JOURNAL OF CONTROLLED RELEASE
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2025
·
IF 11.5
Hui Wang,Cui Tang,Hanfeng Zhang,Lina Guo,Chan Zou,Shengting Zhang,Jinlong Liu,Qianping Huang,Yujun Liu,Wenhu Zhou,Guoping Yang,Xiang Gao
Intracellular protein therapeutics offer great promise for treating diseases involving intracellular targets, yet their clinical translation remains limited by inefficient delivery systems. Here, we report the development of a simple, versatile, and biocompatible protein delivery platform based on tea polyphenol nanoparticles (TPNs) formed via the oxidative self-polymerization of epigallocatechin gallate (EGCG). Through noncovalent interactions between EGCG and proteins, TPNs enable efficient encapsulation of proteins with diverse molecular weights and isoelectric points under mild conditions. Using urate oxidase (UOx) as a model therapeutic protein, we demonstrate that TPNs protect UOx from enzymatic degradation, preserve its native structure and enzymatic activity, and achieve effective cytosolic delivery via glutathione-triggered release. In disease models of hyperuricemia and gouty arthritis, TPNs/UOx significantly prolonged UOx circulation, lowered serum uric acid levels, reduced joint inflammation, and improved liver and kidney function, with favorable biocompatibility. This work establishes TPNs as a versatile and stimuli-responsive platform for intracellular protein delivery, offering new strategies for the clinical application of protein therapeutics.
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高影响因子
Biosensors-Basel
·
2025
·Vol. 15
·期 5
·281
·
IF 5.6
Jia-Li Xu,Guangyao Zhao,Jiachen Wang,An Tang,Jun-Tao Liu,Zhijie Zhu,Qiang Zhang,Yu Tian
The rapid development of smart electronic skin has led researchers to design a variety of flexible and stretchable devices that can be used to monitor physiological and environmental signals. In this work, we successfully demonstrate a color-adjustable and conductive wearable optical–electronic skin (OE-skin) based on photonic crystal hydrogel that is capable of delivering both optical and electrical signal responses synchronously. The OE-skin is fabricated by incorporating a structural colored layer, composed of periodically aligned magnetic nanoparticles, into a polyacrylamide hydrogel matrix that contains tea polyphenols and borax. The dynamic boronate ester bonds formed between borax and the catechol groups of tea polyphenols are able to enhance the mechanical properties of the OE-skin, while also conferring excellent electrical conductivity, high sensitivity, and a rapid electrical response. Additionally, the tea polyphenols, which are natural active compounds derived from tea, possess diverse bioactive properties, thereby endowing the OE-skin with excellent antibacterial and biocompatibility characteristics. In addition, the developed electronic skin successfully demonstrates its capability in synergistic electronic and optical sensing during human motion monitoring, indicating broad application prospects in the field of smart wearable sensors.
研究领域:
材料科学
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生物医学工程
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传感器技术
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.7
Gongde Lan,Yuchen Liu,Hongyuan Mao,Han Yu,Weicheng Huang,Pengxiang Chen,Xin Chen,Qingxu Song,Yufeng Cheng,Yuxia Luan
Boron neutron capture therapy (BNCT) is a promising strategy for selective tumor eradication. However, the clinical application of the boron delivery agent p ‑boronophenylalanine (BPA) is limited by challenges such as poor solubility, suboptimal tumor accumulation, and lack of effective imaging capabilities. Here, we present a metal polyphenol-based boron nanodrug (EB@Gd NPs), designed to address these challenges and enhance the efficacy of BNCT. Self-assembled from epigallocatechin-3-gallate (EGCG), BPA, and gadolinium ions (Gd 3+ ), the EB@Gd NPs exhibit significantly improved tumor targeting and enable real-time magnetic resonance imaging (MRI). These nanoparticles show enhanced tumor accumulation, with MRI providing dynamic insights into boron distribution, thus aiding in determining optimal timing for neutron irradiation. Furthermore, EGCG potentiates therapeutic effect of BNCT by inhibiting DNA repair and promoting efficient DNA double-strand breaks. Therefore, the EB@Gd NPs demonstrate potent tumor growth inhibition in BNCT, holding great potential for improving precision and efficacy of BNCT in cancer therapy.
