Catalysts
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2024
·Vol. 14
·期 1
·36
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IF 3.8
Min Zheng,Xiangzhou Li,Dulin Yin,Steven R. Kirk,Hui Li,Peng Zhou,Yanhong Yang
Carveol is a rare fine chemical with specific biological activities and functions in nature. The artificial synthesis of carveol from plentiful and cheap turpentine is expected to further improve development of pharmaceutical and industrial applications. A new green catalytic system for the preparation of high-value carveol from α-epoxypinane is presented. A novel ammonium salt solid acid (AC-COIMI-NH4PW) was obtained from phosphotungstic acid bonded with imidazole basic site on nitrogen-doped activated carbon which, after ammonia fumigation, presented an excellent catalytic performance for the selective rearrangement of α-epoxypinane to carveol in DMF as solvent under mild reaction conditions. At 90 °C for 2 h, the conversion of α-epoxypinane could reach 98.9% and the selectivity of carveol was 50.6%. The acidic catalytic sites exhibited superior durability and the catalytic performance can be restored by supplementing the lost catalyst. Based on the investigation of catalytic processes, a parallel catalytic mechanism for the main product was proposed from the rearrangement of α-epoxypinane on AC-COIMI-NH4PW.
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FOOD AND CHEMICAL TOXICOLOGY
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2012
·
IF 2.999
Ying Liu,Rutao Liu
Great attention is devoted to persistent organic pollutant (POP), among which the pesticide dicofol is critical related to food safety and might raise the risk of cancer incidence. To take a comprehensive evaluation of its toxicity, we investigated its interaction with a serine protease α-chymotrypsin by multi-spectroscopic techniques and molecular modeling method. UV–vis absorption, synchronous fluorescence, and circular dichroism data elucidated that dicofol unfolded the framework of α-chymotrypsin and led to secondary structure changes. The fluorescence and lifetime assay determined the static quenching mode and binding parameters. As an auxiliary method, molecular modeling has displayed the specific binding site and information about binding forces and drug-residues distances which were consistent with conclusions from above. Additional, enzyme activity assay gave evidence at the functional aspect to clarify the fact that dicofol could contribute to the conformational changes and furthermore alter the function of the enzyme.
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Journal of Water Process Engineering
·
2025
·
IF 6.7
Yuejie Li,Yan Chen,Xinyue Wang,Khalil Md Ibrahim,Guowen Wang,Xinxin Zhang,Hongchao Ma
Recently, employing photoelectrocatalysis (PEC) strategy to eliminate environmental impact and hazards of hard-to-handle antibiotics such as sulfamethoxazole (SMX) has been given increasing attention. Herein, a “honeycomb” heterostructured α-MnO 2 nanowire/NiCo 2 O 4 hollow nanocages PEC catalyst is fabricated by using a continuous assembly process as following: (1) construction of α-MnO 2 nanowire carrier, (2) surface adhesion of ZIF-67, and (3) Co/Ni ion exchange. The as-synthesized Ti/α-MnO₂@NiCo₂O₄ demonstrated excellent PEC performance for degrading SMX, as compared with that of α-MnO 2 , α-MnO 2 @ZIF-67. Especially, the optimized Ti/α-MnO₂@NiCo₂O₄-30 showed removal rate of 98.2 % for SMX in 30 min, outstanding durability (~8000 s), and tolerable reusability (the removal rate can still reach 76.5 % for SMX after five cycles). The improvement of PEC performance for Ti/α-MnO₂@NiCo₂O₄ can be attributed to that the unique porous structure formed numerous electrochemically active sites, and the α-MnO₂ nanowire as common channel for charge transfer promoted the migration of induced carriers. The DFT calculation indicated that a II-scheme heterojunction can be formed over the α-MnO 2 @NiCo 2 O 4 composite, which can effectively inhibit the recombination of induced carriers, facilitate the degradation process. This work provides a valuable approach for constructing nanohybrids with targeted functionalities, opening new possibilities for the application of nanomaterials in wastewater treatment.
