groups, on the performance of separators, which provides a strong basis for the further research of high-performance separators.
研究领域:
材料科学
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电化学
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能源存储
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产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
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2024
·
IF 6.3
Fubin Luo,Shuguang Yang,Zhehang Shi,Yingbing Zou,Hongzhou Li
Epoxy-based vitrimers appear as a promising alternative to common epoxy materials. Nevertheless, the possibility of epoxy vitrimers in practical applications is limited by their high flammability. In this study, a novel bio-based casein phosphopeptide chelating zinc (CPP-Zn) is purposely developed, specifically designed to serve as a flame retardant and smoke suppressant for epoxy vitrimer, operating through a condensed phase mechanism. To further enhance the fire safety of epoxy resins, DOPO derivative (DDP) is synthesized through grafting with bio-based itaconate and subsequently used as a synergistic flame retardant in combination with CPP-Zn. DDP exhibits gas phase flame retardant mechanism through the release of free radical scavangers generated during combustion. As a result of the combination of condensed and gas phase effect, the composite achieves self-extinguishing within 1 second, attains a V-0 rating in UL-94 testing, and boasts an LOI of 32.3 %. Additional, it shows a remarkable 73.7 % reduction in heat release rate (HRR) and 27.2 % in total smoke production (TSP) compared with neat epoxy vitrimer. The experimental results also evidence that the characteristic features of vitrimers, self-healing and recyclability, have been retained in the prepared flame-retarded composites. The remolded 50D/EST-25Cz is still able to maintain 72.2 % of its tensile strength . This opens promising avenues for the development of highly fire-safe and eco-friendly epoxy resins.
研究领域:
材料科学
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化学工程
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消防安全工程
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环境科学
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产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
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2024
·
IF 6.3
Tong-Yu Bai,Xiang-Xin Xiao,Guan-Qi Zheng,Qin Zhang,Zi-Ni Wang,Li Chen,Bo-Wen Liu,Yu-Zhong Wang
Polycarbonate is a widely used engineering plastic material, but its limited flame retardancy has restricted its application in high-end fields such as aviation and railways. In this study, we propose a novel copolymerization/macromolecular blending strategy to produce a high-performance, fire-safe polycarbonate composite. By copolymerizing with polydimethylsiloxane oligomer and blending with macromolecular polyarylate, the resulting PC-BPDMS 5 /PITR successfully achieved a UL-94 V-0 rating and a high limiting oxygen index value of 34.2%. The peak heat release and total smoke release were significantly reduced by 45.2% and 27.4%, respectively, compared to pure PC. SEM, Raman, and XPS analyses confirmed the condensed-phase dominated flame-retardant mechanism, attributed to the char-forming ability of the polyarylate and polydimethylsiloxane segments. Polydimethylsiloxane segments can decompose to produce small molecules such as methane, and the left structure with silicon, which undergo cross-linking reactions with the substrate during combustion to promote char formation. The polyaromatic ring structure of PITR can also participate in the formation of a dense and stable char layer. The excellent compatibility between the polyarylate and the PC matrix, combined with the superior flexibility of polydimethylsiloxane, allowed the composite to maintain mechanical properties comparable to pure PC. Additionally, the increased molar volume resulted in a low dielectric constant for PC-BPDMS 5 /PITR. This work presents a promising approach for the development of high-performance polycarbonate composites.
研究领域:
材料科学
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聚合物化学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Shuting Zhang,Hong Zhou,Xuan Chen,Shasha Zhu,Dan Chen,Dan Luo,Siyuan Chen,Wei Liu
Although topical application of minoxidil is a widely used, FDA-approved therapy for androgenetic alopecia (AGA) treatment, it suffers from low bioavailability, the requirement for frequent long-term use, and side effects. With a similar structure as minoxidil, kopexil and kopyrrol are less toxic and have been commercialized, but show an inferior hair regeneration effect compared to minoxidil. Herein, we developed a hyaluronic acid (HA)-based dissolvable microneedles (MNs) delivery platform integrated with kopexil and kopyrrol coencapsulated nanoliposomes (KK-NLPs) to effectively and safely treat AGA. Facilitated by nanoliposomes and MNs, the encapsulated KK-NLPs performed efficient skin penetration and enhanced cellular internalization into human dermal papilla cells. Furthermore, within the target cells, the codelivered kopexil and kopyrrol show synergistic effects by orchestrating an upregulation in the expression of Ki67, β-catenin, vascular endothelial growth factor (VEGF), and CD31. These molecular responses collectively foster cell proliferation, migration, and antioxidative effects, thereby facilitating the expedited progression of hair follicles (HFs) into the anagen phase and promoting peripheral angiogenesis. Notably, the KK-NLPs-integrated MNs treatment group exhibits noteworthy enhanced hair regeneration in vivo, with identical or superior therapeutic effects at a much lower dosage than that of minoxidil. These results suggest the great potential of this kopexil and kopyrrol codelivery nanoliposomes-integrated MNs platform for AGA treatment in a safe and efficient way.
