Polymer Chemistry
·
2017
·Vol. 8
·期 39
·6150-6157
·
IF 5.375
Shuo Chen,Qing Bian,Panjun Wang,Xuewei Zheng,Le Lv,Zhimin Dang,Guojie Wang
Here a novel photo, pH, and redox triple-responsive nanogel of poly(acrylic acid-co-spiropyran methacrylate) crosslinked by disulfide-containing N,N-bis(acryloyl)cystamine was prepared. Upon UV light irradiation or at low pH, the hydrophobic spiropyran (SP) isomerized to the hydrophilic merocyanine (MC) and the nanogels swelled-up. Upon the addition of reductant agents, the nanogels were disrupted due to the oxidative scission of the disulfide crosslinkers. The anticancer drug doxorubicin (Dox) could be loaded into the nanogels based on electrostatic interactions with the acrylic acids on the NGs, which would be released upon the stimulation of light, pH and DTT. The in vitro cytotoxicity study indicates that the nanogels loaded with anticancer drugs could kill the cancer cells effectively and the effect would be enhanced when irradiated by UV light. Interestingly, the isomerized MC in nanogels could emit intensive green light even endocytosed into the nucleus of the cancer cells, which afforded great potential in fluorescence cell imaging.
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NANOTECHNOLOGY
·
2016
·Vol. 27
·期 31
·315104
·
IF 3.573
Lei Tan,Tao Wu,Zhao-Wen Tang,Jian-Yun Xiao,Ren-Xi Zhuo,Bin Shi,Chuan-Jun Liu
In this paper, a biocompatible and water-soluble fluorescent fullerene (C60-TEG-COOH) coated mesoporous silica nanoparticle (MSN) was successfully fabricated for pH-sensitive drug release and fluorescent cell imaging. The MSN was first reacted with 3-aminopropyltriethoxysilane to obtain an amino-modified MSN, and then the water-soluble C60 with a carboxyl group was used to cover the surface of the MSN through electrostatic interaction with the amino group in PBS solution (pH = 7.4). The release of doxorubicin hydrochloride (DOX) could be triggered under a mild acidic environment (lysosome, pH = 5.0) due to the protonation of C60-TEG-COO−, which induced the dissociation of the C60-TEG-COOH modified MSN (MSN@C60). Furthermore, the uptake of nanoparticles by cells could be tracked because of the green fluorescent property of the C60-modified MSN. In an in vitro study, the prepared materials showed excellent biocompatibility and the DOX-loaded nanocarrier exhibited efficient anticancer ability. This work offered a simple method for designing a simultaneous pH-responsive drug delivery and bioimaging system.
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MOLECULES
·
2023
·Vol. 28
·期 23
·7703
·
IF 4.6
Hongda Cheng
Metal–organic frameworks (MOFs) are considered to be promising materials for drug delivery. In this work, a Zinc-based MOF nanocomposite IRMOF-3 was introduced as a drug carrier for 10-hydroxycamptothecine (HCPT). Without an extra drug-loading process, a nanoscale drug delivery material HCPT@IRMOF-3 was prepared via one-pot synthesis. The composition and structure of the material were investigated, and the drug release character was measured. Compared with preparing IRMOF-3 first and loading the drug, the one-pot-prepared HCPT@IRMOF-3 exhibited a higher drug-loading capacity. The material presented pH-responsive release. The HCPT release rate at pH 5.0 was significantly higher than that at pH 7.4. The cytotoxicity experiments showed that IRMOF-3 was non-toxic, and HCPT@IRMOF-3 exhibited notable cytotoxicity to Hela and SH-SY5Y cells. One-pot synthesis is a simple and rapid method for the preparation of an MOF drug delivery system, and IRMOF-3 can be potentially used in pH-responsive drug delivery systems.Keywords:IRMOF-3;drug delivery;one pot;pH response;HCPT
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AIP Advances
·
2023
·Vol. 13
·期 11
·
IF 1.6
Liu Jinhua,Zhu Guoren,Liu Yuanan,Wang Xiaohui
The combined treatment method integrated photothermal therapy (PTT) with chemotherapy is extremely promising owing to the synergistic therapeutic effect as compared to single PTT or chemotherapy. To facilitate more novel and facile photothermal-chemotherapy drugs as well as promote controllable combination therapy, we have developed a mild and facile method to fabricate polymer polypyrrole (PPy)-doxorubicin (DOX) nanoparticles (NPs) as pH-responsive drug nanocarriers for synergistic photothermal-chemotherapy. In the nanoplatform, poly-L-lysine (PLL)-modified PPy serves as the photothermal material, and (DOX) molecules are adopted as the chemotherapy agent. Based on the cross-linking reaction of glutaraldehyde, DOX molecules are flexibly and efficiently assembled on the surface of PLL-modified PPy NPs. The obtained PPy-DOX NPs possess high photothermal effect, superior loading capacity of DOX, and controlled drug release behavior. The combination photothermal-chemotherapy based on PPy-DOX NPs has significantly enhanced the antitumor therapy effect. In general, the designed PPy-DOX NPs may be a potential drug delivery nanoplatform for cancer combination therapy.
