CHEMICAL ENGINEERING SCIENCE
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2026
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IF 5.1
Huihui Dong,Guorui Ma,Jingtian Ni,Shuting Xi,Jing Li,Feng Li
The practical deployment of Zinc oxide (ZnO) photoanodes for photoelectrochemical (PEC) water splitting is severely impeded by rapid photogenerated carrier recombination and sluggish oxygen evolution reaction (OER) kinetics. Herein, we elucidate a synergistic structural engineering strategy integrating interstitial boron (B) doping, Type-II heterojunction construction, and coherent grain boundary regulation to tailor high-performance B-ZnO@ZnS nanorod arrays. Comprehensive characterizations corroborate that B-doping introduces abundant oxygen vacancies to modulate the electronic band structure, while the coherent B-ZnO/ZnS interface establishes a robust built-in electric field, thereby facilitating bulk charge separation and accelerating interfacial hole transfer. Consequently, the optimized photoanode exhibits a remarkable photocurrent density of 1.054 mA cm −2 at 1.23 V vs. RHE (representing a 1.67-fold enhancement over pristine ZnO) and a substantial cathodic shift in onset potential to 0.24 V. Notably, in situ ATR-IR spectroscopy captures the dynamic evolution of key *OOH intermediates, corroborating an adsorption evolution mechanism (AEM) where the multidimensional engineering significantly ameliorates the energy barrier for intermediate formation. This work offers a pivotal paradigm for designing durable and high-efficiency photoelectrodes via precise defect and interface manipulation.
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高影响因子
Journal of Advanced Research
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2026
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IF 17.1
Yi Wang,Laiming Zhang,Jiaxiong Wu,Ziyang Deng,Yunxuan Li,Xingqian Ye,Haibo Pan,Shiguo Chen
Introduction Phenolic compounds are regarded as promising α-glucosidase inhibitors for regulating postprandial blood glucose, but their α-glucosidase inhibitory activity in vivo is much lower than that in vitro . The small intestinal mucus layer serves as a barrier that impedes the binding of phenolic compounds to α-glucosidase, thereby attenuating their activity in vivo , yet the solution to this bottleneck remains unclear. Objectives Selecting prodelphinidin B digallate (proDB DG) as a representative phenolic compound, this study aimed to enhance its in vivo α-glucosidase inhibitory activity by screening the compound that can pre-regulate the barrier properties of the mucus layer. Methods The Caco-2/HT29-MTX-E12 co-culture model was used to screen the compound that can enhance the α-glucosidase inhibitory activity of proDB DG in vivo . This enhanced mechanism was analyzed using ultraviolet–visible light spectroscopy, zeta potential, rheological behavior, transmission electron microscopy, molecular dynamics simulation and Transwell mucus diffusion model. The improved α-glucosidase inhibitory activity and its biosafety were further confirmed by animal experiments. Moreover, the screened compound and proDB DG based tablets were developed. Results Ca 2+ improved the activity of proDB DG in lowering postprandial hyperglycemia in vivo . This enhancement of activity is attributed to its pre-regulation on the barrier properties of the mucus layer. Specifically, Ca 2+ -derived mucin aggregation increased the porosity and diffusivity of the mucus layer, thereby improving the permeability of proDB DG and facilitating its binding to α‑glucosidase. Ca 2+ also competitively bound with the mucus layer, and weakened the interaction between proDB DG and mucins. Furthermore, Ca 2+ –proDB DG based tablets possessed significant hypoglycemic effect and biosafety in vivo . Conclusion Ca 2+ regulates the barrier properties of the mucus layer, thereby promoting proDB DG to reach the mucosa quickly and then interact with α-glucosidase effectively, which may break the application limitations of proDB DG and even phenolic compounds as α-glucosidase inhibitors clinically.
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PubMed
高影响因子
MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Yayun Jiang,Youwei Li,E. Jianfei,Qi Xin,Yongyi Chen,Qiang Wen,Yang He,Gang Mai
Group B Streptococcus (GBS) poses a significant health risk to mothers and newborns, requiring rapid and accurate detection for effective treatment. Traditional methods, such as bacterial culture and PCR, are time-consuming and procedurally complex. Herein, we developed a visual nucleic acid assay platform by combining loop-mediated isothermal amplification (LAMP) with LAMP-responsive carbon dots—polyethyleneimine carbon dots (PEI-CDs)—for GBS detection. In a positive LAMP reaction (with target DNA), the negatively charged amplification products (DNA and magnesium pyrophosphate) interact with positively charged fluorescence PEI-CDs via electrostatic adsorption to form a large fluorescent precipitate, while in a negative reaction, PEI-CDs remain dispersed. This visual distinction allows for the straightforward identification of GBS presence. To prevent contamination, PEI-CDs are integrated into the reaction tube lid. This visual detection platform achieves a detection limit of 10 2 copies/μL for GBS within 31 min, demonstrating high sensitivity and rapid visual readout. The platform shows significant potential for clinical practice in nucleic acid diagnostics, with versatility to detect other pathogens through primer substitution.
