COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Ce Cheng,Zhihua Wu,David Julian McClements,Liqiang Zou,Shengfeng Peng,Wei Zhou,Wei Liu
A novel cholesterol-free curcumin delivery system was fabricated by rhamnolipids modified liposomes (RL-Lps). The incorporation of the rhamnolipids increased the sphericity, reduced the size, and decreased the polydispersity of the liposomes compared with pure liposomes (Lps). Analysis of the environmental stability of the RL-Lps showed they have good long-term stability over a wide range of pH (2–3 and 5–8), ionic strengths (0–200 mM), and accelerated centrifugal conditions. The curcumin-loaded rhamnolipids modified liposomes (Cur-RL-Lps) could be prepared with a relatively high loading efficiency (LE > 90%) and loading capacity (LC > 3.5%). The thermal and photochemical stability of the curcumin was improved after encapsulation in the Cur-RL-Lps. In vitro release studies indicated that the sustained release of the curcumin was prolonged when rhamnolipids were incorporated into the liposomes. This study shows that rhamnolipids have great potential for liposomal delivery system suitable for utilization in functional foods, dietary supplements, and pharmaceutical preparations.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2017
·
IF 3.154
Dongliang Zhang,Yanfei Cao,Chengye Ma,Shanfeng Chen,Hongjun Li
There is a paradox when incorporating enzyme into an edible chitosan film that chitosan is dissolved in acid solution and enzyme activity is maintained under mild conditions. A method for maintaining the pH of the chitosan solution at 4–6 to prepare a chitosan film containing β-cyclodextrin, resveratrol−β-cyclodextrin inclusion (RCI), was developed, using glucamylase and acetic acid. A considerable amount of resveratrol was released by the glucamylase-incorporated film within 15 days, and the maximum amount released was 46% of the total resveratrol content. The highest resveratrol release ratio (released resveratrol/total resveratrol) was obtained in the film with 6 mL of RCI. Scratches and spores were generated on the surface of the glucamylase-added film immersed in water (GAFW) for 7 days because of β-cyclodextrin hydrolysis during film drying and water immersion. RCI and β-cyclodextrin were extruded from the film surface and formed teardrops, which were erased by water on the GAFW surface but appeared on the glucamylase-added film without water immersion (GAF). The bubbles generated by the reaction of acetic acid and residual sodium bicarbonate were observed in both glucamylase-free films immersed in water (GFFW) for 7 days and without water immersion (GFF). The FT-IR spectra illustrated that the covalent bond was not generated during water immersion and β-cyclodextrin hydrolysis. The crystal structure of chitosan was destroyed by water immersion and β-cyclodextrin hydrolysis, resulting in the lowest chitosan crystallization peak at 22°. The increasing of water holding capacity determined by EDX presented the following order: GAF, GFFW, GFF, and GAFW.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF NEUROSCIENCE
·
2017
·Vol. 45
·期 10
·1258-1267
·
IF 2.941
Dan Lv,Lijuan Zhou,Xianyu Zheng,Yongcheng Hu
Although the peripheral nervous system has an intrinsic ability for repair and regeneration after injury, bridging long peripheral nerve defects remains a challenge. Functional nerve regeneration depends on interactions among axons, Schwann cells, fibroblasts and immune cells. Macrophages, as immune cells recruited early in this process, show polarization toward phenotypes that are detrimental or beneficial to tissue remodeling depending on the microenvironment of the scaffolds. In this study, we investigated the effects of macrophage phenotypes modulated by collagen VI on axonal regeneration and functional recovery by bridging a 15-mm-long sciatic nerve defect in rats. Our results showed that local delivery of collagen VI within a polycaprolactone (PCL) electrospun conduit increased the recruitment of macrophages and their polarization toward the pro-healing (M2) phenotype. In addition, the axonal regeneration and neurologic functional recovery in the PCL/collagen VI conduit group are equivalent to that of an autograft. In conclusion, the present study confirmed that PCL/collagen VI conduits with sustained release of collagen VI in the local microenvironment may, through triggering macrophage M2 polarization to enhance the nerve regeneration, suggest that our combined biomaterial-immunomodulatory system may be an attractive candidate for peripheral nerve regeneration.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2015
