JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
·
2026
·
IF 1.8
Enyuan Chen,Yu Yin,Xiaoyun Miao,Bin Yu,Jun Yang,Mingming Li,Xiaoyun Wang,Caifang Ni
Objective: To develop S1-4 aptamer-conjugated citric acid-coated Fe3O4 nanoparticles and evaluate their targeting ability and magnetic hyperthermia effect against MCF-7 breast cancer cells.Methods: Citric acid-coated Fe3O4 nanoparticles were synthesized by chemical co-precipitation and subsequently conjugated with the S1-4 aptamer to fabricate S1-4 aptamer-conjugated citric acid-coated Fe3O4 nanoparticles. The nanoparticles were characterized by X-ray diffraction, transmission electron microscopy, dynamic light scattering, zeta potential analysis, Fourier transform infrared spectroscopy, and vibrating sample magnetometry. Biocompatibility was assessed in MCF-7 and MEF cells; cellular targeting was examined by Prussian blue staining; and the magnetic hyperthermia effect under an alternating magnetic field was evaluated by cell viability, live/dead staining, and apoptosis assays.Results: Compared with citric acid-coated Fe3O4 nanoparticles, S1-4 aptamer-conjugated citric acid-coated Fe3O4 nanoparticles exhibited a larger hydrodynamic diameter (17 ± 4 nm vs. 8 ± 3 nm) and a more negative surface charge (−26.7 ± 0.3 mV vs. −19.7 ± 0.5 mV). Fourier transform infrared spectroscopy confirmed successful aptamer conjugation. Both nanoparticles demonstrated good biocompatibility in MCF-7 and MEF cells. Prussian blue staining demonstrated stronger cellular uptake of S1-4 aptamer-conjugated citric acid-coated Fe3O4 nanoparticles in MCF-7 cells. Under alternating magnetic field exposure, S1-4 aptamer-conjugated citric acid-coated Fe3O4 nanoparticles produced a significantly greater hyperthermia effect than the controls, resulting in reduced cell proliferation and increased apoptosis in MCF-7 cells (P < 0.01).Conclusions: S1-4 aptamer-mediated Fe3O4 nanoparticles demonstrated active targeting ability and enhanced the antitumor effect of alternating magnetic field–mediated magnetic hyperthermia in breast cancer cells and maintained low cytotoxicity under the tested conditions, suggesting that they may be a feasible platform for targeted magnetic hyperthermia.
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高影响因子
CERAMICS INTERNATIONAL
·
2026
·
IF 6
Liang Yang,Jianwei Dao,Zhihao Jiang,Tiqun Wei,Zihao Han,Yajie Deng
Narrow-band red phosphors offer highly effective solution to the red-spectral deficiency that has long compromised the color rendering quality of phosphor-converted white light-emitting diodes (LEDs). Herein, we report novel tungstate-based Na 5 Lu(WO 4 ) 4 :Eu 3+ (NLWO:Eu 3+ ) red phosphor synthesized by high-temperature solid-state reaction. The distinctive tetragonal framework of the Na 5 Lu(WO 4 ) 4 host provides non-centrosymmetric Lu 3+ sites that favor the hypersensitive 5 D 0 → 7 F 2 electric dipole transition of Eu 3+ , yielding an exceptionally pure red emission at 618.9 nm with a remarkable color purity of 96.22%. A systematic investigation of the concentration-dependent luminescence reveals that electric dipole-dipole interactions dominate the energy transfer and quenching behavior, with the optimal Eu 3+ content identified at x = 0.21. Importantly, the phosphor retains 78.7% of its room-temperature emission intensity at 423 K, corresponding to activation energy of 0.246 eV, indicative of robust thermal stability suitable for LED application. A full-spectrum white LED device was constructed by integrating the optimized NLWO:Eu 3+ phosphor with commercial blue and green components on 397 nm n-UV chip. The device delivers high-quality white light with a high general color rendering index (Ra = 87.5) and a markedly enhanced R9 value of 89.8, far exceeding that of conventional YAG:Ce-based white LEDs, along with comfortable correlated color temperature of 6038 K. This work presents a viable red phosphor solution for bridging the red gap in full-spectrum lighting, highlighting the potential of tungstate hosts as robust platforms for high-performance phosphor development.
