MACROMOLECULAR MATERIALS AND ENGINEERING
·
2019
·Vol. 304
·期 4
·1800698
·
IF 3.038
Shuifeng Liu,Yang Hu,Jiancheng Zhang,Siqi Bao,Lin Xian,Xianming Dong,Wenxu Zheng,Yiheng Li,Huichang Gao,Wuyi Zhou
Bioactive and biocompatible porous scaffold materials with adjustable pore structures and drug delivery capability are one of the key elements in bone tissue engineering. In this work, bioactive and biocompatible sodium alginate (SA)/hydroxyapatite (HAP) macroporous scaffolds are facilely and effectively fabricated based on 3D printing of the pre-crosslinked SA/HAP hydrogels followed by further crosslinking to improve the mechanical properties of scaffolds. The pore structures and porosity (>80%) of the porous scaffolds can be readily tailored by varying the formation conditions. Furthermore, the in vitro biomineralization tests show that the bioactivity of the porous scaffolds is effectively enhanced by the addition of HAP nanoparticles into the scaffold matrix. Furthermore, the anti-inflammatory drug curcumin is loaded into the porous scaffolds and the in vitro release study shows the sustainable drug release function of the porous scaffolds. Moreover, mouse bone mesenchymal stem cells (mBMSCs) are cultured on the porous scaffolds, and the results of the in vitro biocompatibility experiment show that the mBMSCs can be adhered well on the porous scaffolds. All of the results suggest that the bioactive and biocompatible SA/HAP porous scaffolds have great application potential in bone tissue engineering.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2018
·
IF 2.829
Min Wang,Xiong Li,Tonghui Zhang,Li Deng,Peiyun Li,Xuefen Wang,Benjamin S. Hsiao
A thorough cleanup of heavy metal ions in water bodies is of vital importance for the urgent requirement of clean potable water. In this study, combining the prominent structural characteristics of electrospun nanofibers and the special property of hydrogels, we developed a green strategy to construct an eco-friendly poly(acrylic acid)-sodium alginate nanofibrous hydrogels (PAA-SA NFHs) by electrospinning PAA-SA nanofibers, and followed by a facile thermal cross-linking treatment. The resultant PAA-SA NFHs with high swelling ratio, intrinsic fiber morphology, excellent stability and satisfactory mechanical performances exhibited prominent adsorption performances towards Cu 2+ (q m = 591.7 mg/g) and outstanding regenerability. Notably, by virtue of the synergy of porous network structure, superhydrophilicity and faster adsorption rate, such PAA-SA NFHs membrane permitted extremely high water permeation flux solely driven by gravity (up to 868.5 L m −2 h −1 ) and remarkable removal efficiency, when acted as a free-standing filter for the dynamic removal of Cu 2+ . Furthermore, we also demonstrated a sustainable strategy of converting the toxic Cu 2+ pollutants to valuable Cu nanoparticles for imparting additional functionality of catalysis, and the resultant PAA-SA NFHs with uniformly distributed Cu nanoparticles possessed an excellent catalytic activity. Consequently, constructing such attractive PAA-SA NFHs will provide new insights into the design and exploitation of novel adsorbents or filters for the practical water purification, and to recycle metals (copper and potentially others) for keeping the resources sustainable.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Changlong Bi,Suya Li,Jie Hao,Gaoyuan Gu,Chong Peng,Shuyi Yang,Tao E
The Cu(II) treatment in water environment by adsorption has become a major strategy for water pollution control and water resource protection. In view of the planar configuration characteristics of Cu(II) complex, the construction and optimization of adsorbent's internal structure to achieve improved adsorption performance is still a problem worth exploring. Herein, polyvinyl alcohol (PVA) is introduced into graphene oxide/sodium alginate (GO/SA) gel system to obtain PVA/GO/SA gel material, which not only achieves the construction of slit-shaped structure by self-interlayer stacking for GO nanosheets and its cross-linking with SA, but effectively promotes formation of high cross-linking density internal channels by the introduction of PVA, thus achieving the efficacious and selective Cu(II) removal. Maximum adsorption capacity for PVA/GO/SA can reach 96.81 mg/g, and it also shows excellent selective removal rates in various real water environments. Molecular dynamics simulation is used to explore the key roles of each component of PVA/GO/SA on gel formation, slit-shaped structure and internal channel construction, and adsorption reaction activity, and to validate the efficacy components and adsorption mechanism of PVA/GO/SA in Cu(II) adsorption based on density-functional theory (DFT) and simulation calculations. Our study can provide a new structural design idea for the efficient selective Cu(II) adsorption materials.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Haixin Chen,Ziyun Zhou,Bingde Zheng,Hongjie Yang,Yi Chen,Yayan Huang,Na Zhang,Xueqin Zhang,Meitian Xiao,Jing Ye,Yucheng Yang
