Advanced Healthcare Materials
·
2025
·
IF 9.6
Xianyu Zhu,Lingli Gao,Yanbo Zheng,Peng Fei Zhao,Hanrui Wei,Ruixue Liu,Liping Zhao,Junyi Zhang,Qi Sun,Lingling Zheng,Han Lv,JiGang Yang,Jianhua Gong,Zhenchang Wang
Poor prognosis and chemotherapy response stem from difficulties in precise targeting and the lack of effective synergistic treatments. Nanozymes show promising potential in tumor chemodynamic therapy (CDT) by catalyzing hydrogen peroxide (H₂O₂) decomposition and glutathione depletion in the tumor microenvironment (TME). However, integrating precise chemotherapy targeting with CDT remains challenging. In this study, a porous Fe/Cu bimetallic nanozyme carrier (FeCuNPs) is developed for co-loading with the humanized 3F8 anti-GD2 disialoganglioside antibody (3F8) and the novel pyridazinone-based chemotherapeutic agent (IMB), forming a nanoreactor (3F8@FeCuNPs@IMB) for targeted chemotherapy and CDT. The nanoreactor responds specifically to the acidic TME as a primary insurance, allowing for the controlled release of IMB at the tumor site. The targeting antibody 3F8 coating on the surface of the nanozyme carrier acts as a secondary insurance, minimizing chemotherapy drug leakage during the delivery process and ensuring precise targeting for effective chemotherapy. Furthermore, FeCuNPs act as peroxidase-like (POD) and glutathione oxidase-like (GSHOX) enzymes, catalyzing hydroxyl radical (•OH) generation and depleting excess GSH, enhancing CDT. The results in vitro and in vivo indicate that the dual insurance designed 3F8@FeCuNPs@IMB offers a promising prospect for a targeted, precise, and effective combination of chemotherapy and CDT against melanoma.
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PubMed
高影响因子
Materials Advances
·
2024
·
IF 5.2
Catherine Afriyie,Xingwang Zhang
Photocatalytic methane conversion is a sustainable approach to transform methane under mild conditions into its value-added derivatives for the petrochemical industry. However, obtaining high productivity and selectivity of desired products still remains a great challenge. In this work, high-efficiency Fe-doped two-dimensional BiVO4 nanosheets have been synthesized and evaluated for photocatalytic methane conversion with H2O, O2 or H2O2 as the oxidizer. The Fe-doped and undoped samples were obtained by hydrothermal synthesis using 3-dodecylbenzenesulfonate (SDBS) as the morphology-directing agent, and examined by XRD, SEM, EDS, TEM, XPS, UV-DRS and BET characterization techniques. The replacement of some Bi3+ with Fe3+ was a successful approach to enhance the photoexcitation process and the adsorption properties of BiVO4, resulting in an improvement in the yield of methyl oxygenates. Complete selectivity of methyl oxygenates (CH3OH and CH3OOH) was achieved, and the yield reached 217.6 μmol gcat−1 h−1 in 2 h under visible light irradiation under mild conditions over 1.0 wt% Fe-doped BiVO4 nanosheets in the presence of H2O2, outperforming most reported studies on this reaction. This work provides new insight into the choice of a suitable oxidizer for methane conversion in the BiVO4 photocatalyst system by projecting H2O2 as the relevant oxidant.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Shuzhuang Sun,Bocheng Yu,Yanmei Shen,Yu Liu,Hongman Sun,Xuan Bie,Mengna Wu,Yongqing Xu,Chunfei Wu,Hui Zhou
Integrated CO 2 capture and utilization (ICCU) using “capture-conversion” dual functional materials (DFMs) paves a cost-effective path for restricting CO 2 emissions by eliminating the energy-intensive intermediate processes. The interactions between catalysts and absorbents are believed pivotal in ICCU; however, there is a lack of environment-friendly strategy to fabricate the interaction for industrial applications. Here, we propose a solvent-free mechanochemical approach to promote the interaction by improving the proximity between natural calcium and iron sources. The interaction was systemically investigated and confirmed using XRD, XPS, TEM, TPR, etc. As a result, the mechanochemical approach derived DFM achieved 5.5 mmol g −1 CO 2 capacity, 87 % CO 2 conversion, and 100 % CO selectivity at 650 °C, significantly outperforming the CaO-alone benchmark (CO 2 capacity < 4.5 mmol g −1 , CO 2 conversion < 73 %). Further incorporating MgO would alleviate the sintering and promote the CO 2 capture stability (< 15 % decrease after 20 cycles) by acting as a thermal-stable barrier. Based on in situ XRD, it is further confirmed that Fe-Ca interaction exhibits a dynamic looping mechanism in ICCU. The techno-economic analysis strongly supports the superiority of ICCU catalyzed by naturally sourced DFMs on eliminating the energy and H 2 consumption for CO 2 capture and upgradation. As a result, producing CO via ICCU using mechanochemical derived DFMs exhibits 20 % and 10 % cost decrease compared to the conventional CCU and ICCU using CaO alone scenarios, pointing out the potential of ICCU technology in industrial applications.
