Biomedical Materials
·
2026
·Vol. 21
·期 3
·035002
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IF 3.9
Shanchun Zhang,Xiangyu Cheng,Jingtong Wu,Yunuo Song,Liping Ren
To address the challenge of preventing peri-implantitis, the present study developed a pH-responsive drug delivery coating on titanium (Ti) implants for controlled aspirin release. A hierarchical metal-organic framework coating was constructed on alkali- and heat-treated titanium by sequentially synthesizing Zeolitic imidazolate framework-L (ZIF-L) and ZIF-8 (denoted AHTL8). Material characterization confirmed the successful fabrication of a hierarchical micro–nano structure, which significantly enhanced surface hydrophilicity. The AHTL8 system exhibited a remarkably high aspirin-loading capacity (0.227 mg) and intelligent release kinetics, with sustained delivery (77.36% over 72 h) at physiological pH (7.4) and rapid, extensive release (97.39% over 72 h) under acidic conditions pH (6.5). Furthermore, the coating demonstrated excellent cytocompatibility, and the aspirin-loaded AHTL8 significantly promoted the proliferation of mouse osteoblastic MC3T3-E1 cells. These findings indicate that the ZIF-L/ZIF-8 composite coating serves as a highly efficient pH-triggered platform with high drug-loading and responsive release capacity, and its excellent cytocompatibility and MC3T3-E1 proliferation-promoting effect provide a preliminary basis for its potential application in promoting osseointegration.
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FOOD CHEMISTRY
·
2026
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IF 10.4
Hanbin Chen,Jie Shi,Junjie Tang,Jianxi Zhang,Ziyang Wu,Cailing Tong,Jie Pang
Novel dual sustained-release film with antioxidant/antibacterial synergy. • PACS grafting enables persistent antioxidant activity. • CV@ZIF-8 nanoparticles provide prolonged antibacterial release. • Enhanced barrier, mechanical and UV-shielding properties. • Effectively preserves strawberry quality and extends shelf life. Few bio-based active packaging films simultaneously achieve sustained antioxidant and antibacterial functions, making a dual sustained-release system highly desirable. To extend postharvest fruit shelf life, this study developed an active packaging film based on konjac glucomannan (KGM). A dual-release antioxidant and antibacterial system was constructed by introducing proanthocyanidin-grafted chitosan (PACS) and carvacrol-loaded ZIF-8 nanoparticles (CV@ZIF-8). The resulting KPCZ-3 film exhibited a tensile strength of 34.36 MPa, a water vapor permeability of 2.72 g·mm·m −2 ·day −1 ·kPa, and an oxygen permeability of 1.27 × 10 −3 g·s −1 ·m −2 . In strawberry preservation tests at 25 °C, the film synergistically delayed quality deterioration and maintained optimal sensory and nutritional quality for over 4 days. In addition, the film showed good biodegradability and biocompatibility. These results indicate that KGM/PACS/CV@ZIF-8 films, as novel degradable active packaging, have promising application prospects. Download: Download high-res image (159KB) Download: Download full-size image
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Materials Today Communications
·
2025
·
IF 4.5
Fangyu Liu,Zichen Liang,Yi Zhang,Siyu Qin,Siqi Zhang,Tao Zhang,Bo Li,Xiaoling Liao,Xiaoming Li,Shuang Yang
Rapamycin (RAPA) is widely used in biomedical applications due to its antitumor, autoimmune disease and neuroprotective effects. However, direct administration of RAPA may lead to side effects such as excessive suppression of the immune system, severe infections and increased risk of tumors. Zeolitic imidazolate framework-8 (ZIF-8) is one of the most promising MOFs that shows great potential in the field of drug delivery. In this study, we successfully prepared nano-ZIF-8 particles of uniform size and monodispersity by optimizing the reaction time, stirring time, and reactant concentration. ZIF-8 was used as a carrier loaded with RAPA (ZIF-8@RAPA), which was characterized by XRD, FTIR, UV vis, TGA, and zeta potential, and the results revealed that ZIF-8@RAPA with a dodecahedral morphology, a particle size of 82 nm ± 4.7 nm, and a drug-loading rate of up to 11.53 % was successfully synthesized and that the loaded RAPA could achieve long-lasting slow release. Furthermore, we monitored the structural evolution of ZIF-8@RAPA in PBS. We found that the structural stability of ZIF-8@RAPA could be maintained for up to 6 weeks, followed by the gradual cleavage and disintegration of the crystal structure, and the reformation of micro-crystals (dia(Zn)) at 8 weeks, which is presumed to be affected by the [HPO 4 ] 2- in the PBS solution. In addition, the biocompatibility of the ZIF-8@RAPA delivery system was comprehensively evaluated using macrophage RAW 264.7 and the zebrafish embryo model. The results revealed that the biotoxicity of ZIF-8@RAPA was concentration dependent and that it had good biocompatibility when it was applied at concentrations lower than 100 μg/mL. In summary, our study preliminarily elucidated the in vitro disintegration and reconstruction mechanisms of nano-ZIF-8@RAPA crystals and demonstrated their feasibility for application in biomedical fields.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yaning Li,Yue Wang,Hongchao Ma
