COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Shilong Zhang,Shuyang Tan,Yajun Deng,Bo Wu,Yanling Yang,Jiangfan Chang,Xianhui Zhang,Baiyi Chen,Jianhua Wu
Traditional antifouling coatings often lack the combined capabilities of static antifouling and dynamic fouling-release, which are critical for marine propellers. This study addresses this limitation by developing pH-sensitive polysiloxane coatings that integrate both functionalities. Two coating systems, PS-Levo and PS-PLL, were synthesized by incorporating levofloxacin (Levo) and polylysine (PLL) as antifouling agents, respectively. PS-Levo was synthesized via an epoxy-carboxylic acid ring-opening reaction, while PS-PLL was obtained through an amine-hydrosilylation reaction, using APTES as the curing agent. A key innovation of these coatings is their pH-triggered hydrolysis. Marine microorganisms that form biofilms on the coating surface can alter the microenvironmental pH through their metabolic activities, either lowering or raising it, thereby promoting the release of antifouling agents. The coatings exhibited remarkable antifouling efficacy, achieving bactericidal and anti-algal rates of over 99% and 97%, respectively. Following a 180-day immersion of the coated panels in natural seawater, minimal marine biofouling adhered to the coated surfaces and could be effortlessly removed by simple rinsing, thereby demonstrating excellent static antifouling and dynamic fouling-release performance. Moreover, the PS-Levo and PS-PLL coatings exhibited outstanding adhesion, mechanical properties, and corrosion resistance. This research introduces an innovative strategy for combating biofouling on marine propellers and presents significant potential for practical applications in the marine antifouling industry.
研究领域:
海洋科学
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材料科学
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表面工程
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环境化学
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生物技术
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DOI
高影响因子
ADVANCES IN POLYMER TECHNOLOGY
·
2025
·Vol. 2025
·期 1
·8256208
·
IF 2.5
Zhiqiang Li,Shanzhai Shang,Xinyi Fang,Jingmei Han,Tinghua Li,Xia Zhang,Dong Xiao,Qiaomei Sun,Hui Li,Ping Lei
The controlled release of volatile compounds is one of the important research topics in the field of food. In order to improve the flavor release ability of menthol and to achieve a temperature-controlled release of menthol, chitosan (CS) and polycaprolactone (PCL) are used as raw materials to prepare nanofibrous membranes by electrostatic spinning and menthol-loaded nanofibrous membranes are subsequently prepared by incorporating a menthol flavor. Scanning electron microscopy (SEM), Fourier transform infrared (FTIR), XRD, and solid-state NMR are applied to characterize the morphology and chemical structure of the nanofibrous membranes. Thermogravimetric analysis (TGA) is used to test the thermal stability and release characteristics of the menthol-loaded nanofibrous membranes. The gas chromatography (GC) assay shows that the CS/PCL nanofibrous membrane has a menthol loading of 57.64% and can gradually release menthol from 85 to 260°C, thus, achieving a temperature-controlled release of menthol. A 14-day stability test shows that the nanofibrous membrane retains menthol up to 40.23% and cytotoxicity experiments confirm their good biocompatibility and biosafety. The method of embedding menthol proposed in this paper can offer the possibility of controlling the temperature to release menthol and providing potential ideas for the application of menthol in food and pharmaceuticals.