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高影响因子
ADVANCED MATERIALS
·
2023
·Vol. 35
·期 16
·2208800
·
IF 29.4
Tianyang Wang,Xuan Luo,Jingjing Gao,Zhongzhu Jiang,Wei Wang,Xingcai Yang,Nan Zhou,Xiaoguang Zhu,Lei Zhang,Wenjian Lu,Wenhai Song,Hongyan Lv,Yuping Sun
Weyl semimetal T d -MoTe 2 has recently attracted much attention due to its intriguing electronic properties and potential applications in spintronics. Here, Fe-intercalated T d -Fe x MoTe 2 single crystals (0 < x < 0.15 ) are grown successfully. The electrical and thermoelectric transport results consistently demonstrate that the phase transition temperature T S is gradually suppressed with increasing x . Theoretical calculation suggests that the increased energy of the T d phase, enhanced transition barrier, and more occupied bands in 1T′ phase is responsible for the suppression in T S . In addition, a ρ α –ln T behavior induced by Kondo effect is observed with x ≥ 0.08, due to the coupling between conduction carriers and the local magnetic moments of intercalated Fe atoms. For T d -Fe 0.15 MoTe 2 , a spin-glass transition occurs at ≈10 K. The calculated band structure of T d -Fe 0.25 MoTe 2 shows that two flat bands exist near the Fermi level, which are mainly contributed by the d yz and d x 2 − y 2 ${{\rm{d}}_{{x^2} - {y^2}}}$ orbitals of the Fe atoms. Finally, the electronic phase diagram of T d -Fe x MoTe 2 is established for the first time. This work provides a new route to control the structural instability and explore exotic electronic states for transition-metal dichalcogenides.
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高影响因子
Nanoscale Research Letters
·
2018
·Vol. 13
·期 1
·1-10
·
IF 3.125
Zhang Shiyu,Zhang Chao,Liu Mingyue,Huang Renliang,Su Rongxin,Qi Wei,He Zhimin
Nanoscale zero-valent iron (nZVI) has shown considerable promise in the treatment of chlorinated organic compounds, but rapid aggregation and inactivation hinder its application. In this study, palladium-doped zero-valent iron nanoparticles involving poly (γ-glutamic acid) (Fe-Pd@PGA NPs) were synthesized. The nanoparticles were small (~100 nm), uniformly distributed, and highly stable. The dechlorination performance of Fe-Pd@PGA NPs was evaluated using p -CP as a model. The results demonstrated that Fe-Pd@PGA NPs show high activity even in weakly alkaline conditions. The maximum rate constant reached 0.331 min − 1 at pH 9.0 with a Fe to p -CP ratio of 100. Additionally, the dechlorination activity of Fe-Pd@PGA NPs is more than ten times higher than that of the bare Fe-Pd NPs, demonstrating the crucial role of PGA in this system. Furthermore, we investigated the dechlorination performance in the presence of different anions. The results indicated that Fe-Pd@PGA NPs can maintain high activity in the presence of Cl − , H 2 PO 4 − , and humic acid, while HPO 4 2− and HCO 3 − ions slightly reduce the dechlorination activity. We believed that PGA is a promising stabilizer and promoter for Fe-Pd NPs and the Fe-Pd@PGA NPs have the potential for practical applications.
