FOOD CHEMISTRY
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2025
·
IF 9.8
Quanyu Zhang,Youling Feng,Hanyu Liu,Hao Zhang,Zhixun Ma,Xin Du,Xiufang Xia
Black soybean seed coat anthocyanins (BBSACN) have garnered considerable attention for their strong antioxidant and health-promoting properties, yet their inherent instability severely hinders practical applications. Cyclodextrin metal-organic frameworks (CD-MOFs) are commonly utilized for safeguarding and delivering active compounds. However, their susceptibility to damage in aqueous environments restricts the efficient loading of hydrophilic active ingredients. This study aimed to create a cross-linked CD-MOF (CLCD-MOF) system to enhance the stability of BBSACN under diverse conditions. Diphenyl carbonate was used as the crosslinker to generate a CLCD-MOF that maintained structural stability in water for 7 days. Thorough physicochemical characterization, including SEM, FTIR, XRD, and TGA, and molecular dynamics simulations verified the successful encapsulation of anthocyanins. The findings indicated that non-covalent interactions such as hydrogen bonding and hydrophobic forces notably enhanced the stability of anthocyanins during extended storage, heating, and light exposure. In comparison to free anthocyanins, those encapsulated in CLCD-MOF showed about 35 % higher retention under light exposure and even greater improvements during storage and heating. In conclusion, this study presents promising opportunities for utilizing CD-MOF carriers to tackle the increasingly intricate challenges in the food industry.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Qiuyang Zhang,Ruirui Ma,Kunpeng Jia,Shunhang Dong,Jie Chen,Changjiang Pan
Titanium and its alloys, as the most prevalent materials for orthopedic implants, face two critical challenges in clinical practice: inadequate osseointegration and susceptibility to bacterial infection. To resolve these issues, a multifunctional coating (TNT+XGPP) was developed on Ti implants via three steps: electrochemical anodization to construct TiO 2 nanotube (TNT), hydrothermal loading of bone-affinity Ga 3+ ions (TNT+XG) at different concentrations, and carbodiimide-mediated grafting of γ-polyglutamic acid (γ-PGA) via a polydopamine intermediate layer. The morphology, composition, surface wettability, and ion release behavior of the prepared coatings were thoroughly characterized. The coatings were assessed for early-stage osteoblast growth behavior, Ca-P apatite formation capacity, and antibacterial activity. The characterization results confirmed that Ga 3+ ions and γ-PGA were successfully incorporated into TiO 2 nanotubes, significantly enhancing hydrophilicity. The TNT+XGPP coating, in conjunction with the nanotubes, Ga 3+ ions at appropriate concentrations (5, 20, and 50 mM), and γ-PGA, not only facilitated osteoblast adhesion and proliferation, but also upregulated the expression of osteogenic functional factors (e.g., alkaline phosphatase, osteocalcin, and runt-related transcription factor-2). In contrast, an elevated concentration of Ga 3+ ions (100 mM) in the coating exerted a certain inhibitory effect against osteoblast growth. The TNT+XGPP coating accelerated the in-situ deposition of bone-like Ca-P apatite, attributing to the synergy of γ-PGA and Ga 3+ ions. The released Ga 3+ ions exerted remarkable antibacterial effects against E. coli and S. aureus , with their concentration positively associated with antibacterial activity. This work offers a novel strategy for enhancing the bone affinity and antibacterial properties of Ti-based orthopedic implants.
