Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 26
·5128-5136
·
IF 4.543
Yike Fu,Heng Liu,Zhaohui Ren,Xiang Li,Jie Huang,Serena Best,Gaorong Han
Photodynamic therapy (PDT) and photothermal therapy (PTT) have been explored widely for application in cancer treatment. In this work, we describe the synthesis of CaTiO3:Yb,Er (CTO) nanofibers co-conjugated with Rose Bengal (RB) and gold nanorods (AuNRs), which offer the potential for combined upconversion photoluminescence (UCPL) and enhanced, synergistic PDT and PTT. Based on this delivery platform, RB and AuNRs served as the PDT and PTT agents, respectively. RB and AuNRs have strong and well-matched absorption with the green and red emissions of UCPL CTO nanofibers respectively, hence a single 980 nm continuous wave laser with deep tissue penetration can be employed to allow PDT and PTT to occur simultaneously. The nanocomposite can effectively convert the near-infrared (NIR) radiation from the laser into a combination of targeted hyperthermia and generation of reactive oxygen species (ROS). In comparison with PDT or PTT alone, the combined PDT/PTT treatment showed significantly enhanced suppression of the viability of Hep G2 cells in vitro, demonstrating its potential for use in oncology.
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Journal of Physical Chemistry C
·
2018
·
IF 4.484
Raheel Ahmed Janjua,Chan Gao,Rucheng Dai,Zhilei Sui,Muhammad Aqeel Ahmad Raja,Zhongping Wang,Xianxu Zhen,Zengming Zhang
Ultrasmall pure hexagonal phase NaYF4:Yb,Er is successfully prepared via the solvothermal method. The upconversion (UC) luminescence of hexagonal phase NaYF4:Yb,Er nanocrystals is ten times stronger than that of cubic phase nanocrystals with the same size of 6 nm. XRD results reveal that heating above 673 K leads to conversion of the hexagonal phase to the high-temperature cubic phase, whereas the cubic nanocrystals undergo phase transformation from normal cubic at room temperature to hexagonal at 673 K and further to high-temperature cubic above 773 K. The hexagonal nanocrystals exhibit emission enhancement after heat treatment up to 573 K. Further heating above 773 K induces a decreasing trend in emission due to the phase transition to the high-temperature cubic phase. The cubic phase exhibits decreasing luminescence with temperature due to strong cross relaxation and then increasing luminescence above the temperature of 673 K due to the hexagonal phase transformation. The luminescent properties of both the normal cubic phase and high-temperature cubic phase indicate that different crystal fields exist in these two phases due to the rearrangement of ligands around Er3+ at high temperature.
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JOURNAL OF MATERIALS CHEMISTRY
·
2011
·Vol. 22
·期 3
·944-950
·
IF 5.101
Yuan Ren,Min Chen,Linfeng Hu,Xiaosheng Fang,Limin Wu
This paper presents an oil/water interface self-assembly strategy for the fabrication of hydrophobic nanoparticles into mono- and multi-layered nanofilms with NaYF4:Yb,Er nanoplatelets as a prototype. In this approach, hydrophobic β-NaYF4:Yb,Er nanoplatelets dispersed in chloroform solvent are used as the sub-phase, then a certain amount of water is added to produce a chloroform/water interface. When ethanol is added, the up-conversion NaYF4:Yb,Er nanoplatelets are found to readily self-assemble at the oil/water interface into a closely-packed mono- or multi-layer nanofilm with a preferred [001] orientation. Compared with the previous water/oil interface self-assembly strategy, the present method is not only used for fabrication of hydrophobic nanoparticles into high quality nanofilms, but also is environmentally friendly and is safe to the operator.
