ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2020
·Vol. 27
·期 24
·30778-30788
·
IF 3.056
Wang Guanghui,Luo Qiuyan,Dai Jialing,Deng Nansheng
In this work, the β-cyclodextrin modified magnetic graphene oxide (β-CD/MGO) composite was fabricated by the in situ co-precipitation method and characterized by Fourier transform-infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), vibrating sample magnetometer (VSM), and particle size analysis. The adsorption behavior of dichromate ions on the β-CD/MGO was investigated, and the mechanism of adsorption was also studied using FT-IR and XPS. The results from SEM and TEM showed that the graphene oxide (GO) layer became rough, and many fine particles were attached after compounding with ferroferric oxide and β-cyclodextrin. The characterization results of FT-IR and XPS show that that β-cyclodextrin and ferroferric oxide have been perfectly compounded to the graphene oxide layer and β-CD/MGO has a particle size of about 460 nm, a specific surface area of 252.3 m 2 g −1 , and a saturation magnetization of 73.5 emu g −1 . The adsorption amount of dichromate ions on the β-CD/MGO is affected by pH, adsorbent dosage, and adsorption time. Kinetic studies showed that the adsorption process followed a pseudo-second-order kinetic model. Equilibrium data agreed very well with the Langmuir model, the maximum adsorption amount of dichromate ions on the β-CD/MGO was 49.95 mg g −1 . After five successive adsorbent reuses, the reuse rate is still 73%, indicating the excellent potential reusability of β-CD/MGO adsorbent. β-CD/MGO exhibits excellent adsorption performance for dichromate ions. As an environmentally friendly magnetic adsorbent, β-CD/MGO is suitable for the treatment of dichromate-containing wastewater.
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高影响因子
FOOD HYDROCOLLOIDS
·
2020
·
IF 7.053
Yao Hu,Yang Qin,Chao Qiu,Xueming Xu,Zhengyu Jin,Jinpeng Wang
In this study, a starch-based nanocarrier was fabricated to allow tangeretin to avoid the disadvantages of poor aqueous solubility and weak stability. A green technique comprised of a combination of ultrasonication and recrystallization was applied, which ensured the products would be more applicable in the food , pharmaceutical, and cosmetic industries. Debranched starch (DBS) and β-cyclodextrin (β-CD) underwent ultrasonic irradiation and were self-assembled at 4 °C to form CD/DBS-nanoparticles (NPs). By developing CD/DBS-NPs with different degrees of polymerization of DBS and under varied durations of ultrasonic irradiation, the correlation between particle construction and tangeretin loading ability of CD/DBS-NPs was revealed. The maximum loading amount and loading efficiency of tangeretin in tangeretin-loaded CD/DBS-NPs (TAN@CD/DBS-NPs) were 17.91 ± 0.03 μg/mg and 83.20 ± 0.15%, respectively. Furthermore, the TAN@CD/DBS-NPs displayed a homogenous distribution and satisfying stability in a series of human microenvironments, including ionic strength (physiological saline), temperature (37 °C), and acidic stomach conditions (pH 2.1). In addition, the maximum retention index of tangeretin in TAN@CD/DBS-NPs reached 99.21 ± 0.17% after a 20-day storage period, suggesting an outstanding effectiveness of CD/DBS-NPs for tangeretin preservation. The prepared nanocarriers were demonstrated to be non-toxic to cells, showing promising potential for applications in the food, pharmaceutical, and cosmetic industries.
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Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Jiao Zou,Jin-Gang Yu
In this work, we have fabricated nafion (NF) stabilized black phosphorus nanosheets (BPNSs) and 6-O-α-maltosyl-β-cyclodextrin (G2-β-CD) composite (BPNSs-G2-β-CD) as novel electrochemical sensoring platform for chiral recognition of tryptophan (Trp) enantiomers. BPNSs-G2-β-CD composite modified glassy carbon electrode (BPNSs-G2-β-CD/GCE) was further coated with NF which served as a protective film to immobilize BPNSs-G2-β-CD on the electrode surface to achieve high stability. Under the optimum conditions, the oxidation peak current ratio of L-Trp to D-Trp (I L /I D ) and the difference between the peak potential (ΔEp = E D - E L ) were observed to be 1.49 and 20 mV at NF/BPNSs-G2-β-CD/GCE by square wave voltammetry (SWV). In addition, a linear calibration curve could be obtained for peak current versus Trp enantiomers in the concentration range 0.01–1.00 mM with detection limits of 1.07 μM and 1.71 μM for L-Trp and D-Trp (signal-to-noise ratio of 3, S/N = 3), respectively. The chiral recognition mechanism was also proposed, and the intermolecular hydrogen bonding interactions as well as the hydrophobic-cavity-triggered embedding effect dominated the effective chiral recognition. Moreover, the proposed NF/BPNSs-G2-β-CD/GCE showed excellent stability, good reproducibility and anti-interference capability. Therefore, the designed chiral sensor is expected to be practically applied for the sensitive recognition of Trp enantiomers in real samples.
