RARE METALS
·
2026
·Vol. 45
·期 3
·e70185
·
IF 12.1
Chenyang Shu,Yimin Chen,Chuanlan Xu,Xinru Xu,Lingtao Sun,Jiayi Niu,Cherkasova Tatiana,Chaozhong Guo,Yuan Niu,Quan Xu
en This link goes to a English section zh This link goes to a Chinese section Platinum (Pt)-based catalysts are crucial for the commercialization of hydrogen/metal air batteries, but they suffer from Pt scarcity, high cost, and nanoparticle dissolution/agglomeration, mainly leading to performance degradation. We address this by synthesizing a PtFe alloy catalyst (PtFe–PA–NC) via a phytic acid (PA) assisted pyrolysis strategy, featuring Pt-skin-coated PtFe alloy nanoparticles on hierarchically porous N-doped carbon (NC). PA treatment simultaneously enhances the support's surface area and pore structure for better mass transport, and incorporates P into the carbon framework via P–C bonds. It can induce charge delocalization, regulating the electronic structure of PtFe alloys and strengthening Pt–Fe coupling. The Pt-skin suppresses Fe dissolution, whereas the PtFe core optimizes oxygen reduction reaction (ORR) intermediate adsorption (e.g., *OH). Theoretical calculations confirm that the Fe atom adjusts the d-band center of the Pt atom, intensifying oxygen binding and shifting the rate-determining step. Electrochemically, PtFe–PA–NC achieves a half-wave potential of 0.85 V and retains 95.8% of specific energy density after more than 140 h in zinc-air batteries. In alkaline fuel cells, it delivers a peak power density of 508 mW cm −2 at an ultralow Pt loading (0.017 mg cm −2 ), approximately twice that of 5 wt% Pt/C (0.025 mg cm −2 ). This work showcases synergistic electronic and interfacial regulation through heteroatom doping and alloying, promoting high-performance hydrogen/metal air batteries. 摘要 en This link goes to a English section zh This link goes to a Chinese section 铂基催化剂是氢/金属空气电池商业化的关键,但铂资源稀缺、成本高昂且纳米颗粒易溶解/团聚 , 是导致其性能衰减的主要原因。为此 , 本论文通过植酸(PA)辅助热解策略合成了一种 PtFe合金催化剂(PtFe–PA–NC) , 其结构为: Pt 壳层包覆的PtFe合金纳米颗粒负载于分级多孔氮掺杂碳(NC)载体上。通过植酸处理过程可同时实现了两个效果 : 一是提升了载体的比表面积与孔结构, 优化了传质效率 ; 二是通过 P–C 键将磷引入碳骨架,诱导电荷离域 , 从而调控 PtFe 合金的电子结构、强化 Pt–Fe 耦合作用。其中, Pt 壳层可抑制 Fe 的溶解, 而 PtFe 核则能优化氧还原反应(ORR)中间产物(如 * OH)的吸附行为。理论计算表明: Fe 原子可调节 Pt 原子的 d 带中心, 增强氧的结合作用并改变反应的决速步。电化学测试表明: 在锌空气电池中, PtFe–PA–NC 的半波电位达 0.85 V, 且在 140 h 以上的运行后仍保持 95.8% 的能量密度; 在碱性燃料电池中, 当 Pt 载量低至 0.017 mg cm −2 时, 其峰值功率密度达 508 mW cm −2 , 约为商用 5 wt% Pt/C (载量为 0.025 mg cm −2 ) 的两倍。本研究工作通过杂原子掺杂与合金化实现了电子结构与界面的协同调控, 为高性能氢/金属空气电池的开发提供了新思路。
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Phytochemistry Letters
·
2026
·
IF 1.7
Zhenzhen Zhang,Longfei Zhang,Mengting Yang,Zhenhui Wang,Xueqian He
One undescribed aniline-containing phthalide was induced by SAHA. • Azoxy compound 2 was generated via the biotransformation of SAHA. • Talarophthalide D showed antibacterial activity against Proteus mirabilis . A previously undescribed aniline-containing phthalide derivative, talarophthalide D ( 1 ), and an azoxy compound, azoxybenzene ( 2 ), were obtained from the Yellow River wetland-derived Talaromyces funiculosus HPU-Y01 treated with the histone deacetylase inhibitor SAHA (suberanilohydroxamic acid). The structures of 1–2 were elucidated by comprehensive analysis of NMR spectroscopy and HRESIMS data. Talarophthalide D ( 1 ) is characterized as a hybrid incorporating an aniline-phthalide moiety and a long-chain unsaturated fatty acid. Azoxybenzene ( 2 ) was produced via a rare fungal-catalyzed biotransformation of aniline, a degradation product of SAHA. Talarophthalide D showed antimicrobial activity against Proteus mirabilis with MIC value of 6.25 μ M. Download: Download high-res image (104KB) Download: Download full-size image