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APPLIED CATALYSIS A-GENERAL
·
2019
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IF 4.63
Wenfeng Han,Lingyu Wang,Zhi Li,Haodong Tang,Ying Li,Chao Huo,Guojun Lan,Xiazhen Yang,Huazhang Liu
Iron catalyst was fabricated via simple solid-state reaction of metal nitrates mixture (Fe, K, Al, Ca, Mg, Sm) with oxalic acid dihydrate at room temperature. Iron catalysts prepared by conventional methods, such as co-precipitation and fusing, are also included as comparison. The performances of catalysts were evaluated by the Fischer-Tropsch Synthesis (FTS) in a fixed bed reactor. The results indicate that uniform nanoparticles were obtained with surface area as high as 38.7 m 2 /g prepared by solid-state reaction. Following calcination at 500 °C, γ-Fe 2 O 3 were obtained as the catalyst precursor. By contrast, α-Fe 2 O 3 was the main precursor derived from co-precipitation. In addition, γ-Fe 2 O 3 prepared by solid-state reaction facilitates the formation of active phase, Fe 5 C 2 with the exposure of (021) facet. High Miller index surface (021) facilitates the adsorption and the dissociation of CO, which contributes the high activity and high selectivity to light olefins. Consequently, compared with conventional catalysts, solid-state reaction derived catalysts exhibit much higher FTO reaction activity and selectivity to lower olefins. The FTY value of 5.62 × 10 ̶ 3 mol CO g Fe ̶ 1 s ̶ 1 was obtained which is almost two times higher than that of catalyst prepared by co-precipitation (3.19 × 10 ̶ 3 mol CO g Fe ̶ 1 s ̶ 1 ) or 3 times higher than that of catalyst prepared by fusing method (1.98 × 10 ̶ 3 mol CO g Fe ̶ 1 s ̶ 1 ). The selectivity to light olefins of around 40% is obtained which is significantly higher than that of the reference catalysts (25% and 33% respectively). The present study provides a promising pathway to prepare iron based catalysts at room temperature.
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BIOMEDICINE & PHARMACOTHERAPY
·
2026
·
IF 7.5
Weiqi Zhang,Han Yin,Chenchen Wang,Xiaowei Ma,Dazhuang Miao,Guimiao Li,Wei Chen,Zhiyong Hou,Xianda Gao,Yingze Zhang,Di Zhang
Oxidative stress and apoptosis mediated senescence of nucleus pulposus cells (NPCs) and the degradation of extracellular matrix (ECM), which represent a key mechanism underlying intervertebral disc degeneration (IVDD). Mesenchymal stem cell-derived exosomes hold therapeutic potential for tissue repair; however, their clinical application is limited by rapid clearance, short half-life, and poor target specificity. To overcome these challenges, this study developed poly(lactic-co-glycolic acid) (PLGA) microspheres as a sustained-release carrier for exosomes derived under either normoxic (Exos, 21% O₂) or hypoxic (H-Exos, 1% O₂) conditions. The PLGA microspheres demonstrated high exosome-loading efficiency and provided controlled release for over four weeks. Released hypoxic exosomes activate PPAR-γ pathway, exerting better effects by reducing NPCs SA-β-gal positive rate by 59.8% and elevates Col II and ACAN levels by 30.7% and 25.5%. Animal experiments confirmed that this system effectively attenuated IVDD progression indicating its potential for clinical translation.
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Energy Materials
·
2026
·Vol. 6
·期 6
·N
·
IF 11.9
Yabo Wu,Zhiqiang Zhang,Yihao Zhang,Zhaoxin Ma,Changji Deng,Song Zhang,Bowen Bai,Weicong Liu,Yifan Huang,Qingfeng Zhang,Yongming Hu
Polymer dielectrics are promising materials for electrostatic capacitors because of their high dielectric strength and fast charge-discharge capability. However, improving the energy-storage density of fluorinated ferroelectric polymers remains challenging because enhanced polarization is often accompanied by reduced breakdown strength. In this work, all-organic poly(vinylidene fluoride- trifluoroethylene-chlorofluoroethylene)/poly(methyl methacrylate) [P(VDF-TrFE-CFE)/PMMA] dielectric films are prepared by solution blending and casting. By tuning the blend ratio, the intermolecular interactions and crystallization behavior of the films are systematically regulated, resulting in distinct changes in their electrical properties. The results suggest that dipolar interactions between PMMA carbonyl groups and polar groups in P(VDF-TrFE-CFE) disturb chain packing and suppress crystallization, thereby reducing dielectric loss and improving breakdown stability. At the optimized composition, the P(VDF-TrFE-CFE)/PMMA (50/50 wt.