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ACS ES&T Water
·
2023
·
IF 5.3
Yansu Lan,Yicheng Huang,Die Zhou,Xi Zhang,Lei Xia,Raf Dewil,Bart Van der Bruggen,Yan Zhao
Carboxylates, which are considered high-value platform chemicals, are by-products produced during the fermentation of organic waste. There is a major challenge in effectively separating and recovering carboxylates from the fermentation broth. Electrodialysis (ED) has been considered a promising technology with its high selectivity in the absence of chemical additives. Here, a class of internally cross-linked anion exchange membranes (referred to as QPSF-n AEMs) were synthesized by using chloromethylated polysulfone (CMPSF) and varying amounts of 1,4-diazabicyclo [2.2.2] octane through quaternization and cross-linking reactions to recover carboxylates. The resulting membrane (QPSF-0.88) showed a high anion exchange capacity of 2.79 mmol g–1 but a low water content of 3.3% and an excellent swelling rate of 13.9%. To evaluate the separation efficiency of carboxylates, the membrane was tested with single solutions of acetate, oxalate, and citrate in 15.0 V (constant voltage) ED for 180 min. The removal efficiencies of QPSF-0.88 for acetate, oxalate, and citrate were 92.6, 87.9, and 85.9%, respectively, indicating a monocarboxylate selectivity for QPSF-0.88. After immersion in acidic or basic solutions, the change in the ion exchange capacity of QPSF-0.88 is less than 2%, indicating a high resistance to pH changes. This study presents innovative concepts in developing a membrane for the desalination of carboxylate.
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ACS Applied Bio Materials
·
2023
·
IF 4.7
Lingli Jin,Fengjiao Chen,Xianwu Chen,Shun Zhang,Zhenjiang Liang,Lingling Zhao,Hui Tan
Thrombolytic therapy for ischemic stroke still has several limitations, such as a narrow therapeutic time window and adverse effects. Therapeutic hypothermia is a neuroprotective strategy for stroke. In this study, we developed pH/temperature dual-responsive protein–polymer conjugates (PEG–uPA–PEG–PPG–PEG) by modifying a urokinase-type plasminogen activator (uPA) with polyethylene glycol (PEG) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (PEG–PPG–PEG, a thermosensitive polymer) via pH-sensitive imine bonds and disulfide bonds, respectively. At 37 °C and pH 7.4 (normothermia and physiological pH), PEG–uPA–PEG–PPG–PEG exhibits antiprotease hydrolysis and masked bioactivity of uPA due to the protective effect of the polymer segments wrapped around the protein surface. However, at 33 °C and pH 6.0 (hypothermia and pH at the thrombotic site), uPA loses the protective effect and recovers its bioactivity due to PEG dissociation and PEG–PPG–PEG stretching. The masked bioactivity of uPA at normothermia and physiological pH could reduce the risk of acute hemorrhage complication, and the recovery of protein activity at acidic pH and 33 °C is of great significance for thrombolytic therapy at mild hypothermia. Thus, PEG–uPA–PEG–PPG–PEG provides promising potential for therapeutic hypothermia in ischemic stroke.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Lijing Wang,Tianyi Yang,Xiangyu Xu,Guangya Zhang,Yunming Liu,Amin Ju,Gang Zhou,Bo Feng,Guangbo Che,Zhao Zhao
As a wastewater treatment technology, the activity of advanced oxidation process (AOPs) is strongly dependent on pH value. Herein, considering the low activity of AOPs under alkaline conditions, the acid organic ligand (nitrilotriacetic acid, NTA) was chosen to design Co-NTA metal-organic catalyst for efficient photo-Fenton reaction at full pH range. The experimental results indicate the acid ligands in Co-NTA offers more·OH that can achieve high activity under alkaline conditions. To further enhance the electron injection ability and redox cycles of Co(II)/Co(III), Ferrocene (Fc) nanoparticles was introduced to form bimetallic organic catalyst Fc-Co-NTA. The mechanism study indicates that the synergistic effect between Co-NTA and Fc promotes the activation of potassium persulfate and improves the stability of the catalyst under extreme pH conditions, while the π-π interaction between TC and Fc-Co-NTA can improve the electron injection capability and accelerate the production of·OH/SO 4 •- , so as to accelerate the redox cycles of Fe(II)/Fe(III) and Co(II)/Co(III), bringing about prolonged carrier lifetime and better photocatalytic activity. The possible degradation pathway of TC was investigated by Fukui function and LC-MS. A machine learning model is used to optimize the synthesis and photocatalytic parameters of Fc-Co-NTA. This study provides a new design idea to prepare highly efficient and stable photo-Fenton advanced oxidation technology at full pH range.
