Frontiers in Marine Science
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2025
·
IF 3
Wenpeng Jia,Lidong Sun,Huanjun Li,Tingjin Lv,Yongzheng Tang,Yongrui Pi
The remove of oxytetracycline hydrochloride (OTC) antibiotics from water presents both significant challenges and importance. In this study, magnetic activated carbon (MAC) was synthesized from powdered activated carbon and ferric compounds using an alkaline co-precipitation process. Various characterizations techniques employed to assess the microscopic morphology, pore structure, and surface functionality of the adsorbents. The maximum equilibrium adsorption (qm) of MAC for OTC at temperature of 20, 25, 30, 35, and 40°C were found to be 93, 112, 118, 108, and 117 mg/g, respectively, as determined by the Langmuir isotherm adsorption model. Thermodynamic and adsorption site energy analyses indicated that the adsorption process is a spontaneous endothermic reaction at elevated temperatures. During the OTC removal process, both chemisorption and physisorption mechanisms were observed, with adsorption site energies ranging from 4 to 16 kJ/mol, suggesting that chemical adsorption likely played a predominant role. The adsorbent material demonstrated excellent adsorption efficiency and a spontaneous nature, making it a promising candidate for the environmentally friendly treatment of antibiotic-contaminated wastewater.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Yufei Liang,Lihong Zhao,Liangbin Chen
As typical antibiotic pollutants, oxytetracycline (OTC) and chlortetracycline (CTC) are widely present in water bodies and difficult to degrade naturally, posing potential threats to ecosystems and human health. To address this issue, this study successfully prepared two novel types of kaolin/corn straw biochars through high-temperature pyrolysis and nanoparticle modification, and investigated their adsorption performance for OTC and CTC in water. The characterization results showed that the two modified biochars had a high specific surface area and developed pore structures, which were conducive to improving adsorption efficiency. The batch adsorption experiments showed that the nano-CuFe2O4 modified biochar (KLBCCF) was superior to the nano-CuO modified biochar (KLBCC) in terms of adsorption capacity, interference resistance, and regeneration performance. The pseudo-second-order kinetic model and the Langmuir model can better fit the OTC and CTC adsorption processes by KLBCCF. At 318.15 K, the adsorption capacities of KLBCCF for OTC and CTC were determined to be 170.21 and 316.26 mg g−1, respectively. The thermodynamic analysis showed that the adsorption process was spontaneous, heat-absorbing, and entropy-increasing. The adsorption mechanisms of OTC and CTC on KLBCCF included pore filling, hydrogen bonding, surface complexation, electrostatic interactions, and π–π interactions. This study promotes the development process of efficient adsorbents and provides a theoretical basis for the effective removal of antibiotics.
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高影响因子
MICROCHIMICA ACTA
·
2013
·Vol. 180
·期 9
·829-835
·
IF 3.434
Zhao Huimin,Gao Sheng,Liu Meng,Chang Yangyang,Fan Xinfei,Quan Xie
We report on a fluorescent assay for oxytetracycline (OTC) using a fluorescein-labeled long-chain aptamer assembled onto reduced graphene oxide (rGO). The π-π stacking interaction between aptamer and rGO causes the fluorescence of the label to be almost completely quenched via energy transfer so that the system has very low background fluorescence. The addition of OTC leads to the formation of G-quadruplex OTC complexes and prevents the adsorption of labeled aptamer on the surface of rGO. As a result, fluorescence is restored, and this effect allows for a quantitative assay of OTC over the 0.1–2 μM concentration range and with a detection limit of 10 nM. This method is simple, rapid, selective and sensitive. It may be applied to other small molecule analytes by applying appropriate aptamers.
A simple and sensitive fluorescent assay for oxytetracycline detection based on the different interaction intensity of fluorescein-labeled long-chain aptamer, G-quadruplex-OTC complex with reduced graphene oxide was designed.