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INDUSTRIAL CROPS AND PRODUCTS
·
2017
·
IF 3.181
Jiao Yang,Dongyu Gu,Miao Wang,Dan Kou,Hong Guo,Jing Tian,Yi Yang
The essential oil of Pinus tabulaeformis Carr. needle has extensive bioactivities. However, due to the low-polarity and complex compositions, it is difficult to understand the specific active ingredients. The present investigation was to identify the chemical compositions responsible for the activity of PTNO. A simple and efficient method combined GC–MS with molecular docking was developed and established. As a result, thirty-two compounds were identified by GC–MS, and longifolene with a high affinity for α-amylase was screened by molecular docking. The activity of longifolene was proofed by the experiment in vitro. Its IC 50 against α-amylase was 79.85 ± 0.23 μg/mL, which indicated that it possessed the potential activity against α-amylase. All of results suggested that the present method screened the active composition from the needle oil of Pinus tabulaeformis effectively. The present strategy also can facilitate the discovery of the active compounds from herbal medicine.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2017
·
IF 9.446
Yuyang Liu,Wei Jin,Yaping Zhao,Guangshan Zhang,Wen Zhang
Novel hybrid nanostructures or nanocomposites are receiving increasing attention due to their newly evolved properties. In this work, α-Fe 2 O 3 anchored to graphene oxide (GO) nanosheet (α-Fe 2 O 3 @GO) was synthesized through a facile hydrolysis process and its photo-catalytic performances and durability in heterogeneous Fenton system were fully evaluated. The decolorization rates of methylene blue in α-Fe 2 O 3 @GO + H 2 O 2 + UV system within a wide pH range were approximately 2.9-fold that of classical Degussa P25 TiO 2 + UV and 2.4-fold that of α-Fe 2 O 3 + H 2 O 2 + UV. This enhanced decolorization of methylene blue (MB) in α-Fe 2 O 3 @GO + H 2 O 2 + UV system were attributed to the unique incorporation of GO into the catalyst which not only mediated the morphology of active sites α-Fe 2 O 3 nanoparticles but also offered high electron conductivity and electrostatic attraction between negatively charged GO with positively charged MB. High efficiencies of degradation were achieved on various surface charged organic pollutants (around 96–100%), such as cationic compounds of MB and rhodamine B (RhB), anionic compound Orange II (OII) and Orange G (OG), neutral compounds of phenol , 2-nitrophenol (2-NP) and endocrine disrupting compound 17β-estradiol (E2). The dominant reactive oxygen species (ROS) responsible for decolorization, such as hydroxyl radicals ( OH) and superoxide anion radicals (O 2 − ) generated by activation of H 2 O 2 on the surface of α-Fe 2 O 3 @GO were detected and quantified by free radical quenching methods. The possible degradation mechanism of MB involved the rupture of phenothiazine ring by desulfurization and the rupture of phenyl ring due to the attack of ROS, which was analyzed by LC/MS/MS. The reduction of MB and its intermediates was consistent with the decreasing trend of the acute toxicity towards luminous bacteria with the increasing irradiation time. The results lay a foundation for highly effective and durable photo-Fenton technologies for organic wastewater within wider pH ranges than the conventional photo-Fenton reaction.
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CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Zhihao Xu,Hezhong Ouyang,Haoda Zhang,Lei Sun,Shasha Li,Ruijiang Liu
A highly sensitive label-free electrochemical aptamer biosensor with magnetically induced self-assembly had been developed to detect gastrin-releasing peptide precursor (ProGRP), which is not only a highly specific tumour marker for small-cell lung cancer (SCLC), but also very stable in serum, and thus had robust clinical utility. Based on the advantages of high specific surface area and facile separation and recycling, magnetic α-Fe 2 O 3 /Fe 3 O 4 nanorods with the average length of 175 nm, the average diameter of 28 nm, and the saturation magnetization of 66.9 emu/g were used as the matrix, and Au nanoparticles (AuNPs) were loaded on the surfaces of the nanorods to enhance the electrochemical signal. The aptamer double-stranded probe with high specificity to the target protein was bound to the surface of α-Fe 2 O 3 /Fe 3 O 4 @Au. The thiol-modified oligonucleotides could quickly and stably bind to AuNPs to form Au-S, which provided a guarantee for the immobilization of the probe and the controllable self-assembled molecular layer. Then, the sensor after capturing the target was self-assembled on the surface of the magnetic glassy carbon electrode (MGCE) by liquid phase incubation for electrochemical detection. The construction and detection performance of the sensor were evaluated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). Under the optimized conditions, the sensor had remarkable linearity in the range of 0.1 pg/mL - 100 ng/mL (R 2 = 0.998), the limit of detection (LOD) was 17.51 fg/mL, while the limit of quantitation (LOQ) was 58.39 fg/mL. Additionally, the biosensor had excellent stability, reproducibility and anti-interference ability, as well as satisfactory recovery in spiked serum samples (99.46 %–103.32 %).
