International Journal of Electrochemical Science
·
2024
·
IF 1.3
Haifan Chen,Gongwei Xia,Jianfang Chen,Hao Zheng
Phenolic compounds are considered to be major environmental pollutants because of their toxicity and hazard on the marine ecosystem and human health even at low concentrations. An ultrasensitive biosensor was fabricated by immobilizing polyphenol oxidase into a composite of transition metal carbides (MXene)-yttrium oxide (Y 2 O 3 ) for the detection of catechol in environmental water bodies. The morphology and electrochemical performance of the as-prepared biosensors were investigated using scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV), respectively. Under the optimal pH value and applied potential, the biosensor exhibited a linear response range from 0.04 to 3.2 µM (R 2 = 0.9974) with an excellent sensitivity of 2294.8 mA·M −1 . The limit of detection (LOD) was found to be 7 nM (S/N = 3) with acceptable repeatability and reproducibility. The interference from ascorbic acid, uric acid, CuSO 4 , MgSO 4 , FeCl 3 , CaCl 2 , and ZnSO 4 was also investigated. The proposed biosensor was used for the determination of trace catechol in real water samples with satisfactory results compared with that of HPLC. The construction of MXene-Y 2 O 3 composite is expected to be a platform for immobilizing enzymes to prepare versatile electrochemical biosensors.
研究领域:
环境科学
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分析化学
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材料科学
·
电化学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2018
·
IF 6.434
Hailong Wang,Quanqin Hu,Yuan Meng,Zier Jin,Zilin Fang,Qinrui Fu,Wenhua Gao,Liang Xu,Yibing Song,Fushen Lu
Reduced graphite oxide (rGO) was incorporated into a metal organic framework (MOF) MIL-101(Cr) for the modification of carbon paste electrode. Taking advantages of the large surface area of MOF and the electrical conductivity of rGO, the resulted electrodes exhibited high sensitivity and reliability in the simultaneous electrochemical identification and quantification of catechol (CC) and hydroquinone (HQ). Specifically, in the mixture solution of catechol and hydroquinone (constant concentration of an analyte), the linear response ranges for catechol and hydroquinone were 10–1400 μM and 4–1000 μM, and detection limits were 4 μM and 0.66 μM (S/N = 3) for individual catechol and hydroquinone, respectively. Therefore, the relatively easy fabrication of modified CPE and its fascinating reliability towards HQ and CC detection may simulate more research interest in the applications of MIL-101(Cr)-rGO composites for electrochemical sensors.
研究领域:
分析化学
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材料科学
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环境科学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Xian-En Zhao,Ya-Nan Zuo,Yinghui Xia,Jing Sun,Shuyun Zhu,Guobao Xu
Although fluorescent nanozymes exhibit great potential in sensing fields, few current nanozyme-based sensors are designed to discriminate catechol (CC) from its two isomers. Herein, fluorescent metal-organic framework (MOF)-based nanozyme is utilized for ratiometric and selective detection of CC without the interferences of hydroquinone (HQ) and resorcinol (RC). NH 2 -Cu-MOF plays multiple roles: (1) it exhibits excellent photoluminescence at 435 nm owing to the 2-amino-1,4-benzenedicarboxylic acid ligand; (2) Cu 2+ imparts MOF oxidase activity to trigger the oxidation of o -phenylenediamine (OPD) into luminescent products (oxOPD) with emissive peak at 571 nm, which quenches the intrinsic fluorescence of NH 2 -Cu-MOF (435 nm) through inner filter effect (IFE); (3) Cu 2+ can complex with CC specifically to produce complex containing o -semiquinone, which not only inhibits MOF’s oxidase-like activity but also quenches the fluorescence of MOF. Therefore, the presence of CC induces the decrease of fluorescence at 571 nm followed by the slight recovery of fluorescence at 435 nm. Notably, HQ and RC have negligible influences on the fluorescence of NH 2 -Cu-MOFs/OPD system. Based on these facts, a ratiometric fluorescence platform for CC has been constructed. It exhibits high sensitivity towards CC with LOD of 0.1 μM.