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高影响因子
RSC Advances
·
2015
·Vol. 5
·期 72
·58895-58901
·
IF 3.84
Fang Yuan,Huimin Zhao,Zhinan Zhang,Lichen Gao,Jintao Xu,Xie Quan
A fluorescent assay for oxytetracycline (OTC) detection was presented based on an indirectly fluorescein-labelled aptamer probe, which was fabricated through the partial hybridization of an OTC long-chain aptamer with a FAM-labelled short-chain ssDNA (S1). Upon combination of the target OTC and its aptamer, S1 with quenched fluorescein was released from the probe to the graphene sheet freely. Subsequently, it was hybridized with the complementary ssDNA (C1) and escaped from the quencher graphene to the solution, resulting in the restoration of fluorescence. Benefiting from the labelling of S1 instead of the OTC aptamer directly, the restoration of fluorescence was independent of the long-chain aptamer, perfectly avoiding the negative effects of the intrinsically existing secondary structure. Together with the high affinity of the aptamer for its target, this assay exhibited excellent sensitivity and selectivity. The linear response for OTC was found to be 0.01–0.2 μM with a limit of quantitation of 0.01 μM. Furthermore, the feasibility of the developed assay in a fresh water system and a milk sample was verified through the recovery experiments using spiked samples. This achievement based on such an indirect labelling method is also expected to lay a foundation to realize effective analysis of small molecule pollutants in the environment, for which the specific aptamers are long-chain nucleotide sequences.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 29
·29459-29467
·
IF 2.8
Zhen Lisha,Gu Jie,Hu Ting,Chen Zhixue
Veterinary antibiotics can enter agricultural fields via the application of livestock manure containing antibiotics. However, the response of soil microorganisms to compost containing antibiotics is not well understood. A 120-day pot experiment was conducted to investigate the impact of compost containing oxytetracycline (OTC) on the enzyme activities and microbial communities in maize rhizosphere soil. Swine manure was artificially spiked with OTC at four concentrations, 35, 70, 105, and 140 mg kg −1 , and combined with straw to produce compost. The compost products were applied to soil planted with maize. Rhizosphere soil samples were collected on days 1, 15, 30, 60, and 120. The results indicated that the urease activities first increased and then declined, while in contrast, the alkaline phosphatase activities first decreased and then increased slightly. Catalase exhibited dose-related activation during the maize growth period. At the end of the experiment, the soil enzyme activities were similar to their initial values, indicating that the soil enzymes showed a level of recovery. The carbon metabolic activity levels were higher in the soils with high OTC concentrations than in the control, whereas the Shannon diversity index was higher in the control soil. The results of principal component analysis (PCA) indicated that the application of compost containing OTC shifted the structure of the soil microbial community and negatively affected its stability. These results suggest that the compost containing OTC exerted selective pressure on enzyme activities and microbial communities in maize rhizosphere soil and decreased their resilience to antibiotic pollution.
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PubMed
高影响因子
Water
·
2021
·Vol. 13
·期 24
·3497
·
IF 3.103
Zhongda Hu,Zijing Fan,Qixuan Song,Rabia Khatoon,Mei Zhang,Ning Wang,Xingzhang Luo
Tetracycline antibiotics (TCs) are a common type of antibiotic found in swine wastewater. Oxytetracycline (OTC) is a significant type of TC. This study mainly examined the influence of OTC on high-temperature anaerobic digestion by adding OTC to collections of swine wastewater at different times during the digestion process. The results showed that high-temperature anaerobic digestion was suitable for the removal of TCs, with an 87% OTC removal efficiency achieved by day 20. Additionally, OTC added from external sources was found to inhibit the chlortetracycline degradation process and affect the first-order degradation kinetic model of TCs. Complexation reactions were the main ways in which OTC affected the heavy metal content of the water. The exogenous addition of OTC was found to inhibit the activity of some digester microbial strains, reduce the proportion of dominant strains, such asMBA03, and kill certain specific strains. This performance alteration was most obvious when OTC was added in the middle of the reaction.Keywords:swine wastewater;high-temperature anaerobic digestion;tetracycline antibiotics;oxytetracycline
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高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2022
·
IF 4.52
Yeqing Xu,Ting Huang,Suao Wang,Yongsheng Yan
Molecularly imprinted sensor has been a common chemical sensor for the selective detection of target. Yet, the rapid detection of target was one of the remaining problems, which needs to be diligently improved. Herein, a molecularly imprinted mesoporous silicon material (N-CDs@mMIPs) was successfully prepared for the rapid, sensitive and selective detection of oxytetracycline (OTC). Non-toxic nitrogen-doped carbon quantum dots (N-CDs) with high fluorescence performance was chosen as a detectable fluorescence signal, OTC was the target analysis, 3-Aminopropyltriethoxysilane (APTES) as the functional monomer, tetraethyl silicate (TEOS) as the crossing link agent and cetyl trimethyl ammonium bromide (CTAB) as the pore-foaming agent. N-CDs@mMIPs was synthesized by the removal of CTAB and OTC. Under the optimal test conditions, the resultant N-CDs@mMIPs showed a faster response time within 0.5 min (30 s) and a lower detection limit of 0.035 μmol·L −1 compared with molecularly imprinted sensor without mesoporous structure (N-CDs@MIPs) and other molecularly imprinted sensors. Consequently, N-CDs@mMIPs was applied for the detection of OTC in milk and honey, satisfied recovery rates of 99.80 %–100.60 % and 99.75 %–102.10 % were obtained respectively. In general, the pore structure in mesoporous silicon accelerated the mass transfer rate between target and fluorescent substance, which greatly shortened the detection time of N-CDs@mMIPs to OTC. Furthermore, the pore structure in mesoporous silicon could effectively avoid the self-aggregation of N-CDs, thus improved the sensitivity of N-CDs@mMIPs.
