LWT-FOOD SCIENCE AND TECHNOLOGY
·
2022
·
IF 6.056
Tianfeng Han,Hui Xue,Xiaobo Hu,Ruiling Li,Huilan Liu,Yonggang Tu,Yan Zhao
In this paper, the effects of NaOH, NaCl, and heat on the appearance, physical characteristics, and gel structure of duck egg white (EW) jointly induced by NaOH, NaCl, and heat were investigated. Results showed that the absolute value of zeta potential (TAV-ZP) of gel samples increased, hunter whiteness decreased, gel opacity decreased, and the microstructure of gel appeared as a loose network structure with increased NaOH addition. With the increase of NaCl addition, TAV-ZP of gel samples decreased, hunter whiteness increased, gel opacity increased, the microstructure of gel became dense. With the increase of heating temperature, TAV-ZP of gel samples decreased, hunter whiteness decreased, gel opacity increased, the microstructure of gel became dense first and then loosened. The results of SDS-PAGE, surface hydrophobicity, T 2 , hardness, cohesiveness indicated that protein molecules underwent cross-linking, aggregation, and unfolding during duck EW gelation jointly induced by NaOH, NaCl, and heat. The results of strain-stress curve showed that all gel samples had a good anti-compressed ability. The results of central composite design showed that the best treatment of gel was heating temperature 91 °C, NaOH 0.48%, and NaCl 0.3%.
研究领域:
食品科学
·
化学
·
生物物理学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
·
IF 5.268
Bao Jiang,Liping Wang,Gang Wu,Lin Zhou,Shaohua Wei
The chemodynamic therapy (CDT) effect is restricted by the neutral pH environment in the tumor, also, the protein corona formed on the surface of the CDT catalyst reduces its activity. Here, we synthesized a core-shell CDT drug consisting of Fe/Fe 3 C core and mesoporous graphite carbon shell with biotin modification (denoted FeCNB). The shell and core form a galvanic cells in the physiological electrolyte solution to achieve high-efficiency CDT under physiological pH conditions. The mesoporous in the shell effectively separates the protein corona from the Fe/Fe 3 C, avoiding the influence of the protein corona on the catalyst. However, the mesoporous is permeable for the substrate and product of the catalytic reaction . FeCNB also has T2-magnetic resonance imaging (MRI) function and photothermal conversion ability under 808 nm laser irradiation. The tumor heating further improves the CDT effect to achieve a satisfactory synergistic photothermal therapy (PTT)/CDT outcome. In addition, FeCNB degrades in the microenvironment to ensure its excellent biocompatibility. It is the first study of CDT drug design and fabrication based on the mechanism of the galvanic cells.
研究领域:
癌症治疗
·
材料科学
·
生物医学工程
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Drug Delivery and Translational Research
·
2023
·Vol. 14
·期 2
·555-570
·
IF 5.4
Huang Jian,Wang Zhengji,Chen Zihe,Huang Chunxin,Wang Ying,Li Xing,Lv Weiyang,Qi Guiqiang,Liu Huilin
Celastrol (CST) has positive pharmacological effects on various cancers, but clinical application is limited because of poor water solubility and systemic toxicity. Ferric oxide (Fe 3 O 4 ) has a large specific surface area and can be functionalized by inorganic modification to form complex magnetic drug delivery systems. Herein, Fe 3 O 4 was surface-modified with citric acid and polyethylene glycol (PEG) (via) the Mitsunobu reaction and then covalently bound to CST. Finally, magnetic microbubbles (MMBs) containing perfluoropropane (C 3 F 8 ) and Fe 3 O 4 -PEG 2K -CST particles were constructed with poly(lactic-co-glycolic acid) (PLGA) as the shell membrane. In vitro studies showed that ultrasound-mediated MMBs exhibited improved inhibition of VX2 cell proliferation compared to inhibition achieved using MMBs without ultrasound mediation, blank MMBs, or free CST. In ultrasound mode, MMBs have favorable imaging properties. After the application of a high mechanical index, MMBs collapse through the cavitation effect, releasing their internal Fe 3 O 4 -PEG 2K -CST. The CST is then delivered to the tumor microenvironment under acidic conditions. In magnetic resonance imaging T2 mode, a specific hypointense signal was observed in the tumor area compared with that before treatment, whereas no significant change occurred in the signal intensity of the surrounding organs. After treatment, pathological examination of tumor-bearing rabbit tissues showed that iron elements accumulated in several apoptosis cells in the tumor area, with no apparent abnormalities found in other areas. Thus, ultrasound-mediated MMBs could significantly improve the drug uptake of solid tumors and inhibit tumor growth with favorable biological safety. Graphical Abstract
