SEPARATION AND PURIFICATION TECHNOLOGY
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2025
·
IF 9
Huapu Zhao,Yaru Kong,Man Xu,Cunwen Wang,Yuan Liu,Yanbo Li
Pervaporation (PV) membranes for desalination show significant potential, attracting increasing attention. Herein, polyphenol (tannic acid) was used to crosslink chitosan to prepare composite membranes for pervaporation desalination. The effects of the coating method, the concentrations of chitosan (CS) and tannic acid (TA), the deposition time of CS and TA, and the thermal annealing time on the desalination performance of the pervaporation membranes were investigated to explore the relationship between membrane structure and pervaporation desalination performance. After optimizing the synthesis conditions, a high flux pervaporation desalination membrane (44 kg·m −2 ·h −1 at 50°C and 92 kg·m −2 ·h -1 at 70°C) with a NaCl rejection higher than 99.9 % was prepared by co-depositing chitosan and TA on a polysulfone support. This work demonstrates TA crosslinked CS composite membranes have promising research prospects and potential applications in pervaporation desalination.
研究领域:
材料科学
·
环境工程
·
化学工程
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产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Hao Huang,Zexin Liu,Hanxin Jian,Yuan Yao,Bing Xue,Shuguang Yang
Humidity is a critical environmental parameter that greatly affects the performance of many materials. Alginate (ALG) and chitosan (CHI) are abundant naturally occurring polymers, and their complex based on electrostatic interaction is widely used in various fields, especially in the biomedical area. Due to the strong hygroscopicity of ALG and CHI, the mechanical properties of ALG/CHI complex are significantly influenced by humidity; however, there remains a lack of quantitative understanding regarding this phenomenon. Here, we prepared ALG/CHI complex fiber and systematically studied the humidity effect. The humidity-adaptive behaviors of ALG/CHI fiber were investigated by tensile test, stress relaxation, and creep. Time–water superposition (TWSP) and time–temperature superposition (TTSP) principles were applied to elucidate the mechanical behaviors in a long-time scale using the dynamic mechanical analysis (DMA) data of frequency sweep at different humidity and temperature. The cyclic humidification and dehumidification test demonstrated that ALG/CHI fiber quickly and reversibly responds to environmental humidity variation. The study provides fundamental understanding on humidity adaptability of ALG/CHI fiber, which can facilitate further development of ALG/CHI complex as an advanced responsive and adaptive material.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
MOLECULES
·
2018
·Vol. 23
·期 8
·1921
·
IF 3.098
Huanlu Song,Hao Wu,ShuJing Li,Huafeng Tian,YanRu Li,JianGuo Wang
Using a solvent formed of alkali and urea, chitosan was successfully dissolved in a new solvent via the freezing–thawing process. Subsequently, quaternized chitosan (QC) was synthesized using 3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CHPTAC) as the cationic reagent under different incubation times and temperatures in a homogeneous system. QCs cannot be synthesized at temperatures above 60 °C, as gel formation will occur. The structure and properties of the prepared QC were characterized and quaternary groups were comfirmed to be successfully incorporated onto chitosan backbones. The degree of substitution (DS) ranged from 16.5% to 46.8% and the yields ranged from 32.6% to 89.7%, which can be adjusted by changing the molar ratio of the chitosan unit to CHPTAC and the reaction time. QCs inhibits the growth ofAlicyclobacillus acidoterrestriseffectively. Thus, this work offers a simple and green method of functionalizing chitosan and producing quaternized chitosan with an antibacterial effect for potential applications in the food industry.Keywords:chitosan;homogeneous system;quaternization;characterization;Alicyclobacillus acidoterrestris
研究领域:
生物化学
·
食品科学
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DOI
PubMed
高影响因子
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2020
·Vol. 109
·期 6
·911-920
·
IF 2.831
Xin Yi,Chengyong Wang,Xiao Yu,Weiwei Su,Zhishan Yuan
Chronic wounds are greatly health threatening owing to the increasing morbidity, and bacterial biofilm is a major cause of chronic wounds. The critical for bacterial biofilm eradication is overcome the barrier of extracellular polymeric substances (EPS) produced by the bacteria, and promote the diffusion of drugs within the biofilm. In this article, composite microneedles (MNs) of chitosan and zinc nitrate (CS-Zn[II] MNs) were investigated to eradicate bacterial biofilm. The CS-Zn(II) MNs combined the structure characteristic of MNs with the antibacterial properties of CS and Zn 2+ . The MNs can pierce the EPS due to the needle-like structure, and can transport directly the CS and Zn 2+ into the bacterial biofilm. The needle-like structure of MNs also increased the contact area between drug carrier and bacterial biofilm nearly 14–23% comparing with membrane without needle-like structure, and facilitated the diffusion of drugs. What is more, the synergistic effect of CS and Zn 2+ make the CS-Zn(II) MNs obtain excellent antibiofilm properties. Counting the colony forming units and bacterial live/dead staining tests confirmed the fascinating antibacterial abilities (up to 100% inhibition) and biofilm eradication properties, respectively, of the CS-Zn(II) MNs. The inhibition zone test shown that the antibiofilm effect of MNs was superior to membrane and the antibiofilm effect of MNs was become increasingly obvious along with the increase of the treatment time. Besides, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays proved that the CS-Zn(II) MNs possess brilliant cytocompatibility. These results indicate that the CS-Zn(II) MNs are promising method for bacterial biofilm eradication.
