JOURNAL OF SOLUTION CHEMISTRY
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2017
·Vol. 46
·期 5
·1048-1058
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IF 1.342
Li Qiang,Liu Bijun,Tian Yin,Yu Qianhong,Mu Wanjun,Wei Hongyuan,Wang Dongqi,Li Xingliang,Luo Shunzhong
N -(phosphonomethyl)- l -proline is an analogue of glyphosate. The protonation for N -(phosphonomethyl)- l -proline was studied by potentiometry, calorimetry, 31 P NMR spectroscopy and quantum chemical calculations to further understand the protonation process of glyphosate. The results confirmed that the order of successive protonation sites of totally deprotonated N -(phosphonomethyl)- l -proline are a phosphonate oxygen, amino nitrogen, and finally the carboxylate oxygen. The results can improve the understanding of the biological activity of these types of molecules in solution.
研究领域:
热力学
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溶液化学
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物理化学
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环境化学
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生物无机化学
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高影响因子
FOOD CHEMISTRY
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2026
·
IF 10.4
Lijun Wang,Kunrong Zhao,Minghui Luo,Yi Li,Xiao Yang,Xianggui Chen
A dual-recognition strategy was developed to detect glyphosate. • The dual-recognition system incorporated Fe/Cu-N-C SAzymes and aptamers. • The LOD was 0.0581 μg/mL. • The method had high specificity and excellent tolerance to matrix effects. • Recovery rates of the proposed method ranged from 90.00% to 96.67%. While nanozyme-based inhibition strategies are attractive for on-site detection of pesticides, their sensitivity is primarily hampered by insufficient interactions at the nanozyme-pesticide interface. To address this, we developed a dual-recognition system that integrates a Fe/Cu-N-C single-atom nanozyme (SAzyme) with an aptamer for sensitive detection of glyphosate. The Fe/Cu-N-C SAzyme overcomes the low atomic exposure of conventional nanozymes by offering abundant metal atomic sites for glyphosate binding. Meanwhile, the surface-grafted aptamers on the SAzyme facilitate glyphosate enrichment on the SAzyme surface, thereby increasing the inhibition efficiency from 14.4% to 26.1%. Under optimized conditions, this enhancement translated into a detection limit of 0.0581 μg/mL, along with high specificity and excellent tolerance to matrix effects. Validation experiments with three spiked samples yielded recoveries ranging from 90.00% to 96.67%, comparable to the results of liquid chromatography-tandem mass spectrometry, demonstrating the reliability of this approach for glyphosate detection in foods. Download: Download high-res image (136KB) Download: Download full-size image
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BIOLOGICAL TRACE ELEMENT RESEARCH
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2026
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IF 4.3
Zhong Zhao-Jin,Chen Kai,Qiu Bo,Chen Pan,Lian Cai-Yu,Wang Lin
Cadmium (Cd) and glyphosate (GLY) are two prevalent environmental contaminants. Their widespread use in agricultural activities has caused frequent co-contamination incidents within ecosystems. The kidney is a primary target organ and the major excretory organ for these pollutants. However, the nephrotoxic effects of their co-exposure on mammals remain unclear. Sixty healthy mice housed in a specific pathogen-free facility were randomly divided into 4 groups ( n = 15) and exposed to GLY (8.75 mg GLY/kg feed) and/or Cd (1.45 mg Cd/kg feed) via diet for 24 weeks; subsequently, the urine, serum, and kidney samples were collected for respective analyses. Data showed that serum levels of renal injury biomarkers in the combined group were significantly higher than those in the alone group, consistent with the renal pathological findings. Urinary levels of proteins and enzymes in the combined group were also markedly higher than those in the alone group, respectively, consistent with the ultrastructural changes of proximal tubular microvilli. Moreover, mitochondria and nuclei in the renal cortex of combined group exhibited more severe ultrastructural damage than those in the alone group, indicating the characteristic of apoptosis. Data from apoptotic assays further suggested that the combined group exhibited more obvious apoptotic damage than those in the alone group. Collectively, these findings demonstrated that GLY itself exhibits low nephrotoxicity, but combined exposure to GLY and Cd significantly enhances Cd’s nephrotoxic effects, characterized by exacerbated apoptotic damage to proximal tubule cells.