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高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2021
·Vol. 21
·期 12
·6126-6134
·
IF 0
Chi Lili,Zhang Yuetong,Hua Yusheng,Xu Qiqi,Lv Mingzhu,Wang Huan,Xie Jiani,Yang Shengtao,Yong Yuan
Nanomaterials with intrinsic enzyme-mimicking characteristics, refered to as nanozymes, have become a hot research topic owing to their unique advantages of comparative low cost, high stability and large-scale preparation. Among them, Single-atom nanozymes (SAzymes), as novel nanozymes
with abundant atomically dispersed active sites, have caused specific attention in the development of nanozymes for their remarkable catalytic activities, maximum atomic utilization and excellent selectivity, the homogeneous catalytic sites and clear catalytic mechanisms. Herein, a novel single-atom
nanozyme based on Fe(III)-doped polydiaminopyridine nanofusiforms (Fe-PDAP SAzyme) was successfully proposed via facile oxidation polymerization strategy. With well-defined coordination structure and abundant Fe-Nx active sites similar to natural metalloproteases, the Fe-PDAP SAzyme exhibits
superior peroxidase-like activity by efficiently decomposing H2O2 for hydroxyl radical (.OH) species formation. Based on their superior peroxidase-like activity, colorimetric biosensing of H2O2 and glucose in vitro was performed by using a
typical 3,3,5,5-tetramethylbenzidine through a multienzyme biocatalytic cascade platform, exhibiting the superior specificity and sensitivity. This work not only provides a novel promising SAzyme-based biosensor but also paves an avenue for evaluating enzyme activity and broadens the application
of other nanozyme-based biosensors in the fields of biomedical diagnosis.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2026
·
IF 9.2
Jing Peng,Haoran Lei,Dandan Cao,Xiuhua Wang
CoFeP-Ni nanorods provide a large electrochemical active surface area. • CoFeP-Ni only need 55 mV for HER and 180 mV for OER to reach 10 mA cm −2 • CoFeP-Ni needs 1.443 V to acquire 10 mA cm −2 for overall water splitting. • CoFeP-Ni exhibits outstanding stability and durability for both HER and OER. The engineering of robust, inexpensive bifunctional non-precious electrocatalysts exhibiting both high efficiency and operational stability is essential for scalable water splitting systems toward sustainable energy conversion. This study developed Fe and Ni co-doped CoFeP-Ni nanorods through a hydrothermal phosphidation approach. The as-synthesized CoFeP-Ni nanorods demonstrate exceptional bifunctional electrocatalytic performance, achieving remarkably low overpotentials of merely 55 mV for HER and 180 mV for OER at 10 mA cm −2 , along with exhibiting outstanding prolonged stability. The CoFeP-Ni catalyst demonstrates superior water-splitting performance in a two-electrode system, achieving industrially relevant current densities (10/100 mA cm −2 ) at competitively lower voltages (1.443/1.692 V), eclipsing the Pt/C||RuO 2 benchmark and existing non-noble metal catalysts. This study provides fundamental insights into bifunctional catalysts while offering a new strategy for developing stable, efficient, and economical first-row transition metal electrocatalysts based on transition metals.
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高影响因子
BIOTECHNOLOGY LETTERS
·
2020
·Vol. 42
·期 3
·445-451
·
IF 1.977
Zhang Lei,Xu Danyu,Kong Deyong,Ji Min,Shan Lianbin,Zhao Yongjiao
Objectives To investigate the effect of zero-valent iron and copper (Fe/Cu) micro-electrolysis on dark fermentative hydrogen production from glucose by a mixed bacterial consortium and the possible mechanisms of increasing hydrogen yield. Results Compared to zero-valent iron and activated carbon (Fe/C) micro-electrolysis, Fe/Cu micro-electrolysis could increase hydrogen yield by 32.2%, hydrogen production potential by 27.1%, and the maximum hydrogen production rate by 62.0%. Meanwhile, the number of ferrous ions released into the liquid phase with Fe/Cu micro-electrolysis was about 27.0% greater than that released by Fe/C micro-electrolysis, because the dispersion of copper on the surface of iron could markedly improve electrochemical corrosion activity. Metabolic analysis revealed that Fe/C micro-electrolysis promoted acetate formation, which may have been responsible for the observed improvement in fermentative hydrogen production. Further investigation indicated that Fe/Cu micro-electrolysis increased the activity of hydrogenases and stimulated the expression of the [FeFe]-hydrogenase gene. Conclusion Fe/Cu micro-electrolysis is better than Fe/C micro-electrolysis or Fe corrosion alone for dark fermentative hydrogen production.