研究领域:
分析化学
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生物传感
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材料科学
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DOI
高影响因子
International Journal of Polymeric Materials and Polymeric Biomaterials
·
2021
·
IF 2.604
Yan Zhang,Hai-Chao Zhao,Li-Jing Zhu
Mussel-inspired bionics technology has attracted extensive attention for the surface modification of porous materials. The adhesion effect of the mussel mucin comes is mainly from hydroxylation. Hence, polysulfone membrane was modified by co-deposition of catechol with hydroxyl and L-lysine with biocompatibility. Flux of the membrane exceeds 120 L m−2 h−1, the ultra-high rejection rate to bovine serum albumin and lysozyme. Moreover, the modified membranes exhibited enhanced antifouling ability, antibacterial property and adhesion resistance to E. coli with the synergy between catechol and L-lysine. The fabricated membranes can further lay the foundation for the industrial production of deposited membranes.
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SURFACE & COATINGS TECHNOLOGY
·
2021
·
IF 4.158
Lixuan Ren,Yanzhen Zhao,Liu Yang,Wenling Cao,Huifang Wang,Xiaojie Lian,Xianghua Gao,Baolong Niu,Wenfeng Li
The bacterial infection is one of the main reasons for the failure of implant surgery. In this paper, catechol functionalized chitosan (CSCT) was used as a reducing agent and stabilizer to synthesize CSCT-Ag NPs. The composite coating of titanium surface was then electrodeposited by a CSCT layer initially, followed by spin-coating of a CSCT/gelatin (G)/CSCT-Ag NPs layer. The results of XRD , UV–Vis, and TEM showed that the silver nanoparticles were successfully synthesized with uniform distribution, and the particle size was 4–22 nm. The cytotoxicity test results of CSCT-Ag NPs on A549 and EA.Hy926 cells showed when the concentration of CSCT-Ag NPs was less than 25 μg/mL, the survival rate of the two kinds of cells was greater than 80%. First electrodeposition and then spin-coating is feasible through the coating adhesion test and the adhesion level up to 5B. Compared with the pure Ti substrate, the corrosion resistance and hydrophilicity of the composite coating surface are significantly improved. The antibacterial rate of the composite coating against E. coli and S. aureus can reach 99% and 96%. In conclusion, CSCT-Ag NPs and the method of preparing coatings by electrodeposition and then spin-coating have good clinical application potential.
研究领域:
材料科学
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生物医学工程
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纳米技术
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表面化学
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生物材料
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DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
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2026
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IF 7.3
Chengyuan Qian,Yunhua Zhang,Xiaofeng Dang,Yating Shao,Chengyan Chu,Zijian Guo,Chen Xu,Xiaoyong Wang
Modulation of mitochondrial dynamics is a viable strategy for lifespan extension. Reactive oxygen species (ROS) play key roles in aging, acting either as signaling molecules to facilitate longevity-associated processes or as stimulators of oxidative stress, exerting deleterious effects on physiological functions. The hybrid molecule MC1 is designed by integrating melatonin and catechol moieties to reconstruct mitochondrial dynamics and selectively regulate the generation of ROS. MC1 combats cell senescence under oxidative stress and DNA damage, and reprograms the mitochondrial energy metabolism by inhibiting the tricarboxylic acid cycle and glycolysis, while initiating fatty acid oxidation to increase energy production. More importantly, MC1 significantly extends the lifespan of Caenorhabditis elegans, accompanied by an improvement in muscle strength and physiological functions. The lifespan-extending effect of MC1 arises from its intervention in mitochondrial membrane fusion, the electron transport chain, and differential modulation of ROS. Regulating mitochondrial dynamics and ROS production shows great potential for longevity extension.