%) film delivers a dischaged energy density of 17.12 J/cm3 with an energy-storage efficiency of 88.11%. Further γ-irradiation of the optimized film at doses of 10-150 kGy leads to additional improvement in dielectric energy-storage performance. These results demonstrate that regulating intermolecular interactions and crystalline morphology through all-organic blending and irradiation is an effective strategy for developing high-performance polymer dielectrics.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Zhentao Chen,Lijing Lei,Xiangze Fan,Jinhua Zhu,Haodong Zhou,Yun Zhang,Fanyi Ma,Xiuhua Liu,Md. Zaved H. Khan
ZIF-8 as multi-dentate crosslinking hub converts weak CS/γ-PGA complexes into robust dual-network hydrogel. • Ultra-large pores eliminate diffusion limitation (Da ≈ 0.001) with K m increase of only 2.2-fold. • HSP regression (R 2 = 0.76, p ≈ 0.0002) validates synergistic thermodynamic exclusion and size-sieving mechanism. • Immobilized α-Glu@PC/ZIF-8 enables ligand fishing of two α-glucosidase inhibitors via capture-wash-elute workflow. Herein, a composite hydrogel based on two natural macromolecules—chitosan (CS) and γ-poly(glutamic acid) (γ-PGA)—was developed, crosslinked by zeolitic imidazolate framework-8 (ZIF-8) nanoparticles, which serve as reactive crosslinking hubs to covalently connect the biopolymer chains for efficient immobilization of α-glucosidase (α-Glu). A carboxyl-terminated poly(ethylene glycol)–poly(glutamic acid) copolymer was first synthesized and its activated carboxyl groups underwent amidation with amino groups of CS to rapidly form a three-dimensional PC/ZIF-8 hydrogel. The effects of ZIF-8 content and CS concentration on micro-morphology, swelling behavior, and rheological properties were systematically investigated. ZIF-8-mediated crosslinking was essential for gel formation, enabling effective modulation of network density and pore architecture. The optimized hydrogel showed no inhibitory effect on α-Glu. Immobilized α-Glu@PC/ZIF-8 exhibited enhanced pH stability (retaining 53% and 70% activity at pH 4.0 and 9.0), outstanding storage stability (>90% after 4 weeks), excellent organic solvent tolerance (>90% in most solvents), and good reusability (near 100% activity over 6 cycles). Mass transfer studies confirmed that the designed crosslinking density provided efficient substrate/product diffusion channels, minimizing product inhibition. Hansen solubility parameter analysis revealed a synergistic “thermodynamic exclusion + size-sieving” mechanism for solvent tolerance. Coupled with HPLC, the immobilized enzyme successfully identified two α-glucosidase inhibitors—batatasin I and 2,4-dimethoxy-6,7-dihydroxyphenanthrene—from Dioscorea opposita Thunb. peel. This work demonstrates that rational chemical modification of natural macromolecular networks via MOF crosslinkers provides an effective strategy for constructing high-performance enzyme immobilization platforms. Download: Download high-res image (72KB) Download: Download full-size image
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Xinyuan Zhang,Pei Xie,Yongkang Lai,Jiulong Zhao,Qiuping Gu,Yingfeng Wei,Zheng Chen,Liang Zhang,Shige Wang,Hongxin Sun,Chunping Zhu
Helicobacter pylori ( H. pylori ) is a globally prevalent bacterial pathogen associated with various gastrointestinal diseases, including gastritis, peptic ulcers, and gastric cancer. However, the effectiveness of oral medications is often compromised by the harsh gastric environment, leading to limited therapeutic outcomes. In this study, we developed a novel carboxymethyl chitosan/poly-γ-glutamic acid/polyvinyl pyrrolidone (CMCS/γ-PGA/PVP, CPP) sponge with a high swelling ratio and mechanical stability for gastric retention and targeted drug delivery. The CPP sponge demonstrated rapid swelling in acidic environments (38.16 g/g) and prolonged intragastric retention for up to 3 days while maintaining structural integrity under gastric peristalsis. Loaded with amoxicillin and ebselen, the CPP sponge significantly enhanced drug bioavailability and achieved a 98.59 % bacteriostasis ratio against H. pylori in a mouse model. Additionally, the sponge could alleviate gastric inflammation. The CPP sponge's triple-network structure, combining intramolecular amide bonds, intermolecular amide bonds, and hydrogen bonds, provided excellent mechanical stability and swelling properties. This study highlights the potential of the CPP sponge as an effective therapeutic platform for H. pylori infection, offering sustained drug release, improved gastric retention, and enhanced therapeutic efficacy.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2023