研究领域:
药理学
·
纳米技术
·
肿瘤学
·
生物医学工程
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2013
·Vol. 3
·期 33
·13915-13925
·
IF 2.562
Leyong Zeng,Lingchao Xiang,Wenzhi Ren,Jianjun Zheng,Tianhua Li,Bin Chen,Jichao Zhang,Chengwen Mao,Aiguo Li,Aiguo Wu
Due to non-invasive deep imaging and therapy, multifunctional agents of magnetic resonance (MR)/upconversion luminescence (UCL) imaging and photodynamic therapy (PDT) play an important role in clinical diagnosis and treatment of cancers, and also in the assessment of therapy effect. In this paper, tetra-sulfonic phthalocyanine aluminium (AlPcS4) photosensitizers-conjugated Fe3O4@NaYF4:Yb/Er (NPs-AlPcS4) nanocomplexes were synthesized for the T2-weighted MR/UCL imaging and PDT of cancer cells. The PEG-coated Fe3O4@NaYF4:Yb/Er nanoparticles (NPs) with a core–shell structure showed strong T2-weighted MR relaxivity (r2 = 42.131 mM−1 s−1) and UCL emission in the visible region (the bands at about 654–674 nm, 545 nm and 524 nm), and were conjugated successfully with AlPcS4 photosensitizer by electrostatic interaction. By direct observation of XFM and staining with Prussian blue, the element distribution and location of NPs in MCF-7 cells were characterized, respectively. Under irradiation from a 980 nm laser, the death ratio of MCF-7 cells incubated with NPs-AlPcS4 nanocomplexes could be up to about 70%. The results indicated that the as-prepared NPs-AlPcS4 nanocomplexes would be a potential candidate as multifunctional nanoprobes for the dual-modal T2-weighted MR/UCL imaging and PDT of cancers in the future.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
·
影像医学
✓ 已验证
DOI
高影响因子
NMR IN BIOMEDICINE
·
2025
·Vol. 38
·期 9
·e70116
·
IF 2.7
Fei-Xiang Hu,Deng-Deng Liu,Xiao-Wen Ma,Pu-Yeh Wu,Wei-Jun Peng,Dan Wang,Tong Tong
This study aims to design and evaluate a two-dimensional Ti 3 C 2 -MXene contrast agent, codoped with iron and manganese, with the aim of achieving T 1 /T 2 dual-mode magnetic resonance imaging contrast, and to investigate its effect on Chemical Exchange Saturation Transfer (CEST) contrast agents. Single-layer Ti 3 C 2 was synthesized via the HCL/LiF etching technique, with the flake size subsequently tailored and the hydroxylated surface modified through a hydrothermal process. Fe 3 O 4 nanoparticles and MnO 2 nanosheets were integrated onto the two-dimensional Ti 3 C 2 -MXene surface using an in situ doping approach, and the final modification was achieved with carboxymethyl chitosan. Various characterization techniques were employed to assess the physical and chemical properties of the probe, which were then combined with a CEST contrast agent to investigate the mechanisms of multimodal magnetic resonance imaging and in vitro photothermal effects. Upon integrating the multi-modal molecular probe with Ioversol for imaging purposes, at a magnetic field strength of B 1 = 1.25 μT and with a molecular probe concentration of 0.5 mg/mL, the CEST signal from Ioversol is almost entirely suppressed. This allows for the successful identification of a distinct concentration range where both contrast agents can coexist. In vitro photothermal studies on MXene codoped with iron and manganese have shown that the composite molecular probe exhibits excellent photothermal efficiency. The method combining complex nanoprobes with CEST contrast agents successfully achieved simultaneous imaging of both contrast agents. In vitro MRI experiments successfully obtained distinguishable concentration ranges for both, with changes in CEST signals reflecting the concentration variations of the complex molecular probes, which also exhibit good photothermal therapy (PTT) capabilities.