The tumor microenvironment (TME), characterized by hypoxia, limited H 2 O 2 availability, and elevated glutathione (GSH) concentrations, challenges reactive oxygen species (ROS)-based therapies. To address these, we developed a GOx@Cu-ZIF-8/DOX (GCZD) nanoplatform combining chemotherapy (CT), chemodynamic therapy (CDT), and starvation therapy (ST). This system utilizes Cu-incorporated ZIF-8 (Cu-ZIF-8) as a versatile carrier to load glucose oxidase (GOx) and doxorubicin (DOX). Under acidic TME conditions, GCZD disintegrates, releasing GOx, Cu 2+ , and DOX. GOx catalyzes intratumoral glucose oxidation, producing gluconic acid and H 2 O 2 to achieve a triple-therapeutic effect. Gluconic acid maintains a weakly acidic environment for continuous GCZD degradation. Glucose depletion induces metabolic starvation. Generated H₂O₂ serves as substrate for Cu 2+ -mediated Fenton-like reactions, boosting ROS production. Cu 2+ exhibits catalytic activity, efficiently converting TME and GOx-generated H 2 O 2 into cytotoxic ·OH. Increased ROS concentration enhances biological macromolecule oxidation damage, intensifying CDT. Additionally, Cu 2+ oxidizes GSH to form GSSH and Cu + . This inhibits GSH-mediated ROS degradation and leverages excellent Fenton-like activity of Cu + to further enhance CDT. Simultaneously, DOX exerts chemotherapeutic effects by intercalating into DNA and inhibiting topoisomerase II, blocking tumor cell proliferation. This integrated approach, combining enhanced ROS generation, tumor cell metabolic intervention, and DNA damage, demonstrates enhanced antitumor efficacy by simultaneously targeting multiple cancer cell vulnerabilities.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yunfei Tang,Mengmeng Xiao,Tongtong Duo,Xiaowan Zhang,Ziyue Chen,Wei Wei
The abnormal expression of monoamine oxidase B (MAO-B) and the soluble oligomer (Aβo) formed by β-amyloid deposition play key roles in the pathogenesis of Alzheimer’s disease. However, the simultaneous detection of MAO-B and Aβo remains a huge challenge. Herein, a bimetallic core–shell probe ZIF-8 embedding rhodamine 6G (Au/Rh6G/Pd@ZIF-8) with peroxidase-like activity is designed to detect MAO-B and Aβo simultaneously. MAO-B catalyzes the substrate phenethylamine (PEA) to produce H2O2, which oxidizes thiamine with the catalysis of Au/Rh6G/Pd@ZIF-8 to produce a fluorescent product that emits a strong fluorescence at 440 nm. When Aβo is present in the system, due to the specific coordination between Aβo and Zn2+, the intact ZIF-8 structure collapses, leading to Rh6G release and fluorescence recovery. The simultaneous determination of MAO-B and Aβo by Au/Rh6G/Pd@ZIF-8 is realized. The results showed that the designed biosensor had high specificity and sensitivity, a wide detection range, and a low detection limit for MAO-B and Aβo simultaneous detection. Fluorescence signals for MAO-B and Aβo detection did not interfere with each other because they are excited separately, which provides more valuable data for the diagnosis of Alzheimer’s disease.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.5
Amatjan Sawut,Yurou Feng,Rena Simayi,Manfang Pan
Heavy metal ion pollution in wastewater, particularly Cu 2+ contamination, threatens ecology and human health, demanding efficient adsorption materials in environmental remediation. However, conventional adsorbents suffer from insufficient capacity, poor mechanical stability, weak selectivity, and low reusability, restricting their practical application. Herein, a semi-interpenetrating network composite hydrogel (ZIF-8-AVA) was fabricated via in situ self-assembly, integrating ZIF-8 nanocrystals into a poly(acrylamide- co -vinylimidazole)/sodium alginate (AVA) matrix. Vinylimidazole units served as nucleation anchors, firmly immobilizing ZIF-8 on the polymer backbone via metal-ligand coordination to form a stable system. ZIF-8 significantly enhanced AVA's mechanical properties and Cu 2+ adsorption performance: the composite followed the Langmuir monolayer adsorption model with a maximum adsorption capacity of 355.9 mg/g, achieving 93.81% Cu 2+ removal efficiency at an initial concentration of 50 mg/L. Furthermore, the ZIF-8-AVA hydrogel exhibited excellent selectivity for Cu 2+ in multi-competing-ion systems and maintained high adsorption efficiency after 5 consecutive adsorption-desorption cycles. The key innovation lies in the in situ self-assembly strategy that realizes the intimate integration of ZIF-8 with the hydrogel matrix via coordination-driven anchoring, overcoming the common issue of MOF particle leaching and synergistically enhancing adsorption capacity, selectivity, and mechanical stability. This work offers a novel approach for tunable MOF hydrogels, with great potential in heavy metal wastewater treatment.