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2026
·
IF 6.8
Kun Liu,Yao Long,Jiahao Zhou,Xinrui Zhang,Weiyu Luo,Wenwen Lin,Haofeng Zhu,Shikun Zhao,Xupeng Han,Jundong Xu,Fengli Xie,Kang Zhang,Lijun Li
VBMP serves as both a weakly coordinating polarity regulator and a pendant functional group, achieving “one reagent, two functions” and enabling quantitative functionalization with controlled microstructure. • The significantly higher reactivity of VBMP ( r VBMP = 2.79–3.10) over PD ( r PD = 0.02–0.11) provides a thermodynamic basis for constructing composition-gradient sequences in functionalized polydienes. • A synergistic N–Li coordination involving both chain-end active centers and in-chain tertiary amine groups explains how low mole fractions of VBMP dramatically affect chain segment regularity in non-polar solvents. To develop 1,3-diene-based polymers with both tertiary amine functionalization and controllable microstructure, in this work, 4-vinylbenzylpiperidine (VBMP) was used as a tertiary amine functional monomer and achieves the controlled copolymerization of VBMP and 1,3-Pentadiene (PD) under mild conditions above room temperature in cyclohexane solvent by using living anionic polymerization. By taking advantage of the dual functions of VBMP as both a comonomer and a polarity regulator, and through optimizing the monomer feed ratio, poly(PD- co -VBMP) copolymers with controllable molecular weight and narrow molecular weight distribution (1.08 < Đ < 1.15) were successfully prepared. 1 H NMR spectroscopy and Fourier Infrared analysis confirmed that VBMP was inserted into the polymer backbone through in situ copolymerization, with a controlled functionalization degree. The detailed instantaneous composition distribution under different feed ratios was obtained through online 1 H NMR analysis. The reactivity ratios ( r PD = 0.02–0.11 and r VBMP = 2.79–3.10) were obtained by Fineman-Ross and Kelen-Tudos methods. Moreover, DSC analysis indicated that as the content of VBMP increased, the glass transition temperature ( T g ) of the copolymers gradually rose from −10 °C to 49 °C, and the regularity of the chain segments was significantly improved. In addition, the LAP (living anionic polymerization) chain end active center coordination mechanism, and the N-Li coordination synergy mechanism in the polymer backbone were proposed to explain the experimental results. In summary, this polymerization system not only exploits the weak regulatory effect of the tertiary amine group of VBMP on anionic polymerization but also achieves tertiary amine functionalization of 1,3-pentadiene-based gradient sequence copolymers, providing an efficient approach for preparing functional materials with both elastic properties and reactive sites. Download: Download high-res image (144KB) Download: Download full-size image
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高影响因子
POLYMER
·
2026
·
IF 5.1
Wan Ting Cui,Pei Zhi Zheng,Qiu Xiang Wang,Peng Cheng Hu,Shu Feng Zhou,Ao Nan Lai
To develop high-performance anion exchange membranes (AEMs) with excellent alkaline stability and high hydroxide conductivity, a series of poly(styrene-co-4-vinylpyridine) (PSD-m/n) were rationally designed and synthesized. Based on mature synthetic strategies, this work optimized a superior molecular configuration. The prepared polymers possess a flexible all-carbon backbone and adopt a side-chain grafting strategy to anchor industrial ionic liquids. Such aryl ether-free membrane architecture can effectively suppress the alkaline degradation behavior of conventional AEMs under harsh working conditions. Target quaternized AEMs (QPSD-m/n) were successfully fabricated by reacting PSD-m/n with an industrial ionic liquid 3-Bromo-N,N,N-trimethylpropan-1-aminium bromide (abbreviated as BTPA, counterion: Br − ). The content of pyridine-functionalized segments in the polymer backbone was precisely tailored by adjusting the molar feed ratio of styrene to 4-vinylpyridine, enabling a systematic investigation of the membrane structure-property relationship. The optimized QPSD-m/n AEMs exhibit desirable ion exchange capacity (IEC) of 1.53-2.13 meq g −1 , show low water uptake (WU) (15.22-31.03%) and restrict swelling ratio (SR) (10.11-23.90%) at 80 °C. The membranes achieve a high hydroxide conductivity of 58.32-90.06 mS cm −1 at 80 °C under test conditions. Moreover, the QPSD-m/n AEMs possess excellent thermal stability and optimizable alkaline durability. This work demonstrates that the QPSD-m/n membranes exhibit favorable performance and hold promising application prospects.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 33
·26031-26042
·
IF 6.7
Luo Bo,Wu Yanbing,Zhang Qingsi,Liu Xinyi,Cui Huanxi,Gao Zhanghan,Niu Wenjing,Zhao Xiaoyang,Li Dan,Feng Xiaoyu,Hu Yihan,Chai Jianqi,Fang Kun,Zhu Dongyang
In this study, 30 tetrahydroquinoline-based pyrazole-4-carboxamide
derivatives were designed, synthesized, and screened for antifungal
activities. Among them, compound 6m displayed the strongest
inhibitory activity against Rhizoctonia solani , with a half-maximal effective concentration (EC 50 ) as
low as 0.03 μg/mL, superior to Boscalid (EC 50 = 0.40
μg/mL) and Fluxapyroxad (EC 50 = 0.06 μg/mL).
Further detached-leaf assays on rice verified that 6m could markedly suppress the growth of R. solani with strong protective and curative effects even at 50 μg/mL.
Follow-up mechanistic studies indicated that compound 6m might exert antifungal activity through SDH inhibition-related mechanisms.
These findings suggested that compound 6m might be a
potent candidate as a succinate dehydrogenase inhibitor (SDHI) against R. solani . Further research, including field trials
and biosafety assessment, was needed to realize the potential of compound 6m as an effective tool for rice protection.