研究领域:
药学
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纳米技术
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皮肤科
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Jingyan Huang,Chong Xu,Jia Wang,Zengjie Fan,Lei Xu,Yu He,Xingyu Zhang,Bing Ding,Xiaogang Zhang
Compared to liquid electrolytes, gel polymer electrolytes (GPEs) offer enhanced safety and represent an up-and-coming option for high-energy–density lithium metal batteries (LMBs). However, several challenges hindered the practical application of GPEs for LMBs, such as low ionic conductivity at room temperature, decomposition at high voltage, and poor interfacial compatibility with lithium anode. In this study, a non-flammable fluorinated GPE was synthesized using 2,2,2-trifluoroethyl acrylate (TFEA) and ethoxylated trimethylolpropane triacrylate (ETPTA) as precursor materials, with succinonitrile (SN) incorporated as a plasticizer and a dual-salt system of lithium bis(trifluoro-methane) sulfonimide and lithium difluoroxalate borate. Notably, the as-prepared GPE exhibits a high ionic conductivity of 1.33 mS cm −1 at 30 °C, an electrochemical stability window of 5.15 V ( vs . Li + /Li), and excellent interfacial compatibility with the high-nickel LiNi 0.93 Co 0.035 Mn 0.035 O 2 (NCM-93) cathode and lithium metal anode. Consequently, the Li|NCM-93 cells demonstrated outstanding cycling stability at a cutoff voltage of 4.3 V at room temperature as well as exceptional safety performances under high-temperature conditions and intense radiation conditions. Furthermore, the fluorinated GPE effectively suppresses the gas generation from high-nickel cathode materials and inhibits the growth of lithium dendrites on the anode. This work offers a novel avenue for developing safe and high-voltage solid-state LMBs for working in harsh environments.
研究领域:
材料科学
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能源存储技术
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产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
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2023
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IF 8
Conglian Yang,Tingting Wu,Yuting Qin,Yan Qi,Yu Sun,Miao Kong,Xue Jiang,Xianya Qin,Yaqi Shen,Zhiping Zhang
Background Doxorubicin (DOX) is an effective chemotherapeutic agent but severe side effects limit its clinical application. Nanoformulations can reduce the toxicity while still have various limitations, such as complexity, low drug loading capability and excipient related concerns.Methods An amphiphilic conjugate, doxorubicin-dichloroacetate, was synthesized and the corresponding nanoparticles were prepared. The in vitro cytotoxicity and intracellular uptake, in vivo imaging, antitumor effects and systemic toxicities of nanoparticles were carried out to evaluate the therapeutic efficiency of tumor.Results Doxorubicin-dichloroacetate conjugate can self-assemble into nanoparticles with small amount of DSPE-PEG2000, leading to high drug loading (71.8%, w/w) and diminished excipient associated concerns. The nanoparticles exhibited invisible systemic toxicity and high maximum tolerated dose of 75 mg DOX equiv./kg, which was 15-fold higher than that of free DOX. It also showed good tumor targeting capability and enhanced antitumor efficacy in murine melanoma model.Conclusion This work provides a promising strategy to simplify the drug preparation process, increase drug loading content, reduce systemic toxicity as well as enhance antitumor efficiency.
研究领域:
药剂学
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肿瘤学
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纳米医学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
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2021
·Vol. 9
·期 6
·1546-1556
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IF 6.331
Junmei Tang,Sihao Liu,Yuemei Han,Rui Wang,Jiayi Xia,Hao Chen,Quankui Lin
Posterior capsular opacification (PCO) is an emerging complication in cataract phacoemulsification and intraocular lens (IOL) implantation surgery, mainly stemming from the adhesion, proliferation, and trans-differentiation of the post-surgery residual lens epithelial cells (LECs). Previous investigations have shown that an anti-proliferative drug eluting coating on the IOL surface provides an effective way to inhibit PCO. However, due to the undesirable elution of the anti-proliferative drug, the safety of such modification is one of the important issues to be solved. In this investigation, photodynamic coating was introduced into IOL surface modification. The photosensitizer chlorin e6 grafted α-cyclodextrin (α-CD-Ce6) was synthesized and self-assembled onto the poly(poly(ethylene glycol) methacrylate) (PPEGMA) brush established IOL surface via the supramolecular interaction between α-CD and poly(ethylene glycol) chains. The results of investigation into its optical properties, including transmittance, refractive index, and surface morphology, showed no obvious alterations after photodynamic coating modification on the IOL surface. The in vitro LEC behaviour investigation optimized the photodynamic therapy parameters when light illumination was used for the cell elimination on the photodynamic coating modified IOL. The results have also shown that this functional coating modification effectively eliminates the cells on the surface of the IOL material when treated with light illumination, whereas it keeps excellent cytocompatibility in the absence of light illumination. The investigation of the cell elimination mechanism shows that this kind of functional coating eliminates the adherent cells by ROS induced apoptosis. The in vivo implantation result confirms the excellent PCO inhibition effect, as well as their safety and biocompatibility to the surrounding tissues. As a result, the proposed photodynamic coating provides a safer and effective alternative of IOL modification for preventing PCO.