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MACROMOLECULAR BIOSCIENCE
·
2021
·Vol. 21
·期 5
·2100025
·
IF 4.979
Qinping Yang,Yanliang Dong,Xuanyu Wang,Zhihao Lin,Mingyu Yan,Weiwei Wang,Anjie Dong,Jianhua Zhang,Pingsheng Huang,Changrong Wang
pH-sensitive polyelectrolytes provide enormous opportunity for siRNA delivery. Especially, their tertiary amine structures can not only bind genes but also act as pH-sensitive hydrophobic structure to control genes release. However, the influence of molecular structures on siRNA delivery still remains elusive, especially for the asymmetric alkyl substituents of the tertiary amine groups. Herein, a library of N -methyl- N -alkyl aminoethyl methacrylate monomers (MsAM) with asymmetric alkyl substituents on the tertiary amine group is synthesized and used to prepare a series of tri-block polycationic copolymers poly(aminoethyl methacrylate)-block-poly ( N -methyl- N -alkyl aminoethyl methacrylate)-block-poly(ethylene glycol methacrylate) (PAMA-PMsMA-PEG). And the properties of these polycations and their self-assembled micelles are characterized, including molecular structure, proton buffering capacity, pH-sensitivity, size, and zeta potential. With the length increase of one alkyl substituent, the proton buffering capacity of both monomers and polycations is demonstrated to be narrowed down. The siRNA delivery efficiency and cytotoxicity of these micelles are also evaluated on HepG2 cells. In particular, poly(aminoethyl methacrylate)-block-poly( N -methyl- N -ethyl aminoethyl methacrylate)-block-poly(ethylene glycol methacrylate) (PAMA-PMEMA-PEG) elicited the best luciferase knockdown efficiency and low cytotoxicity. Besides, PAMA-PMEMA-PEG/siRRM2 also induced significant anti-tumor activity in vitro. These results indicated PAMA-PMEMA-PEG has potential for further use in the design of gene vehicles with the improved efficiency of siRNA delivery.
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PROPELLANTS EXPLOSIVES PYROTECHNICS
·
2021
·Vol. 46
·期 5
·690-696
·
IF 1.887
Naimeng Song,Li Yang,Pingan Liu
This paper mainly introduces the Ph−Fe/RDX(HMX) composite microspheres prepared by ultrasonic spray drying. Their morphology was observed by SEM and found that the composite microspheres were spherical. Also, the composite microspheres exhibited good dispersion. The results of the granularity data show that the D 50 data of Ph−Fe/RDX and Ph−Fe/HMX were 580.78 nm and 496.52 nm, respectively. The DSC data showed that the catalytic effect of the composite microspheres was significantly better than that of the mixed powder. The DSC data showed that the decomposition peak temperature of the Ph−Fe/RDX(HMX) composite microsphere was 229.6 °C (279.6) lower than the 235.6 °C (284.3) of the mixed powder. The DSC data demonstrated that the catalytic performance of the composite microspheres was significantly better than that of the mixed powder. Therefore, the ultrasonic spray drying method has great potential for preparing energetic composite microspheres.