研究领域:
纳米材料
·
磁共振成像
·
对比剂
·
多模态成像
·
光热治疗
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 8
·期 6
·1202-1211
·
IF 5.047
Kecan Lin,Yanbing Cao,Dongye Zheng,Qin Li,Hui Liu,Peiwen Yu,Jiong Li,Yanan Xue,Ming Wu
The development of nanotheranostic agents integrating diagnosis and therapy has gained tremendous attention in the past few decades, but many of them are inherently hydrophobic and need complicated phase-transfer and tedious surface modifications. This work proposed a facile method of transferring hydrophobic Fe3O4@Cu2−xS nanoparticles from oil to water by using red blood cell membrane to create theranostic nanobeads for T2-weighted MRI and second near-infrared photothermal ablation. The obtained nanoplatform, namely SCS@RBCM, showed a core–shell structure with the inner core densely packed with Fe3O4@Cu2−xS nanoclusters and the surface coated with a layer of RBCM. SCS@RBCM displayed a stable nanostructure, high NIR II light absorption and photothermal conversion ability, T2-weighted MR imaging and magnetic field targeting ability. Meanwhile, the RBCM cloaking endowed SCS with reduced elimination by macrophages. With the navigation of an external magnetic field (MF), the tumor accumulation of SCS@RBCM was dramatically increased, thus achieving good performance of MR imaging and antitumor efficacy through the PTT effect under NIR II irradiation. Therefore, our strategy presents a new and desirable paradigm in the phase-transfer of hydrophobic nanotheranostics for optimizing their biomedical performance.
研究领域:
生物医学工程
·
材料科学
·
纳米技术
·
癌症治疗
·
医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Jingyi Wu,Qianqian Wang,Zhuang Deng,Shuo Zhang,Zhen Jiao
A novel drug nanocarrier with a magnetic core and an organic framework (MOF) shell was constructed by in situ growth of a three-dimensional network ZIF-8 on the surface of carboxy-functionalized Fe3O4. The resulting drug delivery system (DDS) showed strong superparamagnetism, boasting exceptional magnetization saturation at 11.15 emu/g, an impressive magnetocaloric effect of a temperature rise of 12.9 °C within 6 minutes at 20 A, and a significant T2-weighted MR image property. The drug encapsulation ability was investigated by loading a model drug namely curcumaol (CUR) onto the nanocarriers through supercritical solution impregnation (SSI) technology. The resulting Fe3O4@ZIF-8-CUR achieved a maximum loading content of 2.2 wt%, displaying 3.4 times higher than that using ethanol impregnation process. As expected, a continuous drug release behavior of Fe3O4@ZIF-8-CUR was observed. This study presents a state-of-the-art methodology of designing biocompatible DDSs with magnetic responsiveness for advanced drug delivery applications.
