Materials Science & Engineering C-Materials for Biological Applications
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2020
·
IF 5.88
Lin Zhang,Yunsheng Dong,Na Zhang,Jie Shi,Xiangyun Zhang,Chunxiao Qi,Adam C. Midgley,Shufang Wang
Periodontal disease is a common complication and conventional periodontal surgery can lead to severe bleeding. Guided tissue regeneration (GTR) membranes favor periodontal regrowth, but they still have limitations, such as improper biodegradation, poor mechanical property, and no effective hemostatic property. To overcome these shortcomings, we generated unique multifunctional scaffolds. A chitosan/polycaprolactone/gelatin sandwich-like construction was fabricated by electrospinning and lyophilization. These composite scaffolds showed favorable physicochemical properties, including: appropriate porosity (<50%), pore size (about 10 μm) and mechanical stability (increasing with more PCL), good swelling and hydrophilicity. Appropriate degradation rates were approved by degradability analysis in vitro and in vivo , which resembled tissue regeneration process more closely. As shown in cell viability assay, cell attachment assay and Sirius red staining, we knew that the scaffolds had good biocompatibility, did not adversely affect cell ability for attachment, and induced high levels of collagen secretion. Experiments of blood clotting measurement in vitro showed that composite scaffolds were capable of accelerating blood clotting and could realize effective hemostasis. The results from subcutaneous implantation revealed the scaffolds had strong cell barrier effects and protection from external cell invasion. In summary, our multifunctional composite scaffolds showed optimised structure, enhanced regenerative capabilities, and serve as a basis for approaches to improve GTR designs for periodontal regeneration.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 137
·期 18
·48636
·
IF 2.188
Liang Chen,HongYing Hao,WanTing Zhang,Ziqiang Shao
Based on the structural characteristics of chitosan (CTS) and carboxymethyl starch (CMS)， CTS–CMS composites were prepared by crosslinking. The composites had a plurality of reactive functional groups such as NH 2 , NH 3 + , COOH, and OH and are applied to the adsorption of Cu 2+ in aqueous solution. The adsorption capacity and stability in acidic solution of the composites were preferable to that of raw material. The effects of temperature, contact time, initial concentration, and pH on the adsorption of Cu 2+ were investigated. Infrared spectroscopy, scanning electron microscope–energy dispersive spectrometer, X-ray diffraction, and X-ray photoelectron spectroscopy were used to explore the adsorption mechanism. The experiment showed that chemisorption and physisorption coexisted in the adsorption process. It is promising to apply this adsorbent to remove the metal ions in wastewater. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48636.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2019
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IF 5.107
Nana Xiong,Peng Wan,Guocheng Zhu,Fubing Xie,Shengnan Xu,Chuanqu Zhu,Andrew S. Hursthouse
A series of environmental and health problems caused by the release of large quantities of antimony into the water environment have received wide social concern in a number of regions worldwide. Finding a feasible treatment technology is the best choice for the sustainable remediation of antimony pollution. A novel nano-modified chitosan (NMCS) was prepared by grafting iron oxide nanoparticles (Nano-Fe 3 O 4 ) and carboxylate metal organic frameworks (MOFs) denoted as MIL-100(Fe) onto chitosan. The NMCS before and after adsorption was characterized by analytical tools including Fourier transform infrared and X-ray photoelectron spectroscopy. Batch experiments with variable NMCS dose, solution pH, and competing anions were used to evaluate the most efficient way to remove Sb (III) from aqueous solutions. The results showed that removal efficiency increased with the increase of the NMCS concentration and solution pH, respectively. The maximum removal efficiency of Sb(III) was 96.8%, at pH 11 with 1.5 g/L of NMCS when treating a Sb(III) model solution of 10 mg/L, which is much higher than that with Nano-Fe 3 O 4 or MOFs. Compared with the efficient removal of Sb(III) under acid conditions, NMCS has a higher removal efficiency under alkaline conditions. The effect of common