研究领域:
食品科学
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材料科学
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制药技术
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纳米技术
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风味递送系统
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DOI
高影响因子
AAPS PHARMSCITECH
·
2026
·Vol. 27
·期 3
·145
·
IF 5.1
Liu Hongfei,Zhang Zhen,Tang Xinyi,Feng Yingshu,Firempong Caleb Kesse,He Haibing,Zhang Guoqing
Glaucoma therapy is often limited by poor ocular bioavailability and the short residence time of conventional eye drops, highlighting the need for sustained-release delivery systems. This study presents the development of a thermosensitive in situ hydrogel incorporating cation-exchange resin (CER) for sustained delivery of betaxolol hydrochloride (BH) in glaucoma therapy. CER microspheres were prepared using a seed swelling method, and drug loading was achieved through an ion-exchange interaction to obtain BH@CER, which was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM). A thermosensitive hydrogel-microspheres composite (BH@CER@P407) was formulated using optimized concentrations of poloxamer 407 (P407), exhibiting a sol-to-gel transition at approximately 34°C for easy administration and prolonged ocular retention. In vitro release studies indicated that BH@CER@P407 achieved sustained release (85% over 12 h), in contrast to the pronounced burst release of commercial BH eye drops (Betoptic® S, 90% within 2 h). In vivo evaluations in New Zealand rabbits revealed strong ocular adhesion and retention for up to 8 h, correlating with sustained intraocular pressure (IOP) reduction. Ocular irritation studies confirmed excellent biocompatibility. Compared to Betoptic® S, the BH@CER@P407 offers enhanced ocular residence and prolonged therapeutic efficacy, presenting a promising strategy for improving glaucoma treatment. Graphical
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DOI
PubMed
高影响因子
DRUGS IN R&D
·
2026
·
IF 2.5
Liu Yang,Shi Qiong-zhi,Wang Yanchen,Long Ze-chun,Han Man,Zeng Yuan,Xie Xiang-yang,Liu Hui
Background and Objective Lornoxicam (LOX) is a nonsteroidal anti-inflammatory drug used for pain management but requires frequent dosing due to its short half-life. This study aimed to develop a biphasic-release multiple-unit tablet (MUT) to achieve rapid and sustained LOX release with dose flexibility. Methods LOX-loaded extended-release (ER) pellets were prepared by fluidized-bed coating of microcrystalline cellulose cores and optimized using a Box–Behnken design. The pellets were coated with Eudragit ® RL/RS and combined with an immediate-release (IR) component to form MUTs by conventional tableting. Pellets and tablets were evaluated for physicochemical properties and in vitro drug release. Results Optimized ER pellets showed high drug-loading efficiency (92.2 ± 3%) and good mechanical properties. Drug release from ER pellets was best described by the Korsmeyer–Peppas model, indicating Fickian diffusion. The MUTs exhibited an initial LOX release of approximately 38%, followed by sustained release for 24 h, with > 90% cumulative release. Split tablets demonstrated release profiles comparable to intact tablets ( f 2 > 50). Conclusion The developed biphasic-release MUTs provide rapid onset, sustained LOX delivery, and reliable dose flexibility, representing a promising oral formulation for LOX therapy.
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DOI
高影响因子
JOURNAL OF MATERIALS CHEMISTRY
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2012
·Vol. 22
·期 47
·24856-24861
·
IF 5.968
Cheng-an Tao,Jianfang Wang,Shiqiao Qin,Yanan Lv,Yin Long,Hui Zhu,Zhenhua Jiang
A novel graphene oxide (GO)-based hydrogel with drug molecules as crosslinking agents was fabricated. Metformin hydrochloride (MFH), which has no aromatic groups, but only has N-containing functionalities, was chosen as a model drug. When a very small amount of MFH was introduced into a GO solution, a supramolecular assembled hydrogel was rapidly formed without any polymers or chemical additives. The gelation process can be influenced by the weight ratio of MFH to GO. The driving forces were hydrogen bonding and electrostatic attraction. Both air-dried and freeze-dried samples of GO–MFH hydrogels were utilized for controlled drug release in water (pH = 7) and hydrochloric acid (pH = 1, 3 and 5). The release mechanism of capsulated MFH was Fickian diffusion according to the fitted results. Both the freeze-dried and air-dried samples released around 74% of the MFH in a strongly acidic medium after 70 h, but only 50% in a neutral solution. This pH-sensitivity makes it a potential candidate for the controlled release of drugs in the acidic environment of the stomach.
研究领域:
材料科学
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药学
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生物医学工程
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DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2018
·
IF 2.955
Yufeng Li,Cong Jia,Xiao Zhang,Yanghui Jiang,Min Zhang,Panfang Lu,Hongkun Chen
Nearly 1 billion tons of bagasse are discarded annually in the production process. In this work, a novel controlled release fertilizer was successfully produced by coating urea particles with bio-based epoxy (EPCU). The bio-based epoxy coating was synthesized from the liquefied bagasse (LB) and bisphenol-A diglycidyl ether (BDE) with the different mole ratios of LB to BDE. The chemical structure and microscopic morphology of EPCU were examined by FTIR, 1 HNMR, SEM. The nutrient release behaviors and mechanism of EPCUs were also discussed in detail. Results showed that EPCU3 improved the thermal stability by 60.3 °C (T 10% ), increased the nutrient release longevity by 12 times, and raised the water contact angle of surface by 12%, and then significantly slowed the nitrogen release rate of the EPCU. This work indicated that the environment-friendly EPCU with superior controlled release properties could be especially useful in horticultural and agricultural applications.