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Food Science & Nutrition
·
2025
·Vol. 13
·期 11
·e71153
·
IF 3.8
Jinjia Liu,Yuning Zhang,Furong Lv,Chengming Wang,Jixiang Wang,Lijuan Li,Jinqiang Wu,Lina Lai
In this study, we aimed to investigate the hepatoprotective effects of plantagoside (PLA) against D-galactose (D-gal)-induced liver injury in aged mice. PLA treatment significantly alleviated the D-gal-induced body weight loss and the elevated liver index in mice, and effectively reduced oxidative stress, inflammatory response, and liver tissue damage in vivo. Transcriptomic analysis identified 513 differentially expressed genes (DEGs) regulated by PLA, and enrichment analysis revealed that these genes were primarily associated with the PI3K-Akt signaling pathway and purine metabolism. Metabolomic analysis revealed that PLA regulates purine metabolism by modulating key metabolites, such as hypoxanthine and cAMP. Integrated omics analysis suggested that PLA exerts protective effects by regulating purine metabolism, thereby enhancing antioxidant capacity and suppressing inflammation. In conclusion, PLA significantly alleviated D-gal-induced liver injury, reduced oxidative stress, and attenuated inflammation by regulating purine metabolism, thereby demonstrating its potential as an anti-aging and hepatoprotective drug and providing a new theoretical basis for the treatment of age-associated liver diseases.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Da-Yuan Wang,Jing Li,Xiao-Han Tian,Siyu Zhang,Yao Chen,Feihe Ma,Henk.J. Busscher,Jing Shen,Linqi Shi
Light-activatable CO-generating molecules such as 3-hydroxyflavone (3-HF) derivates, are water-insoluble, which limits their applicability for infectious biofilm control. Here, a 3-HF-modified type of D-alanine (3-HFD) was coupled with hexadecyltrimethylammonium-bromide (CTAB) to self-assemble into water-suspensible, hydrophilic nanoparticles. Self-assembled 3-HFD nanoparticles did not generate CO upon visible-light irradiation, but dynamically disassembled upon metabolic-incorporation in bacterial cell-wall peptidoglycan of Gram-positive and Gram-negative periodontal pathogens, leaving molecular 3-HFD inside the cell-wall that generated CO upon visible-light irradiation. In vitro , visible-light irradiation of aerobic Staphylococcus aureus and anaerobic Porphyromonas gingivalis biofilms in presence of 3-HFD nanoparticles yielded CO-generation with strong antibiofilm activity under atmospheric oxygen conditions and in a nitrogen atmosphere. 3-HFD nanoparticles were subsequently applied for treatment of ligature-induced periodontitis in specific-pathogen-free rats with P. gingivalis inoculated, periodontal pockets. Irrigation with nanoparticle suspensions and visible-light irradiation of P. gingivalis infected periodontal pockets was demonstrated to yield in-pocket CO-generation. CO-generation improved bone-regeneration, modulated macrophages to attenuate immune-inflammation and reduced P. gingivalis colony-forming-unit counts, while hardly affecting total colony-forming-unit counts. This points to selective elimination of CO-susceptible pathogens and restoration of a healthy periodontal microbiome, as confirmed using 16S rRNA microbiome analyses. Herewith, an effective, non-surgical and non-antibiotic based three-in-one CO-based treatment of periodontitis is proposed.
