Materials
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2025
·Vol. 18
·期 17
·4165
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IF 3.2
Heng Zhang,Yiping Yang,Shengchao Yang,Yuchang Qin,Xuan Lv,Lin Cui,Wei Jia,Zhiyong Liu
The impact of encapsulating gemcitabine (GEM) into nanoparticles on its delivery remains underexplored, with the potential benefits of targeted drug delivery and stimuli-responsive release yet to be fully clarified. Herein, we designed a near-infrared (NIR) light-responsive polymeric nanoparticle, ZnPc@P(PEG-CMA-TKGEM), which integrates reactive oxygen species (ROS) generation and cell imaging capabilities. The self-assembled polymeric micelles exhibit a hydrodynamic size of ~134 nm. Under NIR irradiation, the cumulative drug release rate reaches 51% within 48 h, which is three times higher than that of the non-irradiated control group. In cytotoxicity assays, the cell viability of the NIR-irradiated drug-loaded group is approximately 17%, while that of the NIR-irradiated blank group (without drug loading) remains above 80%. These results confirm that the nanocarriers successfully deliver GEM to target cells and achieve controlled drug release via NIR stimulation.
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CARBOHYDRATE POLYMERS
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2020
·
IF 7.182
Jie Ding,Zi Qiao,Yusheng Zhang,Danrui Wei,Suping Chen,Jiajia Tang,Lu Chen,Dan Wei,Jing Sun,Hongsong Fan
Conductive and self-healing hydrogel sensor is perspective in human-machine interaction applications. However, the design of ideal self-healing hydrogels are always challenging. Herein, by introducing disulfide modified Ag nanowires (AgNWs), we show a novel self-healing hydrogel strain sensor with superior mechanics, conductivity, antibacterial property , and firstly realizing of self-healing with both recovery of mechanics and sensing properties. We demonstrate that the covalent and reversible non-covalent hydrophobic blocks in hydrophobic modified polyacrylamide (HMPAM) achieves the basic self-healing network; dextran with plentiful hydroxyl groups synergistic helps the self-healing by hydrogen bonds ; disulfide on the AgNWs surface forms a NIR-responsive and dynamic Ag-S coordination bridge between HMPAM and AgNWs. The resulted hydrogel sensor exhibits comprehensive electromechanical properties, and precisely monitors human motion and subtle electromyography (EMG) signals. Importantly, we firstly achieved the recovery of sensing properties on human motion detection and EMG signal detection after self-healing. This work provides a promising exploration to manufacture bionic strain sensors for potential applications in wearable electronics.
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JOURNAL OF MEDICINAL CHEMISTRY
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2016
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IF 5.589
Zhao Ma,Yuxing Lin,Yanna Cheng,Wenxiao Wu,Rong Cai,Shouzhen Chen,Benkang Shi,Bo Han,Xiaodong Shi,Yubin Zhou,Lupei Du,Minyong Li
Fluorescent ligands are gaining popularity as tools to aid GPCR research. Nonetheless, in vivo application of such tools is hampered due to their short excitation wavelengths in the visible range and lack of fluorogenic switch. Here we report the discovery of fluorescent ligands (3a–f) for α1-adrenergic receptors (α1-ARs) by conjugating the environment-sensitive fluorophore cyane 5 (Cy5) with the quinazoline pharmacophore. Among them, the conjugated compound 3a, with acylated piperazine and the shortest carbon chain spacer, exhibited potent binding and remarkable changes in fluorescence (10-fold) upon binding to α1-AR. Furthermore, it could be employed to selectively and specifically label α1-ARs with no washing procedures in single cells, prostate tissue slices, intact tumor xenografts and organs in living mice. Especially, the slice imaging results gave direct and visual evidence that there is a close relationship between α1-ARs and pathological prostate. It is anticipated that our fluorescent tools will find broad applications in the study of α1-AR pharmacology and physiology to aid development of novel therapeutics.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2020
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IF 4.845
Xiaoyue Wei,Chunyang Liu,Zhiyong Wang,Yongxiang Luo
Localized therapy using hydrogels-based drug delivery system (DDS) is a promising strategy for the treatment of diseases such as cancer in superficial tissues. In this study, we presented a facile method to prepare core-shell hydrogel fibers/scaffolds with controlled drug delivery and designed structures for the treatment of the residual breast cancer and prevention of local recurrence after surgery. Mixtures of polydopamine (PDA) and concentrated alginate inks (15.3 wt%) as the shell layer, and drug-loaded temperature-sensitive hydrogels as the core part were co-injected and coaxial 3D printed into core-shell hydrogel fibers and scaffolds. Under near infrared (NIR) irradiation, PDA with excellent photothermal effect could raise the temperature of core-shell fibers, which induced the gel-sol transition of the core gels, and subsequently resulted in the drug release from the loosened hydrogel network. The photothermal effect and the released drugs could eliminate cancer effectively. Thus, our prepared core/shell fibers and scaffolds with NIR-triggered on-demand drug release would be promising candidates to fill the cavity of breast tissues after surgical resection of cancer achieving a therapeutic effect for the residual and recurred cancer.