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JOURNAL OF HAZARDOUS MATERIALS
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2026
·
IF 10.6
Yiqing Wu,Lina Qin,Yimeng Zhang,Yifan Jia,Yaoyang Lü,Nianlong Wang,Hao Zheng,Liang Li,Zijing Zhang
Microplastics, as emerging persistent environmental contaminants, can act as vectors for the absorption of other pollutants in ecosystems, such as pesticide residues. However, the combined toxicological effects of microplastics and pesticides on pollinators remain poorly understood. Here, we evaluated the toxicity of polystyrene microplastics (PS) and glyphosate (GLY), both individually and in combination, in honeybees ( Apis mellifera ). While no significant changes in body weight gain or food consumption were observed after 20 days of exposure, co-exposure to PS and GLY significantly increased bee mortality and induced midgut damage and microbial dysbiosis. In the gut, pathways associated with cell proliferation and differentiation, along with genes related to oxidative stress, detoxification, and immunity, were significantly downregulated. Furthermore, the combination of PS and GLY impaired sucrose responsiveness, a key cognitive behavior in bees. Brain transcriptomics indicated a downregulation of serotonergic synapse-related genes, which were correlated with shifts in core gut bacteria such as Snodgrassella and Lactobacillus . Our findings demonstrate that co-exposure to PS and GLY exacerbates gut homeostasis disruption and impairs cognitive behavior, suggesting a potential role of the gut–brain axis. This study extends our understanding of the combined ecological risks posed by multiple environmental contaminants to bees as insect pollinators and emphasizes the need for comprehensive hazard assessments in insect conservation.
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高影响因子
FOOD CHEMISTRY
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2025
·
IF 9.8
Ziyi Qin,Jinju Xu,Yuanxin Cao,Chunhui Liao,Tian Lan,Shuyun Shi
Highly sensitive monitoring of pesticides has garnered attention for food safety. Here, a ratiometric fluorescent probe (AG-CDs-Al 3+ /CdTe QDs) was fabricated for specific and sensitive sensing of glyphosate. Surface modifications revealed the chelation-enhanced fluorescence process between the surface -OH of AG-CDs and Al 3+ . Positively charged green-emission AG-CDs-Al 3+ assembled with negatively charged red-emission CdTe QDs, and photoinduced electron transfer (PET) occurred from CdTe QDs to AG CDs-Al 3+ . Glyphosate specifically coordinated with Al 3+ , causing remarkable variations in F 500 /F 630 (linear range, 0.2–4.0 μM; detection limit, 5.7 nM) and a distinguishable green-yellow-red color change on the paper platform (linear range, 0.5–8.0 μM; detection limit, 26 nM). Furthermore, for real sample analysis, the sensor has the advantages of fast response (5 min), excellent accuracy (spiked recoveries, 95.0–105.0 %), high precision (relative standard deviation, < 3.33 %), and superior specificity, which endowed the designed sensing platform with great potential practicality in the field of food analysis.
研究领域:
食品安全
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分析化学
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环境科学
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2024
·
IF 12.2
Yuhong Li,Yujun Cheng,Yutian Huang,Pengcheng Zhao,Junjie Fei,Yixi Xie
Glyphosate (Gly), as a widely used broad-spectrum herbicide, may lead to soil and water pollution due to its persistence in the environment. Herein, the co-reduction method was employed to anchor bimetallic PdCu onto the Ni and nitrogen-doped 3D Flower-like Carbon Materials (Ni@NC), creating a composite material (PdCu/Ni@NC) with high specific surface area and good catalytic performance. This composite was used to modify screen-printed electrodes (SPE) to develop a portable and efficient Gly detection platform. In the presence of Cl⁻, the copper active sites convert to CuCl, achieving signal amplification. Upon the addition of Gly, a competitive reaction between Cu and Gly converts CuCl into a Cu-Gly complex, resulting in a sharp decrease in the electrochemical signal. This signal drop is used to detect Gly. The bimetallic PdCu nanoparticles (NPs) endowed the sensing platform with better stability and electrochemical performance due to their synergistic effect, and their stability was simply verified by Density functional theory (DFT). The sensor demonstrates a linear detection range spanning from 1 × 10⁻¹ ³ to 1 × 10⁻⁵ M, with a limit of detection (LOD) of 3.72 × 10⁻¹ ⁴ M. The sensor demonstrated a recovery rate of 95.9 % to 104.5 % in actual samples such as water and soil, indicating its potential for practical application.