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高影响因子
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
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2025
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IF 3.2
Li Die,Wang Ting,Zhao Ruike,Wang Weiqun,Zhang Yu,Long Ai,Bi Haojie,Wang Hanying,Wang Daoshuang,Shi Jingpei,Li Yupeng,Lyu Lechun
Post-inflammatory hyperpigmentation (PIH) is a reaction process caused by an increase in melanin or abnormal melanin distribution due to inflammatory skin diseases, skin disease treatments, and external stimuli. Ultraviolet radiation can exacerbate PIH. It stimulates melanocytes, increases melanin production and deposition, and deepens the color and prolongs the duration of PIH. This study aims to investigate the inhibitory effects of Coelonin, an extract from Dendrobium officinale, on melanin production and its underlying mechanisms. Through molecular docking analysis, we found that Coelonin has significantly stronger binding capabilities to tyrosinase (TYR) and melanocortin 1 receptor (MC1R) than kojic acid, a well-known whitening agent. This stronger binding ability suggests that Coelonin may inhibit melanin production by regulating the activity of melanin metabolism-related proteins, thereby exerting its whitening effect. Compared with kojic acid, Coelonin demonstrates superior binding characteristics at the molecular level, providing stronger evidence for its potential as a whitening active ingredient. In cell experiments, Coelonin had no significant effect on the proliferation of B16-F10 melanoma cells within the concentration range of 20–40 µM, but it could significantly reduce the intracellular reactive oxygen species (ROS) levels and inhibit TYR activity and melanin production. Western blot results showed that Coelonin could downregulate the expression of TYR, MITF, TRP-1, and TRP-2 proteins. In in vivo experiments, a guinea pig model of PIH was established by Ablative Fractional Resurfacing CO₂ Laser (AFR CO 2 ) combined with UV-B irradiation. It was found that Coelonin treatment could significantly improve skin pigmentation, reduce melanin granule deposition, and did not cause skin inflammation or hyperplasia and other side effects. This study indicates that Coelonin is an efficient and safe melanin synthesis inhibitor and has the potential to be developed as a plant-derived skin whitening agent.
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PubMed
高影响因子
CARBON
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2024
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IF 10.5
Zhengsen Wang,Dezhi Jiao,Li Cheng,Lanyue Cui,Peimin Hou,Chengbao Liu
Wear microcracks and corrosion are inescapable for marine equipment thus resulting in operational issues, lifespan reduction and even catastrophic failures. Despite significant research has been conducted in anti-wear and corrosion resistant coatings, simultaneous achieving wear-resistant, anticorrosive and visual monitoring of wear damage and corrosion pits remains a significant challenge. Herein, we propose a novel strategy for in-situ and real-time visualization of wear cracks and interfacial corrosion in lubricant coating by utilizing MXene@Rhodamine B (MXene@RhB) fluorescent probes. Through strategic engineering of fluorophores and polyurea networks, conspicuous fluorescence intensification is observed at wear and damaged area, not only immediately upon occurrence but also accompanied with crack propagation. Besides, the precise ion recognition and coordination property of RhB with Fe 3+ brings about distinct fluorescence quenching, enabling visual monitoring of coating wear degradation and interfacial corrosion failure. Moreover, the imbedding of layered MXene significantly improved the tribological performance of composite coating with reduced friction and wear rate. Furthermore, electrochemical investigations revealed that the electrolytes intrusion and steel corrosion reactivity were greatly inhibited through forming numerous shielding layers. The ingenious integration of fluorescent motifs and lubricating units contributes to the development of novel protective coatings, providing reliable strategy for coating lubrication and real-time wear monitoring.
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高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
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2024
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IF 4.2
Han Sun,Xu Pang,Jian-Rui Li,Hu Li,Mei Tang,Tao Zhang,Li-Yan Yu,Zong-Gen Peng
Abnormal cell adhesion between leukocytes and endothelial cells is closely associated with the development of numerous inflammation-related diseases, with adhesion molecules playing a crucial role. The disruption of cell adhesion directly or indirectly inhibits excessive cell adhesion and thus produces a therapeutic effect. However, there are only a few clinically available antagonists of cell adhesion. One of the biggest challenges is the development of novel and efficient cell adhesion inhibitors. Recently, the anti-inflammatory pharmacological activity of natural products of microbial origin has also received increasing attention. Here, we obtained a potential cell adhesion inhibitor isoechinulin B, an indole diketopiperazine derivative, from the Antarctic fungus Aspergillus sp. CPCC 401072, which is active against cell adhesion. Isoechinulin B decreased the expression of vascular endothelial adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) by inhibiting the activation of the NF-κB signaling pathway, thereby inhibiting cell adhesion between leukocytes and endothelial cells to reduce macrophage infiltration in the liver and significantly attenuate lipopolysaccharide-induced acute liver injury in mice. Conclusion Isoechinulin B is a novel cell adhesion inhibitor derived from fungi found in extreme environments.