anions such as sulfate, carbonate, nitrate and chloride ions, on the removal of Sb(III), was minor. The removal of Sb(III) could be clearly described by pseudo-second order sorption kinetics and Freundlich isotherm, which suggested inner-sphere surface binding mechanisms. The presence of Sb (III) on NMCS was confirmed by an X-ray photoelectron spectroscopic analysis, and those functional groups binding to Sb (III) were identified using Fourier transform infrared analysis. The ability of NMCS to be regenerated was good and further enhanced by the possibility of magnetic recovery. Overall, the findings tested in this study showed that the NMCS developed can effectively remove Sb(III) from aqueous solutions and can be effectively recovered and reused.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2019
·Vol. 20
·期 24
·6198
·
IF 4.183
Fang Wang,Chong Xie,Liying Qian,Beihai He,Junrong Li
Electro-actuated polymer (EAP) can change its shape or volume under the action of an external electric field and shows similar behavioral characteristics with those of biological muscles, and so it has good application prospects in aerospace, bionic robots, and other fields. The properties of cellulose-based electroactive materials are similar to ionic EAP materials, although they have higher Young’s modulus and lower energy consumption. However, cellulose-based electroactive materials have a more obvious deficiency—their actuation performance is often more significantly affected by ambient humidity due to the hygroscopicity caused by the strong hydrophilic structure of cellulose itself. Compared with cellulose, chitosan has good film-forming and water retention properties, and its compatibility with cellulose is very excellent. In this study, a chitosan/cellulose composite film doped with ionic liquid, 1-ethyl-3-methylimidazolium acetate ([EMIM]Ac), was prepared by co-dissolution and regeneration process using [EMIM]Ac as the solvent. After that, a conductive polymer, poly(3,4-ethylenedioxythiophene)/poly (styrene sulfonate) (PEDOT: PSS), was deposited on the surface of the resulted composite, and then a kind of cellulose-based electroactive composites were obtained. The results showed that the end bending deformation amplitude of the resulted material was increased by 2.3 times higher than that of the pure cellulose film under the same conditions, and the maximum deformation amplitude reached 7.3 mm. The tensile strength of the chitosan/cellulose composite film was 53.68% higher than that of the cellulose film, and the Young’s modulus was increased by 72.52%. Furthermore, in comparison with the pure cellulose film, the water retention of the composite film increased and the water absorption rate decreased obviously, which meant that the resistance of the material to changes in environmental humidity was greatly improved.Keywords:electroactive materials;electroactive properties;chitosan/cellulose composite film;[EMIM] Ac;mechanical properties
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Qiang Luo,Qianqian Han,Lixiang Chen,Xinran Fan,Ying Wang,Zhenghao Fei,Hongmei Zhang,Yanqing Wang
Chitosan-α-lipoic acid (CS-LA) conjugates were prepared by amino reaction. The methotrexate (MTX) was successfully loaded within CS-LA copolymer by the ring-opening polymerizations of disulfide bond under the action of reducing agent. The obtained copolymer was investigated by fourier transform infrared spectrometer (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and nuclear magnetic resonance ( 1 H NMR) analysis. The ring-opening polymerization process effected on rheological properties were studied. The graft of LA increased the apparent viscosity of CS-LA, and the loaded of MTX by redox reduced its apparent viscosity enormously. The load of MTX under the action of DTT decreased the apparent viscosity and moduli of CS-LA-MTX hydrogel. In dynamic oscillatory experiment, the package of MTX reduced the rigidity of CS-LA and damaged the gel structure of CS-LA. The antimicrobial ability of CS-LA against E. coli was processed by the inhibition zone and growth curves. The modification of LA raised the antibacterial activity of CS-LA. The cytotoxicity assay of CS-LA-MTX to prostate cancer cells (RM-1) was examined. The load of MTX within CS-LA-MTX greatly enhanced the cytotoxicity to RM-1 cells. In summary, CS-LA hydrogel may provide a new copolymer carrier for drug package in food and biomedical application.