·
IF 2.752
Hui Li,Xiaohong Zhu,Hui Zhou,Shian Zhong
A novel hydrophobic organic–inorganic hybrid nanocomposite was prepared for sustained release of analgesic. Using enlarged halloysite nanotubes (EHNTs) as nanocontainer and organosilane (OS) as the hydrophobic layer, nanocomposite denote as EHNTs@OS was readily prepared with a mild reaction. Then the EHNTs@OS was characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, energy dispersive X-ray analysis, and high-performance liquid chromatography. The hydrophobic layer composed of tetraethoxysilane and octyltriethoxysilane made a difference on the wettability of the EHNTs@OS. It was proved that the nanocomposite exhibited excellent hydrophobicity with a water contact angle of 132°. Moreover, an enhanced capacity for adsorption (25%) and the sustained-release performance (100 h) of the EHNTs@OS toward IBU were demonstrated and it followed the power law kinetic model. In conclusion, the drug-release platform explored in this work is suitable for other drugs and shows further comprehensive application prospect.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 11
·6287-6298
·
IF 3.049
Yuanfeng Wei,Jianjun Zhang,Yazhen Zheng,Yaxiang Gong,Meng Fu,Chengran Liu,Liang Xu,Changquan Calvin Sun,Yuan Gao,Shuai Qian
The present study aims to develop cubosomes with surface cross-linked chitosan for sustained drug delivery and enhanced oral bioavailability of vinpocetine (VPT). GMO based liquid cubosomes with VPT loading were prepared by the high pressure homogenization method. In order to enhance the anti-digestion effect, chitosan was cross-linked on cubosomes by the Schiff reaction, followed by solidification via spray drying. The obtained spray-dried cubosomes (chito-cubosomes) are spherical microspheres with nano-sized holes on the surface. After reconstitution, the particle size and zeta potential of chito-cubosomes were determined to be ∼250 nm and +35.9 mV, respectively. In comparison to unmodified liquid cubosomes, chito-cubosomes exhibited a significant anti-digestion effect with a typical sustained release profile. In comparison to a VPT suspension, liquid cubosomes showed a 2.5-fold higher Cmax and 3.0-fold higher AUC0–∞, while chito-cubosomes further enhanced bioavailability (5.0-fold) with prolonged MRT (2.2-fold) and delayed Tmax (2.8-fold). The results suggested that chito-cubosomes could be a promising drug carrier for enhancing oral absorption with sustained release behavior.
研究领域:
药剂学
·
药物递送系统
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Qi Tao,Hang Yao,Zehao Gu,Xiaofei Yang,Zhonglian Wu,Dong-An Wang,Yu Cao,Hui Chong
Chronic wounds are susceptible to bacterial aggregation, which could lead to severe infections and a complicated healing process. Addressing bacterial infections is crucial for effective wound repair. In this study, we developed an antibacterial nanozyme sustained-release system, Arg-CDs/ZIF-8, by doping arginine carbon dots (Arg-CDs) into the zeolitic imidazolate framework (ZIF-8) to achieve pH-responsive release. ensuring prolonged action at the wound site. In the presence of hydrogen peroxide, Arg-CDs/ZIF-8 demonstrates superior generation of NO and reactive oxygen species capability, exhibiting promising synergistic antibacterial effects against E. coli and S. aureus. In vivo animal experiments also demonstrated the excellent wound-healing ability of Arg-CDs/ZIF-8 in the presence of H2O2. The in vivo toxicity results confirm that Arg-CDs/ZIF-8 has good biosafety, providing a promising nonantibiotic approach to combat wound infections, and highlighting its potential in the development of antimicrobial materials.
