Pharmaceuticals
·
2024
·Vol. 17
·期 4
·489
·
IF 4.3
Hao Wang,Chenxuan Zheng,Fanyu Tian,Ziyao Xiao,Zhixiong Sun,Liye Lu,Wenjuan Dai,Qi Zhang,Xuefeng Mei
Curcumin (CUR) is a natural polyphenolic compound with various pharmacological activities. Low water solubility and bioavailability limit its clinical application. In this work, to improve the bioavailability of CUR, we prepared a new co-crystal of curcumin and L-carnitine (CUR-L-CN) via liquid-assisted grinding. Both CUR and L-CN have high safe dosages and have a wide range of applications in liver protection and animal nutrition. The co-crystal was fully characterized and the crystal structure was disclosed. Dissolution experiments were conducted in simulated gastric fluids (SGF) and simulated intestinal fluids (SIF). CUR-L-CN exhibited significantly faster dissolution rates than those of pure CUR. Hirshfeld surface analysis and wettability testing indicate that CUR-L-CN has a higher affinity for water and thus exhibits faster dissolution rates. Pharmacokinetic studies were performed in rats and the results showed that compared to pure CUR, CUR-L-CN exhibited 6.3-times-higher AUC0–tand 10.7-times-higher Cmax.
研究领域:
药剂学
·
生物化学
·
药物开发
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DOI
PubMed
高影响因子
FOOD CONTROL
·
2024
·
IF 5.6
Fangqu Wang,Zipeng Xu,Lin Chen,Ziyan Qiao,Yayun Hu,Xiaojing Fan,Yaping Liu,Zhuangli Kang,Feng Huang,Minyi Han,Huijuan Yang,Xianchao Feng
In order to better showcase the freshness of fresh meat, merchants usually place absorbent pads under tray packaging for preservation. However, the current absorbent pads can only absorb a small amount of blood water and cannot effectively inhibit the growth and reproduction of microorganisms in tray packaging. Herein, a super absorbent aerogel pad for preserving fresh meat was prepared through the Schiff base reaction. Benefiting from the superhydrophilicity and porous structure of aerogels, the prepared G3D1BC0.5 (Gelatin: Dialdehyde starch = 3:1, Bacterial cellulose : 0.5%) aerogel not only possessed excellent adsorption performance but also rapidly regain their shape under 70% compression strain. The G3D1BC0.5 aerogel incorporating curcumin (Cur) showed the good antibacterial ability where the survival rate of Listeria monocytogenes , Staphylococcus aureus , Escherichia coli and Salmonella typhimurium significantly decreased to lower than 45% with the increase of Cur content ( P < 0.05). Furthermore, the prepared aerogels had the excellent preservation effect on fresh meat during storage. The G3D1BC0.5-Cur0.7 aerogels can extend the shelf-life of fresh pork to 12 days by inhibiting microbial growth , protein oxidation, and lipid oxidation. Therefore, the prepared aerogel in the present study had great potential for preservation of fresh pork.
研究领域:
食品科学
·
材料科学
·
微生物学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2018
·
IF 3.862
Yuzhen Hu,Miao Li,Mengmeng Zhang,Yiguang Jin
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with high mortality and poor prognosis. Curcumin shows anti-inflammatory effect by suppressing pro-inflammatory cytokines and inhibiting NF-κB mediated inflammation. Here, we developed inhalable curcumin-loaded poly(lactic-co-glycolic)acid (PLGA) large porous microparticles (LPMPs) for the treatment of IPF. Curcumin LPMPs were rough and loose particles with many pores on the surfaces and channels in the inner spaces. The mean geometric diameter of them was larger than 10 µm while the aerodynamic diameter was only 3.12 µm due to their porous structures. They showed a fine particle fraction (FPF) <4.46 μm of 13.41%, 71% cumulative release after 9 h, and more importantly, they avoided uptake by alveolar macrophages. Therefore, most of released curcumin had opportunities to enter lung tissues. Rat pulmonary fibrosis models were established via once intratracheal administration of bleomycin . Curcumin powders and curcumin LPMPs were administered on Days 2, 7, 14, and 21. Curcumin LPMPs remarkably attenuated lung injuries, decreased hydroxyproline contents, reduced the synthesis of collagen I, and inhibited the expressions of TNF-α, TGF-β1, NF-κB p65 and MMP9 . Moreover, curcumin LPMPs showed higher antifibrotic activity than curcumin powders. Curcumin LPMPs are a promising inhalable medication for the treatment of IPF.