研究领域:
眼科学
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
Chemistry-An Asian Journal
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2013
·Vol. 9
·期 3
·790-796
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IF 4.572
Yang Zhao,Yingchun Zhu,Jingke Fu,Lianzhou Wang
Graphical Seeds of success : After accumulation in tumors and endocytosis to lysosomes, mesoporous silica nanoparticles with internal hydrophobic mesopores can act as bubble nucleation seeds responding to low-intensity ultrasound. This drastically amplifies the ultrasonic cavitation effect, a process that can disrupt the lysosomal membrane and release lysosomal proteases, thus leading to cell necrosis. β-Cyclodextrin (β-CD)-capped mesoporous silica nanoparticles with hydrophobic internal nanovoids were prepared and used for effective cancer cell killing in synergistic combination with low-energy ultrasound (≤1.0 W cm −2 , 1 MHz). The water-dispersible nanoparticles with hydrophobic internal nanovoids can be taken up by cancer cells and subsequently evoke a remarkable cavitation effect under irradiation with mild low-energy ultrasound (≤1.0 W cm −2 , 1 MHz). A significant cancer cell killing effect was observed in cancer cells and in a mouse xenograft tumor model treated with the nanoagents together with the low-energy ultrasound, showing a distinct dependence on the concentration of nanoagents and ultrasound intensity. By contrast, an antitumor effect was not observed when either low-energy ultrasound or nanoagents were applied alone. These findings are significant as the technique promises a safe, low-cost, and effective treatment for cancer therapy.
研究领域:
纳米技术
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肿瘤学
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生物医学工程
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治疗学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Xinyu Mai,Zheng Bai,Yun Ji,Ming Jin,Yihui Liu,Rui Cao,Long Chen,Chunzhong Li
Sodium-ion batteries (SIBs) have emerged as a promising alternative to lithium-ion batteries (LIBs); yet the simultaneous achievement of long cycle life, a wide operating temperature range, and high safety remains a critical challenge. Herein, we exploit the unique ring-opening polymerization behavior of ethoxy (pentafluoro) cyclotriphosphazene (PFPN) in a methyl acetate (MA) based electrolyte to construct an inorganic-polymeric homogeneous mixed interface. Furthermore, the flame-retardant PFPN preferentially interacts with MA molecules rather than Na + , facilitating desolvation and endowing the electrolyte with excellent low-temperature performance and fast-charging capability. The designed electrolyte enables hard carbon (HC) anodes and Na 4 Fe 3 (PO 4 ) 2 P 2 O 7 (NFPP) cathodes to exhibit stable cycling over 1,000 cycles. Notably, the NFPP cathode delivers a high specific capacity of 100.4mAh g −1 at an ultrahigh rate of 20C. Moreover, the commercial NFPP||HC pouch cell retains 87.4 % of its initial capacity after 1,200 cycles, and even 80 % at − 20 °C. The commercial NaNi 1/3 Fe 1/3 Mn 1/3 O 2 (NFM)||HC high-voltage pouch cell achieves a capacity retention of 91.9 % after 400 cycles. This study clarifies the unique interfacial chemistry of cyclophosphazene-based additives in ester-based electrolytes and provides a practical strategy for designing high-performance electrolytes for SIBs.