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ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
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2019
·Vol. 45
·期 1
·29-40
·
IF 1.518
Liu Xiaoli,Xie Wancui,Yang Xihong,Zhan Xiaobei,Xia Wenshui
The aim of this work was to develop a novel, nontoxic, bioactive antimicrobial material based on a natural polymer, chitosan oligosaccharides (COS), a natural pyrone compound, kojic acid (KA), and piperazine. The COS-based polymer (COS-O-MB) has been synthesized by selective partial alkylation reaction to graft kojic acid, KA, and piperazine onto the COS molecular chain. Then, physicochemical properties and bioactivity of the COS-O-MBs were evaluated and it was characterized by FT-IR, NMR spectroscopy, Mw, PID, antimicrobial activity, hemolysis assay, biocompatibility, animal toxicity, and antimicrobial action mode studies. The results revealed that the alkylation reaction took place at the C-6 position of COS, and the as-prepared COS-O-MB significantly enhanced the antimicrobial activity and biocompatibility and reduced the hemolytic activity in vitro in comparison with that of the free COS and KA. Meanwhile, the antimicrobial action mode studies proved that COS-O-MB can pass through the anionic microbial membrane, destroy the cytomembrane integrity, and potentially affect protein denaturation, demonstrating that exposure to COS-O-MB results in the death of microbial cells. But importantly, COS-O-MB is not toxic to human cells. Hence, low hemolytic activity to human red blood cells, and nontoxic nature to female mice of SLAC KM strain, made this novel polymer material a promising and effective compound for food and pharmaceutical industries.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Fang Wang,Qian Zhang,Kexin Huang,Jiarui Li,Kun Wang,Kai Zhang,Xinyue Tang
The objective of this study was to synthesize and characterize cystamine dihydrochloride (CYS) crosslinked carboxymethyl cellulose/quaternized chitosan (CMC/HACC) composite hydrogel film. Firstly, the glycidyl-based quaternary ammonium chitosan derivative (HACC) was synthesized using nucleophilic substitution reaction. Then HACC was analyzed by FTIR, 1 HNMR spectra and the composite films at different blending ratio of CMC and HACC were studied by rheology measurement, mechanical and swelling tests. When the composite films were prepared under optimized conditions (CMC: HACC = 7:1), they showed excellent mechanical properties (with improved 93.3% tensile strength and 2.3% elongation at break) and swellability (equilibrium swelling ratio increased 270%) compared to pure CMC film. 5-Fluorouracil (5-FU) was used as drug model which has broad-spectrum anticancer properties. The 5-FU/CMC/HACC composite films showed redox and pH responsive of drug release properties along with well biocompatibility. The in vitro cytotoxicity and cell apoptosis studies showed the drug loaded composite films with obvious toxicity against HepG2 cells especially in the presence of GSH. In addition, CMC/HACC composite films showed good antibacterial against S. aureus and E. coli , while pure CMC film had no antimicrobial activities. It can be concluded that CMC/HACC composite films can be potentially used as targeted drug delivery system.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Xialian Fan,Yijin Li,Xiumin Li,Yonghui Wu,Keyong Tang,Jie Liu,Xuejing Zheng,Guangming Wan
Here an injectable antibacterial aerogel was fabricated with oxidized cellulose nanofiber and chitosan for rapid hemostasis of noncompressible hemorrhage application. Especially, cellulose nanofiber was modified with carboxyl groups by pre-oxidizing in 2,2,6,6-tetramethylpiperidine-1-oxyl combined with high pressure homogenization. Whereafter, the realized carboxyl group of cellulose nanofiber was reacted with the amidogen of chitosan to yield a strong composite aerogel with a nanofiber/nanosheet interlaced structure, which increased the compressive mechanical strength up to 75.4 kPa. In addition, the nanocellulose/chitosan composite aerogel exhibits high water absorption capacity, rapid shape recovery and good antibacterial ability (via Escherichia coli and Staphylococcus aureus ). Once absorbing water, the nanocellulose5/chitosan5 compressed aerogel could rapidly recover its shape within 30 s. The in vitro coagulation ability measurement showed that the composite aerogel has a good adhesion and aggregation effect to red blood cells and platelets. Hemolysis and cytotoxicity analysis results indicated a good biocompatibility for the composite aerogel.