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高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2019
·Vol. 91
·期 1
·54-62
·
IF 1.986
Deng Senlin,Zhang Xubin,Lv Guojun,Zhai Yi,Yang Zebin,Zhu Yongqiang,Li Haichao,Wang Fumin
Fe-doped zeolites with Mobil Five (MFI) structure have been widely used as heterogeneous Fenton catalysts to eliminate dyes from wastewater. However, the influence of carriers on degradation efficiency has not been reported yet. In this work, we have prepared three Fe-doped zeolite catalysts, FeS-1, FeZSM-5, and FeTS-1, with silicalite-1 (S-1), zeolite socony mobil-5 (ZSM-5), and titanium silicalite-1 (TS-1) as carriers, respectively. Characterizations, such as X-ray diffraction (XRD), scanning electron microscopy, energy-disperse X-ray spectroscopy, Fourier transform infrared spectroscopy, ultraviolet-visible diffuse reflection spectroscopy (UV–Vis DRS), X-ray fluorescence spectrometer, zeta potential, and N 2 adsorption/desorption isotherms, were used to investigate the morphologies and physicochemical properties of the synthesized materials. The catalytic performances of all zeolite catalysts were evaluated in the degradation experiments. The results depicted that the degradation efficiency of FeZSM-5 was higher than that of FeS-1 and FeTS-1 owing to its higher hydrophilic property, larger external specific surface area, and more negative zeta potential value. Therefore, the ZSM-5 could be a more suitable solid matrix for heterogeneous Fenton reactions than S-1 and TS-1.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Suding Yan,Xinping Zhang,Yue Shi,Hui Zhang
The natural Fe-bearing manganese ore (FMO) and bioelectricity supplied by a single-chamber microbial fuel cell (MFC) were employed to construct the peroxymonosulfate (PMS) activation system (FMO/MFC/PMS) for the degradation of bisphenol A (BPA). The FMO was characterized by X-ray fluorescence (XRF), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, Brunauer-Emmett-Teller (BET), field-emission scanning electron microscopy (FESEM) and transmission electron microscopy (TEM). The results show that ε-MnO 2 and α-Fe 2 O 3 were the active components of the natural FMO and they could greatly facilitate the bioelectro-activation of PMS for the oxidation of BPA. When FMO dosage, PMS concentration and current density were set as 0.5 g L −1 , 10 mM and 100 mA m −2 , respectively, 97.8% of BPA degradation could be achieved at natural pH of BPA solution after 80 min reaction and about 80% of TOC could be removed when the reaction time was prolonged to 120 min. Based on the electron paramagnetic resonance result, scavenging tests, fluorescence spectra experiment and X-ray photoelectron spectroscopy analysis, both radical oxidation (sulfate and hydroxyl radical) and non-radical reactions (such as singlet oxygen and direct electron transfer) were considered to be responsible for BPA removal. The FMO exhibited good stability and could be recycled at least 3 runs without any additional special treatment. 10 mM of Cl − and HCO 3 − could suppress the degradation of BPA while 10 mM of NO 3 − showed negligible effects on BPA removal. The FMO/MFC/PMS process could be applied in natural water without the decrease of BPA removal.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 45
·20881-20889
·
IF 3.3
Zairan Liu,Yifei Yang,Jiaoning Tang,Yuanming Deng
Here we report a simple topochemical method to prepare Ni–Fe layered double hydroxide (LDH). Ni(II)Fe(II) hydroxide was prepared via coprecipitation of Ni2+ and Fe2+ by NH4HCO3 under anaerobic conditions at room temperature. Ni–Fe LDH was obtained via oxidation intercalation by exposing the precipitate to air. The structure of the LDH was characterized and the performance in the electrochemical oxygen elution reaction (OER) was determined. Residual Fe(II) was observed by XPS due to incomplete oxidation, resulting in Fe replacing the Ni site in the LDH. It is found that LDH embedded with both Fe–O–Fe and Ni–O–Fe moieties is beneficial to the OER in terms of a low overpotential (240 mV at 10 mA cm−2), small Tafel slope (25 mV dec−1) and high electrochemical stability.
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高影响因子
STAR Protocols
·
2022
·
IF 0
Xiao Wang,Wei Zhou,Hao Wu,Wei-Qiao Deng
Summary Single-atom catalysts (SACs) have promising atomic utilization efficiency and catalytic activity, but their construction with a specific coordination mode remains challenging. This protocol describes the synthesis of a coordinated Fe-SAC@COF for boosted electrocatalytic oxygen evolution reaction (OER). We also detail the steps for single iron atoms confinement and characterization of the COF and Fe-SAC@COF with X-ray diffraction and transmission electron microscopy technique. For complete details on the use and execution of this protocol, please refer to Wang et al. (2022) .
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