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Nutrients
·
2025
·Vol. 17
·期 20
·3298
·
IF 5
Bingsi Li,Yuxuan Gu,Libing Zhou,Rui Chen,Yiwei Liu,Zexuan Wan,Ziyi Liang,Yukang Wang,Renlei Ji,Zhian Liu
Background/Objective: Cellular senescence is increasingly recognized as a key mechanism underlying sarcopenia, an age-related muscle disorder with no effective therapeutic. 6,4′-Dihydroxy-7-methoxyflavanone (DMF), a flavonoid isolated from Dalbergia odorifera T. Chen, has shown anti-senescence potential. This study aimed to investigate the protective effects of DMF against myoblasts senescence and elucidate the underlying molecular mechanisms. Method: A cellular model of senescence was established in C2C12 myoblasts using D-galactose (D-gal). The effects of DMF pretreatment were evaluated by assessing senescence phenotypes, myogenic differentiation, and mitochondrial function. The role of Sirtuin3 (SIRT3) was confirmed using siRNA-mediated knockdown. Results: DMF Pre-treatment effectively attenuated D-gal-induced senescence, as indicated by restored proliferation, reduced senescence-associated β-galactosidase activity, decreased DNA damage, and the downregulation of p53, p21Cip1/WAF1and p16INK4a. Furthermore, DMF rescued myogenic differentiation capacity, enhancing the expression of Myoblast determination protein 1, Myogenin, Myosin heavy chain and Muscle-specific regulatory factor 4, and promoting myotube formation. Mechanistically, DMF was identified as a SIRT3 activator. It enhanced SIRT3 expression and activity, leading to the deacetylation and activation of the mitochondrial antioxidant enzyme superoxide dismutase 2. This consequently reduced mitochondrial reactive oxygen species, improved mitochondrial membrane potential and ATP production, and suppressed the NF-κB pathway by inhibiting IκBα phosphorylation and p65 acetylation/nuclear translocation. Crucially, all the beneficial effects of DMF—including oxidative stress reduction, mitochondrial functional recovery, anti-inflammatory action, and ultimately, the attenuation of senescence and improvement of myogenesis—were abolished upon SIRT3 knockdown. Conclusions: Our findings demonstrate that DMF alleviates myoblasts senescence and promotes myogenic differentiation by activating the SIRT3-SOD2 pathway, thereby reducing oxidative stress and NF-κB-driven inflammation responses. DMF emerges as a promising therapeutic candidate for sarcopenia.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Lijun Zhu,Wenjie Huang,Jingjing Shi,Fei Li,Xiuxia Sun,Jianxi Xiao
The degradation of elastin in aged skin results in the loss of elasticity, the formation of wrinkles, and even a reduced ability for wound healing after injury. However, previous studies about elastin material have been limited by high immunogenicity of animal-derived elastin, the use of single elastin peptide sequences, and residual crosslinking agents. In this study, we designed a multipotent anti-aging recombinant human elastin (rElastin) and utilized it to counteract caudal fin shrinkage in zebrafish and D-galactose-induced intrinsic skin aging in mice. The rElastin demonstrated thermoresponsive reversible phase-transition closely resembling that of natural elastin. In vitro , cell experiments demonstrated that rElastin effectively promoted the proliferation, adhesion, and spreading of HFF-1 cells. In a D-galactose-induced intrinsic aging mouse model, rElastin significantly restored dermal density, skin hydration, and TEWL to levels approaching those of healthy skin. Histological analysis further confirmed that rElastin facilitated the deposition of collagen and regeneration of elastic fibers, thereby promoting structural and functional repair of aging skin. Additionally, rElastin obviously inhibited the tail fin shrinkage after UV radiation. rElastin effectively targets skin symptoms associated with intrinsic aging, providing fresh insights into anti-aging therapies and showcasing strong potential for applications in regenerative medicine and cosmetic dermatology.
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Food & Function
·
2025
·
IF 5.4
Le Wang,Houzhen Lu,Haitao Gui,Zifu Ni,Zhongke Sun,Zihua Wang,Zhihua Wang,Xuanyan Liu,Qipeng Yuan
Ulcerative colitis (UC) is a prevalent inflammatory bowel disease (IBD) posing a significant health threat. This study explored the protective effects of D-tagatose against DSS-induced colitis in mice and its underlying mechanisms using H&E staining, AB-PAS staining, immunofluorescence, immunohistochemistry, ELISA, qPCR, western blotting, and other assays. D-Tagatose improved colitis by increasing body weight and colon length, with decreased DAI (disease activity index) and histopathological scores. The results showed that D-tagatose inhibited the secretion of myeloperoxidase (MPO), inflammatory enzymes (iNOS and COX-2) and pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) as well as increased the content of anti-inflammatory cytokines (IL-10) in vitro. In addition, D-tagatose enhanced the expression of tight junction proteins (ZO-1 and Occludin) and mucin (MUC-2). Furthermore, D-tagatose was able to modulate the gut microbiota dysbiosis caused by DSS-induced UC and increased the content of short-chain fatty acids (SCFAs). This study indicated that D-tagatose attenuated DSS-induced UC by modulating inflammatory cytokines, restoring intestinal barrier function, maintaining gut microbiota homeostasis, and enhancing SCFA production. These findings provide D-tagatose as a safe and effective novel functional food strategy for the prevention and treatment of UC.