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JOURNAL OF FOOD SCIENCE
·
2020
·Vol. 85
·期 4
·1105-1113
·
IF 2.479
Yuanyuan Zhong,Wenhui Li,Lidan Ran,Ran Hou,Ping Han,Shiling Lu,Qingling Wang,Wei Zhao,Yi Zhu,Juan Dong
The purpose of this study was to prepare and characterize inclusion complexes between tea polyphenol (TP) and hydroxypropyl-β-cyclodextrin (HP-β-CD), and to evaluate their antioxidant properties. Freeze-drying was used to prepare the inclusion complex of TP/HP-β-CD at different component ratios (1:0.5, 1:1, and 1:2). The supermolecular structure of the TP/HP-β-CD complex was characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). Molecular docking was used to simulate the positions and interactions of the binding sites of TP/HP-β-CD inclusion complexes and target protein receptors. In addition, the effects of TP/HP-β-CD inclusion complexes on myofibrillar protein (MP) from lamb tripe were observed under oxidative conditions. Results showed that TP was encapsulated in the cavity of HP-β-CD to form an optimal complex with 1:2 molar ratio of stoichiometry, while the FTIR, TGA, and SEM studies also support the inclusion process. Molecular modeling results were systematically analyzed to determine the stability of inclusion complexes and protein. Furthermore, the addition of an appropriate concentration (5 to 105 µmol/g) of TP/HP-β-CD inclusion complex decreased the carbonyl content, hydrophobicity, and protein aggregation of MP from lamb tripe, whereas it increased the sulfhydryl content. This improved antioxidant activity and bioavailability of the inclusion complexes will be beneficial for its potential applications in food. Practical Application Tea polyphenol was an antioxidant with potential for the field of food. In this study, the unstable properties of tea polyphenols were evaluated and were improved by inclusion of HP-β-cyclodextrin. The binding mode of the inclusion complex with protein was revealed via the molecular docking method, and the application of inclusion complex to control protein oxidation was studied. Results showed that the inclusion complex could effectively inhibit protein oxidation, which can provide a reference for the application of polyphenols in meat products and the improvement of protein properties.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2020
·Vol. 31
·期 6
·4797-4807
·
IF 2.22
Lyu Cong,Ju Lunan,Yang Xuejiao,Song Lan,Liu Ning
Iron-based catalysts as peroxymonosulfate (PMS) activator are commonly used to oxidize and degrade azo dye. However, there are still some issues such as low catalytic performance, relatively less reactive oxygen species and high metal iron dissolution. As such, a novel iron oxyhydroxide (FeOOHs) with four crystal form was synthesized and employed as efficient PMS activator for AO7 degradation in this study. It was found that the crystal form of catalyst had significant influence on its catalytic performance. β -FeOOH exhibited the best catalytic performance, owing to its smallest lattice size, maximum specific surface area and highest surface hydroxyl density. β -FeOOH/PMS system possessed a great high apparent reaction rate constant (1.3919 h −1 ), which was about 17, 3, 31, 20, 14, 49 and 23 times higher than that in β -FeOOH/persulfate(PS), Fe 0 /PMS, Fe 0 /PS, Fe 2 O 3 /PMS, Fe 2 O 3 /PS, Fe 3 O 4 /PMS and Fe 3 O 4 /PS system, respectively. More importantly, radical quenching tests and Electron spin resonance (ESR) analysis revealed that OH . , SO 4 .− , O 2 .− and 1 O 2 were involved in the reaction process. The catalytic mechanism proposed that β -FeOOH had the effective electron transfer rate performance, and Fe 3+ underwent a reduction to Fe 2+ during the β -FeOOH/PMS catalytic oxidation process. Then, the regeneration of Fe 2+ on the hydroxylated surface of FeOOH promoted the formation of FeOH + , which was crucial for PMS activation and reactive oxygen species (ROS) generation. The recyclability tests proved good stability and reusability of β -FeOOH. This study provides a kind of new understanding of peroxymonosulfate activation for environmental remediation and advances the study of iron-based oxyhydroxide in heterogeneous catalysis.