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Nature Communications
·
2026
·
IF 18.1
Wang Zixin,Lv Zeen,Ge Yuxuan,Xue Ruiyang,Wu Fang,Han Haijie,Wang Yin
The management of ocular surface inflammation, particularly in conditions like dry eye disease (DED), remains challenging due to multiple pathogenic causes and ocular barriers. Traditional eye drops usually provide transient and partial symptom relief, necessitating combined therapies to break the vicious cycle of oxidative stress and inflammation. To surmount these limitations, a polyphenol-based eye drop is developed via the self-polymerization of rosmarinic acid in the presence of hyaluronic acid, followed by co-assembly with cerium ions to afford monodispersed RHC NPs. To enhance the ocular retention efficiency, thiol groups are further decorated on NPs (termed as s -RHC NPs). In two mouse models of DED, topical administration of s -RHC NPs leads to comprehensive relief of symptoms, including inflammatory response suppression, corneal epithelial defect repair, and tear secretion recovery. We envision that this work might facilitate the treatment of DED and inspire the design of polyphenol-based nanoparticles via a self-polymerization strategy.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Haibo Mu,Hua Liang,Liangliang Hu,Xinqi Liu,Jinyou Duan,Qianjin Liu
Infected diabetic wounds remain a major clinical challenge owing to the complex pathological microenvironment characterized by persistent bacterial infection, excessive reactive oxygen species (ROS), prolonged inflammation, and impaired angiogenesis. Herein, we report a triple-responsive, injectable, adhesive, and self-healing hydrogel (RCGel) designed to dynamically regulate the diabetic wound microenvironment and promote efficient tissue regeneration. RCGel was constructed through reversible Schiff-base and boronate-ester cross-linking between CMCS-PBA and OChS-DA and was incorporated with rosmarinic acid-cerium nanoparticles. RCGel exhibited a sustained and potent ROS-scavenging capability. Meanwhile, RCGel enabled on-demand photothermal antibacterial therapy under mild near-infrared irradiation, effectively eradicating MRSA and P. aeruginosa. In vitro studies demonstrated excellent cytocompatibility, reduced intracellular ROS levels, macrophage M2 polarization, and enhanced angiogenic potential. In vivo, RCGel significantly accelerated wound closure, suppressed infection and inflammation, promoted neovascularization and collagen deposition, and improved tissue remodeling in both diabetic noninfected and MRSA-infected wound models, without evident systemic toxicity. Overall, this work presented a microenvironment-adaptive multifunctional hydrogel dressing that integrated antibacterial, antioxidative, immunomodulatory, and pro-regenerative functions, offering a promising therapeutic strategy for infected diabetic wound treatment.
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POLYMER BULLETIN
·
2024
·Vol. 81
·期 11
·9911-9931
·
IF 3.1
An Feng-Kun,Fu Zhen
Incorporation of aminated starch (AS)-polyphenol conjugates to improve corn starch (CS) film properties were explored. AS-polyphenols (gallic acid (GA), syringic acid (SA) and vanillic acid (VA)) conjugates were synthesized by laccase and the grafting rates of GA, SA and VA were 36.59, 69.71 and 68.85%, respectively. Incorporation of the three conjugates (AS-GA, AS-SA and AS-VA) into the corn starch film improved a variety of properties of the CS film. The CS film without the conjugates was smooth and flat, while surface of the CS film with the conjugates became relatively rough and wrinkled and there were some small particles on the surface. Incorporation of the conjugates improved the thermal stability of the CS film during the polymer depolymerization phase. The thickness of the CS film with AS-VA conjugates was significantly larger than that of the CS film and the incorporation of the conjugates improved the hydrophobicity of the CS film. The tensile strength (TS) of both the CS films with AS-GA conjugates and AS-VA conjugates was significantly enhanced, while the TS of the CS film with AS-SA conjugates was significantly reduced. The incorporation of AS-polyphenol conjugates could improve the antioxidant ability and antibacterial ability of the CS film, especially the CS films containing AS-GA conjugates.