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2026
·
IF 5.9
Qiangbing Wei,Yuyang Quan,Yuxin Gao,Yixin Zhang,Shen Song,Dedai Lu,Rongnian Xu
Abstract Hydrogel coatings are promising candidates for biomedical surface functionalization. However, developing multifunctional hydrogel coatings that simultaneously integrate robust lubrication, effective antibacterial capacity, and stable interfacial adhesion remains challenging. Herein, a simple, substrate-independent in situ interfacial polymerization strategy was proposed to construct multifunctional hydrogel coatings, which is driven by a catechol−Fe3+ dual self-catalytic system. The pre-coated polydopamine adhesive coating captures Fe3+ ions from monomer solution and forms redox pairs with intrinsic catechol moieties, which spontaneously triggers interfacial radical polymerization and enables precise control of hydrogel coating thickness. Zwitterionic monomer and aminoglycoside antibiotic are incorporated synergistically to endow the hydrogel coatings with significant hydrophilicity, excellent lubrication, and antibacterial performance. The obtained hydrogel coatings exhibit steady low friction coefficients over 12,000 reciprocating cycles and high antibacterial efficacy against Escherichia coli and Staphylococcus aureus. This versatile method is compatible with diverse engineering materials and medical catheters, establishing a practical pathway toward biomedical hydrogel coatings.
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DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2026
·
IF 3.9
Ke Pan,Jinlin Li,Li Liu,Guangfeng Wu
Conventional self-healing waterborne polyurethanes (WPUs) often suffer from an intrinsic trade-off between mechanical robustness and healing efficiency. To address this limitation, inspired by the hierarchical structure and dynamic interactions found in marine mussel byssus, a dual dynamic network WPU was synthesized via step-growth polymerization by integrating dopamine-derived catechol groups and aromatic disulfide bonds. Subsequently, F e C l 3 FeCl 3 $$ {\mathrm{FeCl}}_3 $$ was introduced to provide Fe 3+ species capable of forming additional reversible coordination interactions with oxygen-containing groups in the polyurethane network, including catechol groups and potentially DMPA-derived carboxylates. The combined presence of these reversible interactions may contribute to network rearrangement and energy dissipation during deformation, thereby improving mechanical performance while retaining self-healing capability. Experimental results demonstrate that at an optimal F e C l 3 FeCl 3 $$ {\mathrm{FeCl}}_3 $$ content of 0.1 wt%, the DWPU- F e C l 3 FeCl 3 $$ {\mathrm{FeCl}}_3 $$ -0.1% film exhibited a tensile strength of 29.8 MPa, an elongation at break of 553.2%, and a toughness of 83.3 MJ m −3 . Furthermore, the damaged film recovered 98.2% of its original tensile strength after thermal healing at 60°C for 2 h. These results demonstrate that the combined incorporation of multiple reversible interactions provides a feasible strategy for achieving a favorable balance between mechanical performance and self-healing capability under the investigated conditions. Graphical A mussel-inspired waterborne polyurethane incorporating aromatic disulfide bonds and Fe 3+ –catechol coordination is developed to balance mechanical performance and self-healing capability. An optimal Fe 3+ content enhances strength, toughness, and energy dissipation while maintaining high healing efficiency, demonstrating the effectiveness of combining multiple reversible interactions within a dynamic polyurethane network.
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高影响因子
Food Bioscience
·
2025
·
IF 5.9
Ruilu Sun,Wei Li,Minjie Liao,Yiran Yu,Yao Mou,Junfu Ji,Fang Chen,Xiaosong Hu,Lingjun Ma
Resveratrol (RES) and its catechol analog piceatannol (PIC), natural polyphenols, exhibit benefits in relieving glucose metabolism disorders. This study compared their effects on glucose metabolism regulation through in vivo and in vitro studies combined with quantitative analysis. Results showed that PIC significantly ameliorated insulin resistance and inhibited gluconeogenesis in obese mice, exhibiting superior efficacy to RES. Specifically, the area under the curve (AUC) of the intraperitoneal glucose tolerance test (IPGTT) was 2007.38 mmol・L −1 ・h for PIC, lower than 2450.88 mmol・L −1 ・h for RES; the phosphoenolpyruvate carboxykinase (PEPCK) concentration was 172.80 ng・L −1 in the PIC group, lower than 182.12 ng・L −1 in the RES group. At equimolar phenolic hydroxyl concentrations, PIC promoted greater glucose uptake and glycogen accumulation in human hepatocellular carcinoma (HepG2) cells compared to RES. Additionally, PIC accelerated tricarboxylic acid (TCA) cycle flux toward glucose utilization. These findings indicate that PIC is more effective than RES in regulating glucose metabolism, highlighting the critical role of the catechol moiety. This study provides guidance for screening natural bioactive polyphenols.