研究领域:
生物材料学
·
医学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2024
·
IF 5.3
Yafang Xu,Shuai Zhang,Cong Li,Chao Liu,Chenyu Zhao,Heng Xu,Liang Fang
In this study, a sustained-release paliperidone (PAL) patch was developed using a combination of ion-pair strategy and percutaneous permeation enhancers (PPEs). The ion-pair strategy was used to improve drug-adhesive miscibility and control drug release. PPEs were used to break SC barrier function to facilitate drug skin permeation. The in vitro skin permeation experiments using single-factor experiments and Box-Behnken design gave the optimized formulation, a 55 μm adhesive thickness patch with 7 % ( w/w ) PAL-LA (Lauric acid), 9.7 % ( w/w ) Plurol® Oleique CC 497 (POCC). Moreover, the pharmacokinetic study confirmed its potential in sustained-release transdermal patch with longer MRT 0-t (18.35 ± 3.11 h) and higher BA (63.14 %) than the gavage group ( C max = 6.64 ± 2.61 μg/mL, MRT 0-t = 2.88 ± 1.06 h, BA = 45.70 %) without significant increasing C max . The mechanism study revealed that forming ion-pairs effectively modulated drug’s physicochemical properties and doubly ionic H-bond strength to improve drug miscibility in patches. To summarize, a sustained-release patch of PAL was successfully developed, which provided a strategy for sustained-release patches with good drug-polymer miscibility, drug controlled-release, and feasible drug utilization features.
研究领域:
药剂学
·
药物递送系统
·
皮肤药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yunlai Zhang,Yan Zhang,Mengqi Jian,Ying Pei,Jie Liu,Xuejing Zheng,Keyong Tang
In this work, carboxymethylated curdlan (CMCD) was utilized as a capping and stabilizing agent for the green synthesis of silver nanoparticles. Subsequently, quaternized curdlan (QCD) was introduced as the second capping layer through electrostatic attraction, leading to the preparation of double-capped silver nanoparticles (AgNPs@CQ). The successful synthesis of silver nanoparticles was characterized using UV–vis, FTIR, XRD, TEM, and DLS. AgNPs@CQ were incorporated into gelatin and a AgNPs@CQ/Gel composite hydrogel was obtained. The incorporation of AgNPs@CQ imparts excellent antibacterial properties to the composite hydrogel, thereby enhancing its antimicrobial efficacy. The presence of double-capping layers significantly retards the release rate of silver, contributing to prolonged antimicrobial activity. The MTT and live/dead fluorescence staining results demonstrate that the gelatin hydrogel incorporating double-capped AgNPs exhibits enhanced cell viability compared to the one incorporating single-capped AgNPs. Additionally, the composite hydrogel exhibits remarkable mechanical strength and adhesive performance. The AgNPs@CQ/Gel composite hydrogel demonstrates a cost-effective and facile preparation, showing significant potential in the field of dressings.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CLAY SCIENCE
·
2022
·
IF 5.907
Jiangxin Xiang,Runliang Zhu,Qingze Chen,Guocheng Lv,Yixuan Yang
The development of clay mineral-based soil amendments has drawn significant concerns in modern agriculture . However, little attention was paid to multifunctional amendments enabling both soil remediation and nutrients sustained release. In this work, a novel montmorillonite (Mt)-based amendment (denoted as KMt-P) was developed by modifying Mt with alkali followed by decoration with phosphate, and was further applied to remediate Cd/REEs contaminated soil. The XRD pattern of KMt-P demonstrated the presence of various silicophosphate and aluminophosphate phases. 27 Al and 29 Si MAS NMR results indicated the destruction of crystal structure of Mt. FTIR and XPS analyses confirmed the formation of Si-O-P, P-O-P, and Al-O-P bonds in KMt-P, which, as we envisioned, should be conductive to the immobilization of Cd and sustained release of nutrients. The addition of KMt-P to soil (1 wt%) could effectively reduce the bioavailable Cd in soil by 91.3% within 30 days. Sustained release of multiple nutrients was also achieved: the concentration of soluble K, Si, and P increases by 15, 3, and 135 times, respectively, in comparison with the control treatment. The increased K and P contents arose from the added modifiers, and that of Si could be ascribed to the destruction of Mt crystal structure under alkali attack. Application of only 1% KMt-P could reduce the concentrations of 17 REEs in the soil by 92.01%–98.89%. In general, KMt-P has proven a promising multifunctional amendment enabling both Cd/REEs immobilization and sustained release of nutrients.