As environmental awareness grows, developing non-toxic, environmentally friendly, and biodegradable water- and oil-resistant coating layers using bio-based materials for paper-based packaging has become a key field of research. In this work, sodium alginate (SA) and sodium carboxymethyl cellulose (CMC) were used as the oil-resistant coating layer, while shellac (LAC) and ethyl cellulose (EC) formed the water-resistant coating layer, to produce a water- and oil-resistant coated paper. The effect of the mass ratio of these materials on performance was analyzed, demonstrating that the interaction between SA and CMC enhances the compactness of coating, thereby improving oil resistance. Similarly, the addition of LAC to EC increases coating compactness, which improves water resistance. The resulting coated paper has excellent water resistance (Cobb value: 3.42 g/m 2 ) and oil resistance (Kit rating: 12/12) and shows no leakage after holding hot water and hot oil for 30 min, indicating good resistance to both. Additionally, the coated paper demonstrates good mechanical properties, thermal stability, biodegradability and recyclability. The materials used are widely available and low-cost, and the preparation method is straightforward, making this research highly valuable for advancing paper-based packaging materials.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 19
·4518
·
IF 4.2
Pengbo Chang,Shuyang Zhou,Tongchao Wang,Dangling Hua,Shiliang Liu,Oseweuba Valentine Okoro,Armin Shavandi,Lei Nie
This study investigates the removal efficiency of Cu2+from wastewater using a composite hydrogel made of carbon nanotubes (CNTs), sodium alginate (SA), and polyacrylic acid (PAA) prepared by free radical polymerization. The CNTs@SA/PAA hydrogel’s structure and properties were characterized using SEM, TEM, FTIR, XRD, rheology, DSC, EDS, elemental mapping analysis, and swelling. The adsorption performance for Cu2+was tested in batch adsorption experiments, considering the pH, dosage, initial concentration, and contact time. The optimal conditions for Cu2+removal were pH 5.0, an adsorbent dosage of 500 mg/L, and a contact time of 360 min. The adsorption followed pseudo-second order kinetics. Isotherm analyses (Langmuir, Freundlich, Temkin, Dubinin–Radushkevich, Sips, Toth, and Khan) revealed that the Freundlich isotherm best described the adsorption, with a maximum capacity of 358.52 mg/g. A thermodynamic analysis indicated that physical adsorption was the main interaction, with the spontaneity of the process also demonstrated. This study highlights the high efficiency and environmental friendliness of CNT@SA/PAA composites for Cu2+removal from wastewater, offering a promising approach for water treatment.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2024
·
IF 11
Bo Qiu,Huijuan Jing,Shengyi Han,Shuobo Zhang,Furong Ba,Lvwan Xu,Siyuan Xie,Wang Gao,Yilun Huang,Hang Xiao,David Julian McClements,Björn Berglund,Lanjuan Li,Mingfei Yao
Faecalibacterium prausnitzii ( F. prausnitzii ) exhibits a variety of biological functions that make it suitable for use as a next-generation probiotic . However, its high sensitivity to oxygen and digestive fluids currently limits its application. Riboflavin is known to support the growth of F. prausnitzii in oxygen environments, but it is important that it is in close proximity to the probiotics. Layer-by-layer assembly can be used to form protective coatings around probiotics, which can protect them from adverse environmental conditions. Moreover, riboflavin can be conjugated to these coatings, thereby increasing its efficacy by bringing it close to probiotic surfaces. In this study, we therefore evaluated the potential of electrostatic layer-by-layer assembly to protect F. prausnitzii by coating them with riboflavin-alginate and glycol-chitosan layers. Initially, we showed that riboflavin could be successfully conjugated to alginate, with a grafting ratio of around 4.35%. Then, the layer-by-layer method was used to coat F. prausnitzii using cationic glycol chitosan and anionic riboflavin-alginate. The coating formed was found to have a thickness of approximately 18.5 nm. Encapsulation did not adversely affect the growth of F. prausnitzii , but it significantly enhanced its resistance to oxygen and digestive fluids. The encapsulated probiotic was shown to have enhanced mucoadhesive properties using an in vitro intestinal monolayer model. Furthermore, the encapsulated probiotics colonized the colons of rats for longer than nonencapsulated ones. These results show that coating F. prausnitzii with riboflavin-rich biopolymer layers improves its resistance to oxygen and digestive fluids, and enhances its mucoadhesion and colonization properties, which should enhance its potential as an orally administered probiotic.