研究领域:
药理学
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生物化学
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营养学
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细胞生物学
·
代谢紊乱
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产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2025
·
IF 3.6
Sirui Chen,Chengao Li,Yanhong Teng,Huiqiong Wei,Cuixia Lu,Hua Yang
This study focuses on the preparation and evaluation of a catechol-modified hydroxypropyl chitosan/silver nanoparticle/phenylboronic acid alginate composite hydrogel (C/S/A/P/P). Hydroxypropyl chitosan (HCS) was modified with 3,4-dihydroxybenzaldehyde (DBA) via Schiff base reaction to produce adhesive catechol-modified hydroxypropyl chitosan (CHCS). The mechanical properties and self-healing ability of the hydrogel were enhanced by grafting phenylboronic acid (PBA) onto sodium alginate (SA) to form SA-PBA. The incorporation of polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) further improved the mechanical properties, water absorption, and moisture retention of the hydrogel. Silver ions were reduced to silver nanoparticles (AgNPs) by the reducing property of catechol and integrated into the hydrogel network, endowing it with antibacterial functionality. The C/S/A/P/P hydrogel exhibits excellent mechanical properties (tensile stress of 391.99 kPa and strain of 149.11%), photothermal properties, and antibacterial performance (inhibition rates of 95.1% against Escherichia coli and 64.3% against Staphylococcus aureus). This green preparation method offers a new approach for developing advanced wound dressings.
研究领域:
材料科学
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纳米技术
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生物医学工程
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高分子化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 8
·8302-8307
·
IF 1.338
Wang Yong,Qu Jianhang,Li Shufang,Qu Jianying
In this study, a simple and sensitive electrochemical analytical method is developed for detection of catechol based on laccase and ZnS:Ni/ZnS quantum dots with core/shell structure modified glassy carbon electrode using cyclic voltammetry. The proposed biosensor showed an excellent
catalytic activity toward the reduction of catechol, which exhibited a linear response to the concentrations ranging from 0.1 to 100 μmol · L−1 with a low detection limit of 35 nmol · L−1 for catechol (S/N = 3). The reproducibility,
interference and stability of the measurements were also favorable with a high retention rate of 95.31% of the peak current after 30 days. Moreover, this novel method has been successfully applied to determination of catechol in real water with satisfactory recoveries. The resulting biosensor
will provide important improvements for electrochemical biosensors in application for environment.
研究领域:
环境科学
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电化学
·
生物传感器
·
分析化学
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DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2024
·
IF 4.1
Feng Wen-Jun,Wu Yan-He,Liu Xiao-Yang,Wang Zheng-Ke
Shear-thinning hydrogels have emerged for endoscopic submucosal dissection, while wound intervention after surgery has rarely been mentioned. Herein, a catechol-modified chitosan hydrogel with shear-thinning property was developed for simultaneously facilitating endoscopic submucosal dissection and postoperative wound healing. Benefiting from the shear-thinning and self-healing characteristics, the asprepared hydrogel showed easily endoscopic injectability. It also performed very well as submucosal cushion, which could remain above 70% after injection for 120 min in ex vivo porcine large intestine model. In fact, the cushion height of normal saline dramatically decreased to 46% of the initial height at 30 min. Ag nanoparticles encapsulated into the network endowed the hydrogel with almost reached 100% antibacterial effect against E. coli and S. aureus . The hemolysis ratio of the hydrogel was calculated to be as low as 0.8%. Combined with good hemocompatibility and cytocompatibility, the as-prepared hydrogel displayed much higher in vivo wound closure and healing efficacy than normal saline. These results demonstrated the superiority of the shear-thinning chitosan hydrogel in facilitating clinical endoscopic submucosal dissection surgery.
研究领域:
生物材料学
·
医学工程
·
药剂学
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DOI
高影响因子
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