研究领域:
食品科学
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高分子科学
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材料工程
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生物化学
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高影响因子
ACS Omega
·
2019
·
IF 2.584
Xi Yang
It is a huge challenge to have a controllable interfacial polymerization in the fabrication process of nanofiltration (NF) membranes. In this work, a polyphenol interlayer consisting of polyethyleneimine (PEI)/tannic acid (TA) was simply assembled on the polysulfone (PSf) substrate to fine-tune the interfacial polymerization process, without additional changes to the typical NF membrane fabrication procedures. In addition, three decisive factors in the interfacial polymerization process were examined, including the diffusion kinetics of fluorescence-labeled piperazine (FITC-PIP), the spreading behavior of the hexane solution containing acyl chloride, and the polyamide layer formation on the porous substrate by in situ Fourier transform infrared (FT-IR) spectroscopy. The experimental results demonstrate that the diffusion kinetics of FITC-PIP is greatly reduced, and the spreading behavior of the hexane solution is also impeded to some extent. Furthermore, in situ FT-IR spectroscopy demonstrates that by the mitigation of this PEI/TA interlayer, the interfacial polymerization process is greatly controlled. Moreover, the as-prepared NF membrane exhibits an increased water permeation flux of 65 L m–2 h–1 (at the operation pressure of 0.6 MPa), high Na2SO4 rejection of >99%, and excellent long-term structural stability.
研究领域:
材料科学
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环境工程
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ACS Applied Bio Materials
·
2022
·
IF 0
Jiabo Shi,Ruizhen Zhang,Jiajing Zhou,Wonjun Yim,Jesse V. Jokerst,Yi Zhang,Bradley W. Mansel,Na Yang,Yuxuan Zhang,Jianzhong Ma
Functional bionanocomposites have evoked immense research interests in many fields including biomedicine, food packaging, and environmental applications. Supramolecular self-assembled bionanocomposite materials fabricated by biopolymers and two-dimensional (2D) nanomaterials have particularly emerged as a compelling material due to their biodegradable nature, hierarchical structures, and designable multifunctions. However, construction of these materials with tunable properties has been still challenging. Here, we report a self-assembled, flexible, and antioxidative collagen nanocomposite film (CNF) via regulating supramolecular interactions of type I collagen and tannic acid (TA)-functionalized 2D synthetic clay nanoplatelets Laponite (LAP). Specifically, TA-coordinated LAP (LAP-TA) complexes were obtained via chelation and hydrogen bonding between TA and LAP clay nanoplatelets and further used to stabilize the triple-helical confirmation and fibrillar structure of the collagen via hydrogen bonding and electrostatic interactions, forming a hierarchical microstructure. The obtained transparent CNF not only exhibited the reinforced thermal stability, enzymatic resistance, tensile strength, and hydrophobicity but also good water vapor permeability and antioxidation. For example, the tensile strength was improved by over 2000%, and the antioxidant property was improved by 71%. Together with the simple fabrication process, we envision that the resulting CNF provides greater opportunities for versatile bionanocomposites design and fabrication serving as a promising candidate for emerging applications, especially food packaging and smart wearable devices.
研究领域:
生物材料学
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食品科学
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环境科学
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BIOMACROMOLECULES
·
2021
·
IF 6.988
Zhiqing Liu,Wei Yu,Wenbo Sheng,Rui Li,Helin Guo,Xiantao Feng,Qian Li,Rongjie Wang,Wei Li,Xin Jia
A facile and general strategy for preparing uniform and multifunctional polyphenol-based colloidal particles through amine-catalyzed polymerization-induced self-assembly is described. The size and interfacial adhesion of polyphenol spheres can be easily controlled over a wide range via adjusting the concentration of the cosolvent and monomer. Moreover, the polyphenol spheres showed excellent thermal and chemical stability and highly active properties and could efficiently deplete the reactive oxygen species (ROS), which are helpful for in vivo ROS regulation for inflammatory therapeutic. The accessible and versatile method provides a feasible way for the rational engineering of multifunctional polyphenol spheres, which have great potential in many fields.