研究领域:
农业科学
·
环境科学
✓ 已验证
DOI
高影响因子
CARBON
·
2012
·
IF 5.378
Dong Ma,Jiantao Lin,Yuyun Chen,Wei Xue,Li-Ming Zhang
Graphene oxide nanosheets were used to induce the in situ gelation of doxorubicin hydrochloride as an antitumor drug. When a very small amount of the graphene oxide was introduced into an aqueous solution of doxorubicin hydrochloride at room temperature, a strong and thixotropic gel was rapidly formed without any polymers or chemical additives. The gelation mechanism was investigated by fluorescence spectroscopy, X-ray diffraction and scanning electron microscopy. The encapsulated doxorubicin hydrochloride was found to show sustained release and antitumor efficacy.
研究领域:
药剂学
·
材料科学
·
肿瘤学
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2020
·
IF 0
Xuan Wang,Fanfan Li,Huanhuan Zhao,Yanwu Zhang
In order to improve the sustained release properties of carriers and explore the effect of copolymer sequence structures on sustained release, 5 groups of 12 block copolymers (12-BCPs) with different sequences were prepared using 4 monomers and the microstructure was controlled by changing the sequence of monomers. The results show that each polymer chain contains an average of 228 monomers and the proportion of 4 monomers basically conforms to 1:1:1:1. The release kinetics of fluorescein sodium (FS) as a drug model molecule was detected by UV–vis spectroscopy, and the result proves that sequence microstructures have great effect on their sustained release behaviors. The five groups of copolymers all show high initial loading (49.6–74.6 mg/g) and long sustained release time (18–30 days). The copolymer with the largest monodisperse self-assembly size (13.40 μm) in which the block sequence is 2-hydroxyethyl acrylate/styrene/4-vinylpyridine/tert-butyl acrylate has the optimal drug loading capacity (74.6 mg/g) compared with others. At the same time, it owns the most stable release state and the longest sustained release time (30 days).
研究领域:
高分子化学
·
药物传递系统
·
生物材料
✓ 已验证
DOI
Journal of Renewable Materials
·
2021
·Vol. 9
·期 10
·1673-1684
·
IF 1.67
Li Qiaoguang,Yan Xuming,Chen Jialong,Shu Xugang,Jia Puyou,Liang Xiangjun
Environmental cleaning is an important aspect of bacteria control. Ethyl cellulose microcapsules containing potassium monopersulfate (PMCM) were prepared by emulsified solvent diffusion method. The chemical structure and microstructure of the obtained PMCM was characterized by methods
of Fourier transform infrared spectroscopy (FT-IR), optical microscopy, scanning electron microscopy and X-ACT energy dispersive X-ray spectroscopy. The SEM micrographs of the PMCM containing 21.6% of C, 46.8% of O, 10.7% of S and 19.4% of K was relatively smooth. Thermal stability, sustained
release performance, and antimicrobial activity of PMCM were investigated. The results showed that the drug loading and encapsulation efficiency of PMCM were 30.3% and 42.6% respectively. Potassium monopersulfate was fully released after 8 h, following a Fickian diffusion mechanism. Results
showed that the microcapsules prepared with a high concentration of potassium monopersulfate solution showed a good antimicrobial effect. The microcapsule wall of the resulting PMCM increased with increasing ethyl cellulose content and had high thermal stability from the data of 69% residue
rate. The excellent thermal stability and high sustained release performance of PMCM showed high application value.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）