研究领域:
环境科学
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分析化学
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材料科学
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电化学
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高影响因子
Journal of Cleaner Production
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2025
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IF 10
Danyi Chen,Rongrong Zhao,Honglin Liu,Hailin Tian,Yiqun Tian,Di Huang,David Johnson,Yingping Huang
Developing efficient strategies for glyphosate (PMG) degradation while minimizing the formation of the toxic intermediate, aminomethylphosphonic acid (AMPA), is crucial for environmental remediation. In this study, two Schiff base metal complexes, Fe-SPA and Cu-SPA (SPA: salicylaldehyde o-phenylenediamine), were prepared and evaluated for their catalytic activity in activating H 2 O 2 under visible light irradiation (Vis, λ ≥ 420 nm) to degrade PMG. The Fe-SPA/H 2 O 2 (Vis) system achieved 99.9% degradation of 200 μmol/L PMG within 2 h, while the Cu-SPA/H 2 O 2 (Vis) system achieved complete degradation within 5 h. Interestingly, the Fe-SPA/H 2 O 2 (Vis) system selectively catalyzed PMG degradation via an environmentally friendly pathway, producing glycine as the final product. While in the Cu-SPA/H 2 O 2 (Vis) system, in addition to glycine, initially produced toxic AMPA, which was subsequently mineralized into non-toxic inorganic products. These differences in degradation pathways could be attributed to the preferential adsorption behavior of PMG and H 2 O 2 on the M-SPA complexes. Specifically, Fe-SPA selectively adsorbed the phosphate group of PMG, facilitating the C−P bond cleavage. Conversely, Cu-SPA preferentially adsorbed H 2 O 2 , resulting in a nonselective PMG degradation. Furthermore, hydroxyl radicals (·OH) and photogenerated holes (h⁺) were identified as the dominant reactive species in both systems. Fe-SPA exhibited excellent stability and maintained high catalytic performance across a wide pH range (3–10) and after five cycles of use. These findings highlighted the pivotal role of the central metal in determining pollutant degradation pathways. This study offers a promising strategy for efficient and environmentally safe PMG remediation.
研究领域:
环境科学
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催化化学
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高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
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2023
·
IF 3.8
You-Ping Jin,You Lu,Yue Gao,Qing Li
The sensitive and selective detection of glyphosate (Gly) in the environment is urgently need because it has significant implications for human health and environmental safety. In this work, a GSH-AuNCs/Cu 2+ sensing probe was fabricated via the coordination between Cu 2+ and GSH-AuNCs, which resulted in the suppression of the fluorescence of GSH-AuNCs. Glyphosate can competitively grasp Cu 2+ from GSH-AuNCs/Cu 2+ , leading to fluorescence recovery. Thereby, a simple and sensitive “turn-on” fluorescence strategy was developed for the quantitative detection of glyphosate. The linear range of glyphosate detection is 0.25 ∼ 1.25 μM, with a detection limit of 92.16 ng/mL. This method was demonstrated selectivity, fast response, and sensitivity, making it suitable for the quantitative determination of glyphosate in real water samples. Furthermore, a paper-based test strip was constructed using the sensing probe, which enabled on-site visual and semiquantitative detection of Gly. Overall, our strategy provides new opportunities for determination of organophosphorus pesticides in the environment.
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高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
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2016
·
IF 3.187
Bijun Liu,Lan Dong,Qianhong Yu,Xingliang Li,Fengchang Wu,Zhaoyi Tan,Shunzhong Luo
Glyphosate [N-(phosphonomethyl)glycine] has been described as the ideal herbicide because of its unique properties. There is some conflicting information concerning the structures and conformations involved in the protonation process of glyphosate. Protonation may influence the chemical and physical properties of glyphosate, modifying its structure and the chemical processes in which it is involved. To better understand the species in solution associated with changes in pH, thermodynamic study (potentiometry, calorimetry and NMR spectroscopy) about the protonation pathway of glyphosate is performed. Experimental results confirmed that the order of successive protonation sites of totally deprotonated glyphosate is phosphonate oxygen, amino nitrogen, and finally carboxylate oxygen. This trend is in agreement with the most recent theoretical work in the literature on the subject ( J. Phys. Chem. A 2015,, 119, 5241−5249). The result is important because it confirms that the protonated site of glyphosate in pH range 7–8, is not on the amino but on the phosphonate group instead. This corrected information can improve the understanding of the glyphosate chemical and biochemical action.