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Environmental Science-Nano
·
2026
·
IF 5.1
Shiyi Tu,Wenpeng Li,Yangyang Xu,Li Gan,Xiulan Weng,Zuliang Chen
The increasing release of antimony (Sb) into water environments due to anthropogenic activities poses significant ecological risks. This study developed a novel hybrid material, zeolitic imidazolate framework-8-iron nanoparticles (ZIF-8-Fe NPs), which demonstrates a synergistic adsorption-oxidation mechanism for efficient removal of Sb(III) from aqueous solutions. Major findings reveal that at an initial Sb(III) concentration of 1 mg L-1, ZIF-8-Fe NPs achieved a 73.3% removal efficiency within three hours through the dual processes of direct adsorption and oxidation of Sb(III) to Sb(V). Scanning electron microscopy-energy dispersive spectrometry (SEM-EDS), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS) revealed that the removal mechanism involved both direct adsorption of Sb(III) by ZIF-8-Fe NPs and oxidation of Sb(III) to Sb(V), with two distinct morphologies of Sb adsorbed on the surface. The formation of covalent bonds (Zn-OH-Sb and Fe-O-Sb) was identified as the key factor in removing both Sb(III) and Sb(V) from aqueous solutions. The adsorption process conformed to the Langmuir adsorption isotherm and pseudo-second-order kinetics, with correlation coefficients (R²) of 0.959 and 0.999, respectively. The proposed mechanism suggests that the formation of Zn-OH-Sb and Fe-O-Sb covalent bonds plays a crucial role in Sb(III) removal. Significantly, ZIF-8-Fe NPs achieved removal efficiencies of 91.5% and 94.8% for Sb(III) at environmentally relevant concentrations of 100 µg L-1 and 20 µg L-1, in actual mining wastewater, demonstrating its practical applicability. This study establishes that ZIF-8-Fe NPs constitute an effective nanomaterial with significant potential for Sb(III) remediation in wastewater.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Xuefan Yang,Dandan Ruan,Feng Ye,Xinlan Qiu,Sitong Li,Lei Huang,Christos C Zouboulis,Xiaohui Mo,Xiping Jiang,Qiang Ju
Background: Acne Vulgaris (AV) lesions exhibit an acidic, sebum-rich, and inflammation-prone microenvironment in which conventional minocycline therapy is constrained by the stratum-corneum barrier and systemic exposure. Here, we present the fabrication and application of dissolvable silk fibroin microneedles encapsulating minocycline-loaded zeolitic imidazolate frameworks (Mino@ZIF-8/SF MNs) to achieve sebaceous gland-targeted, pH-responsive delivery and multimodal therapy. Results: The Mino@ZIF-8/SF MNs display uniform conical morphology, excellent mechanical robustness (peak failure force ≈ 0.4 N per needle), rapid dissolution (< 1 min), high drug loading (≈ 40.11%) and encapsulation efficiency (≈ 70.2%), and negligible hemolytic activity. Under mildly acidic conditions (pH 5.5), minocycline release was markedly accelerated compared to physiological pH 7.4, reflecting the acidified acne microenvironment. Functionally, Mino@ZIF-8/SF MNs achieved > 95% inhibition of Cutibacterium acnes at 30 µg/patch and substantially attenuated sebocyte inflammatory responses. In heat-killed C. acnes-stimulated SZ95 sebocytes, the Mino@ZIF-8/SF MNs downregulated NFKB1, IL-1α, IL-1β, IL-6, IL-8 and MMP9 expression, along with suppression of cytokine-cytokine receptor interaction, IL-17 and NET-associated signaling pathways. RNA-sequencing also suggested that sebocyte metabolism may undergo reprogramming involving enhanced apoptosis, maintenance of mitochondrial oxidative activity, and modulation of PPARγ-related lipid metabolism, which could collectively contribute to reduced lipid droplet accumulation. In a C. acnes-induced acne-like mouse model, Mino@ZIF-8/SF MNs markedly accelerated lesion resolution, reduced lesion elevation, eschar formation, and diameter scores, normalized epidermal thickness, and decreased sebaceous lipid accumulation, while exhibiting no detectable systemic toxicity as confirmed by histology, hematology, and serum biochemistry. Conclusion: Collectively, this study establishes a nanobiotechnology platform that integrates metal-organic frameworks(MOF)-based pH-responsive delivery with antibacterial, anti-inflammatory, and metabolic reprogramming activities, offering a precise and minimally invasive multimodal strategy for sebaceous gland-targeted acne therapy.