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COLLOID AND POLYMER SCIENCE
·
2020
·Vol. 298
·期 3
·303-312
·
IF 1.536
Gao Feng,Wang Qiang,Yang Xiaochun
Synthesis of amphiphilic poly( β -amino esters) (PBAE) was optimized by stepwise feeding of monomers (PBAE-(P-H)) compared with one-pot synthesis (PBAE-(P&H)) based on poly(ethylene glycol) diacrylate (PEGDA) and 1,6-hexanediol diacrylate (HDDA). Interestingly, optimized synthetic PBAE-(P-H) had smaller critical micelle concentration (CMC) of 6.6 μg/mL on average than one-pot synthetic PBAE-(P&H) (10.4 μg/mL). Nanoparticles were prepared based on PBAE-(P-H) and PBAE-(P&H), respectively. PBAE-(P-H) nanoparticles exhibited more narrow size distribution (average size, 105.3 nm; PDI, 0.103) than PBAE-(P&H) nanoparticles (average size, 117.8 nm; PDI, 0.233) demonstrated by dynamic light scattering and transmission electron microscopy. Afterward, PBAE-(P-H) and PBAE-(P&H) nanoparticles were selected to further investigate the properties including charge conversion and pH responsiveness. Doxorubicin (DOX) was encapsulated into nanoparticles. DOX release in vitro was enhanced as the decrease of pH value. Furthermore, DOX-loaded PBAE-(P-H) and PBAE-(P&H) nanoparticles exhibited enhanced cytotoxicity and cellular uptake against HCT116 cells compared with DOX under tumor microenvironment.
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NEUROPHARMACOLOGY
·
2020
·
IF 4.431
Kaiyang Ma,Xiao Ding,Qiqi Song,Zhitao Han,Hang Yao,Jianhua Ding,Gang Hu
In recent years, with the discovery and research of lactate-specific receptor HCAR1(hydroxycarboxylic acid receptor 1), lactate is not only as a product of Glycolysis in astrocytes, but also as a signaling molecule which has gradually received attention. Studies have found that lactate can be used as an intercellular signaling molecule involved in synaptic plasticity , and so that peripheral administration of lactate can produce antidepressant effects. Here, we focus on HCAR1 on the most widely distributed astrocytes in the brain, found and verified that lactate could cause Arc/arg3.1 protein overexpression in astrocytes through HCAR1. However, the expression of Arc/arg3.1 does not depend on the Gi protein pathway of HCAR1, and we found that lactate enhanced the expression of Arc/arg3.1 protein through the HCAR1-β-arrestin2 pathway. In summary, lactate acts on HCAR1 of astrocytes. It enhances the expression of MAPK-dependent Arc through β-arrestin2, thereby reducing the influx of calcium ions when astrocytes are exposed to glutamate damage, achieving the role of protecting astrocytes and indirectly enhancing the absorption of glutamate by astrocytes. These results also demonstrate that HCAR1 in the brain is a potential therapeutic target in an experimental in vitro model of glutamate damage, which is strongly associated with many neurodegenerative diseases .
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高影响因子
BIOMACROMOLECULES
·
2021
·
IF 6.988
Haonan Sun,Yunjian Yu,Yufei Zhang,Jie Li,Yijie Cheng,Siyuan Huang,Wenbo Wang,Xinge Zhang
Antibiotics are currently first-line therapy for bacterial infections. However, the curative effect of antibiotic remedies is limited due to increasingly prevalent bacterial resistance. The strategy to reverse intrinsic acquired drug resistance presents a promising option for reinvigorating antibiotic therapy. Here, we developed a β-lactamase-inhibiting macromolecule composed of benzoxaborole and dextran for precise transport of β-lactam antibiotics to strains overexpressing β-lactamase. Benzoxaborole-derived nanotherapeutics enabled specific recognition and rapid internalization, and the nanotherapeutics with a high affinity toward bacteria distinctly inhibited the catalytic activity of bacterially secreted β-lactamase by a reversible competitive mechanism. Thus, the system entrapping cefoxitin harbored a significantly enhanced ability to kill drug-resistant Escherichia coli compared to the ability of the drug by specifically overcoming the membrane barrier and acquired resistance mechanism of β-lactamase overproduction. The reversible competitive nanotherapeutics exhibited a robust therapeutic efficacy in rat wounds infected with drug-resistant bacteria; the efficacy was due to efficient bacterial elimination and collateral benzoxaborole-dependent amelioration of the inflammatory response. The above results offered insights into the facile design of precise macromolecular adjuvants to exclusively reverse the acquired bacterial resistance mechanism and increase the utility of antibiotic therapies against antibiotic-resistant bacterial infections.