研究领域:
药理学
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肺病学
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材料科学
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2025
·
IF 5
Xu Weihua,Liu Tianxi,Han Yingying,Zheng Yu,Yan Shijing,You Hui
Sustainable polyurethane materials derived from biomass or degradable components hold great promise. In this study, we polymerized UV-photoreactive curcumin (Cur), hydroxyethyl hexahydrotriazine (HT), and polyethylene glycol (PEG) with isophorone diisocyanate to craft a bio-based polyurethane (Cur-PU) film that exhibits both degradability and UV cross-linking capabilities. The feed ratio, encompassing NCO/OH and the hydroxyl groups of the raw materials, was meticulously optimized through a series of structural and physicochemical tests to yield high-performance, degradable Cur-PU films. FT-IR spectra confirmed the successful synthesis of the material. Property assessments revealed that adjusting the relevant ratios enhanced the structural rigidity and crosslinking density of the Cur-PU, leading to improved thermal stability, mechanical strength, and accelerated degradation time. Specifically, at an NCO/OH ratio of 1.6 and a PEG-OH/HT-OH/Cur-OH ratio of 2/4/4, the Cur-PU film exhibited balanced performance characteristics, including a tensile strength of 12.1 MPa, an elongation at break of 516%, a glass transition temperature of 90.7 °C, a 5% weight loss temperature of 230 °C, and a degradation time of 2.12 h in 2 M phosphoric acid/ethanol. Furthermore, the optimally prepared Cur-PU showcased exceptional recyclability and UV-photocrosslinking properties. Its recycled products retained PEG and Cur components, and the high UV-photocrosslinking content contributed to enhanced Young’s modulus and thermal properties. When compared to conventional PU materials, the PU material developed in this study demonstrates environmental friendliness and broader application potential, thanks to its recyclability and photosensitivity advantages.
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产品关联
DOI
高影响因子
Journal of Cosmetic Dermatology
·
2022
·Vol. 21
·期 10
·5081-5091
·
IF 2.189
Zhigang Zhang,Huiya Chen,Wanlu Shen,Juqing Deng,Chunling Bai,Yun Xiao,Lechun Lyu
Background Curcumin can promote wound healing, but its drug delivery medium needs to be improved further. Objectives A curcumin-loaded thermosensitive hydrogel was prepared, its characterization was evaluated, and its promoting effect on wound healing was observed. Methods Curcumin-loaded thermosensitive hydrogels were prepared with different percentages of poloxamer 188 and poloxamer 407. A small tube inversion assay was used to observe the sol-gel transition temperature, and a rotational rheometer was used to detect the sol viscosity, sol-gel phase transition temperature, and phase transition time. The microstructure of the gel was observed by scanning electron microscopy, and Fourier infrared spectroscopy was used to evaluate whether curcumin was successfully loaded. Finally, its promoting effect on wound healing was observed in vivo and in vitro . Results Poloxamer 407 24% and poloxamer 188 1% were selected to prepare curcumin-loaded thermosensitive hydrogels. After 60 ± 15 s at 32°C, the sol-gel transition process was completed, with certain elastic behavior and solid-like rheological properties. Scanning electron microscopy showed that the pores of the curcumin-P407/P188 thermosensitive hydrogel were interconnected, with an average pore size ranging from 5 to 10 μm. Hydrogels showed a higher swelling ratio. Fourier transform infrared spectroscopy showed that curcumin had been incorporated into the hydrogel. Live/dead cell assays suggested that the hydrogel was not toxic to fibroblasts. Curcumin-loaded thermosensitive hydrogels can promote an increase in S-phase fibroblasts and improve wound healing. Conclusions Curcumin-loaded P407/P188 thermosensitive hydrogel improves wound healing. More in-depth research is needed in the future.