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PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 8.8
Xupeng Li,Hyeon Keun Cho,Shuai Yang,Shuwei Li,Gang Wang,Young Moo Lee
This research was dedicated to the development of high-performance proton exchange membranes (PEMs) via the synthesis of two sulfonated poly(benzothiazole)-b-poly(benzimidazole) (sPBTx-PBI) block copolymers.The structural difference between them is primarily in the length of their hydrophilic chains. Excellent solubility was achieved through the incorporation of hexafluoroisopropyl and phenylphosphine oxide units. Partially cross-linked PEMs (sPBTx-PBI-y) were subsequently fabricated via thermal cross-linking of the hydrophobic PBI segments. The elongation of the hydrophilic block was found to promote water uptake, swelling, and proton conductivity at the expense of oxidative stability. Cross-linking effectively mitigated swelling and greatly improved durability while preserving high proton conductivity. The proton conductivity of the sPBT12-PBI-20% membrane reached 0.115 S cm −1 at 80 °C and 100% RH—exceeding Nafion 117—and maintained a stable operating voltage of 0.79 V over 20 h. Under anhydrous 200 °C conditions, single-cell power densities reached up to 510 mW cm −2 . These results demonstrate that partially cross-linking of sPBT-PBI block copolymers provides a promising pathway toward mechanically robust and highly conductive PEMs for wide-temperature fuel cell applications.
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高影响因子
CERAMICS INTERNATIONAL
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2026
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IF 6
Fang Yu,Chaohai Li,Dong Yang,Jiayu Li,Xiaodan Cao,Biaolin Peng,Kailiang Ren
The electrocaloric (EC) effect in ferroelectric materials has attracted extensive attention because of its high efficiency and potential applications in chip cooling. In this work, we successfully prepared a Pb(Sc 0.25 Ta 0.25 In 0.25 Nb 0.25 )O 3 (PSINT) ceramic via a solid-state reaction method with high-polar entropy. Next, the prepared ceramics were quenched at 1050 °C for various durations. The grain size of the quenched PSINT samples initially decreased to 0.39 μm and then gradually increased to 0.61 μm with a quenching time of 50 h. X-ray diffraction (XRD) patterns of the PSINT ceramics indicate that the PSINT sample transforms from the tetragonal (pseudo-cubic) to an R-3C rhombohedral phase. The measurements of the electrocaloric effect revealed a significant adiabatic temperature change (Δ T ) of approximately 1.98 K at 60 kV cm −1 and room temperature with a quenching time of 40 h. This value is 0.5 K higher than that of untreated PSINT ceramics. Moreover, the B-site atoms of the PSINT high-polar-entropy ceramics changed from a long-range ordered phase to a disordered phase after quenching. This study provides a new technical approach for room-temperature cooling devices by designing B-site disorder in relaxor ferroelectric ceramics.
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高影响因子
AQUACULTURE
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2026
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IF 4.4
Yuhua Lin,Yiwen Chai,Jugan Han,Weiheng Shi,Along Gao,Jianmin Ye,Liting Wu
The CC motif chemokine ligand 25 (CCL25), which specifically binds to the CC chemokine receptor 9 (CCR9), plays a critical role in immune responses during bacterial infections. Although its importance is well-established in mammals, comprehensive studies on the CCL25/CCR9 axis in fish remain limited. In this study, we identified and characterized two alternatively spliced isoforms of CCL25 ( On CCL25a and On CCL25b) and two isoforms of CCR9 ( On CCR9a and On CCR9b) in Nile tilapia ( Oreochromis niloticus ). These genes were expressed in various tissues, with OnCCR9 showing significantly higher expression in IgM + B cells compared to IgM − leukocytes. Following infection with Streptococcus agalactiae or Aeromonas hydrophila , the expression levels of the CCL25/CCR9 axis components were significantly up-regulated in leukocytes from peripheral blood (PBL), spleen (SPL), and head kidney (HK). To investigate functional roles, recombinant On CCL25a and On CCL25b proteins were utilized. Our finding revealed that the CCL25/CCR9 axis promotes B cells differentiation without inducing their differentiation into plasma cells. Additionally, the axis did not influence the migration of PBL, SPL, HK leukocytes, or IgM + B cells, nor did it affect the behavior of HK monocytes/macrophages. Most importantly, the CCL25/CCR9 axis exhibited strong antibacterial activity, including both direct antibacterial effects of On CCL25 and indirect in vivo effects mediated through immune regulation. Specifically, the axis reduced bacterial load and improved survival in Streptococcus agalactiae -infected Nile tilapia. This study provides the first comprehensive characterization of the CCL25/CCR9 axis in Nile tilapia, elucidating its regulatory mechanism on immune cells and highlight s its critical role in host defense against bacterial pathogens.