研究领域:
材料科学
·
纳米技术
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Bioactive Materials
·
2020
·
IF 8.724
Gaofeng Shu,Minjiang Chen,Jingjing Song,Xiaoling Xu,Chenying Lu,Yuyin Du,Min Xu,Zhongwei Zhao,Minxia Zhu,Kai Fan,Xiaoxi Fan,Shiji Fang,Bufu Tang,Yiyang Dai,Yongzhong Du,Jiansong Ji
Hepatic cancer is a serious disease with high morbidity and mortality. Theranostic agents with effective diagnostic and therapeutic capability are highly needed for the treatment of hepatic cancer. Herein, we aimed to develop a novel mesoporous polydopamine (MPDA)-based theranostic agent for T1/T2 dual magnetic resonance imaging (MRI)-guided cancer chemo-photothermal therapy. Superparamagnetic iron oxide (SPIO)-loaded MPDA NPs ( [email protected] ) was firstly prepared, followed by modifying with a targeted molecule of sialic acid (SA) and chelating with Fe 3+ ( [email protected] /Fe 3+ NPs). After that, doxorubicin (DOX)-loaded [email protected] /Fe 3+ NPs ( [email protected] /DOX/Fe 3+ ) was prepared for tumor theranostics. The prepared [email protected] /Fe 3+ NPs were water-dispersible and biocompatible as evidenced by MTT assay. In vitro photothermal and relaxivity property suggested that the novel theranostic agent possessed excellent photothermal conversion capability and photostability, with relaxivity of being r 1 = 4.29 mM −1 s −1 and r 2 = 105.53 mM −1 s −1 , respectively. [email protected] /Fe 3+ NPs could effectively encapsulate the DOX, showing dual pH- and thermal-triggered drug release behavior. In vitro and in vivo studies revealed that [email protected] /DOX/Fe 3+ NPs could effectively target to the hepatic tumor tissue, which was possibly due to the specific interaction between SA and the overexpressed E-selectin. This behavior also endowed [email protected] /DOX/Fe 3+ NPs with a more precise T1-T2 dual mode contrast imaging effect than the one without SA modification. In addition, [email protected] /DOX/Fe 3+ NPs displayed a superior therapeutic effect, which was due to its active targeting ability and combined effects of chemotherapy and photothermal therapy. These results demonstrated that [email protected] /DOX/Fe 3+ NPs is an effective targeted nanoplatform for tumor theranostics, having potential value in the effective treatment of hepatic cancer.
研究领域:
医学影像学
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2025
·Vol. 54
·期 30
·11601-11606
·
IF 3.3
Guansong Zheng,Wang Zhao,Xiaoyu Wu,Hongshan Wang,Yinxia Du,Juanjuan Lu,Xiao-dong Zhou,Junjie Li
Chalcohalides, combining the structural and property advantages of chalcogenides and halides, have been demonstrated to be a promising system for the design of advanced photoelectric functional materials. Herein, a new chalcohalide compound, Cs9Si8Se20Cl, has been rationally designed by introducing a nonlinear optical (NLO)-active [Si4Se10] T2-supertetrahedral unit into a halide system and synthesized experimentally by the flux method with CsCl as the flux. The compound is composed of [CsSe7Cl] polyhedral, [CsSe6] octahedral, and [Si4Se10] T2-supertetrahedral units. To the best of our knowledge, the [CsSe7Cl] mixed anionic unit appears for the first time in the compound, and the rare [Si4Se10] T2-supertetrahedral unit has been demonstrated to be a potential NLO-active unit for the design of infrared NLO materials with balanced optical properties. The theoretical calculations uncovered that the strong orbital hybridization between Si-3p, Se-4p and Cl-3p orbitals results in a wide band gap of 3.075 eV in the title compound. The results enrich the structural diversity of chalcohalide compounds and provide valuable insights into the design of wide band gap selenides.
研究领域:
材料化学
·
无机化学
·
光学材料
·
固态化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xinyu Zhang,Hui Liu,Chenyu Wang,Yuan Gao,Shiqi Zhao,Mengyao Mu,Ke Ren,Yufang Gong,Qing Fan,Xiao Sun
Biodegradable Two-dimensional (2D) nanomaterials have attracted tremendous interest in biomedical application. Herein, a biodegradable ferrous sulfide nanosheet with ultrathin structure and uniform size was developed. Following its development, the application of the self-enhanced photothermal nanoplatform (FMPN) in vivo by combining Mn-DOTA and dimeric PD-L1 affibody for targeted dual-mode magnetic resonance imaging (MRI) guided synergistic tumor therapy is explored. Dual-contrast enhanced subtraction imaging (DESI) was used to evaluate the excellent T1-T2 MRI ability of FMPN. FMPN displayed excellent photothermal conversion efficiency (η = 40.33 %) and biodegradability, thus had good tumor photothermal therapy effects with good biosafety. In addition, FMPN with pH-responsive Fe 2+ release can effectively induce tumor cell ferroptosis, further intensifying PTT and subsequent immunologic cell death. PD-L1 affibody could endow this nanoplatform with efficient tumor targeting, terminating T cells’ immune suppression by effectively blocking the interaction between PD-1 and PD-L1. Systemic delivery of FMPN significantly inhibited tumor progression in primary, metastatic and abscopal tumors, and showed obvious dual-mode MRI enhancement. Therefore, this nanoplatform exhibited promising potential for MRI-guided synergistic ferroptosis/photothermal/immunotherapy.