研究领域:
医学
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材料科学
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微生物学
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DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
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2020
·
IF 6.551
Xiaolong Yu,Juan Zhang,Yan Zheng
Perchlorate (ClO 4 − ) in water is an emerging contaminant that threatens human health by inhibiting the uptake of iodine in the thyroid gland . Biopolymer adsorbents including chitosan hydrogel beads (CSBs) have attracted increasing attentions in water treatment for their low costs, ease in preparation, and environmental friendliness. However, the adsorption capacity for ClO 4 − by several crosslinked CSBs has been shown to be low. To overcome this, epichlorohydrin (ECH) crosslinked CSBs (ECH-CSBs) that preserved -NH 2 functional groups as potential sites for adsorption are synthesized and characterized, followed by batch adsorption experiments to evaluate adsorption and desorption reactions. The point of zero charge is determined to be 5.1 ± 0.1. Both XPS spectra and DFT calculations support that electrostatic interaction between ClO 4 − and protonated -NH 3 + functional groups is responsible for adsorption that reaches a capacity of 63.4 to 76.3 mg/g between pH of 4.0–10.0 at 303.15 K that follows Langmuir isotherm. ECH crosslinking also enhances hydrophilicity of CSBs to allow for increased adsorption for ClO 4 − . Adsorption of ClO 4 − (10 and 100 mg/L) follows a pseudo-first order kinetics with equilibrium time of 2–6 h but is limited by intra-particle diffusion. Anions common in natural waters exhibit interference effects due to similar electrostatic attraction mechanism, thus HCO 3 − and SO 4 2− with high abundance in natural waters need pre-treatment. Regeneration of the adsorbents to 100% of its adsorption capacity by rinsing with 0.1 M NaOH is demonstrated for 12 cycles due to complete desorption of ClO 4 − via electrostatic repulsion, assuring reusability.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Marine Drugs
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2020
·Vol. 18
·期 5
·233
·
IF 4.073
Tingting Yan,Songzhi Kong,Qianqian Ouyang,Chengpeng Li,Tingting Hou,Yu Chen,Sidong Li
Our earlier research indicated that chitosan-gentamicin conjugate (CS-GT) possesses superior antimicrobial activity and good water solubility. To develop CS-GT-based scald dressings, the antibacterial properties of CS-GT were further studied, and the biosafety of CS-GT and the healing mechanism of CS-GT hydrogel was systematically explored in this article. It was found that cell viability shows a declined inclination with the prolonged culture time and the increased concentration of CS-GT. After three day’s culture, the cell viability could still remain at 79.72% when CS-GT concentration was as high as 1000 μg/mL. On the other hand, the hemolysis rate of CS-GT was lower than 5% when its concentration is 800 μg/mL. Therefore CS-GT has good cytocompatibility and hemocompatibility. A wound-healing experiment has shown that the skin healing rate of CS-GT hydrogel was the highest at 99.61%, followed by the positive control (wet burn ointment) 94.98%, GT hydrogel 87.50%, and matrix 77.39%. The blank control group, however, possessed the lowest healing rate of 75.45%. Further analysis indicated that CS-GT hydrogel could promote the synthesis of total protein (TP) in skin granulation tissue, resulting in the enhanced hydroxyproline (HYP) content, which facilitated collagen fibrogenesis, reduced cytokine expression in an inflammatory response, and, ultimately, accelerated wound healing. To sum up, CS-GT hydrogel is a promising scald dressing.Keywords:chitosan-gentamicin conjugate;antimicrobial;anti-inflammatory;scald repair
研究领域:
药学
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生物医学工程
·
伤口愈合
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产品关联
DOI
PubMed
高影响因子
Frontiers in Pharmacology
·
2018
·
IF 3.831
