WATER AIR AND SOIL POLLUTION
·
2024
·Vol. 235
·期 2
·1-12
·
IF 3.8
Wang Tiantian,Liu Haicheng
Utilizing the allelopathic effect of plants to inhibit algae growth has gained significant attention from researchers in recent years. However, there are large amounts of microplastics in the aquatic environment, which may influence the inhibitory effects of allelochemicals on algae. Consequently, this research aimed to examine the individual and combined toxicity of gallic acid (GA) and polyethylene glycol terephthalate (PET) microplastics on Microcystis aeruginosa. At a concentration of 50 mg/L, PET significantly enhanced algal cell growth and chlorophyll a synthesis, while inducing oxidative stress without damaging the cell membrane. On the other hand, low concentrations of GA promote algal cell growth. However, high concentrations of GA not only inhibit growth and photosynthesis but also result in cellular abnormalities and severe oxidative damage, as well as membrane disruption. Moreover, it was observed that the exposure of PET diminished the toxicity of GA to M. aeruginosa . The combined exposure to GA and PET resulted in a slight increase in chlorophyll a content, as well as phycocyanin (PC), alloxyphycocyanin (APC), and phycoerythrin (PE) content, along with maximum photochemical efficiency (Fv/Fm), compared to GA exposure alone. In the combined system of GA and PET, the contents of superoxide dismutase (SOD) and malondialdehyde (MDA) were lower than those in the single GA system. Additionally, both systems showed a degree of improvement compared to the control group. Scanning electron microscopy (SEM) observed that the presence of PET resulted in reduced damage to algal cells compared to exposure to GA alone. This research establishes a foundation for understanding the synergistic impacts of allelochemicals and microplastics on M. aeruginosa , thereby providing a reference for managing cyanobacteria in water blooms.
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APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Qifang Zheng,Liuyang Dong,Peilun Shen,Tianfu Zhang,Dianwen Liu
Scheelite and cassiterite are common tungsten and tin oxide minerals that often coexist in nature. However, the similar oxidation degrees and solution and surface chemical properties of scheelite and cassiterite pose challenges to their flotation separation. Moreover, research in this area is currently limited. This study investigated the selective depression mechanism of gallic acid (GA) in the flotation separation of scheelite and cassiterite and successfully achieved the effective separation of the two minerals. Single mineral and artificially mixed mineral experiments were performed to analyze the flotation separation behavior of scheelite and cassiterite. The results revealed that in the absence of a depressant, scheelite and cassiterite exhibited recovery of 93.43 % and 89.72 %, respectively. After the addition of 5 × 10 −4 mol/L GA to the mineral slurry, the grades of WO 3 and Sn in the flotation concentrates were 48.93 % and 18.13 %, with recovery of 82.50 % and 31.62 %, respectively. Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, zeta potential, adsorption amount, contact angle, and atomic force microscopy imaging analyses were conducted to examine the selective depression mechanism of GA in the flotation separation of scheelite and cassiterite. In the slurry, the cassiterite surface provided active Sn sites for the chemical adsorption of GA. Moreover, the phenolate O- donor atoms of the deprotonated polar groups of GA will undergo coordination with metal ions and then adsorb on the mineral surface. GA forms metal gallate through adsorption of its –COOH and –OH groups on mineral surface and produces textured oxide layer rich in OH groups, thus reducing the surface hydrophobicity of cassiterite and then depressing cassiterite. The selective adsorption of GA on the cassiterite surface hindered the further adsorption of NaOL, thereby reducing its surface hydrophobicity. Therefore, GA finally realized the flotation separation of the two minerals.
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JOURNAL OF REINFORCED PLASTICS AND COMPOSITES
·
2024
·
IF 2.3
Lin Liu,Xin Xu,Jing Wu,Lin Zhang
A novel method, drawing inspiration from the chemistry principle observed in mussels, has been recently developed to augment the wettability and adherence of carbon fibers (CFs) within epoxy resin matrix. This technique entails the concurrent application of gallic acid and aminopropyl double terminated polydimethylsiloxane on CF surfaces via a direct method. Advanced analytical techniques like scanning electron microscopy, X-ray diffraction, infrared and Raman spectroscopy, along with X-ray photoelectron spectroscopy, confirmed the effective simultaneous deposition of these agents, possibly via Michael addition or Schiff base reactions. Incorporation of these treated fibers into epoxy composites resulted in notable performance enhancements. The composites with gallic acid and polydimethylsiloxane modified fibers exhibited up to 14%, 13%, and 27% improvements in interlaminar shear strength, flexural modulus, and flexural strength, respectively, compared to their counterpart with untreated fibers. These results indicate that combining gallic acid and polydimethylsiloxane on CFs is a potent approach to boost the interface qualities of CF-reinforced epoxy resin composites.