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OPTICAL MATERIALS
·
2026
·
IF 4.3
Yunqing Lu,Yu Feng,Mengmeng Li,Ji Xu,Jin Wang
The photocatalytic conversion of CO 2 into solar fuels presents a sustainable approach to alleviate climate change and address energy crisis. To address the limitations of conventional photocatalysts, such as their restricted visible-light response and rapid charge recombination, we have developed a ternary nanocomposite consisting of zeolitic imidazolate framework-8 (ZIF-8), plasmonic gold nanoparticles (Au NPs), and titanium dioxide (TiO 2 ). In this system, ZIF-8 provides high-density CO 2 adsorption sites, enhancing the local concentration of CO 2 and facilitating its subsequent reduction. The incorporation of Au NPs induces a strong localized surface plasmon resonance (LSPR) effect, significantly broadening the visible-light harvesting capability of the composite and promoting efficient charge transfer between TiO 2 and ZIF-8. TiO 2 serves as a stable photocatalytic platform, enabling effective charge separation and transfer. Comprehensive characterization verifies the uniform integration of the three components and the formation of close interfacial contacts. The ternary nanocomposite demonstrates significantly improved visible-light absorption, reduced charge recombination, and enhanced photogenerated carrier separation and transfer, as supported by UV-vis diffuse reflectance spectroscopy (DRS), photoluminescence (PL), electrochemical impedance spectroscopy (EIS), and photocurrent measurements. Under simulated sunlight, the ZIF-8/Au/TiO 2 photocatalyst achieves CO 2 -to-fuel conversion rates of 1.56 μmol g −1 h −1 for methane (CH 4 ) and 4.65 μmol g −1 h −1 for carbon monoxide (CO). This enhancement is attributed to the synergistic effects of plasmonic sensitization by Au nanoparticles and CO 2 adsorption enrichment by ZIF-8, which collectively enhance photon utilization, reactant concentration, and interfacial charge transfer dynamics.
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DESALINATION
·
2026
·
IF 9.9
Jiaxue Zhang,Yingbo Chen,Pengcheng Wang,Yanling Fang,Guangcun Liu,Liangliang Li
LbL-confined in situ ZIF-8 growth enabled high-performance NF membranes. • ZIF-8 nanochannels improved ion sieving and transport regulation. • The membrane achieved 98.5% Na 2 SO 4 rejection with improved permeance. • The membrane achieved 93.8% flux recovery and excellent operational stability. In this study, a high-performance nanofiltration membrane was developed by integrating layer-by-layer (LbL) polyelectrolyte assembly with confined in situ growth of zeolitic imidazolate framework-8 (ZIF-8). A PEI/PSS multilayer was constructed on a polyethersulfone (PES) support through sequential electrostatic deposition, providing a nanoscale confined environment for regulating ZIF-8 nucleation and growth. Zn 2+ ions and 2-methylimidazole were subsequently introduced into the multilayer structure, enabling the formation of ZIF-8 nanocrystals within the polyelectrolyte matrix rather than conventional particle incorporation. The optimized membrane achieved a Na 2 SO 4 rejection of 98.5 ± 0.3% with a permeance of 7.1 ± 0.1 L m −2 h −1 bar −1 , representing a 65% enhancement compared with the PEI/PSS counterpart. Meanwhile, MgCl 2 rejection increased from 64.6% to 93.0%, indicating improved divalent ion selectivity. These improvements were attributed to the confined ZIF-8 nanostructures, which optimized the selective layer architecture, reduced non-selective defects, and regulated ion transport behavior. Furthermore, the membrane maintained high salt rejection (>93%) under Na 2 SO 4 concentrations of 1–5 g L −1 and exhibited excellent antifouling performance with a flux recovery ratio of 93.8 ± 0.8%. This work provides an aqueous-phase strategy for constructing MOF-polyelectrolyte hybrid selective layers with enhanced ion selectivity, antifouling capability, and operational stability for advanced water separation applications. Download: Download high-res image (92KB) Download: Download full-size image
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 15
·1-24
·
IF 3
Zang Shuyan,Wang Shuai,Li Xue,Chen Xinru,Wang Qian,Wang Juan