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Small
·
2023
·
IF 13.3
Min Hou,Rui Guo,Tianyu Ren,Tao Wang,Jian-Hui Jiang,Jianjun He
Dysfunctional transcription factors that activate abnormal expressions of specific proteins are often associated with the progression of various diseases. Despite being attractive drug targets, the lack of druggable sites has dramatically hindered their drug development. The emergence of proteolysis targeting chimeras (PROTACs) has revitalized the drug development of many conventional hard-to-drug protein targets. Here, the use of a palindromic double-strand DNA thalidomide conjugate (PASTE) to selectively bind and induce proteolysis of targeted activated transcription factor (PROTAF) is reported. The selective proteolysis of the dimerized phosphorylated receptor-regulated Smad2/3 and inhibition of the canonical Smad pathway validates PASTE-mediated PROTAF. Further aptamer-guided active delivery of PASTE and near-infrared light-triggered PROTAF are demonstrated. Great potential in using PASTE for the selective degradation of the activated transcription factor is seen, providing a powerful tool for studying signaling pathways and developing precision medicines.
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ACS Applied Materials & Interfaces
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2023
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IF 9.5
Muqun Wang,Shaofeng Liang,Shuangliang Zhao,Wei Gao,Zequan Li
High-performance interlayer materials have garnered considerable interest owing to their low manufacturing costs and applicability in smart windows. In this study, a novel smart-window interlayer material capable of selective shielding against both near-infrared (NIR) and ultraviolet (UV) radiation is developed based on the light transmittance control mechanism. An excellent thermoresponsive liquid, denoted as CDs@TRL (viz., carbon quantum dots at thermal-responsive liquid), is synthesized by compositing biomass-based fluorescent carbon quantum dots (CDs) and poly(N-isopropylacrylamide) (pNIPAM) at natural ambient temperature and in an aqueous phase. Due to the characteristics of CDs and synergistic effect of hydrogen bonds, CDs@TRL exhibits a high specific heat capacity (4.41 kJ kg–1 K–1), large thermal storage capacity (264.6 kJ kg–1), and better UV–NIR-blocking properties, compared to pure pNIPAM, as well as improves the sensitivity of thermal response. When injected into a window as a liquid interlayer, CDs@TRL can intelligently adjust the light transmittance according to ambient light intensity to achieve an intelligent response. The shielding rate of a 10 mm-thick CDs@TRL composite liquid against UV radiation (200–400 nm) was more than 95% in an overcast environment with insufficient light and close to 100% in a well-lighted environment. In addition, CDs@TRL is a cost-effective material that can be prepared from a wide range of raw material sources using a simple preparation process and exhibits excellent mobility and recyclability. Because of these features, it is considered to be a promising candidate for developing energy-saving and climate-adapted smart windows.