·Vol. 103
·期 6
·3129-3138
·
IF 4.1
Zonghan Wang,Chao Guo,Deyang Li,Dayong Zhou,Donghong Liu,Beiwei Zhu
BACKGROUND Epigallocatechin-3-gallate (EGCG) is well known for excellent chain-breaking antioxidant capability. However, browning by oxidation and aggregation of EGCG is a non-negligible defect that hinders its applications as an antioxidant in various foodstuffs. Therefore, how to eliminate or mitigate browning efficiently, while retaining functionalities as food additive is a challenge in the food industry. RESULTS Our results demonstrated that EGCG could be anchored within the internal cavity of γ-cyclodextrin (γ-CD) to form an inclusion structure, where hydrophobic interaction, hydrogen bonding, and π-stacking were identified to be the primary drivers. The interplay between two molecules and the steric hindrance from γ-CD could restrict the motion and aggregation of EGCG efficiently, thus alleviating the browning effect. In addition, the conformational adaption of EGCG within the inclusions would result in general decreases in hydrogen-bond dissociation enthalpies for the pyrogallol-type structure on the b ring, thus enhancing the antioxidant capability. In practical application, the nanoscale γ-CD/EGCG inclusion complexes were validated preliminarily as efficient additives in the preservation of shrimp surimi, presenting significant effects on prolonging the shelf-life of products. CONCLUSION Here, nanoscale γ-CD/EGCG inclusion complexes as alternatives to EGCG were tailored as food antioxidants for the preservation of shrimp surimi products, exerting antioxidant effects while mitigating the browning effects of EGCG on products. Through self-assembly, EGCG would be anchored with the cavity of γ-CD, which could regulate the release modes and restrict the aggregation of EGCG. This facile strategy has great potential in food preservation. © 2023 Society of Chemical Industry.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Sitan Wang,Xuan Meng,Naiwang Liu,Li Shi
Sulfated zirconia, as a promising catalyst in various acid-catalytic reactions, still suffer from unsatisfactory catalytic stability and regeneration performance due to severe leaching of sulfur species, while aluminum modification can effectively overcome these drawbacks. Unfortunately, the limited acceptability of aluminum content by co-precipitation and milling methods remains a critical issue. Herein, an effective strategy of coating sulfated zirconia on the surface of γ-Al 2 O 3 was developed to synthesize the novel Al 2 O 3 @SO 4 2- /ZrO 2 catalyst with high aluminum content. The synthesis variables were investigated and systematically optimized. The structural and acidic properties of Al 2 O 3 @SO 4 2- /ZrO 2 were determined by XRD, HR-TEM equipped with EDX, N 2 adsorption-desorption isotherms, EA, FT-IR, NH 3 -TPD and Py-FTIR. Results indicated that the unique structure constructed by sulfated zirconia coated on γ-Al 2 O 3 not only realized the stabilization of favorable tetragonal zirconia phase even at exceedingly high aluminum content but also promoted Brønsted acid sites. Accordingly, the optimal Al 2 O 3 @SO 4 2- /ZrO 2 - 50% performed outstanding catalytic activity and stability, given the olefins conversion of 98%-75% during the continuous reaction experiment. Owing to the alleviation of sulfur loss by Al-promoting effects, excellent regeneration performance, with olefins conversion only slightly declining after 4 consecutive reaction-regeneration cycles, was also obtained. The mechanistic pathway for the alkylation of olefins with aromatics over Al 2 O 3 @SO 4 2- /ZrO 2 was also investigated and proposed by GC–MS analysis.