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Chemistry-An Asian Journal
·
2022
·Vol. 17
·期 14
·e202200161
·
IF 4.839
Bo Ling,Yaguang Wang,Ruo Mi,Di Wang,Hongqi Chen,Xiaohu Li,Ye Zhang,Lun Wang
Graphical NaGdF 4 ,Yb,Er@NaGdF 4 ,Yb,Tm@NaYF 4 core@shell@shell three-layer structure of upconversion nanoparticles coated with Fe−TCPP metal-organic frameworks nanocomposite was designed and constructed for multimodal imaging and synergetic chemodynamic therapy/photodynamic therapy of tumors. Here, NaGdF 4 ,Yb,Er@NaGdF 4 ,Yb,Tm@NaYF 4 core@shell@shell three-layer structure of upconversion nanoparticles (UCNPs) coated with Fe−Tetrakis (4-carboxyphenyl) porphine (TCPP) metal-organic frameworks (Fe-MOFs) nanocomposite (UCNPs@MOFs) was designed and constructed for multimodal imaging and synergetic chemodynamic therapy (CDT)/photodynamic therapy (PDT) of tumors. The UCNPs@MOFs were successfully applied for tumor cells imaging in vitro and in vivo in near-infrared (NIR) region. The doped Gd was used as contrast agent for the magnetic resonance imaging (MRI) of mouse tumors. The luminescence in the UV-vis region was absorbed by the Fe-MOFs to produce singlet oxygen ( 1 O 2 ) for PDT. The Fe 3+ doped in the MOFs can catalyze H 2 O 2 to produce oxygen and hydroxyl radical (⋅OH). Hydroxyl radical is used in CDT and cooperates with the 1 O 2 of PDT. Based on the CDT/PDT synergistic effects, the UCNPs@MOFs nanocomposite had obviously enhanced tumor inhibitory efficiency in vivo. These results described that the asprared UCNPs@MOFs nanocomposite have great potential in the effective multimodal imaging and treatment of tumors.
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高影响因子
CRYSTENGCOMM
·
2021
·Vol. 23
·期 21
·3892-3900
·
IF 3.545
Dandan Ju,Xiaoli Gao,Shouchao Zhang,Yang Li,Wenjing Cui,Yinhui Yang,Mingyan Luo,Shujing Liu
Temperature is one of the physical parameters that affects the emission luminescence properties of upconversion (UC) materials. Temperature-dependent emission color tuning and good temperature sensitivity in multifunctional β-NaYF4:Yb/Er@β-NaYF4:Yb/Tm microcrystals were achieved under 980 nm excitation. Based on the different emission bands (blue, green and red bands) and spectral sensitivities of the core–shell structured microcrystals to temperature, intense white-light emission was obtained at room temperature and a real-time naked-eye recognizable emission color change from white to the purplish-pink region was realized with the temperature increasing from 300 to 500 K. Furthermore, optical temperature sensing properties of the sample with good sensitivity (from 0.0034 to 0.0044 K−1) were investigated by using a fluorescence intensity ratio between 521 nm (2H11/2 → 4I15/2 transition) and 540 nm (4S3/2 → 4I15/2 transition) in the temperature range from 300 to 500 K. The results indicate that the sample has high sensitivity in a relatively wide range of temperature intervals, especially in the low temperature region. We believe that the multifunctional core–shell structured microcrystals exhibit promising applications in white-light emitting diodes, the anti-counterfeiting field, and temperature sensing.
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CRYSTENGCOMM
·
2015
·Vol. 17
·期 31
·5900-5905
·
IF 4.034
Bin-Bin Ding,Kun Liu,Fu Zhang,Yang Wang,Sheng Cheng,Yang Lu,Hai-Sheng Qian
Upconversion fluorescent nanostructures with controlled sizes and morphologies have attracted much attention due to their potential and important applications in bioimaging, photodynamic therapy, solar cells and so on. In this work, we describe a facile successive process to fabricate β-NaGdF4:Yb,Er nanocrystals coated with an ultrathin layer of CaF2 with enhanced upconversion fluorescence and stability. The as-prepared β-NaGdF4:Yb,Er@CaF2 nanoparticles were investigated by X-ray diffraction (XRD), transmission electron microscopy (TEM, JEM 21000), fluorescence spectroscopy (Hitachi High-Technology Corporation, F-2700) and inductively coupled plasma atomic emission spectroscopy (ICP-AES). The as-prepared core–shell nanoparticles show enhanced upconversion fluorescence and superior magnetic resonance (MR) relaxivity. In addition, the as-prepared β-NaGdF4:Yb,Er@CaF2 nanoparticles show enhanced chemical stability after surface functionalization and transfer into aqueous solutions.