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2024
·Vol. 13
·期 24
·4047
·
IF 4.7
Jinxiu Zhang,Xinzhong Hu,Zhen Ma
Starches with different degrees of debranching (DBS30, DBS60, and DBS90) and sodium alginate were used as the wall material for encapsulating particles ofLacticaseibacillus rhamnosusGG (LGG). The structural characteristics of these encapsulated particles were examined, along with the impact of varying levels of debranching on the encapsulation efficiency, the in vitro release of LGG under the simulated gastrointestinal environment, and the storage stability of the encapsulated particles. The results revealed a transformation in the crystalline polymorph from C- to B+V-type following debranching and retrogradation. This process also resulted in a significant decrease in molecular weight and polydispersity index, accompanied by an increase in amylose and resistant starch levels along with the relative crystallinity of the debranched lentil starch. Comparatively, DBS60-LGG and DBS90-LGG exhibited higher encapsulation efficiency and encapsulation yield than UDBS-LGG and DBS30-LGG. Furthermore, these encapsulated particles provided enhanced protection for LGG in both the simulated gastrointestinal environment and the storage process. It can be inferred that a superior encapsulation performance of the debranched lentil starch–sodium alginate-based encapsulated LGG particles was associated with higher debranching levels, a more uniform molecular weight distribution, and a more ordered multi-scale structure of the debranched lentil starch.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Hongyang Zhou,Qi He,Xuran Liu,Qianqian Jiang,Dawang Chu,Qiong Wang,Xuan Yang,Tongling Zhang,Hongkun Wang,Zhenglong Li
Cellulose has outstanding potential for application in energy storage batteries due to its high temperature resistance, high electrolyte affinity, renewability, and suppression of the shuttle effect, but single cellulose membranes still suffer from problems such as inhomogeneous pore distribution and unstable three-dimensional network structure. In this study, a green and sustainable regenerative cellulose (RC)/sodium alginate (SA) gel electrolyte membrane is developed by sol-gel process, the double crosslinked network scaffold centered on Zn 2+ was constructed by the synergistic hydrogen-bonding and metal ion- coordination network, the stable and uniform pore structure was also formed. The obtained RC-SA gel electrolyte membrane exhibits outstanding performance, featuring a dual crosslinked network with abundant pore structure and numerous polar groups that effectively enhance Zn 2+ transport, significantly improving battery cycling performance. The corresponding RC-SA gel electrolyte membrane demonstrates high ionic conductivity (6.30 mS·cm −1 ) and Zn 2+ transference number (0.66), leading to excellent reversible capacity (159 mA·h·g −1 ) and self-discharge suppression capability (maintaining 99.2 % of capacity after a 24 h standstill) in Zn//V 2 O 5 full-cell. The coulombic efficiency and cycling stability of the Zn//Cu half-cell and Zn//Zn symmetric cell using RC-SA gel electrolyte membrane outperforms that of the glass fiber separator, highlighting its multifunctionality and potential applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Guohua Wang,Yicheng Wang,Guoqiang Lu,Shiyu Dong,Ruifen Tang,Yingying Zhao,Jun Nie,Xiaoqun Zhu
Hydrogel tubes made of sodium alginate (SA) have potential applications in drug delivery, soft robots, biomimetic blood vessels, tissue stents, and other fields. However, the continuous preparation of hollow SA hydrogel tubes with good stability and size control remains a huge challenge for chemists, material scientists, and medical practitioners. Inspired by the plant apical growth strategy, a new method named soft cap-guided growth was proposed to produce SA hydrogel tubes. Due to the introduction of inert low gravity substances, such as air and heptane, into the extrusion needle in front of calcium chloride solution to form a soft cap, the SA hydrogel tubes with controllable sizes were fabricated rapidly and continuously without using a template through a negative gravitropism mechanism. The SA hydrogel tubes had good tensile strength, high burst pressure, and good cell compatibility. In addition, hydrogel tubes with complex patterns were conveniently created by controlling the motion path of a soft cap, such as a rotating SA bath or magnetic force. Our research provided a simple innovative technique to steer the growth of hydrogel tubes, which made it possible to mass produce hydrogel tubes with controllable sizes and programmable patterns.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Research and Technology-JMR&T
·
2024
·
IF 6.2
Qian Zhang,Jiawei Li,Qingdi Qu,Shuang Pan,Kunyang Yu,Yushi Liu
The challenge of precisely regulating temperature during the photo-thermal bone promotion remains unresolved. Phase change material (PCM), capable of undergoing a phase transition at a specific temperature, offers a solution by photothermal temperature regulation through the storage and release of heat. This study incorporated biocompatible polyethylene glycol (PEG) with specific phase transition points as PCM. A phase change hydrogel scaffold was then synthesized through semi-crosslinking PEG with calcium-ion-chelated sodium alginate (SA) acting as the structural framework. Additionally, the newly developed graphene oxide (GO) modified composite scaffolds (GO-PHSC), featuring 0.5 wt% GO, not only demonstrated outstanding photothermal conversion efficiency and an optimal phase change temperature (42.2 °C) but also exhibited desirable values for latent enthalpy (100 J/g) and latent heat recovered (LHR) (93.3%). Moreover, the form-stability test demonstrated the PCM scaffolds' exceptional resistance to leakage and maintenance of shape stability even at elevated temperatures (70 °C). Beyond achieving passive temperature control in photothermal therapy, experimental findings highlighted that the phase change hydrogel, incorporating calcium ions and GO, met various requirements such as physicochemical properties, microstructure, mechanics, mineralization, biocompatibility, and cell affinity. These collective attributes suggest that GO-PHSC emerges as a promising scaffold composite candidate for temperature-controlled photothermal therapy in bone regeneration.