Guo Xi,Sun Tong,Zhong Rui,Ma Lu,You Chao,Tian Meng,Li Hao,Wang Chengwei
Chitosan oligosaccharide (COS) is known for its unique biological activities such as anti-tumor, anti-inflammatory, anti-oxidant, anti-bacterial activity, biological recognition, and immune enhancing effects, and thus continuous attracting many research interests in drug, food, cosmetics, biomaterials and tissue engineering fields. In comparison to its corresponding polymer, COS has much higher absorption profiles at the intestinal level, which results in permitting its quick access to the blood flow and potential contacting with blood components. However, the effects of COS on blood components remain unclear to date. Herein, two COS with different molecular weight (MW) were characterized by FTIR and 1H NMR, and then their effects on human blood components, including red blood cells (RBCs) (hemolysis, deformability, and aggregation), coagulation system [activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), and the concentration of fibrinogen (Fib)], complement (C3a and C5a activation), and platelet (activation and aggregation), were comprehensively studied. In the case of RBCs, COS exhibited a low risk of hemolysis in a dose and molecular weight dependent manner and the irreversible aggregation was observed in their high concentration. For coagulation system, COS has a mild anticoagulation activity through blocking the intrinsic coagulation pathway. In addition, COS showed no effect on complement activation in C3a and C5a and on platelet activation while inhibition of platelet aggregation was evident. Finally, the mechanism that effects of COS on blood components was discussed and proposed.
研究领域:
医学
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生物化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Qiang Luo,Qianqian Han,Ying Wang,Hongmei Zhang,Zhenghao Fei,Yanqing Wang
Chitosan-1-(mercaptomethyl)-cyclopropane acetic acid (CS-MCA) copolymer was synthesized by amino linkage. The obtained copolymer was characterized by FTIR, 1 H NMR, XRD, TGA and SEM. Porous and reticulate morphologies were found on the CS-MCA surface. The effects of pH on the rheological properties of CS-MCA were investigated. On the one hand, the apparent viscosity of CS-MCA indicated a shear-thinning behavior. The graft of MCA enhanced the moduli and the maximum elastic properties were observed at pH = 7.00. The addition of dithiothreitol reduced the viscosity and modulus of CS-MCA hydrogel, and the gelation time, temperature and frequency were obtained in dynamic oscillatory tests. The antibacterial effect of CS-MCA against E . coli was investigated for the inhibition zone and bacterial growth curve. These results showed that CS-MCA had better antibacterial ability than chitosan without modification. Therefore, the rheological behavior and functional activities can be applied for the hydrocolloid gels in food and pharmaceutical applications .
研究领域:
食品科学
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药学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2015
·
IF 3.52
Benqiao He,Yixuan Shao,Mengzhu Liang,Jianxin Li,Yu Cheng
Guanidinylated chitosan (GCS), as a heterogeneous alkaline catalyst for the transesterification of soybean oil with methanol, was synthesized by grafting aminoiminomethanesulfonic acid onto chitosan. The structure and properties of GCS membrane were investigated by Fourier transform infrared spectroscopy, thermogravimetry and X-ray photoelectron spectroscopy. The soybean oil conversion reached 98.8% at the first run and 96.6% at the fifth run under the reaction conditions: catalyst amount of 20 wt.%, methanol/oil mass ratio of 2.5:1 at 60 °C for 6 h. Results show that the transesterification mainly took place on the surface of the catalytic membrane. The kinetics study of the transesterification was undertaken in terms of pseudo-homogeneous model and performed as a first order reaction with an activation energy of 76.95 kJ/mol and pre-exponential factor of 7.94 × 10 9 min −1 .