研究领域:
药学
·
材料科学
·
生物医学工程
·
药理学
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DOI
PubMed
高影响因子
Current Drug Delivery
·
2024
·
IF 2.8
Zhang Ziyi,Tian Jinyuan,Xu Xiaoqing,Shi Wei,Qi Yajuan,Liu Zhanjun
Introduction: Polymer prodrug nanoparticles have become an emerging drug delivery
system in cancer therapy due to their high drug loading. However, their poor drug release and lack of
tumor cell targeting limit their clinical application.
Objective: This study aimed to prepare targeted and reduction-reactive polyprodrug nanocarriers
based on curcumin (CUR) for co-delivery of doxorubicin (DOX), labeled as DOX/HAPCS NPs, and
to investigate their anticancer activity.
Methods: The polymer was synthesized and characterized by chemical method. The drug loading
and drug release behavior of DOX and CUR in polymer nanoparticles were determined. Moreover,
the antitumor effects of polymer nanoparticles were evaluated using an MTT experiment and tumor
inhibition experiment, and the synergistic effect of co-delivered DOX and CUR was explored.
Results: The particle size of DOX/HAPCS NPs was 152.5nm, and the potential was about -26.74
mV. The drug-carrying capacity of DOX and CUR was about 7.56% and 34.75%, respectively, indicating
high drug-carrying capacity and good stability. DOX and CUR released over 90% within 24
hours in the tumor environment. Compared with free DOX, DOX/HAPCS NPs demonstrated significantly
enhanced cell and tumor inhibitory effects (P<0.05) in vivo and in vitro and changed drug
distribution to avoid toxic side effects on normal tissues. The combined index showed that DOX and
CUR showed synergistic anticancer effects at a set ratio.
Conclusion: The prepared reduction-responsive targeted polymer nanomedical DOX/HAPCS NPs
exhibited a synergistic anti-cancer effect, with high drug loading capacity and the ability to release
drugs in proportion, making it a promising polymer nanoparticle drug delivery system.
研究领域:
药剂学
·
肿瘤学
·
生物医学工程
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DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Litao Liu,Ruinian Hua,Xuan Zhang,Xiang Li,Wei Zhang,Xiaohui Qi,Tieying Zhang,Siwei Yang,Heqiu Zhang,Hongwei Liang
Curcumin is a natural organic substance that has attracted much attention because of its medicinal properties. Because of its immunomodulatory, anti-inflammatory, analgesic and anticarcinogenic effects, medicines containing curcumin are used to treat fever, jaundice, and skin diseases, especially cancers. The luminescence resonance energy transfer (LRET) technique is a powerful and widely used analytical method to verify analytes. In this work, we propose core/shell-structured upconversion nanoparticles (UCNPs) modified with amino groups as a luminescence probe for curcumin detection via LRET; the method is highly sensitive, rapid, easy to operate, and simple and has a low detection limit. In the detection process, curcumin can be brought into close proximity to the core/shell-structured UCNPs@NH 2 via electrostatic attraction and absorb the luminescence of the UCNPs. The results show that the detection limit of curcumin is 0.625 ng/mL. This study indicates that core/shell-structured UCNPs@NH 2 could be used as a valuable probe to detect curcumin.