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高影响因子
Journal of Building Engineering
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2026
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IF 8.1
Xi Deng,Kaiyuan Li,Yongqiang Ye,Xinke Huo,Wei He,Fei Xiao
The inherent combustibility of wood represents a critical vulnerability, compromising the structural integrity and fire safety of wooden buildings. This work reports on a highly fire-safe P/N/B wood composite. This material was fabricated based on the freeze-thaw strategy, involving the co-impregnation of amino trimethylene phosphonic acid (ATMP) and boric acid (BA) into the wood substrate. Benefiting from the pore size changes caused by freeze-thaw cycles, the total loading of ATMP and ATMP/BA in wood increased by 37.5% and 21.9%, respectively, as compared the untreated sample. The freeze-thawed wood composite exhibited an ultra-high limiting oxygen index (LOI) of 87.9 % and a V-0 rating was reached in the UL-94 vertical burning test (5 mm). The peak heat release rate (pHRR) and total heat release rate (THR) decreased by 57% and 91%, respectively, as compared to untreated wood. The results showed that the improved fire retardancy performances were attributed to the char layer formed during the combustion, which acts as a thermal barrier, preventing the transfer of heat and mass. SEM, Raman, XPS, FTIR, and XRD results confirmed that phosphates and borophosphates species were formed during burning and acted as reinforcing substances to enhance the strength and stability of the char layer. In summary, this study provides a simple and effective approach for modifying the fire safety of wood, with great potential for construction applications.
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高影响因子
FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
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2024
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IF 2.1
Yufei Zhang,Sile Liu,Chuan Tian,Peng Xu,Xinzhong Deng,Congna Lv
To solve the pollution of natural water bodies by organic dyes and the exceeding of indoor HCHO standards caused by renovation, the study realized the band gap modulation of g-C3N5, a novel semiconductor photocatalytic material, by using H3BO3 as a source of nonmetallic B. The prepared B/g-C3N5 has shown excellent photocatalytic performance and stability for organic dye degradation in water bodies and indoor HCHO removal. The degradation rate of methylene blue (MB) reached 95% in 60 min of visible light, and the removal rate of HCHO reached 96.3% in 180 min of visible light. The MB and HCHO were efficiently degraded to small molecule inorganic compounds such as CO2 and H2O under the oxidation of active groups such as ·O2− and h+. The doping of nonmetallic B realizes the efficient separation of e−-h+ of g-C3N5, improve the absorption performance of visible light, and broaden the spectral range significantly. The modulation of the g-C3N5 band gap provides a potential application scenario for the development of novel photocatalytic materials.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Shidi Li,Xiao Zhang,Zhiren Guo,Tengfei Gao,Dagang Li,Jinlei Song,Yihui Yuan,Xiyan Xu
Efficient U(VI) capture and its catalytic reduction to U(IV) is of importance for both environmental protection and uranium resource recovery, whereas the available adsorbents and catalysts are still inefficient or expensive. The current study synthesizes an efficient and cost-effective polyacrylic acid (PAA) cryogel with B-doped TiO 2 nanoparticle photo-active cores (B-TiO 2 @PAA) for adsorptive- photocatalytic capture and reduction of U(VI). The testing results show that the current B-TiO 2 @PAA exhibits a 1.95-fold enhancement compared to that of the pristine PAA gel under simulated sunlight radiation with high stability and selectivity. A synergistic effect between the PAA substrate and the B-TiO 2 active cores for uranium capture is also revealed. B-TiO 2 serves as crosslinkers of the cryogel to improve the porous structure and stability. It reduces the proportion of the medium size pores (3–30 μm) for a lower mass transfer resistance, whereas those of both larger (> 30 μm) and smaller (< 3 μm) size pores are increased. The former provides a better mass transfer condition, and the latter a confinement effect for a fast uranium capture on the activated sites. Meanwhile, B-TiO 2 is also tested as a conductivity regulator of the cryogel to enable semiconducting behavior for an intensified photocatalytic performance. This study provides a novel “Nano-photocatalyst@Cryogel” strategy for the design of U(VI) capture materials from aquatic media.
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高影响因子
危险品化学品经营许可证（带存储）