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INDUSTRIAL CROPS AND PRODUCTS
·
2024
·
IF 5.6
Hongxi Zhang,Zhongke Li,Shuyu Tang,Xiande Yang,Meng li,Jing Yang,Liang Wei
This study examines the use of tetrabutylammonium tetrafluoroborate (TBABF 4 ) as a catalyst for the depolymerization of lignin and its model compound without the addition of oxidants. The impact of electrolytes, reaction times, and solvents on the cleavage of the α-O-4 bond in lignin is investigated. The experimental setup includes specific conditions such as the use of carbon cloth (CC) as the counter electrode and a platinum plate as the working electrode. The TBABF 4 catalyst effectively cleaved the α-O-4 bond in the lignin model molecule with notable selectivity and minimal formation of by-products, resulting in a substantial conversion rate of benzyl phenyl ether (95.7 %) and a high yield of benzaldehyde dimethyl aceta (92.4 %) under specific conditions. This investigation showcases a mild electrochemical catalytic depolymerization approach for lignin model molecules at ambient temperature, thereby presenting novel avenues for further exploration in the field.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Tiantian Wang,Yanli Zhou,Lantao Liu,Hui Dong,Yinghan Xu,Yidan Sun,Yaocun Yue,Jiaqing Tian,Maotian Xu
Abnormal Tumor necrosis factor-α (TNF-α) levels in serum are closely linked to Alzheimer's disease onset, progression, and severity. Highly sensitive and specific detection of TNF-α offers a key biomarker for early diagnosis and disease evaluation, providing significant clinical value for improved disease management. In this study, an iridium complex [(piq)₂Ir(dpppy)] containing a cyclometalated ligand was used as a novel and highly efficient electrochemiluminescence (ECL) luminophore to construct an ultrasensitive electrochemical biosensor for the detection of TNF-α. First, the TNF-α antibody was immobilized in the microplate reactor, and a quasi-specific sandwich immunoassay was performed. Subsequently, aptamers modified with silver nanoparticles-which were in-situ generated on the C-rich sequence-modified aptamer, captured the TNF-α antigen. After dissociation with nitric acid, the solution containing Ag + was transferred to the electrode surface modified with the cyclometalated iridium complex for ECL signal detection. The constructed immunosensor not only exhibited a wide linear range of 0.001 ng mL −1 –100 ng mL −1 , but also showed excellent recovery in human serum samples, ranging from 98.6 % to 101.7 %, with a relative standard deviation of 0.66 %–3.8 %. This strategy not only enhanced the detection sensitivity due to the efficient performance of the iridium complex in the 3 LCπ − π* state, but also this strategy of this biosensor effectively maintained the specificity and stability.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Wei Gao,Ru Yang,Mengli Li,Ming Miao,Tao Zhang
The enzymatic synthesis of amylose is a sustainable solution for the valorisation of non-food cellulose. However, the limited thermostability and catalytic efficiency of existing α -glucan phosphorylases ( α GPs) hinders its potential for industrial scalability. In this study, we identified and characterised a novel α GP from Nicotiana attenuata ( Nicα GP) via genome mining. It exhibited superior catalytic performance, with a specific activity of 82.1 U/mg under optimised conditions (40 °C and pH 5.0), and notable temperature and pH stability. Supplementation of Mg 2+ further enhanced its activity by 5 %. Kinetic analysis revealed a catalytic efficiency ( k cat / K m ) of 27.46 mM −1 s −1 for maltotetraose (G4). Furthermore, a dual-enzyme cascade system integrating Nicα GP with Clostridium thermocellum cellobiose phosphorylase achieved up to 28.4 % cellulose conversion, synthesising amylose with tunable molecular weights (6602 ± 47.13–67,154 ± 47.28 g/mol) by modulating ratios of cellobiose/G4. Molecular docking identified the conserved residues (Gly196, Arg706, Lys711, and Lys821) critical for substrate binding and pyridoxal 5′-phosphate-mediated catalysis. Overall, this study provides a new enzyme component for the artificial synthesis of amylose from non-edible biomass, facilitating the widespread application of non-edible cellulosic resources for food conversion.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yuan Li,Yutong Du,Xue Zhang,Zihan Qu,Di Lian,Jingjing Cui,Li Li