研究领域:
分析化学
·
药理学
·
纳米生物技术
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产品关联
DOI
高影响因子
CHEMICAL PHYSICS LETTERS
·
2021
·
IF 2.328
Chen-Chen Zhao,Yang-Lin Jiang,Rong-Yao Gao,Hai-Dan Yao,Peng Wang,Jian-Ping Zhang
Solvent effects on photophysical and photochemical properties of mono-biotinylated curcumin ( mbt -Cur) in comparison with curcumin (Cur) were studied. Same with Cur, mbt -Cur dominantly adopts ‘enol-keto’ configuration in all solvents stabilized by intramolecular H-bond. In non-protic solvents, the photophysical properties of mbt -Cur depend on the solvent polarity parameter Δ f . In H-bond solvent methanol, dramatic deviation of all photophysical properties from the correlation established in non-H-bond solvent occurred. H-bond capability of solvent was found to determine the excitation dynamic mechanism of mbt -Cur at a microsecond timescale. This research laid the foundation for further application of mbt -Cur in biological systems.
研究领域:
物理化学
·
光化学
·
生物物理学
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产品关联
DOI
高影响因子
DRUG DELIVERY
·
2020
·
IF 4.902
QingQing Leng,Yue Li,XianLun Pang,BiQiong Wang,ZhouXue Wu,Yun Lu,Kang Xiong,Ling Zhao,Ping Zhou,ShaoZhi Fu
Skin repair remains a common problem in plastic surgery. Wound dressing plays an important role in promoting local skin healing and has been widely studied. This study aimed to manufacture a composite film (CPCF) containing curcumin nanoparticles, collagen, and polyvinyl alcohol (PVA) to effectively promote the healing of skin wounds. Sustained drug release from the composite film provides long-term protection and treatment for skin wounds. Both antibacterial property and good histocompatibility of the CPCF were examined by analyzing antibacterial activity and cytotoxicity to validate its applicability for wound management. Moreover, in vivo studies proved that the CPCF had a rapid healing rate of 98.03%±0.79% and mature epithelialization on day 15 after surgery. Obvious hair follicles and earlier re-epithelialization was also noticed in the CPCF group using H&E staining. The result of Masson’s trichrome staining confirmed that CPCF could promote the formation of collagen fibers. In summary, CPCF may be promising as a wound dressing agent in wound management owing to its rapid wound-healing effects.
研究领域:
材料科学
·
生物医学工程
·
药剂学
·
伤口愈合
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2016
·
IF 3.902
Xiang Kang,Chen Zhao,Lesan Yan,Ruogu Qi,Xiabin Jing,Zehua Wang
A polymer-cisplatin(IV) conjugate was prepared by attaching Pt(IV)-COOH to a biodegradable amphiphilic block copolymer containing pendant OH groups. The conjugate can assemble into micelles (M(Pt)) with a mean diameter of ca. 169 nm. Further, curcumin (CM) was used to sensitize platinum drug based nanoparticles to overcome cisplatin resistance and enhance antitumor efficacy. In vitro studies showed that M(Pt)/CM combinations had great synergistic effect both on cisplatin sensitive and cisplatin resistant cell lines (A2780 and A2780DDP). In vivo studies showed that M(Pt)/CM had a much lower systemic toxicity and an enhanced antitumor efficacy compared to cisplatin alone or the corresponding cisplatin/CM combinations. Therefore, polymer-cisplatin(IV) conjugate with small molecules that serve as a non-cytotoxic or minimally cytotoxic sensitizer or enhancer provide a promising strategy, which may have potential clinical implications in the near future.