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ChemistrySelect
·
2025
·Vol. 10
·期 22
·e05941
·
IF 2
Yiyi Qiao,Jian Cao,Yanan Li,Chuanxiao Wang,Jiayu Gao,Linlin Wang,Xiao Zhang,Le Wang,Yuanhao Li,Zhicheng Zuo
Graphical “Donor-Acceptor” structural molecules with ICT and AIE properties were constructed. The sensor Nap-B1 was able to specifically recognize HSA by modifying with pyridinium and quinolinium. In the H2O-EtOH system or highly viscous and solid phase environment, the fluorescence of sensor was turned on in an aggregated. Elevated levels of human serum albumin (HSA) serve as an early indicator of cardiovascular and renal diseases in diabetic and hypertensive patients. This study focuses on the design and synthesis of two fluorescent probes, Nap-B1 and Nap-KL, which were developed by functionalizing the “D–A” structural framework consisting of naphthalimide derivatives (A) and triphenylamine (D) with pyridine/quinoline cations. These sensors are intended for the quantitative detection of HSA in urine, specifically recognizing HSA and inducing fluorescence “turn-on” upon binding. Both Nap-B1 and Nap-KL is demonstrated high selectivity for HSA, stability independent of environmental factors, and sensitivity for rapid detection. Changes in Zeta potential, dynamic light scattering (DLS), fluorescence lifetime, and fluorescence intensity were observed, which result from alterations in HSA conformation before and after sensor binding. Molecular docking experiments further confirmed that the probes bind to HSA via hydrophobic interactions and electrostatic adsorption, forming a probe-HSA complex and triggering the fluorescent response.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2026
·
IF 21.1
Donglei Fu,Wei Zhang,Zhengxiong Zhao,Zhonglin Chen,Pengwei Yan,Jinxiang Zuo,Lianpeng Sun
Element-doped catalysts with oxygen vacancies (OVs) are highly effective in water purification by activating oxidants; however, the interfacial mechanisms and specific contributions of reactive oxygen species (ROS) in metal-doped catalysts featuring OVs for peroxymonosulfate (PMS) activation remain insufficiently elucidated. In this study, Cu-doped NiFe 2 O 4 catalysts with abundant OVs were synthesized via a hydrothermal-calcination process, endowing efficient PMS activation for ROS generation. Remarkably, it mediated more sulfate radicals (SO 4 · − ) and hydroxyl radicals (·OH) generation, accounting for 50.4% and 36.5% of 2,4-dichlorophenoxyacetic acid (2,4-D) degradation, respectively. Benefiting from the formation of OVs, it significantly enhanced PMS adsorption ( E ads = -7.17 eV), markedly lower than that of the pristine NiFe 2 O 4 ( E ads = -4.11 eV). Meanwhile, inducing the regulation of the d-band center of Fe and Ni sites towards the Fermi level, thereby enhancing more electron transfer (0.84 e of NiCu x Fe 2-x O 4 compared to 0.60 e of NiFe 2 O 4 ) from OVs to surface-complexed PMS, and thus voluntarily forming SO 4 · − with lower free energy (△G = -11.7 eV). This work elucidates the OVs-mediated structural regulation of the d-band center and interfacial electron transfer pathway, highlighting a synergistic multi-metal activation mechanism in response to PMS activation, which offers a novel strategy for designing efficient catalysts to trigger interfacial ROS formation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Lu Wang,Chunyan Lu,Shugang Li,Tong Wu,Xiaomeng Ren,Shuang Song,Chunqing Ai
Aging is a multifactorial biological process in which chronic inflammation and oxidative stress are central to the development of age-related disorders, including neurodegenerative decline. Fucoidan, a sulfated polysaccharide extracted from brown algae, has well-documented anti-inflammatory and antioxidant effects, and therefore has the potential to be a neuroprotective agent against cognitive impairment associated with aging. In the present study, the major fucoidan fraction (LJF-2) isolated from Laminaria japonica was examined for its neuroprotective properties in a D-galactose induced aging mouse model. Oral administration of LJF-2 for 8 weeks significantly improved spatial learning and memory and suppressed neuroinflammatory responses and oxidative stress while significantly reducing the activation of astrocytes and microglia. These neuroprotective effects were linked to the regulation of key proteins involved in neuronal protection and synaptic function, such as neprilysin and synapsin, by cAMP response element-binding protein signaling. Furthermore, LJF-2 significantly remodeled the gut microbiota through a reduction in the abundance of the Bacteroidota, Proteobacteria, and several putative pathogenic genera, which enhanced the intestinal barrier integrity and modified the microbial metabolite profiles, especially those associated with tryptophan metabolism. Fecal microbiota transplantation experiments further confirmed the role of the gut microbiota modulated by LJF-2 in mediating its neuroprotective effects through reduction of oxidative stress and inflammation. Collectively, these findings suggest that LJF-2 may be a promising therapeutic approach to address the aging-related cognitive decline by modulating the gut–brain axis.