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Materials Today Energy
·
2025
·
IF 8.6
Yifeng Xia,Ana Xu,Ruicheng Cao,Xiaoyan Zou,Minmin Yuan,Xuan Liu,Peng Wan,Hui Xu,Hong Jin
The massive expansion of silicon anodes during cycling is a challenge that collapses the electrode structure and severely reduces interfacial stability, ultimately shortening battery life significantly. To address these issues, we have utilized gallic acid (GA) to endow sodium alginate (SA) with enhanced properties and designed a multifunctional binder (SG91) capable of inducing the establishment of a functional solid electrolyte interface (SEI) membrane. Significantly, adjusting the dosage of GA has resulted in a substantial boost in the electrode's ionic/electron transport capability and structural integrity. Results clearly show that an appropriate amount of GA not only facilitates the creation of a fluorine-enriched solid-electrolyte interphase but also remarkably accelerates ionic and electronic transport. Based on this, the Si@SG91 electrode maintains 1751 mAh/g even after 500 cycles at 1.6 A/g. The introduction of GA can also effectively enhance the hydrophilicity of conductive carbon black in pure water and reduce the parasitic reactions occurring at the electrode-electrolyte junction. This study fully demonstrates GA's outstanding potential during the research and creation process of silicon-based anode binders applicable to lithium-ion batteries.
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Foods
·
2026
·Vol. 15
·期 3
·556
·
IF 6
Zhenjing Huang,Jiahao Luo,Xiaoyun Fei,Deming Gong,Xing Hu,Guowen Zhang
Covalent modification of polyphenols effectively enhances functional properties of proteins. This study conjugated potato protein isolate (PPI) with gallic acid (GA) via an alkaline method to investigate structural and functional alterations. Successful conjugation was confirmed by a significant decrease in free amino and sulfhydryl groups, coupled with a marked increase in total phenolic content. Multispectroscopic analyses indicated a loosening of the secondary structure and notable changes in the tertiary conformation. Molecular dynamics (MD) simulations corroborated these findings, revealing that GA conjugation induced conformational expansion, improved structural stability, and enhanced surface hydrophilicity. These structural modifications led to substantial functional improvements in the PPI-GA conjugates, including enhanced dispersion stability, improved emulsifying performance, strengthened antioxidant activity, and increased thermal stability. This research may provide effective strategy and technical support for the improvement of functional properties of PPI and expand its application in the food industry.
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Journal of Materials Chemistry B
·
2026
·
IF 6.2
Rui Xu,Wang Sun,Longxiang Yao,Hua Zeng,Xinyu Qu,Jia-Qi Fang,Ziheng Bu,Ximan Yang,Xiaoya Jin,Mengting Yin,Feng Chen,Bing-Qiang Lu
Infected skin defects persist in a pathological state characterized by dysregulation of the immune microenvironment and impaired bioenergetics, requiring coordinated treatment strategies to remold them. The current developing therapies with coordinated effects are often hampered by incomplete targets, high complexity, and limited clinical performance, underscoring the need for minimalist yet effective strategies that integrate both targets. Here, we address this challenge by designing a two-component system, the polyphosphate–gallic acid (polyP-GA) complex with high biocompatibility and adaptability to different material forms (e.g., solution, spray, hydrogel, paste). Based on the mutually complementary and enhanced effects of the two constituents, polyP-GA complex markedly inhibits bacterial infection, reduces reactive oxygen species (ROS) accumulation, as well as suppresses inflammation evidenced by facilitated macrophage polarization toward the reparative M2 phenotype and broad related anti-inflammatory transcriptional effects. Concurrently, polyP-GA complex restores mitochondrial function and elevates intracellular adenosine triphosphate (ATP) levels, thereby activating pathways essential for fibroblast migration and angiogenesis. In a mouse model of infected skin defect, application of polyP-GA complex (in the form of hydrogel and spray sequentially) significantly accelerated wound closure, enhanced collagen deposition and neovascularization, and promoted functional tissue remodeling. This work demonstrates that the minimalist therapeutic design, built on the synergistic pairing of biocompatible but otherwise subtherapeutic agents polyP and GA, can effectively break the cycle of infection-driven regenerative arrest, achieving high performance in promoting the healing of infected skin defects.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Haihua Wang,Jianxia Yao,Ying Hou,Zhuoya Liu,Dong Yang