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zhangkuo Han,Shusen Zhou,Di Jiang,Jiahan Zheng,Huiying Hao,Jie Xing,Jingjing Dong,Hao Liu,Libing Liao
A mineral-dominant dual-clay solid electrolyte was developed. • Dual-clay functional division enables a rigid-flexible electrolyte architecture. • Confined DMSO and the negatively charged Mnt interlayers induce a weak-solvation-like Li + transport state. • The electrolyte delivers improved safety, interfacial kinetics, and cycling stability. Developing solid electrolytes that combine high ionic conductivity, robust mechanical stability, and fast interfacial kinetics is critical for safe lithium metal batteries, yet these requirements are rarely met simultaneously in conventional polymer- or inorganic-dominant systems. Herein, we report a mineral-dominant dual-clay composite solid electrolyte (DCCSE, >50 wt% mineral content), in which montmorillonite serves as the continuous ion-transport phase, attapulgite acts as the rigid reinforcing framework, and their functional division enables a rigid-flexible integrated electrolyte architecture. Through a one-step organic-inorganic synergistic modification strategy, Na + /Li + exchange in montmorillonite is coupled with the replacement of native interlayer water by dimethyl sulfoxide, thereby constructing a Lithium bis (trifluoromethanesulfonyl)-imide−dimethyl sulfoxide modified montmorillonite transport channel. Structural characterization and molecular dynamics simulations reveal that the negatively charged interlayer environment of montmorillonite, together with interlayer DMSO, enlarges the interlayer spacing, lowers the Li + migration barrier, and induces a weak-solvation-like transport state by suppressing TFSI − participation and reconstructing the local coordination of Li + . As a result, DCCSE delivers an ionic conductivity of 2.1 × 10 −4 S cm −1 , an activation energy of 0.48 eV, a Li + transference number of 0.64, and an electrochemical stability window of 4.5 V at 60 °C, together with significantly enhanced mechanical strength, thermal stability, and flame retardancy. Li|Li symmetric cells stably cycle for over 1700 h at 0.1 mA cm −2 , while LFP|DCCSE|Li full cells retain 94.1% of their capacity after 500 cycles at 0.5C. This work proposes a new design concept for solid electrolytes based on the synergistic functional division of dual clays and confined-solvation regulation within minerals, providing a new design paradigm for constructing low-cost, highly safe, and mechanistically tunable solid-state lithium metal battery electrolytes from natural minerals. Download: Download high-res image (279KB) Download: Download full-size image
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DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2020
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IF 5.715
Jie Li,Lanjia Pan,Guangwei Yu,Chunxing Li,Shengyu Xie,Yin Wang
Utilization of sludge pyrochar (SP) is the terminal step to loop the entire harmless disposal process of sewage sludge with pyrolysis . A new, easily recyclable, and safe adsorbent with well-immobilized heavy metals (HMs) was prepared from SP for ciprofloxacin (CIP) adsorption. The operational conditions for the adsorbent preparation were systematically optimized based on recycling rate and adsorption performance. Additionally, the adsorption conditions, adsorption kinetics, isotherms, and regeneration of adsorbents were further investigated in the present study. The results showed that easily recyclable and safe adsorbents were successfully prepared at 1100 °C under N 2 atmospheric conditions (SPA-N-1100) with a maximum CIP adsorption capacity of 10.42 mg/g. SPA-N-1100 exhibited good CIP adsorption performance at an adsorption temperature of 45 °C and pH between 8.0 and 9.0. The adsorbents were regenerated by thermal desorption at 450 °C with a thorough decomposition of CIP. The adsorption mechanism was mainly dominated by its special porous microspheres-accumulation structure and surface species (e.g., FeP and graphite). Moreover, HMs in the adsorbents were well immobilized in SPA-N-1100 by the generation of new metal mineral phases and encapsulation of melting minerals, which had an ultralow potential for ecological risk during application.
研究领域:
环境科学
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化学工程
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水处理
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产品关联
DOI
PubMed
高影响因子
RSC Advances
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2018
·Vol. 8
·期 22
·12315-12321
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IF 2.936
Lixian Xu,Di Wu,Bingrong Zhou,Yang Xu,Wenjuan Wang,Dinghua Yu,Dan Luo
Sunscreen is believed to protect human skin from photo damage due to UV exposure. However, substantial concerns remain associated with skin contact with UV filters and the subsequent reactive oxygen species from photoactivation of UV filters. Herein, we show that the microencapsulation of octyl p-methoxycinnamate (OMC), a typical UV filter, into the nanoporous structure of zeolitic imidazole frameworks (ZIF-8) prevents the skin exposure to UV filters while improving UV protection performance. Meanwhile, the UV filter photostability has been obviously improved due to the nanoconfinement effect. Microencapsulated OMC in ZIF-8 adhered to the stratum corneum could not only reduce OMC transdermal penetration, but also prevent skin exposure to the deleterious reactive oxygen species (ROS) from photoactivation of OMC. Therefore, this microencapsulated UV filter system based on a metal organic frameworks microporous polymer would find important applications in skin care products through providing safe and effective UV protection.
研究领域:
材料科学
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皮肤病学
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）