研究领域:
纳米技术
·
生物医学工程
·
肿瘤学
·
分子影像
·
诊疗一体化
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2014
·
IF 8.312
Ziyong Cheng,Yunlu Dai,Xiaojiao Kang,Chunxia Li,Shanshan Huang,Hongzhou Lian,Zhiyao Hou,Pingan Ma,Jun Lin
A facile method for transferring hydrophobic iron oxide nanoparticles (IONPs) from chloroform to aqueous solution via encapsulation of FITC-modified gelatin based on the hydrophobic–hydrophobic interaction is described in this report. Due to the existence of large amount of active groups such as amine groups in gelatin, the fluorescent labeling molecules of fluorescein isothiocyanate (FITC) and platinum (IV) prodrug functionalized with carboxylic groups can be conveniently conjugated on the IONPs. The nanoparticles carrying Pt(IV) prodrug exhibit good anticancer activities when the Pt(IV) complexes are reduced to Pt(II) in the intracellular environment, while the pure Pt(IV) prodrug only presents lower cytotoxicity on cancer cells. Meanwhile, fluorescence of FITC on the surface of nanoparticles was completely quenched due to the possible Förster Resonance Energy Transfer (FRET) mechanism and showed a fluorescence recovery after gelatin release and detachment from IONPs. Therefore FITC as a fluorescence probe can be used for identification, tracking and monitoring the drug release. In addition, adding pancreatic enzyme can effectively promote the gelatin release from IONPs owing to the degradation of gelatin. Noticeable darkening in magnetic resonance image (MRI) was observed at the tumor site after in situ injection of nanoparticles, indicating the IONPs-enhanced T 2 -weighted imaging. Our results suggest that the gelatin encapsulated Fe 3 O 4 nanoparticles have potential applications in multi-functional drug delivery system for disease therapy, MR imaging and fluorescence sensor.
研究领域:
纳米技术
·
药学
·
生物医学工程
·
癌症研究
·
磁共振成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2019
·
IF 4.511
Chao Wang,Xiaodan Jia,Wenyao Zhen,Mengchao Zhang,Xiue Jiang
In this article, a type of small-sized metal organic framework (MOF), MIL-101(Fe), as an intelligent delivery system was fabricated to load chemotherapy drug dihydroartemisinin (DHA) and photosensitizer methylene blue (MB). In addition, the Fe ions releasedfrom the MOFs in the tumor environment not only enhanced the curative effect of DHA but also catalyzed H2O2 to release O2, which further improved the photodynamic therapeutic effect of the nanocomposites. The nanocomposites can serve as a T2 magnetic resonance imaging contrast agent at the same time. The polylactic acid (PLA) and polyethylene glycol (PEG) were used to modify the surface of MOFs-MB-DHA to acquire the excellent controllable release of drugs and good biocompatibility to decrease the side effects for normal cells. All the results show remarkably increase of the therapeutic efficiency by synergistic chemo-photodynamic therapy. Thus, a smart multifunctional drug delivery system for diagnosis and therapy based on MOFs-MB-DHA@PLA@PEG was constructed for not only real-time imaging but also chemotherapy and photodynamic synergetic therapy to kill the tumor selectively, showing great potential for conquering the existing barrier in chemo-photodynamic synergetic therapy.
研究领域:
纳米技术
·
生物医学工程
·
癌症研究
·
材料科学
·
治疗诊断学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）