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高影响因子
NANO
·
2022
·
IF 1.438
Wan Gao,Yanliang Li,Wuming Xie,Jianzhi Huang,Lei Li,Zhixin Qiu
Antibiotics are a class of organic pollutant in the medical field for hundreds of years. Due to the continuous discharge of antibiotics in the environment, the phenomenon of pseudo-persistence of antibiotics is produced. Therefore, it is necessary to develop an advanced sustainable technology to remove antibiotics from water resources. In this study, Zeolite Imidazole Framework-8 (ZIF-8) was prepared by a simple and rapid method. Oxytetracycline (OTC) degradation was performed using ZIF-8 as a photocatalyst under visible light (VL) (500 W xenon lamp) irradiation. Under different experimental conditions, ZIF-8 has strong catalytic removal performance for OTC. When the reaction conditions are: OTC concentration of 80 mg L − 1 , ZIF-8 concentration of 1.0 g L − 1 , pH 5.96, the OTC removal rate is more than 90%. Through the detection and analysis of degradation intermediates, the possible degradation pathway of OTC was proposed. This study showed that the OTC removal rate of ZIF-8 could still reach 69% after four times of recycling. The results showed that the ZIF-8/VL system had high OTC removal efficiency and good recyclability.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 7.7
Na-Na Ran,Quan Luo,Hong-Wei Li,Yuqing Wu
Herein, a novel ratiometric fluorescent nanosensor was prepared by in-situ incorporation of Eu 3+ into nitrogen-rich carbon dots (Eu-CDs) via a one-step hydrothermal route. The obtained Eu-CDs display dual emission: a strong blue band at 440 nm (carbon core) and a weak red band at 615 nm ( 5 D 0 → 7 F 2 transition of Eu 3+ ). Upon titrating oxytetracycline (OTC) into the system, the blue signal remained invariant as an internal reference, whereas the red emission dramatically enhanced by the OTC-mediated antenna effect. The intensity ratio ( I 615 / I 440 ) increases linearly with OTC concentration over 1.0 – 50 µM, affording a limit of detection of 35 nM. Concomitantly, the dispersion exhibits a naked-eye color switch from blue to red under 365 nm UV illumination. Mechanistic investigations reveal that the specific recognition originates from (i) coordination between Eu 3+ and the β-diketone moiety of OTC and (ii) hydrogen-bonding interactions between OTC and the CDs surface. Although the probe is highly selective toward OTC over common ions and amino acids, it suffers from cross-reactivity among tetracycline antibiotics. This limitation was overcome by coupling the ratiometric read-out with linear discriminant analysis (LDA) of dual-mode (fluorescence and absorption) data, enabling 100% correct classification of OTC, tetracycline (TC), chlortetracycline (CTC), and doxycycline (DC) in both individual and mixed samples. The proposed strategy furnishes a simple, green and low-cost route to Eu-CDs and establishes a robust, portable platform for ultrasensitive quantification and discriminative sensing of tetracycline antibiotics in complex matrices.