研究领域:
农业科学
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材料科学
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Yuanyuan Li,Dongjie Yang,Shuo Lu,Sulin Lao,Xueqing Qiu
Alkali lignin (AL), an anionic polymer, is a byproduct of the paper industry. AL was first modified by quaternization to synthesize quaternized alkali lignin (QAL). The aim of the present study is to reveal the effects of sodium dodecyl benzenesulfonate (SDBS) on the microstructure of QAL. The interaction between SDBS and QAL is studied by means of zeta potential, fluorescence spectrophotometer, and static contact angle measurement. The results indicated that there is an electrostatic interaction and a hydrophobic interaction between QAL and SDBS. The SDBS/QAL complex can self-assemble into lignin-based colloidal spheres (LCSs) in an ethanol/water mixture, which have remarkable avermectin (AVM) encapsulation efficiency and antiphotolysis performance. The cumulative release amount of AVM encapsulated by LCS (LCS@AVM) after 72 h was 77%, and the release was still going on. The release behaviors of LCS@AVM can be controlled by adjusting the ratio (w/w) of LCS to AVM. More than 85% of AVM could be preserved even after 96 h of UV irradiation. LCS showed controlled release and UV-blocking performance for AVM.
研究领域:
材料科学
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农业科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2020
·Vol. 35
·期 3
·658-664
·
IF 0.64
Wang Shouxia,Hu Zhiyi,Hu Jie,Qiu Zhiming,Li Junli,Geng Wei,Su Baolian,Yang Xiaoyu
We have developed a controlled-release drug carrier. Smartly controlled-release polymer nanoparticles were firstly synthesized through RAFT polymerization as the controlled-release core. The structural and particle properties of polymer nanoparticles were characterized by nuclear magnetic resonance spectroscopy ( 1 H-NMR), scanning electron microscope (SEM) and X-ray spectroscopy (EDX). Mesoporous materials were selected as the shell materials to encapsulate the smart core as the stable shell. The mesoporous shell was characterized by transmission electron microscopy (TEM) and scanning electron microscope (SEM). All the results showed that a well-defined core-shell structure with mesoporous structure was obtained, and this controllable delivery system will have the great potential in nanomedicine.
研究领域:
材料科学
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药剂学
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生物医学工程
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产品关联
DOI
高影响因子
GREEN CHEMISTRY
·
2021
·Vol. 23
·期 12
·4560-4566
·
IF 10.182
Yunhao Gao,Zhiyuan Zhou,Xi Chen,Yuyang Tian,Yan Li,Huachen Wang,Xuan Li,Xueyang Yu,Yongsong Cao
Volatilization and leaching are two critical pathways for pesticide transportation from their applied areas to non-target regions. Nanocarrier-based formulations can improve the use efficiency and reduce the off-target effects of pesticides, however, the complicated preparation process seriously restricts the large-scale application of nanopesticides in the agricultural field. In this work, taking 2-(2,4-dichlorophenoxy) acetic acid (2,4-D), 2-methyl-4-chlorophenoxyacetic acid (MCPA), and 3,5-dibromo-4-hydroxybenzonitrile (bromoxynil) as model herbicides, herbicide-intercalated Zn–Al hydrotalcites (herbicide@HTlcs) were facilely fabricated by a modified co-precipitation method without heating, aging, organic solvents, and inert gas. The obtained herbicide@HTlcs showed high entrapment efficiencies (71.7%–86.7%), a sheet structure with an average size of 339.4 nm, and positive surface charges (+40.5). The volatilities of herbicide@HTlcs were reduced more than 3-fold compared with those of pure herbicides. The release rates of 2,4-D@HTlcs were in line with the selectivity sequence of HTlcs for the anions and controlled by non-Fickian diffusion. The leaching experiments performed in two agricultural topsoils collected from Beijing and Yunnan province and a grassland soil from Neimenggu province all demonstrated that the developed 2,4-D@HTlc nanosheets could evidently retard 2,4-D leaching through the soil. Additionally, 2,4-D@HTlcs exhibited no delay in the control efficacy against Amaranthus retroflexus compared with free 2,4-D sodium salt. This study provides a novel insight into the facile fabrication of controlled release formulations of pesticides that can reduce the volatilization and leaching risks simultaneously.