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Analytical Methods
·
2017
·Vol. 9
·期 20
·2977-2982
·
IF 1.9
Yuanhui Ma,Liping Zhang,Lei Wang,Lun Wang,Hongqi Chen
A novel surface plasmon resonance (SPR) enhanced upconversion (UC) luminescence system was designed for the detection of α-fetoprotein (AFP) by using gold nanoparticle (NP) coated NaYF4:Yb,Er,Gd upconversion nanoparticles (UCNPs) as probes. The gold NP coated NaYF4:Yb,Er,Gd UCNPs had a strong emission at 665 nm and were modified with poly(acrylic acid) (PAA) before being conjugated with anti-AFP (Ab1). When the AFP antigens were added to the system, the binding affinity between AFP and Ab1 resulted in a reduced distance between the gold NP coated UCNPs. The UC luminescence intensity of this system was enhanced because of the SPR properties of the gold NPs. The sensing system exhibited a high sensitivity, good specificity, and wide linear range, 0.098–15.0 ng mL−1 for the detection of AFP (R = 0.99), with a detection limit as low as 0.095 ng mL−1 under optimal conditions. The method was successfully applied to AFP sensing in human serum samples.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 15
·1145
·
IF 3.2
Mao Tan,Wang Wei,Liu Peilong,Zha Junyan,Bu Xiran,Song Rui,Luo Xueke
To overcome the intrinsic limitations of TiO 2 , specifically its wide band gap and rapid photogenerated carrier recombination, for dyeing wastewater treatment, a Yb 3+ /Er 3+ co-doped TiO 2 -ZnO heterostructure was fabricated by sol–gel method. X-ray diffraction revealed inhibited anatase-to-rutile phase transition. X-ray photoelectron spectroscopy confirmed Ti 2p binding energy shifts, indicating strong electronic interactions between dopants and the host lattice. Ultraviolet–visible diffuse reflectance spectroscopy showed band gap narrowing to 2.927 eV, with upconversion effect extending light absorption to the near-infrared region. Photoluminescence measurements demonstrated suppressed carrier recombination, and XPS confirmed abundant oxygen vacancies. The optimal sample achieved 74.31% methylene blue degradation under visible light for 6 h and 98.58% under ultraviolet light for 2 h, outperforming commercial P25. The Yb 3+ /Er 3+ co-dopants serve dual functions: they act as upconversion centers to harvest low-energy photons and function as electronic modulators that induce Ti 2p binding energy shifts and create oxygen vacancies, thereby enhancing charge separation and surface reactivity. This work integrates rare-earth co-doping with heterojunction engineering to boost TiO 2 photocatalysis.
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ACS Applied Materials & Interfaces
·
2026
·Vol. 18
·期 30
·41290-41310
·
IF 7.8
Weng Tianfeng,Lamon Simone,Gan Zongsong,Gu Min,Zhang Qiming
All-optical data encoding provides a route to ultrafast, low-energy photonic memory and computation, yet its implementation is hindered by weak nonlinearities and low emission efficiencies in conventional materials. Upconversion luminescence offers strong nonlinear behavior, but typical hosts suffer from inefficient energy transfer, dilute and randomly distributed dopants, and complex excitation demands. Here, we report thermally crystallized BaYF 5 :Yb,Er glass-ceramics that overcome low upconversion efficiency and dopant inhomogeneity through controlled Er 3+ enrichment within BaYF 5 nanocrystals. Thermal crystallization reduces interionic distances, promoting cooperative Yb 3+ –Er 3+ sensitization and Er 3+ –Er 3+ energy migration. The combination of theoretical modeling and experiments shows efficient population of high-energy emitting states, yielding ultrabright upconversion emission with enhancement factors of 113-, 118-, and 110-fold for the blue, green, and red channels under 980 nm excitation. Optimized nanocrystals also prolong emission lifetimes, suppress nonradiative relaxation, and produce clear saturation behavior. Leveraging strongly nonlinear responses, power- and pulse-width-modulated excitation enables precise control of both spectral and temporal outputs, forming a highly reconfigurable platform. This allows multidimensional data encoding and implementation of fundamental optical logic gates with high fidelity and self-referenced decoding. The system offers robust, secure, and scalable functionality for advanced all-optical information processing applications.