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高影响因子
JOURNAL OF FOOD SCIENCE
·
2026
·Vol. 91
·期 5
·e71088
·
IF 4.1
Hui Yuan,Tai Feng Lin,Xue Mei Liu,Zi Qi Xie,Xin Yang,Yun Jing Luo
Human consumption of food contaminated with oxytetracycline (OTC) residues can lead to its accumulation in the body and cause harm. In this study, due to the trace residues of OTC in food, surface imprinting technology was employed to prepare oxytetracycline magnetic molecularly imprinted polymers (OTC-MMIPs). This was achieved using Fe 3 O 4 @SiO 2 as the core, modified with chitosan, and with OTC as the template molecule. OTC-MMIPs were used to adsorb OTC. After combining with AuNPs, the OTC-MMIPs@AuNPs composite was used to adsorb OTC, and then SERS was employed for detection. According to the kinetic adsorption experiment, the maximum adsorption capacity of OTC-MMIPs was 44.58 mg g −1 , with a 7% decrease in adsorption capacity observed after four cycles of reuse. Following the adsorption of OTC onto OTC-MMIPs@AuNPs, detection was performed using SERS. A linear relationship was established between the intensity of the characteristic peak at 1329 cm − 1 and the OTC concentration, achieving a detection limit of 6.67 × 10 −12 M. Furthermore, the method was validated in pure milk samples, the recovery rate ranges from 91.73% to 96.22%. These results demonstrate the feasibility of the proposed method for detecting OTC in pure milk.
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PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 77
·73741-73747
·
IF 3.289
Tianding Hu,Hongting Lv,Shaoyun Shan,Qingming Jia,Hongying Su,Na Tian,Shanchuan He
In this work, highly porous MIL-101 materials using hydrochloric acid (HCl) or hydrofluoric acid (HF) as a mineralizer were synthesized. The products were characterized with X-ray diffraction, scanning electron microscopy, thermal gravimetric analysis, and N2 sorption analysis. The results proved that the mineralizers had an obvious effect on the microstructures and morphologies of MIL-101, and MIL-101(HCl) showed remarkable superiority in a higher specific surface area, smaller particle size and higher crystallinity to the HF counterpart. These materials were then used to adsorb and remove the oxytetracycline (OTC) antibiotics from a water solution and an effective fast adsorption of OTC in aqueous solution was observed in the adsorptive kinetics. Compared with MIL-101(HF), a higher adsorption capacity on the MIL-101(HCl) was obtained, which was probably attributed to the higher specific surface area for the MIL-101(HCl). The adsorption mechanism might be greatly ascribed to π–π interaction, and acid–alkaline interaction between the oxytetracycline molecule and the adsorbent.
研究领域:
材料科学
·
环境化学
·
吸附技术
·
金属有机骨架材料（MOFs）
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高影响因子
Environmental Technology & Innovation
·
2023
·
IF 7.1
Yinfei Wang,Hongyan Deng,Wenbin Li,Min Li,Jinni Wu,Lei Hou,Jiangming Ouyang
To study the effect of litter extract (Le) from Alternanthera philoxeroides on the stability of oxytetracycline (OTC) in riverbank purple soil (P), we used different proportions of Le to modify acidic P (Ac-P), neutral P (Ne-P), and alkaline P (Al-P) to obtain Le-modified P (Le-Ac-P, Le-Ne-P, and Le-Al-P). The basic physicochemical properties of Le-modified Ps were determined, and their microscopic morphology was studied using specific surface area detection ( S BET ), scanning electron microscopy (SEM), energy dispersion spectroscopy (EDS), and Fourier transform infrared (FTIR) spectroscopy. Batch method was used to study the isothermal and thermodynamic characteristics of OTC adsorption on different Le-modified Ps, and the OTC stability differences were compared in terms of the changes in temperature, pH, and ionic strength. Results showed that pH of Le-Ne-Ps and Le-Al-Ps decreased, the S BET of Le-modified Ps decreased, the total organic carbon content of Le-modified Ps increased, and the cation exchange capacity (CEC) of Le-Ac-Ps and Le-Ne-Ps increased with the increased modification proportion of Le. SEM, EDS, and FTIR results all showed that Le modified the surface of different Ps. Langmuir model was more applicable to describe the isothermal adsorption of OTC by different Le-modified Ps than Henry and Freundlich models. The maximum adsorption capacity of OTC by different Le-modified Ps ranged between 5.48–129.10 mmol/kg, and the following trend was observed: Le-Ne-Ps > Le-Ac-Ps > Le-Al-Ps. 20%Le-modified Ps showed excellent adsorption capacity toward OTC. OTC adsorption on different Le-modified Ps decreased with the increase in pH and decrease in temperature. With increased ionic strength, the adsorption stability of OTC increased first and then decreased. OTC adsorption was a spontaneous, endothermic, and entropy-adding reaction. The CEC and pH of Le-modified Ps were the keys to determining the maximum adsorption capacity of OTC.
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