研究领域:
农业科学
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环境科学
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材料科学
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产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 22
·12667-12674
·
IF 3.049
Mo Zhu,Ying Hao,Xun Ma,Lin Feng,Yuanxin Zhai,Yaping Ding,Guosheng Cheng
A new class of stimuli responsive drug delivery systems is emerging to establish new paradigms for enhancing therapeutic efficacy. To date, most electro-responsive systems rely on noble metal electrodes that likely cause the limitations for implantation applications. Herein, a graphene/polypyrrole composite electrode (GN–PPy–FL) was fabricated based on two-dimensional (2D) graphene (GN) film and conductive and biocompatible polypyrrole (PPy) nanoparticles loaded with a negative drug model of fluorescein sodium (FL) via chemical oxidation polymerization. The conductive composite electrode was utilized as a drug carrier to realize the electrically controlled release of the FL. The release rate from conductive nanoparticles can be controlled by the applied voltages. The study provides a multi-stimuli responsive drug release system, demonstrating the potential applications of the controlled release of various drugs, peptides or proteins.
研究领域:
材料科学
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电化学
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生物医学工程
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
Materials
·
2019
·Vol. 12
·期 10
·1610
·
IF 2.972
Wenzhao Jiang,Jianwei Guo,Weiqiu Wen,Yong-Guang Jia,Sa Liu
Polymeric nano-carriers are considered as promising tools in biomedical applications due to multiple attractive characteristics including their low toxicity, high loading capacity, controlled drug release capabilities, and highly tunable chemical properties. Here, a series of pH-sensitive star-shaped copolymers, Ad-P[(EMA-co-MAA)-b-PPEGMA]4, was prepared via electron transfer atom radical polymerization (ARGETE ATRP) and selective hydrolysis. These star-shaped copolymers can be self-assembled into micelles (Dh= 150–160 nm) and their critical micelle concentrations (CMC) were estimated to be 3.9–5.0 mg/L. The pH-sensitiveness of the micelles was evidenced by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The maximal paclitaxel (PTX) loading efficiency (DLC) and entrapment efficiency (EE) were 18.9% and 36%, respectively. In vitro release studies revealed that about 19% of the PTX released at an acidic condition of pH 1.2 over 70 h, whereas more than 70% was released within the same time interval at pH 6.8. In vitro cytotoxicity suggested that the low cytotoxicity of the blank micelles, while the PTX-loaded micelles providing the cytotoxicity close to that of free PTX. These results indicated that this novel pH-sensitive nano-carriers have great potential applications for oral drug-controlled release.Keywords:nano-carrier;pH-sensitive copolymer;drug release;adamantane
研究领域:
药剂学
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高分子化学
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生物医学工程
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DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2021
·
IF 3.423
Huiling Zhang,Xiansheng Zhang,Lei Liu,Xiaoyu Pang,Langfei Yang,Bingjie Xu,Jindan Wu,Dongming Qi
Herein, a type of nanofibrous membrane was prepared by co-electrospinning of polycaprolactone, poly(methyl methacrylate), polyaniline, and roxithromycin. The temperature of the nanofibers increased by 20 °C with 1 min of near infrared (NIR) radiation, and then the drug release was accelerated significantly. The bactericidal rate toward Staphylococcus aureus reached 99% with the synergistic effect of heat and antibiotics. This study provides a new approach to solving the problem of bacterial resistance by synergistic strategies involving photothermal and on-demand release of drugs.
研究领域:
生物医学工程
·
抗菌材料研究
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DOI
高影响因子
危险品化学品经营许可证（带存储）