The development of eco-friendly and multifunctional edible coatings is crucial for mitigating postharvest losses of perishable fruits. Hence, a novel composite coating was engineered based on chitosan (CS) and pullulan (PUL) matrix, enhanced by a gallic acid-grafted chitosan (GS) conjugate synthesized through free radical grafting. The GS conjugate served as a multifunctional crosslinker, establishing a dense intermolecular network within the CS-PUL matrix primarily (CP) through hydrogen bonding, as confirmed by structural characterization. This molecular-level interaction significantly improved the mechanical strength (Tensile stress = 4.95 MPa, Elongation at break =121.21%) and barrier properties of the resulting coating. The chitosan/pullulan-gallic acid grafted chitosan (CP-GS) coating, applicable by spraying or dipping, exhibited remarkable antioxidant activity, achieving 97.8% DPPH radical scavenging (25 °C, 50% RH), the CP-GS coating significantly reduced weight loss, delayed the decline in titratable acidity, and effectively suppressed microbial growth, thereby extending the shelf life by 7 to 9 days compared to the uncoated samples. This study highlights the effectiveness of molecular grafting in designing advanced bio-based coatings and presents a promising strategy for fruit preservation using biological macromolecules.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Xiuqing Guan,Ziwei Ye,Xin Lei,Xinyan Wen,Jie Duan,Xianrui Chen,Lin Wang,Jie Pang
Flower-like KGZn superstructures formed by sequential coordination assembly. • KGZn enhances barrier, mechanical, and UV-blocking properties of KC films. • KC-KGZn films show DPPH (43.40%) and ABTS (97.67%) scavenging activities. • KC-KGZn films exhibit > 92% antibacterial ratios against E. coli , S. aureus , and S. cerevisiae . • KC-KGZn films extend blueberry shelf life to 15 days at 25 °C. The challenge of spoilage and waste in fruits is creating a strong demand for the development of green and efficient active packaging materials. This work presents a flower-like kaempferol–gallic acid–Zn coordination superstructure (KGZn) synthesized via coordination-driven assembly. KGZn was incorporated into a film matrix composed of konjac glucomannan and carboxymethyl chitosan (KGM/CMCS, denoted as KC), yielding the KC-KGZn composite film. Serving as a multifunctional agent, KGZn significantly improves the physicochemical properties of the composite film, enhancing its barrier performance and mechanical properties. Furthermore, the composite film exhibits excellent antioxidant activity, with DPPH and ABTS scavenging rates reaching 43.40 ± 2.10% and 97.67 ± 0.67%, respectively, as well as potent antimicrobial activity, showing inhibition ratios of 92.15%, 100%, and 98.66% against Escherichia coli , Staphylococcus aureus , and Saccharomyces cerevisiae , respectively. In blueberry preservation tests, the KC-KGZn composite film effectively slowed down fruit weight loss and firmness degradation, maintained soluble solids content, and preserved desirable sensory quality after 15 days of storage at 25 °C. These results indicate that the introduction of this flower-like superstructure material is an effective strategy for fabricating high-performance food packaging films, while also promoting the development of metal-polyphenol functional fillers. Download: Download high-res image (173KB) Download: Download full-size image
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Sustainability
·
2025
·Vol. 17
·期 12
·5240
·
IF 3.3
Xulong Jing,Shuyu Liu,Jiapei Wang,Chao Wan,Juan Zhu,Xiaojun He,Biyu Jin
The development of polymer binders with tailored functionalities and green manufacturing processes is highly needed for high-performance lithium–sulfur batteries. In this study, a readily hydrolyzable 3,9-divinyl-2,4,8,10-tetraoxaspiro-[5.5]-undecane is utilized to prepare a water-based binder. Specifically, the acrolein produced by hydrolysis undergoes in situ polymerization to form a linear polymer, while the other hydrolyzed product, pentaerythritol, physically crosslinks these polymer chains via hydrogen bonding, generating a network polymer (BTU). Additionally, gallic acid (GA), a substance derived from waste wood, is further introduced into BTU during slurry preparation, forming a biphenol-containing binder (BG) with a multi-hydrogen-bonded structure. This resilience and robust cathode framework effectively accommodate volumetric changes during cycling while maintaining efficient ion and electron transport pathways. Furthermore, the abundant polar groups in BG enable strong polysulfide adsorption. As a result, sulfur cathode with a high mass loading of 5.3 mg cm−2employing the BG (7:3) binder still retains an areal capacity of 4.7 mA h cm−2after 50 cycles at 0.1 C. This work presents a sustainable strategy for battery manufacturing by integrating renewable biomass-derived materials and eco-friendly aqueous processing to develop polymer binders, offering a green pathway to high-performance lithium–sulfur batteries.