研究领域:
化学工程
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材料科学
·
可再生能源
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Biao Huang,Mingxian Liu,Changren Zhou
Here, chitosan composites hydrogels were prepared by addition of halloysite nanotubes (HNTs) in the chitosan KOH/LiOH/urea solution. The raw chitosan and chitosan/HNTs composite hydrogels were obtained by heat treatment at 60 °C for 8 h and then regeneration in ethanol solution. The viscosity of the composite solution is increased with HNTs content. The Fourier transform infrared spectroscopy (FT-IR) shows that the hydrogen bonds interactions exist between the HNTs and the chitosan. X-ray diffraction (XRD) results show that the crystal structure of HNT is not changed in the composite hydrogels. The compressive property test and storage modulus determination show that the mechanical properties and anti-deformation ability of the composite hydrogel significantly increase owing to the reinforcing effect of HNTs. The composites hydrogel with 66.7% HNTs can undergo 7 times compression cycles without breaking with compressive strength of 0.71 MPa at 70% deformation, while pure chitosan hydrogel is broken after bearing 5 compression cycles with compressive strength of 0.14 MPa and a maximum deformation of 59%. A porous structure with pore size of 100–500 μm is found in the composite hydrogels by scanning electron microscopy (SEM), and the pore size and the swelling ratio in NaCl solution decrease by the addition of HNTs and the immersing of ethanol. Chitosan/HNTs composite hydrogels show low cytotoxicity towards MC3T3-E1 cells. Also, the composite hydrogels show a maximum drug entrapment efficiency of 45.7% for doxorubicin (DOX) which is much higher than that of pure chitosan hydrogel (27.5%). All the results illustrate that the chitosan/HNTs composite hydrogels show promising applications as biomaterials.
研究领域:
生物材料学
·
纳米材料科学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 8
·2919-2924
·
IF 4.58
He Linghao,Guo Chuanpan,Song Yingpan,Zhang Shuai,Wang Minghua,Peng Donglai,Fang Shaoming,Zhang Zhihong,Liu Chun-Sen
The authors describe an electrochemical immunoassay for the β-adrenergic agonist ractopamine (RAC). It is based on the use of chitosan-stabilized gold nanoparticles (chit-AuNPs). Antibodies against RAC (anti-RAC) readily adsorb on the surface of the chit-AuNPs due to their high bio-affinity. The amount of chitosan used to synthesize chit-AuNPs does not affect the size and distribution of the NPs but amplifies the electrochemical signal of the electrode. The assay has a detection limit as low as 2.3 pg∙mL −1 (equivalent to a 6.7 fM concentration), with a response that is linear in the 0.01 to 5 ng∙mL −1 RAC concentration range. The assay is selective, acceptably reproducible, stable, and well applicable to the detection of RAC.
Chitosan-stabilized gold nanoparticles (chit-AuNPs) were prepared for electrochemical immunoassay of the ractopamine (RAC). The assay exhibits a detection limit of 2.3 pg·mL −1 (equal to 6.7 fM), is highly selective, acceptably reproducible, and stable.
研究领域:
分析化学
·
纳米技术
·
食品安全
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2016
·
IF 4.219
Mingxian Liu,Huanjun Zheng,Juan Chen,Shuangli Li,Jianfang Huang,Changren Zhou
Chitin nanocrystals (CNCs) with length and width of 300 and 20 nm were uniformly dispersed in chitosan (CS) solution. The CS/CNCs composite scaffolds prepared utilizing a dispersion-based freeze dry approach exhibit significant enhancement in compressive strength and modulus compared with pure CS scaffold both in dry and wet state. A well-interconnected porous structure with size in the range of 100–200 μm and over 80% porosity are found in the composite scaffolds. The crystal structure of CNCs is retained in the composite scaffolds. The incorporation of CNCs leads to increase in the scaffold density and decrease in the water swelling ratio. Moreover, the composite scaffolds are successfully applied as scaffolds for MC3T3-E1 osteoblast cells, showing their excellent biocompatibility and low cytotoxicity. The results of fluorescent micrographs images reveal that CNCs can markedly promote the cell adhesion and proliferation of the osteoblast on CS. The biocompatible composite scaffolds with enhanced mechanical properties have potential application in bone tissue engineering.
研究领域:
生物材料
·
组织工程
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）