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高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 42
·15897-15905
·
IF 8.067
Hanchang Huang,Maohui Yuan,Zhongyang Xing,Wenda Cui,Tongcheng Yu,Shuai Hu,Guomin Zhao,Chuan Guo,Kai Han
In lanthanide-sensitized upconversion (UC) nanomaterials, the typical sensitizer Yb3+ can significantly modulate the codoped activator (such as Er3+ ions) to generate multiband transitions. However, the kinetics of these multiband emissions affected by the Yb3+ concentration remains unclear. In this work, we employ nanosecond time-resolved spectroscopy to investigate a single optically trapped NaYF4:Yb/Er microcrystal (MC) doped with different Yb3+ concentrations. Interestingly, high doping Yb3+ ions shorten the UC response time by a factor of 10 (from ∼1 μs to ∼100 ns) compared to low doping Yb3+. Meanwhile, 430 nm light (4G7/2 → 4I11/2) emitted before 654 nm (4F9/2 → 4I15/2) with Yb3+ dramatically increasing (opposite to the normal low Yb3+ doping cases), representing a new four-photon pathway (4I15/2 → 4I11/2 → 4F7/2 → 2H11/2 →4S3/2 → 2G7/2 → 4G11/2 → 2H9/2 → 2D5/2 → 4G7/2). Furthermore, we observed a broad range of time-dependent emission color, changing from being initially green over near-white to red. Particularly, the red emission is dominated in the decay process, yielding insight into the fundamental multiband UC kinetics. The result shows that varying the Yb3+ doping concentration provides a way to control the energy flow between the energy levels of Er3+ ions, which can modulate the response time and color evolution of UC on Yb/Er doped materials. This can direct the prospective development of fast-response optoelectronic devices, photocatalysis, and UC displays in the future.
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CRYSTENGCOMM
·
2020
·Vol. 22
·期 19
·3361-3370
·
IF 3.117
Yini Mao,Li Jiang,Pengfei Xian,Qiongfen Fu,Shanshan Hu,Jun Yang
A graphical abstract is available for this content
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ANALYST
·
2018
·Vol. 143
·期 17
·4199-4205
·
IF 3.864
Jinzha Zhang,Yang Shen,Yuhong Liu,Zaiying Hou,Yuanqing Gu,Wenbo Zhao
A novel electrochemiluminescence (ECL) cytosensor was proposed for the quantitative detection of HeLa cells (human cervical cancer cells) with the help of a signal amplification strategy. Firstly, the Au-NaYF4:Yb,Er nanocomposites were prepared by a simple in situ hydrothermal method and characterized by transmission electron microscopy (TEM) images, X-ray diffraction (XRD) patterns, UV-vis spectra and Fourier transform infrared (FTIR) spectra. Compared with the bare NaYF4:Yb,Er nanocomposites, the ECL intensity of Au-NaYF4:Yb,Er nanocomposites was greatly enhanced by about 4.2-fold which can be attributed to the good conductivity of gold nanoparticles (Au NPs). The nanocomposites showed high and stable ECL emission, fast response and superior conductivity, all of which were advantageous to the ECL detection. Furthermore, HeLa cells were immobilized on the modified electrode via the interaction between folic acid and a folate receptor present on the cell surface. The ECL cytosensor showed satisfactory sensitive response to HeLa cells in a linear range of 4.25 × 102–4.25 × 105 cells per mL with a low detection limit of 326 cells per mL. The proposed cytosensor had good sensitivity and stability, which can offer a great potential platform for bioassay analysis.
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