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MOLECULES
·
2026
·Vol. 31
·期 2
·210
·
IF 4.6
Qi Chen,Shuaiwei Cui,Wenwen Zhang,Gang Dong,Baoshan Tang,Jinju Ma,Juan Xu,Jun Zhang,Lanxiang Liu
Gallic acid (GA) exhibits excellent antioxidant properties but suffers from chemical instability due to its carboxyl group, which limits practical application. To address this, we designed and investigated 14 distinct ester derivatives of GA, which were categorized into two major groups based on their substituents: chain alkyl and hydroxyl-substituted alkyl groups. Systematic evaluation revealed a striking decline in the DPPH radical scavenging activity of alkyl esters with increasing carbon chain length, from 91.9% for GA-C3 to 55.6% for GA-C30. The hydroxyl-functionalized GA esters GA-EG, GA-GL, and GA-PT maintain high antioxidant activity (>90%) while improving applicability through carboxyl substitution. In the oil system, all derivatives significantly prolong the oxidation induction time, with GA-C3 exhibiting the highest performance by extending the induction time by 2.15 h. Hydroxyl-functionalized esters such as GA-EG, GA-GL, and GA-PT also demonstrated significant efficacy, prolonging oxidation induction by 1.92 to 2.03 h. The results suggest how the structure of GA esters affects their antioxidant behavior, providing a direction for designing antioxidants suitable for specific systems.
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Journal of Orthopaedic Translation
·
2023
·
IF 6.6
Fengxiang Pang,Shouchang Ding,Nan Li,Zhipeng Li,Nannan Tian,Chuanjian Shi,Fengwei Zhang,Yongxin Mai,Jinfang Zhang,Junyan Wang
Background Osteosarcoma (OS) is the most common primary malignancy in bone tissues, and effective therapeutics remain absent in clinical practice. Traditional Chinese medicines (TCM) have been used for thousands of years, which provide great insights into OS management. Gallic acid (GA) is a natural phenolic acid enriched in various foods and herbs. Several pharmacological activities of GA such as anti-oxidation and anti-inflammation have been well-established. However, its biological function in OS remains not fully understood. Methods The potential anti-cancer properties of GA were evaluated in 143 B, U2OS and MG63 cells. Its effects on cell growth, cell cycle, apoptosis and migration were examined in these OS cells. The lncRNA H19 and Wnt/β-catenin signaling were detected by qPCR, luciferase activity and Western blotting assays. The in vivo effect of GA on tumor growth was investigated using an orthotopic mouse model. Results In the present study, GA was found to suppress the tumor growth in vitro via inducing cell cycle arrest and apoptosis in OS cells, and inhibit the invasion and metastasis as well. Using the orthotopic animal model, GA was also found to suppress tumorigenesis in vivo . Long noncoding RNA (lncRNA) H19 was demonstrated to be down-regulated by GA, and thus disrupted the canonical Wnt/β-catenin signaling in OS cells. Furthermore, the ectopic expression of H19 rescued the GA-induced suppressive effects on tumor growth and metastasis, and partially reversed the inactivation of Wnt/β-catenin signaling. Conclusions Taken together, our results indicated that GA inhibited tumor growth through an H19-mediated Wnt/β-catenin signaling regulatory axis in OS cells. The translational potential of this article The information gained from this study provides a novel underlying mechanism of GA mediated anti-OS activity, suggesting that GA may be a promising drug candidate for OS patients.
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Food Bioscience
·
2022
·
IF 5.318
Tan Hu,Siyi Pan
The self-assembled peptide-based hydrogels have been widely utilized in foods . However, the self-assembled hydrogels still have some shortages such as low mechanical properties and hydrogel stabilities. Herein, we designed two co-assembled C 13 -WS hydrogels conjugated by Gallic Acid (CA) and Epigallocatechin Gallate (EGCG). The introduction of CA and EGCG into C 13 -WS hydrogels can significantly improve the mechanical properties and hydrogel stabilities. The storage modulus (G’) values of co-assembled C 13 -WS/CA and C 13 -WS/EGCG were 13.33 KPa and 16 KPa, respectively. From transmission electron microscope (TEM) results, CA and EGCG contributed to the rearrangement of C 13 -WS molecules during co-assembly. Moreover, the self-/co-assembled C 13 -WS hydrogels showed antimicrobial activity against E. coli , P. aeruginosa , and S. epidermidis . The introduction of CA and EGCG significantly enhanced the antibacterial activity of C 13 -WS hydrogels. Our findings provide a novel strategy for the development of stable supramolecular antibacterial short peptide hydrogels through co-assembly.
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