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MATERIALS RESEARCH BULLETIN
·
2019
·
IF 3.355
Houde She,Ziwei Zhao,Wencai Bai,Jingwei Huang,Lei Wang,Qizhao Wang
Photocatalytic CO 2 reduction is considered as a feasible approach for solving greenhouse effect and energy shortage. Promoting electron migration and inhibiting electron-hole recombination are key challenges for efficient photocatalytic CO 2 reduction. Here, we successfully synthesized Cu:TiO 2 -CS composite as photocatalyst by a facile solvothermal method to improve the high-catalytic effect on CO 2 reduction. The as-prepared composite exhibits excellent photocatalytic CO 2 reduction performance under 300 W xenon lamp irradiation, with the yields of CO and CH 4 up to 4.48 μmol/g and 5.34 μmol/g, which is 10 times higher than that of TiO 2 . This impressive amelioration can be attributed to the synergy of organic polymer (chitosan) and inorganic material (Cu:TiO 2 ). This work may provide a constructing guidance in designing the composite photocatalyst concerning CO 2 photocatalytic reduction.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2019
·
IF 4.175
Li Wang,Hanlun Yang,Lijuan Xu,Canwei Peng,Yonghai Song
A novel Cu–Co-zeolite imidazole framework (Cu–Co-ZIF)-derived CuCo 2 O 4 @carbon nanocomposites supported on three-dimensional porous carbon (3D-KSC) were prepared to develop molecularly imprinted electrochemical sensors for sensing dopamine (DA). Firstly, polyhedral Cu–Co-ZIF was synthesized at room temperature and uniformly arrayed on 3D-KSC, and then the CuCo 2 O 4 @carbon nanostructure was obtained by high-temperature carbonization under nitrogen atmosphere. Finally, the molecularly imprinted polymer (MIPs) DA-imprinted chitosan was covered by potentiostatic electrodeposition to obtain the MIPs/CuCo 2 O 4 @carbon/3D-KSC integrated electrode. The results showed 15 μm-sized polyhedral Cu–Co-ZIF crystals were transformed into smaller irregular porous CuCo 2 O 4 @carbon nanocomposites with rough surface by calcination . Here, the produced 5 nm-sized CuCo 2 O 4 crystals were uniformly embedded into the N-doped porous carbon frameworks. Various experimental conditions including the amount of Cu–Co-ZIF grew on 3D-KSC, calcination temperature, electrodepositing time of MIPs, the eluted time of template molecule and the pH of electrolyte were explored. The as-prepared MIPs/CuCo 2 O 4 @carbon/3D-KSC integrated electrode exhibited excellent anti-interference ability and good stability. The sensitivity for DA detection was 720.8 μA mM −1 cm −2 , the detection range was 0.51 μM–1.95 mM, and the detection limit was 0.16 μM.
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Polymers
·
2019
·Vol. 11
·期 10
·1550
·
IF 3.164
Zhen Li,Shunqi Mei,Yajie Dong,Fenghua She,Lingxue Kong
While electrospinning has been widely employed to spin nanofibers, its low production rate has limited its potential for industrial applications. Comparing with electrospinning, centrifugal spinning technology is a prospective method to fabricate nanofibers with high productivity. In the current study, key parameters of the centrifugal spinning system, including concentration, rotational speed, nozzle diameter and nozzle length, were studied to control fiber diameter. An empirical model was established to determine the final diameters of nanofibers via controlling various parameters of the centrifugal spinning process. The empirical model was validated via fabrication of carboxylated chitosan (CCS) and polyethylene oxide (PEO) composite nanofibers. DSC and TGA illustrated that the thermal properties of CCS/PEO nanofibers were stable, while FTIR-ATR indicated that the chemical structures of CCS and PEO were unchanged during composite fabrication. The empirical model could provide an insight into the fabrication of nanofibers with desired uniform diameters as potential biomedical materials. This study demonstrated that centrifugal spinning could be an alternative method for the fabrication of uniform nanofibers with high yield.Keywords:carboxylated chitosan;centrifugal spinning;nanofiber diameter;empirical model
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JOURNAL OF POROUS MATERIALS
·
2022
·Vol. 30
·期 3
·767-774
·
IF 2.523
Lin Yonghui,Zhao Xiaojun,Jin Qi,Chen Yang,Yang Weiting,Pan Qinhe,Chen Yan,Wang Fuxiang
The shortage of fresh water resources is becoming more and more serious, which endangers human survival and social progress. Atmospheric water harvesting technology is expected to be one of the ideal ways to break through this predicament. However, in the special circumstances such as offshore place or island, the equipment of atmospheric water harvesting is required not only to have good capture ability of water molecules, but also to have the advantages of stable performance, low energy consumption, and simply employment. We designed and prepared a composite of microtube-filled vesicle-like PEDOT wrapped into honeycomb chitosan by vaper-phase polymerization. Under the static adsorption, it reaches high water molecules uptake of 154.0 wt% at 98% relative humidity, and captured water molecules aggregate into droplets to achieve the direct collection without any external force. Moreover, this composite has low density and good stability under high humidity, which indicates its promising application for atmospheric water harvesting in the coastal and offshore areas.
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