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Catalysis Science & Technology
·
2019
·Vol. 9
·期 9
·2103-2110
·
IF 5.726
Shuhui Liang,Yukun Chang,Yue Wang,Dafeng Zhang,Xipeng Pu
A simple combustion method was reported to prepare a novel BiOBr:Yb3+,Er3+/AgBr (BYE/AgBr) heterojunction photocatalyst. Phase composition, morphology and optical properties of samples were characterized. The diffuse reflectance and photoluminescence spectra showed that the as-synthesized BYE/AgBr can be activated under both visible (vis) and near-infrared (NIR) light. Notably, BYE/AgBr composites exhibited enhanced photocatalytic activity for RhB degradation under vis/NIR irradiation. The degradation rate constants of BYE/AgBr-1 : 1.5 for RhB were 0.0220 min−1 and 0.01368 h−1 under visible and NIR irradiation, which are about 2.6 and 4.9 times higher than that of pure BYE, respectively. The upconversion effect of Er3+ can convert the NIR light (∼980 nm) to visible light which was then absorbed by BYE/AgBr to generate e− and h+. Moreover, the formation of the heterojunction also plays a role in the enhanced vis/NIR photocatalytic abilities; and a corresponding plausible photocatalytic mechanism was proposed.
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Nano Today
·
2024
·
IF 13.2
Fapu Wu,Senyao Liu,Bingbing Zheng,Wenwen Cao,Yu Zhu,Jieyu Yang,Hu Xiong
Real-time monitoring of intestinal movement is critical for the clinical diagnosis of bowel diseases, however, the application of organic fluorophores in non-invasive imaging of the intestinal tract via systemic administration is still challenging. We herein report a series of albumin-chaperoned chloro-cyanine dyes for high spatiotemporal tracking of intestinal peristalsis and bowel disease in vivo. By adjusting the size of the central rings, Cy7–5 , with a five-membered ring and meso-chlorine, could covalently bind with circulating endogenous albumin in the blood, generating a bright and stable cyanine-albumin fluorescent complex with ∼1055 nm fluorescence in the near-infrared-II window in situ. Notably, Cy7–5 was able to clearly view intestinal peristalsis by harnessing the inherent intestine tropism of Cy7–5 -albumin complex following intravenous (i.v.) administration. Furthermore, a hydroxyl radical (·OH)-activatable fluorophore ( Hydro-Cy7–5 ) was created, allowing for the selective detection of overproduced ·OH in bowel disease as well as the successful visualization of the inflammatory intestinal tract in vivo after i.v. injection. This work provides a facile strategy for the investigation of intestinal movement and related diseases.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yixin Wang,Ye Zhang,Mengshu Xu,Zhuoran Yang,Wei Guo,Chunyu Yang
Breast cancer is one of the most prevalent malignant tumors worldwide and a leading cause of cancer-related mortality, underscoring the urgent need for innovative therapeutic strategies. In this study, we developed an injectable hydrogel-based system, in which polyvinylpyrrolidone (PVP)-modified NiS 2-x @PVP nanospheres were incorporated with metformin hydrochloride (MH) and dispersed in a hyaluronic acid (HA) hydrogel matrix to form the NiS 2-x @PVP@HA tumor treatment platform. This system exhibits excellent photothermal performance under near-infrared (NIR) light irradiation and can be employed for tumor photothermal therapy (PTT). The Ni 2+ released from the degradation of NiS 2-x @PVP nanospheres can catalyze the decomposition of endogenous hydrogen peroxide in tumor cells, thereby generating toxic hydroxyl radicals for chemodynamic therapy (CDT). By altering the HA concentration, the internal pore structure, mechanical properties, drug release behavior, and swelling capacity of the hydrogel can be modulated. The loaded antitumor drug MH further enhances the therapeutic efficacy. Under NIR and ultrasound stimulation, this platform enables controlled drug release. In vitro and in vivo experiments have demonstrated that the NiS 2-x @PVP@HA hydrogel achieves the synergistic treatment of PTT/CDT/chemotherapy for tumor tissues. Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that activation of the MAPK signaling pathway was a key mechanism underlying tumor cell death. This work presents a rational design strategy that addresses the related challenges in breast cancer and promotes precise cancer therapy.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Fengtian Zhang,Weihong Luo,Zhongjie Min,Darong Lu,Weiliang Chen,Lijuan Wen