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Food & Function
·
2021
·Vol. 12
·期 21
·10550-10562
·
IF 5.396
Ruifeng Wang,Ibrahim Khalifa,Xia Du,Kaikai Li,Yujuan Xu,Chunmei Li
We elucidated the underlying mechanisms of the anti-glycoxidation effects of five structurally different anthocyanins on glycated-β-lactoglobulin (β-Lg). The results indicated that anthocyanins structurally inhibited the formation of advanced glycation end-products, where petunidin-3-rutinoside-(p-coumaryl)-5-glucoside (Pt-Gl) exerted higher effects than those of others (p < 0.05). Through the three main steps of glycoxidation, anthocyanins trapped intermediate dicarbonyls and blocked some of the glycation sites of β-Lg. UPLC-ESI-Q-TOF-MS characterized that these anthocyanins structurally formed mono- and di-GO/MGO adducts, and Pt-Gl formed adducts with both dicarbonyls. More importantly, Pt-Gl interacted with some of the glycation sites of β-Lg such as Lys100, Lys101, and Arg124. Structurally, it was found that high–molecular weight anthocyanins with coumaric acid acylation seem to be better than others, which was followed by di- and mono-glycoside anthocyanins. Overall, GO/MGO-trapping and β-Lg-anthocyanin binding are revealed as the key mechanisms of the anti-glycoxidation effects of anthocyanins on β-Lg, which could be used as effective glycation inhibitors in protein-rich matrices.
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FOOD CHEMISTRY
·
2021
·
IF 7.514
Lanteng Wang,Jin Wang,Ang Zhang,Xin-an Huang,Hongtao Lei
A growing number of β -agonists are illegally using for reducing animal fat deposition in animals, but the development of analytical methods always lags behind the emergence of new illegal compounds. Therefore, class specificity antibody-based immunoassays that can detect a great many β -agonists are important for timely supervision. In this study, a competitive inhibition enzyme-linked immunosorbent assay (ciELISA) based on a clenbuterol monoclonal antibody was developed to recognize 23 β -agonists and analogues. Holographic and three-dimensional quantitative structure–activity relationship (HQSAR and 3D QSAR) revealed that there are two critical binding epitopes on β -agonist hapten affecting antibody specificity, and these epitopes have been further validated using a ractopamine antibody with narrow specificity. Tert -butyl at C-2′ epitope is needed to generate class specific antibodies, and different characteristics of substituents at benzene ring epitope would adjust antibody specificity. This investigation could provide reference for future design of β -agonist haptens.
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Biomass Conversion and Biorefinery
·
2021
·Vol. 13
·期 8
·7175-7184
·
IF 4.987
Yang Chunyan,Zhang Liu,Zhu Yingming,Liu Yingying,Liu Changjun,Wu Kejing,Lu Houfang,Liang Bin
In this study, ordered mesoporous carbon materials are prepared to support β-Mo 2 C catalysts for conversion of Kraft lignin into aromatic monomers. Carbon supports with different porous structures are compared to discuss the critical role of ordered mesopores. The results show a volcano evolution of aromatic monomer yields with the increase in Mo contents over β-Mo 2 C supported on ordered mesoporous carbon, and a high aromatic yield of 0.576 g/g Kraft lignin is achieved at 280 °C for 3 h for only 10% Mo mass content. Dispersion of β-Mo 2 C and confinement of ordered mesopores contribute to the highest aromatic yield per unit Mo. The highly dispersed β-Mo 2 C on the surface of ordered mesoporous carbon exhibits the advances of confined environment and accessibility of lignin fragments to active β-Mo 2 C, resulting high activity of β-Mo 2 C for Kraft lignin decomposition.
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JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Yong Hu,Guojing Mo,Ying Wang,Juan Guo,Chao Huang
The TPP-β-cyclodextrin/chitosan (TPP-β-CD/CS) nanoparticles loading with curcumin (Cur) and vitamin C (Vc) was prepared via controllable self-assembly. The cross-linking reaction between TPP-β-CD and CS, and co-encapsulation of Cur and Vc in TPP-β-CD/CS nanoparticles were confirmed by the fourier-transform infrared (FTIR), UV–Vis (UV), X-ray diffraction (XRD), atomic force microscope (AFM), and particle size analyzer. The results of stability and antioxidant activity indicated that co-encapsulation not only enhanced the chemical stability of Cur and Vc, but also improved antioxidant properties compared with the active ingredients used alone. Release kinetic fitted by Ritger–Peppas model revealed that the release of dual active ingredients were mainly dominated by Fickian diffusion in pH 1.2, while followed non-Fickian or anomalous diffusion in pH 7.4. Furthermore, the two-dimensional UV correlation spectroscopy (2D-UV-COS) confirmed that the release rate of Cur was faster than that of Vc during co-delivery, which helps to precisely elucidate the synergistic nutraceuticals effect of each active ingredient.
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危险品化学品经营许可证（带存储）