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FITOTERAPIA
·
2026
·
IF 2.9
Hengxing Ran,Yan Wen,Yiebi Qin,Kaiwen Kang,Zhengrong Wu,Yifan Li,Yu Wang,Rihui Wu,Dongli Li,Song Ang,Lishe Gan,Jingwei Jin
This study aims to identify the most primary hepatoprotective compound from Hypericum japonicum and elucidate its underlying mechanisms of liver protection. This study screened 15 compounds from Hypericum japonicum against D-GalN-induced AML12 cell injury, identifying TAX ( Compound 8 , taxifolin 7-rhamnoside) as the most hepatoprotective. This study indicates that TAX reduced AST, ALT, and MDA levels, while enhancing SOD and GSH levels in D-GalN-induced AML12 and LPS/D-GalN -induced liver. In addition, TAX attenuated LPS/D-GalN-induced hepatic injury by lowering inflammatory infiltration and pro-inflammatory cytokines (TNF-α, IL-6 and NO) levels. Network pharmacology analysis revealed common targets between TAX and drug-induced liver injury, forming a protein-protein interaction (PPI) network. Functional enrichment (GO/KEGG) and molecular docking indicated strong binding affinity between TAX and AKT1, confirmed by molecular dynamics simulations. Western blot analyses that TAX ameliorated inflammation and oxidative stress through down-regulating the AKT/NF-κB pathways and up-regulating Nrf2/HO-1 pathways in vivo, TAX inhibited apoptosis via up-regulating Bcl-2 and down-regulating Bax in vitro. Collectively, this study demonstrates that TAX ameliorates LPS/D-GalN-induced ALI by attenuating hepatocyte apoptosis, inflammatory responses, and oxidative stress.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Chenxi Gao,Changcun Han,Hao Xiang,Zhuo Peng,Yinbo Tong,Chengyi Zhang,Hui Lv,Yizhong Huang
Precise control of the photogenerated charge dynamics and the electronic configuration of active sites is key to enhancing the performance of photocatalytic hydrogen-producing materials. Here, we report an efficient one-pot strategy to prepare sulfur-doped g-C 3 N 4 (SCN). Furthermore, a PtNd/SCN composite photocatalyst was successfully fabricated by loading a platinum (Pt)‑neodymium (Nd) alloy onto the SCN surface via an H 2 reduction method. Using trithiocyanuric acid as a single precursor to supply C, N, and S enables uniform S doping within the g-C 3 N 4 framework, broadening the light absorption range and optimizing the band structure. Pt serves as the primary hydrogen-evolving active site, while Nd acts as an “electronic co-catalyst” for Pt, forming strong electronic interactions through its unique 4f orbital structure. HRTEM and XPS analyses confirm the formation of a Pt Nd alloy interface and directional electron transfer from Nd to Pt, effectively modulating the Pt d-band center and optimizing the adsorption free energy of hydrogen intermediates, thereby significantly enhancing hydrogen evolution reaction (HER) kinetics. The experimental results show that the optimized PtNd/SCN composite photocatalyst exhibits a markedly enhanced photocatalytic hydrogen production rate under simulated sunlight, reaching 5468 μmol·g −1 ·h −1 —5 times higher than Pt/CN (1074 μmol·g −1 ·h −1 ) and 1.3 times that of Pt/SCN (4076 μmol·g −1 ·h −1 ). PL, TRPL, and photoelectrochemical measurements confirm that the introduction of Nd promotes the migration of photo-generated electrons from SCN to Pt, thereby significantly suppressing carrier recombination. This study reveals the unique mechanism by which the rare earth element Nd acts as an electronic regulator for the d-band center of Pt, providing new insights into the design of photocatalytic systems with low Pt loading. Download: Download high-res image (144KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）