Isoginkgetin is an edible biflavone from ginkgo biloba leaves with many bioactivities. In this work, the inhibition and synergistic effect of isoginkgetin with miglitol or acarbose on saccharomyces cerevisiae α-glucosidase (α-SCG) were tracked via various spectroscopic techniques and computer simulations. Compared with miglitol or acarbose, isoginkgetin displayed more remarkable inhibition effect on α-SCG. In the presence of isoginkgetin, miglitol and acarbose exhibited stronger inhibitory effect on α-SCG than miglitol and acarbose alone. Isoginkgetin exerted the synergistic inhibitory effect by significantly increasing the binding affinity of acarbose or miglitol with α-SCG, leading to larger structural changes in α-SCG. The best binding mode, the stability of the formed complex, and the contribution of key amino acids to the binding were deeply analyzed via dynamics simulation. Isoginkgetin can be used as a strong inhibitor of α-SCG and synergistic inhibitor of miglitol or acarbose.
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Catalysis Science & Technology
·
2025
·
IF 4.2
Ying Hu,Rongkang Yan,Huiyan Pan,Ruyi Cai,Zhili Zeng,Jialun Jiang,Meng Wang,Meng Shan,Shasha Liu,Hai Tang
The integration of adsorption and photocatalysis in heterojunction composites offers a promising strategy for efficient azo dye degradation. Here, a novel α-Fe2O3/perylene-3,4,9,10-tetracarboxylic diimide (PDINH) Z-scheme heterojunction was synthesized via a facile solvent method, showcasing synergistic adsorption–photocatalysis for wastewater treatment. Zeta potential analysis (α-Fe2O3: +14.7 mV; PDINH: −24.3 mV at pH 5.0) and density functional theory (DFT) calculations (binding energy: −3.10 eV) revealed strong electrostatic interactions between α-Fe2O3 and PDINH, enabling uniform nanoparticle dispersion and forming a heterostructure with enhanced specific surface area. Electrochemical measurements confirmed that the Z-scheme heterojunction significantly accelerated charge carrier migration and suppressed electron–hole recombination, facilitated by an internal electric field from well-matched band alignment. Under visible light, the α-Fe2O3-15/PDINH composite achieved 93.4% removal of methyl orange (MO), outperforming PDINH alone (63.1%) due to its positive surface charge (+8.7 mV at pH 5.0) that enhanced selective adsorption of anionic dyes. Quenching experiments identified h+, ·O2−, and ·OH as the primary reactive species, with the Z-scheme pathway retaining strong redox capabilities for efficient degradation. Notably, the composite exhibited an operational cost of $2.41 per ton, significantly lower than other reported processes, and maintained high efficiency (81.8% MO removal) over multiple cycles. This work demonstrates that the α-Fe2O3/PDINH composite integrates adsorption and photocatalysis synergistically, providing a low-cost, scalable solution for azo dye wastewater treatment with potential for industrial application.
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ACS Infectious Diseases
·
2025
·
IF 3.8
Jie Jing,Chunlan Zeng,Long Tian,Jiaqi Han,Longming Chen,Taoran Wang,Zhao Meng,Qingbin Meng
The overuse and misuse of antibiotics resulted in the emergence of multidrug-resistant bacteria. As a promising solution, antimicrobial peptides have attracted much attention. In this research, a series of peptides derived from MP9 through the substitution of tryptophan for alanine and the rearrangement of amino acid residues were designed and synthesized. MP9–10 displayed the highest anti-multidrug-resistant bacterial activity and the lowest cytotoxicity as well as hemolysis among all the derivates. Membrane disruption was the main mechanism for MP9–10 to kill bacteria. The in vivo results on mice also demonstrated that MP9–10 had the capacity to treat infections caused by Staphylococcus aureus bacteria. In summary, MP9–10 is a promising candidate for the treatment of multidrug-resistant bacterial infections.
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