The removal of both organic and inorganic arsenic is crucial for safeguarding the environment and human health, which constitutes a key aspect of sustainable development. In this study, a novel method integrating Fenton oxidation with ZIF-8 adsorption was developed for the simultaneous treatment of roxarsone (ROX) and arsenite (As(III)) from wastewater. ZIF-8 was hydrothermally synthesized and characterized using X-ray Photoelectron Spectroscopy (XPS), Fourier Transform Infrared Spectroscopy (FT-IR), X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Elemental Mapping (EM), Brunauer–Emmett–Teller (BET) surface area analysis, and zeta potential analysis. Comprehensive characterization demonstrated that the synthesized ZIF-8 exhibited a well-defined rhombic dodecahedral morphology with smooth crystal surfaces and an exceptionally high specific surface area of 1836.23 m 2 /g. Under the optimized conditions for Fenton oxidation (4.90 mmol/L H 2 O 2 , 0.1380 g/L FeSO 4 ·7H 2 O, pH 3, 30 min) and ZIF-8 adsorption (0.1 g/L ZIF-8, pH 6, 180 min, 25℃), the integrated system exhibited remarkable removal efficiencies of 92.32% for ROX (20 mg/L) and 95.16% for As(III) (1 mg/L). Specifically, compared to the individual processes, the removal efficiency of ROX was increased by 20.59% (versus Fenton-only) and 52.63% (versus ZIF-8-only), while that of As(III) was enhanced by 29.17% and 35.51%, respectively. Additionally, the integrated system exhibited maximum adsorption capacities of 107.76 mg/g for ROX and 17.70 mg/g for As(III), further confirming the presence of synergistic effects between Fenton oxidation and ZIF-8 adsorption. The adsorption processes for ROX and As(III) followed pseudo-second-order kinetics and were best described by the Langmuir adsorption model, suggesting chemisorption and monolayer adsorption on a homogeneous surface. The removal mechanism in the synergistic method involved three primary pathways: oxidation reactions (•OH), electrostatic interactions (-OH/-NH 2 ), and precipitation (FeAsO 4 ). This study demonstrates that the proposed synergistic method (Fenton@ZIF-8) is a promising technology for the simultaneous removal of both organic and inorganic arsenic species from contaminated water, with strong potential for practical application in wastewater remediation.
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RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2025
·Vol. 95
·期 9
·2457-2467
·
IF 0.8
Sun Yanhua,Kong Xiangyang,Xi Shuoyan,Xu Zhuoyue,Zhang Yuhan
Salvianolic acid (SAB) is a natural flavonoid compound possessing significant pharmaceutical value. However, the extraction and purification of SAB from natural products are hindered by the complexity and low concentration of matrix components. In this research, a new surface imprinted polymer with core-shell structure, denoted as ZIF-8@MIPs, was successfully developed using porous metal-organic frameworks (MOF) ZIF-8 as the scaffold. ZIF-8@MIPs exhibited remarkable selective extraction and enrichment of SAB from Salviorrhiza . Series of characterizations and adsorption experiments demonstrated that ZIF-8@MIPs possessed a typical core-shell octahedral structure with a high specific surface area. The resultant high-density imprinted sites allowed the ZIF-8@MIPs to exhibit a high adsorption capacity (46.7 mg/g) and exceptional selectivity (IF = 3.11) for SAB, while achieving adsorption equilibrium within 90 min. Notably, the ZIF-8@MIPs maintained an adsorption capacity of 89.2% for SAB after 7 cycles of adsorption-desorption experiments, indicating good reusability. Furthermore, a solid-phase extraction column was established utilizing the ZIF-8@MIPs as the adsorbent, and the content of SAB in the Salviorrhiza extract was determined by combining this with HPLC. The spiked recovery rate ranged from 87.70 to 92.90%, with RSD of 2.87–3.43%, demonstrating the reliability and reproducibility of this method. In conclusion, the ZIF-8@MIPs developed in this study offer a promising approach for the selective extraction of active flavonoids from natural matrices, with potential application in application prospects.
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