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2023
·
IF 5.5
Hu Zhimin,Tang Ying,Jiang Bulin,Xu Yue,Liu Siying,Huang Cui
Introduction: Plaque biofilms, mainly formed by Streptococcus mutans (S. mutans), play an important role in the occurrence and development of dental caries. Antibiotic treatment is the traditional way to control plaque. However, problems such as poor drug penetration and antibiotic resistance have encouraged the search for alternative strategies. In this paper, we hope to avoid antibiotic resistance through the antibacterial effect of curcumin, a natural plant extract with photodynamic effects, on S. mutans. However, the clinical application of curcumin is limited due to its low water solubility, poor stability, high metabolic rate, fast clearance rate, and limited bioavailability. In recent years, liposomes have become a widely used drug carrier due to their numerous advantages, such as high drug loading efficiency, high stability in the biological environment, controlled release, biocompatibility, non-toxic, and biodegradability. So, we constructed a curcumin-loaded liposome (Cur@LP) to avoid the defect of curcumin.Methods: Cur@LP functioned with NHS can adhere to the surface of the S. mutans biofilm by condensation reaction. Liposome (LP) and Cur@LP was characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The cytotoxicity of Cur@LP was evaluated by CCK-8 assay and LDH assay. The adhesion of Cur@LP to S. mutans biofilm was observed by confocal laser scanning microscope (CLSM). The antibiofilm efficiency of Cur@LP were evaluated by crystal violet staining, CLSM, and scanning electron microscope (SEM).Results: The mean diameter of LP and Cur@LP were 206.67 ± 8.38 nm and 312 ± 18.78 nm respectively. The ζ-potential of LP and Cur@LP were ∼−19.3 mV and ∼−20.8 mV respectively. The encapsulation efficiency of Cur@LP was (42.61 ± 2.19) %, and curcumin was rapidly released up to ±21% at 2 h. Cur@LP has negligible cytotoxicity, and can effectively adhered to the S. mutans biofilm and inhibited its growth.Discussion: Curcumin has been widely studied in many fields such as cancer, which can be attributed to its antioxidant and anti-inflammatory effects. At present, there are few studies on the delivery of curcumin to S. mutans biofilm. In this study, we verified the adhesion and antibiofilm of Cur@LP to S. mutans biofilm. This biofilm removal strategy has the potential to be translated into the clinic.
研究领域:
牙科学
·
药剂学
·
微生物学
·
药物递送系统
·
抗菌剂
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产品关联
DOI
PubMed
高影响因子
BMC Complementary and Alternative Medicine
·
2017
·Vol. 17
·期 1
·1-10
·
IF 2.288
Chen Long,Liu Tianjun,Wang Qiangsong,Liu Juan
Background Resveratrol and curcumin, as natural flavones products, have good therapeutic effect in acute and chronic inflammation; on the other hand, tetramethylpyrazine (TMP) has angiogenesis and vessel protection effect as well as anti-inflammatory function. In this paper, the anti-inflammatory effect of the tetramethylpyrazine, resveratrol and curcumin (TRC) combination in acute and chronic inflammation was reported in vivo.Methods The dose of the combined three natural products was optimized based on the acute paw swelling mouse model with a Uniform Design methodology. The therapeutic effect of TRC combination on chronic inflammation was investigated by using the collagen-induced arthritis (CIA) rat model based upon the following indexes: the volume of paw swelling, arthritis score, serum mediators and histological examination as well as immunohistochemical staining. The levels of alanine aminotransferase (ALT) and aspartate transaminase (AST) in serum were measured and the pathological sections of liver and kidney were analysed. LD50 was measured based on the acute oral toxicity (AOT) standard method.Results The best formulation was the three components combined at the same mass proportion revealed by the Uniform Design methodology. This combination could significantly reduce the paw swelling in acute paw swelling mouse model, could reduce paw swelling and alleviate the damage in joint structural of ankle, cartilages and fibrous tissue in CIA rat model. The dose relationship was clear in both cases. Immunohistochemical staining of ankle tissue revealed that TRC combination was able to inhibit the expression of NF-κB p65 and TNF-α which were closely related to the inflammatory process. Analysis of serum mediators revealed TRC combination could inhibit the production of TNF-α, IL-1β, and IL-6 in the serum. Toxic study revealed this formulation was low toxic, LD50 was larger than 5 g/kg, both the level of ALT and AST and histopathology in the liver and kidney exhibited no distinctions between the TRC combination and the blank group, no mortality occurred at the administered doses of 5 g/kg.Conclusion sThe results showed this formulation could provide a novel potent treatment for acute and chronic inflammation (RA) without side effect like gastric injury occurring in NSAIDs.
研究领域:
药理学
·
免疫学
·
毒理学
·
风湿病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）