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LANGMUIR
·
2021
·
IF 3.882
Yingying Chai,Yuefei Wang,Bingqi Li,Wei Qi,Rongxin Su,Zhimin He
In this work, lignin/chitosan nanoparticles (Lig/Chi NPs) with controlled structures were synthesized in a simple and scalable microfluidic system. When the positively charged chitosan and the negatively charged lignin solution were blended in a microreactor, Lig/Chi NPs were rapidly formed via the electrostatic coassembly between the amino groups of chitosan and the carboxyl groups of lignin. The ζ potential changes from negative (−13 mV) to positive (+54.5 mV) for Lig NPs and Lig/Chi NPs, respectively. The scanning electron microscopy (SEM) and transmission electron microscopy (TEM) results demonstrated that Lig/Chi NPs have an average particle size of about 180 nm, which can be used as nanocarriers for drug delivery. The anticancer drug nanoparticles with docetaxel (DTX) and curcumin (CCM) were prepared by coassembly with Lig/Chi NPs in a microreactor, which had good drug loading efficiency, biocompatibility, and can release drugs in response to pH in the weakly acidic environment of the tumor. The drug release amounts in acidic solutions that simulated the tumor microenvironment were 51% (DTX@Lig/Chi NPs) and 50% (CCM@Lig/Chi NPs), respectively, which were better than the release amounts at pH 7.4, and have an obvious killing effect on HeLa cells.
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APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2021
·Vol. 193
·期 10
·3062-3078
·
IF 2.926
Wei Yanli,Chen Xi,Yang Ting,Wan Junfen,Cao Xuejun
Aqueous two-phase systems (ATPS) have the advantages of environmentally friendly, high mass transfer efficiency, and mild extraction conditions. However, it is difficult to recycle these polymers, which limits the large-scale application of ATPS. In this study, a novel recyclable ATPS was constructed with thermo-responsive polymer P N and pH-responsive polymer P ADB4.78 for the partition of tea saponin. P N represents poly-( N -isopropylacrylamide), and P ADB4.78 represents poly-(acrylic acid-dimethylamine ethyl methacrylate-butyl methacrylate), where 4.78 in the subscript indicate the isoelectric point of the polymer. The recoveries of P N and P ADB4.78 were 95.36% and 93.48%, respectively, after two cycles. Meanwhile, the phase formation mechanism of ATPS was studied by surface tension and low-field nuclear magnetic resonance (LF-NMR). The effects of polymer concentration, pH, temperature, types and concentrations of salt were investigated on tea saponin partition. In the 1.5% (w/v) P N /3.5% (w/v) P ADB4.78 ATPS, the optimal partition coefficient ( K ) of crude tea saponin were 0.15 in the presence of 1.5 mM KCl at pH 7.6 and 25 °C while the extraction recovery (ER b ) reached 92.13%. The K and ER b of tea saponin from tea seeds were 0.12 and 94.50% with 7.5 mM LiBr at pH 8.0 and 25 °C, respectively.
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BIOSENSORS & BIOELECTRONICS
·
2021
·
IF 10.618
Lei Chen,Yan Li,Luyang Miao,Xiaolong Pang,Tao Li,Yongjun Qian,He Li
In the field of precision medicine, the anticipated features of ideal drug delivery systems (DDS) have high drug loading capacity and effective stimuli-triggered mechanism, which are fitting well with the expected merits of signal labels for enhanced enzyme-linked immunosorbent assay (ELISA). Inspired by this, poly (diallyldimethylammonium chloride)-capped curcumin nanoparticles (PDDA@CUR NPs) with high loading capacity were synthesized as signal labels and further applied to dual-model colorimetric and fluorescence ELISA for the detection of C-reactive protein (CRP). Curcumin (CUR) was elaborately selected as report molecule similar to the roles of drugs in DDS, which dispersed in neutral water exhibits a negligible fluorescence response due to the aggregation of CUR molecules induced quenching effect, stimulated by basic water (BW, pH 12.36), the allochroic effect from colorless to orange occurred and fluorescence restored because of the keto–enol tautomerism in the molecular structure of CUR, just like lighting-up (from signal “OFF” to signal “ON”), yielded a dual-model colorimetric and fluorescent signal readout. PDDA, as a polycationic electrolyte, provided a biological platform that is capable of interacting with CRP label antibodies by virtue of its positive centers. The results show that “lighting-up” CUR NPs-based dual-modal colorimetric and fluorescent ELISA for CRP detection has the merits of easy-to-use, good enough sensitivity and reliability. And more importantly, it brings innovative ideas for the precise identification and quantification of protein biomarkers.
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