研究领域:
材料科学
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生物医学
·
化学工程
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NEW JOURNAL OF CHEMISTRY
·
2023
·
IF 3.3
Zhuorui Zhang,Yunkai Yan,Jinyang Wang,Jianxi Song,Guiquan Jiang
Xylan-based preservative films were prepared using xylan, chitosan, citric acid and Sanguisorba officinalis L. polyphenols (SOPs) as main components. According to the trend of change in the physical properties of the films, the optimal composition was found to be: 1% xylan, 0.9% chitosan, 0.26% citric acid, and 0.15% SOPs. The effects of SOP content on the films were also determined. The results showed that incorporation of SOPs decreased the TS and EAB of the film and improved the water vapor barrier performance of the film. Scanning electron microscopy, contact angle measurements and thermogravimetric analysis showed that incorporation of SOPs enhanced the compactness, hydrophobicity and thermal stability of the films. Moreover, the films exhibited excellent antibacterial activities in the presence of SOPs. Compared to the polyethylene film, the film delayed spoilage bacteria growth during refrigerated storage of pork, effectively prolonging its shelf life to at least 10 days at 4 °C. In summary, xylan-based SOP preservative films meet the requirements for food packaging materials and have good prospects for use in this field.
研究领域:
食品科学
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材料科学
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生物技术
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Inorganics
·
2023
·Vol. 11
·期 4
·148
·
IF 2.9
Yan Guo,Junpo Guo,Bo Li,Yun Zheng,Wen Lei,Jiangmin Jiang,Jincheng Xu,Jingjun Shen,Jielei Li,Huaiyu Shao
The application of organic electrode materials can make the whole cycle of the lithium battery operation effective for green sustainability. However, poor electronic conductivity and strong solubility in nonprotonic electrolytes limit the application of organic anodes. Here, a novel organic anode material, TP-Ni, was fabricated through the simple chelation of tea polyphenols with nickel ions. Benefiting from coordination bonds that alter the intrinsic microstructure of TPs and contribute to pseudocapacitive charging, the TP-Ni anode exhibits remarkable electrochemical properties, including a high specific capacity (1163 mAh g−1at 0.1 A g−1), superb rate capability, and extraordinary cycling stability (5.0 A g−1over 4000 cycles with a capacity retention of 87.8%). This work can provide guidance for the design and synthesis of new high-performance organic electrode materials in the future and help accelerate the process of organic electrode material applications.Keywords:organic anode;chelation reaction;tea polyphenol;lithium-ion batteries;high performance
研究领域:
材料科学
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电化学
·
能源存储
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Small
·
2024
·
IF 13
Guidong Gong,Qimin Yin,Qinling Liu,Yajing Zhang,Jinyuan Liu,Mengyuan Dai,Jiawen Li,Xianglian He,Jiezhou Pan,Yunxiang He,Bo Wang,Jiyu Tong,Junling Guo
Cells existing in the form of clusters often exhibit distinct biological functions from their single-cell counterparts. However, the ability to modulate cell–cell interactions among multiple cell types through molecular scaffolds remains an ongoing challenge. Here, a supramolecular phenolic network on surfaces of live cells designed is engineered to act as modular scaffolds that promote intercellular interactions, presenting a universal platform for the construction of cell–cell assemblies (CCAs). Utilizing the inherent cell surface affinity of supramolecular phenolic network modules, a series of heterotypic CCAs is efficiently established by assembling five distinct microorganisms and five types of mammalian cells. A specific application of CCAs with the combination of L. casei and macrophages ( L. casei @Mφ) is highlighted for enhanced cancer immunotherapy. Upon intravenous administration, L. casei @Mφ allows the chemotactic Mφ to facilitate the accumulation of L. casei at the tumor. The accumulated L. casei enables the polarization of tumor-associated Mφ toward a pro-inflammatory phenotype, markedly improving the immunotherapeutic response, slowing tumor progression, and mitigating lung metastasis. This work demonstrates the potential of polyphenol-scaffolded modular assembly in manipulating cell–cell interactions to enhance multicellular cooperation, offering a general approach to controlling complex cellular behaviors.
研究领域:
生物医学工程
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免疫学
·
癌症研究
·
细胞生物学
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