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Nanoscale Advances
·
2022
·Vol. 4
·期 5
·1414-1421
·
IF 5.598
Hui Zhang,Jianping Zhang,Yi Chen,Tianze Wu,Mingzhu Lu,Zhenxia Chen,Yu Jia,Yongtai Yang,Yun Ling,Yaming Zhou
The size modulation of hollow carbon nanospheres (HCSs) has attracted great interest in the contexts of cellular uptake, drug delivery and bioimaging. In this study, a facile fabrication method was specifically used to minimize all influencing factors except for the particle size. A series of nanoparticles of hollow carbon nanospheres embedded with magnetic resonance imaging (MRI) nanoagent γ-Fe2O3 and GdPO4 nanoparticles (Fe–Gd/HCS), were successfully prepared and applied to in vitro/vivo evaluation with well-defined sizes of ∼100 nm (Fe–Gd/HCS-S), ∼200 nm (Fe–Gd/HCS-M), and ∼300 nm (Fe–Gd/HCS-L), respectively. Then the in vitro size effect of Fe–Gd/HCS was systematically investigated by bio-TEM, CLSM, CCK-8 assay, and flow cytometry revealing that Fe–Gd/HCS could be internalized and the cellular uptake amounts increase with the decrease of size. Furthermore, the in vivo size-effect behavior of Fe–Gd/HCS (∼100 nm, ∼200 nm, ∼300 nm) was tracked by MRI technique, demonstrating that all Fe–Gd/HCS can distinguish the liver, in which Fe–Gd/HCS with the smallest particle size exhibited the best performance among these nanoparticles. By leveraging on these features, Fe–Gd/HCS-S (∼100 nm) was further chosen as a theranostic agent, preliminarily presenting its capability for multi-modal imaging and therapy.
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APPLIED ORGANOMETALLIC CHEMISTRY
·
2022
·Vol. 36
·期 5
·e6646
·
IF 4.072
Yanyun Wang,Yuming Zhou,Jiehua Bao,Jiajia Wang,Yiwei Zhang,Xiaoli Sheng,Yuzhong Huang
Pt nanocatalysts have received enthusiastic attention in the field of clean energy technologies due to their high catalytic activity and selectivity. The growth size and dispersion of Pt particles play significant effects on the reaction activity, especially in high temperature catalytic reactions where catalysts are prone to deactivation due to agglomeration and sintering of Pt particles. Herein, the Pt nanoparticles were effectively stabilized on AIPO-18 molecular sieve by a biomolecule-mediated green synthesis method. Based on the biocompatibility and electrostatic synergy of carboxymethyl chitosan (CMC), a high degree of Pt nanoclusters dispersion in AIPO-18 zeolites was achieved. The hydroconversion of levulinic acid (LA)was carried out at 160°C and 2 MPa hydrogen pressure, and the LA conversion of Pt/AIPO-18 (5CMC) reached 95.2% and the selectivity of γ-valerolactone (GVL) was 97.9% after 2 h. Pt/AIPO-18 (5CMC) exhibited satisfactory results that superior to the initial reactivity of Pt/AIPO-18 (0CMC) after five runs.
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INDUSTRIAL CROPS AND PRODUCTS
·
2021
·
IF 5.645
Qiong Wang,Yunyun Liu,Yi Zhang,Yang Chen,Qifa Feng,Wen Wang,Cuiyi Liang,Yunzi Hu,Wei Qi
The conventional pretreatment method of poplar comprises multiple steps, including different procedures for fractionating hemicellulose and lignin separately. In our study, hemicellulose and lignin were removed simultaneously by a one-step method. In the γ-valerolactone (GVL)–water environment, the cellulose retention, hemicellulose removal, and lignin removal rates of 84.94%, 89.08%, and 72.28%, respectively, were achieved over a magnetic carbon-based solid acid (MMCSA) catalyst, under best conditions (160 °C, 30 min, 2 g of poplar, 2 g of MMCSA, 35 mL of GVL, and 15 mL of water). The pretreatment of fresh poplar in the reused MMCSA–GVL–water environment showed similar fractionation results as the first time. Scanning electron microscopy characterization of the cellulosic residue revealed the presence of noticeable structural fragmentation. Brunauer–Emmett–Teller characterization showed that the total pore volume of the residue was 2.13 times that of the raw material. The above features of the residue confirmed the high enzymatic hydrolysis potential of the pretreated residue. The enzymatic hydrolysis efficiency of the poplar residue was 67% at a cellulase loading of 20 FPU/g cellulose in dry matter, and it increased to 77.02% at 40 FPU/g cellulose in dry matter. Interestingly, the addition of Tween 80 did not improve the enzymatic hydrolysis efficiency at high cellulase loadings (30 and 40 FPU/g cellulose in dry matter) compared to the case at low cellulase loadings. The relative mechanisms were also analyzed. In this study, a one-step pretreatment method comprising the MMCSA–GVL system for the catalytic depolymerization of poplar wood was developed. The system was verified to be very effective for the subsequent enzymatic hydrolysis of the residues.
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