研究领域:
化学
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环境科学
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生物学
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高影响因子
Carbon Letters
·
2023
·Vol. 33
·期 7
·1935-1945
·
IF 4.5
Wang Qian,Wang Miao,Zheng Lufei,She Yongxin,Wang Jing,Jia Minghong,Abd El-Aty A. M.
The widespread and extensive use of glyphosate in agriculture has raised concerns about its potential impact on the quality and safety of agricultural products. Conventional detection methods require long analysis times, making them impractical for the rapid detection of large quantities of samples. Therefore, developing a fast and simple detection system for glyphosate pesticide residues is urgent. In this study, the development of a facile fluorescence probe synthesized using a simple one-pot hydrothermal method for the determination of glyphosate is an important step toward addressing the need for a fast and simple detection system. The present sensor was created using bovine serum albumin (BSA) as a precursor, and the sensor operates by producing an “off–on” fluorescent signal. The bovine albumin-derived BSA-CDs emitted light yellow fluorescence, but this fluorescence was quenched (or suppressed) by the presence of Cu 2+ ions. However, the fluorescence can be restored by the presence of glyphosate, which interacts with the Cu 2+ ions to form a complex and release the BSA-CDs from suppression. The functional groups in glyphosate can capture Cu 2+ and break the BSA-CDs/Cu 2+ combinatorial system. The BSA-CDs/Cu 2+ fluorescence quenching system had good selectivity for glyphosate. The detection limit of the BSA-CD/Cu 2+ fluorescence sensor was 0.05 µg/mL. This developed method was utilized to successfully detect glyphosate in Chinese wheat. The average recoveries ranged from 98.9 to 100.7%, with a relative standard deviation < 3.0%, showing good prospects for practical applicability.
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高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2023
·
IF 4.3
Kuan Wang,Bin Jiao,Haixiang Gao,Xinglu Pan,Xiaohu Wu,Jun Xu,Fengshou Dong,Yongquan Zheng
Persistent weed growing in herbicide-resistant maize and soybean fields is controlled increasingly by glyphosate (GLY) and glufosinate-ammonium (GLU). There is increasing concern that consumers may be exposed to herbicide residues . A Total of 224 samples involved supervised trials and market sampling were carried out. And the levels of GLY and GLU were determined in maize and soybean samples by UPLC−MS/MS method. The residues of GLY and GLU were at a low level in all samples and ranged from <0.04 to 0.29 mg/kg and <0.04 to 0.91 mg/kg, respectively. Deterministic and probabilistic models were used to assess the dietary risk, and the highest risk quotient (RQ) values of GLY and GLU were 2.24 × 10 −4 and 3.27 × 10 −2 , respectively. The RQs of GLU are significantly higher than that of GLY. Risk assessment results showed that GLY and GLU residues should not pose serious health risks to Chinese consumers.
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ACS Sustainable Chemistry & Engineering
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2023
·
IF 8.4
Runran Ma,Lizhu Fu,Nan Long,Haipeng Guo,Yujiao Hou,Ying Li,Peng Li,Jiabo Wang,Lidong Zhou,Weijun Kong
In this work, a novel ratiometric fluorescent nanosensor by coupling mesoporous silica spheres-coated nitrogen-doped carbon dots (N-CDs@SiO2) and bovine serum albumin-stabilized gold nanoclusters (BSA-AuNCs) was developed for sensitive detection of glyphosate. BSA-AuNCs nanocomposites were covalently connected onto the surface of amino-functionalized N-CDs@SiO2 nanospheres, causing the core-satellite probes with two fluorescence emissions at 436 and 651 nm, respectively, under a single excitation of 360 nm. The N-CDs@SiO2@BSA-AuNCs “signal on–off–on” ratiometric fluorescent probes could realize highly selective differentiation and accurate detection of glyphosate based on the fluorescence quenching of Cu2+ on BSA-AuNCs and glyphosate-induced fluorescence recovery due to the strong complexation of glyphosate toward Cu2+. The developed ratiometric fluorescent nanosensor exhibited excellent selectivity to glyphosate, wide detectability in a concentration range of 5–100 ng/mL, high sensitivity with a low detection limit of 3.4 ng/mL, as well as fascinating reliability and practicability in real malt samples with recoveries of 94.81–101.61%. This study provides a universal platform for versatile sensing of more trace analytes in complex matrices and can be extended for wide application in the environment and food safety fields.
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高影响因子
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