✓ 已验证
产品关联
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2024
·
IF 6.5
Zhikun Yang,Biqiong Chen,Haroon Elrasheid Tahir,Zhihua Li,Xiaowei Huang,Mingrui Li,Ke Zhang,Bingxin Li,Xiaodong Zhai,Jiyong Shi,Xiaobo Zou,Jianbo Xiao
This work aims to develop a biodegradable film with enhanced mechanical, water-barrier, and antimicrobial characteristics for the preservation of cherry tomatoes . Here, a persimmon pectin/ovalbumin (PN/OVA) stabilized-neem essential oil Pickering emulsion (NOPE) was added into the gelatin/sodium alginate-based blend matrix (GS). Even the biodegradability and transmittance of NOPE-rich film were decreased as compared to the control film, its flexibility, oxygen-barrier, and water-barrier performances significantly ( P < 0.05) increased by 45.23 %, 32.32 %, and 37.02 %, respectively. The NOPE-loaded films destroyed the hyphal structure and reduced spore germination of Botrytis cinerea through slow-releasing neem essential oil (NO), in turn inhibiting the growth of B. cinerea . Finally, the prepared films were applied for cherry tomato preservation. Compared with the control, 2.0 wt%-loaded GS films greatly reduced the weight loss and disease incidence of cherry tomatoes by 57.33 and 72.4 %, respectively, owing to their excellent water resistance and slow-released properties. Thus, the addition of 2.0 wt% NOPE into GS film is of particular interest in the design of active biodegradable packaging films for fruit preservation.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Guanqun Peng,Jia Hu,Jinnan Guo,Jiahui Dong,Yuanyuan Zhao,Tong Ye,Fengjun Xiao,Zhiyun Meng,Hui Gan,Ruolan Gu,Peng Han,Wenzhong Sun,Guifang Dou,Yunbo Sun,Shuchen Liu
The management of combined radiation-wound injury (CRWI) is a major clinical challenge owing to the delayed and prolonged wound-healing process. Moreover, the mechanisms underlying the healing of CRWI are complex, and chronic wounds can increase vulnerability to multidrug-resistant bacterial infections, vascular disease, and other adverse conditions. Although exosomes from iPSC-derived mesenchymal stem cells (iMSCs) can promote injury repair, the feasibility of encapsulating them within polysaccharide-based hydrogels to treat CRWI remains to be explored. Here, iMSC-derived exosomes were encapsulated within an injectable hydrogel (HACC/OSA) consisting of quaternized chitosan (HACC) and oxidized sodium alginate (OSA). The HACC/OSA hydrogel exhibited good self-healing properties, excellent injectability, and good biocompatibility. In mouse models of CRWI, the HACC/OSA hydrogel could form a protective barrier covering the wound. Due to the presence of quaternary ammonium salts, the hydrogel could provide long-term antimicrobial protection to the wound, which was favorable for wound healing. In addition, the hydrogel could also promote CRWI repair by stabilizing exosome release. The exosome-loaded hydrogel (HACC/OSA@Exos) significantly inhibited bacterial growth and promoted the repair of CRWI, as indicated by enhanced wound healing efficiency, rapid re-epithelialization, favorable collagen deposition, and abundant angiogenesis at the wound site. Together, the in vivo and in vitro results indicated that the exosome-loaded polysaccharide-based hydrogel (HACC/OSA@Exos) can promote the healing of CRWI and potentially serve as a valuable clinical agent for CRWI management.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）