Targeted mitochondrial-based therapeutic strategies for tumors have emerged as a significant research focus in the field of cancer treatment in recent years. Mitochondria, often referred to as the “energy factory” of cells, play a crucial role in the metabolic reprogramming of tumor cells, as well as in oxidative stress and immune evasion. In this study, we utilized a mitochondria-targeted photosensitizer, IR780, to engineer Celastrol (Cela)-loaded lipid nanoparticles, designed as Cela@Lip-IRH, for the synergistic therapy of chemotherapy and photodynamic therapy (PDT) against glioma. Cela@Lip-IRH could respond to the weakly alkaline environment of tumor cell mitochondria for rapid Cela release. Leveraging the mitochondrial targeting capacity and PDT property of IR780, Cela@Lip-IRH nanoparticles showed enhanced cellular uptake and mitochondria targeting distribution in vitro, as well as obvious tumor accumulation in vivo. Cela@Lip-IRH nanoparticles exhibited prominent intracellular reactive oxygen species (ROS) generation upon NIR laser irradiation, which was accompanied by pronounced photocytotoxicity and cell apoptosis, finally producing remarkable tumor growth suppression efficacy in vivo. We further verified that the potential antitumor molecular mechanism was triggered by the release of Cytochrome C, leading to an activated mitochondrial apoptosis pathway, alongside an immune response characterized by enhanced recruitment of CD4+ T cells and CD8+ T cells in tumor tissues. Currently, this mitochondria-targeted nanoplatform presents an ideal method to enhance the synergistic performance of chemotherapy and PDT in glioma, and it is anticipated that such a strategy will provide a promising alternative to optimize the tumor-targeted therapies.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Zengyue Li,Nan Kang,Yixun Jin,Weiyan Yao,Jin Cheng,Zimei Liu,Xiaoqing Qian,Qian Zhang
Accurate diagnosis and effective treatment of pancreatic cancer are essential to improving survival rates, yet current strategies are highly limited by toxicity of therapeutic drugs and efficacy challenges. Herein, we proposed a biodegradable nanosystem (denoted as MnCO3–BSA@DOX/IR820) based on manganese carbonate (MnCO3) loaded with doxorubicin (DOX) and photothermal agent IR820. This platform integrates chemotherapy with photothermal/photodynamic therapy (PTT/PDT) under 808 nm laser irradiation, achieving synergistic antitumor efficacy against pancreatic cancer. Specifically, the MnCO3-based nanosystem can enhance tumor accumulation, while the hydrogen peroxide (H2O2)-enriched acidic tumor microenvironment (TME) triggers oxidative stress pathways to generate reactive oxygen species (ROS). Upon 808 nm laser irradiation, IR820 is activated to exert a combined therapeutic effect. It mediates PDT to generate ROS, while the localized hyperthermia induced by PTT causes direct cellular apoptosis and facilitates DOX release, thereby enhancing therapeutic efficacy. Additionally, the nanosystems integrate magnetic resonance imaging (MRI) and near-infrared fluorescence (NIR) imaging capabilities, enabling real-time treatment monitoring and precise diagnosis. In vivo studies demonstrated that MnCO3–BSA@DOX/IR820 nanosystems effectively inhibit tumor growth without causing notable damage to normal tissues. Therefore, this pH-responsive and MRI/NIR imaging-guided nanoplatform represents a targeted theranostic system for pancreatic cancer, enabling chemo-PTT/PDT synergy.
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Nanoscale
·
2024
·
IF 5.8
Jingjing Jiang,Qiong Zhang,Yue Zhang,Lintong Gao,Yan Feng,Xianshun Sun,Junjun Wang,Xiao-Jiao Zhu,Xingxing Chen,Hong-Ping Zhou
Currently, cuproptosis mainly focuses on the Cu2+ induced morphology of mitochondria (Mito), the observation of endoplasmic reticulum (ER)-related Cu2+ content in cuproptosis is relatively lacking. Herein, we develop a hydroxyflavone (HF) based NIR excited fluorescent probe, BHCO, for exhibiting specific recognition of Cu2+. BHCO can accurately locate in ER and detect Cu2+ content in cuproptosis process. The two-photon fluorescence nature of BHCO enables to track both ferroptosis and cuproptosis processes with high resolution. Furthermore, BHCO can upgrade reactive oxygen species (ROS) under 720 nm excitation, which facilitates ferroptosis occurrence. We firmly convince the nonlinear optical (NLO) small molecules could provide a valid tool for rapid tumors elimination through synergistic ferroptosis and cuproptosis.
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