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2026
·
IF 4.9
Zhaomei Huo,Zhixia Wang,Fulin Li,Hang Song
Artificial formulation has higher antibacterial activity than tea tree oil (TTO). • The formation and physical properties of nanoemulsions is studied systematically. • Nanoemulsions exhibit superior antibacterial efficacy than reported nano-TTO. • Chitosan and the essential oil components exhibit a synergistic antibacterial effect. The volatility and instability of essential oil components often limit their practical application in antibacterial materials. In this study, a chitosan-based nanoemulsion (NE) loaded with an artificially designed synergistic formulation of two key components from tea tree oil (TTO) was developed to achieve enhanced and sustained antibacterial activity. The optimal 9:1 (v/v) ratio of terpinen-4-ol to 1,8-cineole, produced inhibition zones of 25.8 mm against S. aureus and 22.8 mm against E. coli , thereby outperforming commercial TTO (14.5 mm and 12.5 mm). Guided by pseudo-ternary phase diagrams, the formation of NE was determined. A 3:1 mass ratio of surfactant Tween 80 to co-surfactant ethanol yielded the largest nanoemulsifying region (38.33%), whereas 0.1% chitosan aqueous solution provided optimal antibacterial efficacy, uniform particle size (Z-Ave: 16.89 nm; PDI: 0.26), and good stability. Conductivity and viscosity changes were conducted to analysis the critical transition points of NEs, and NEs transitioned to the oil in water (O/W) phase when chitosan aqueous content exceeded 60% by mass. Interestingly, unlike the essential oil, the nanoemulsion exhibited higher antibacterial activity against E. coli than S. aureus , with minimum inhibition concentration of 3.91 μL·mL -1 and 7.81 μL·mL -1 , respectively. Chitosan rendered the nanoemulsion positively charged, facilitating easier interaction with the negatively charged cell walls of gram-negative bacteria. SEM revealed that NEs disrupted bacterial cell wall and membrane structures, leading to cell death and antibacterial activity. Additionally, the NEs demonstrated notable long-lasting effects. Overall, these eco-friendly NEs offer a promising alternative to antibiotics, especially for gram-negative bacteria inhibition. We designed chitosan-based nanoemulsion (NE) loaded with an artificially designed synergistic formulation of two key components from tea tree oil (TTO), achieving enhanced and sustained antibacterial activity. Guided by pseudo-ternary phase diagrams, the formulation of NE was determined. Moreover, conductivity and viscosity changes were conducted to analysis the critical transition points of NEs. Notably, the nanoemulsion exhibited minimum inhibition concentration of 3.91 μL·mL -1 and 7.81 μL·mL -1 against Escherichia coli and Staphylococcus aureus , respectively, which outperformed reported nano-TTO of 48.8 μL·mL -1 . Additionally, the NEs demonstrated notable long-lasting effects. Overall, these eco-friendly NEs offer a promising alternative to antibiotics. Download: Download high-res image (263KB) Download: Download full-size image
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RSC Advances
·
2026
·Vol. 16
·期 22
·20381-20390
·
IF 6.1
Fan Mo,Chen Tian,Rongrong Ji,Shixing Dong,Linwei Liang,Ling Zhou,Hao Wu,Xipo Zhao
Poly(ester amide) (PEA) contains both ester bonds (–COO–) and amide bonds (–NHCO–) within its molecular backbone. Through strategic monomer selection and molecular structure design, PEAs have the potential to simultaneously exhibit excellent biodegradability and mechanical properties, making them a promising class of materials with significant research interest and application potential. In this study, poly(lactic acid) (PLA) was synthesized from L-lactic acid via melt polycondensation, followed by terminal thiolation modification. Subsequently, a biodegradable PLA-b-PA4 block poly(ester amide) was prepared through a thiol–ene click reaction with the synthesized polyamide 4 (PA4). The molar ratios of polyester to polyamide repeating units in the copolymers were 11 : 26 and 23 : 26. Comprehensive structural characterization of thiol-terminated PLA and the synthesized block poly(ester amide) was conducted using MALDI-TOF MS, FTIR, Raman, XPS, and 1H-NMR spectroscopy. Systematic study revealed that variations in PLA chain length significantly influenced the properties of the PEA, with the PLA and PA4 segments undergoing phase separation in the melt and exhibiting mutually suppressed crystallization behavior. Electrospinning was employed to process the PEA. The electrospinning process reduces the crystallinity of both PLA and PA4. The morphology and properties of the electrospun fibers were influenced by the PLA block ratio. Poly(ester amide)s containing short-chain PLA segments produced electrospun fibers with larger diameters, exhibiting better mechanical strength and ductility. As the PLA chain length increased in the copolymer, bead formation appeared in the electrospun fibers, accompanied by a decrease in fiber diameter and a deterioration in mechanical performance. This study provides experimental evidence and theoretical insights into the structure–property relationships of fully biodegradable block poly(ester amide)s and their application in electrospinning.
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高影响因子
Journal of Water Process Engineering
·
2026
·
IF 6.6
Lang Liu,Yanqing Zhao,Jianyi Zhang,Yuanyuan Liu,Jingwen Zeng,Shengtao Ma,Meiqing Lin,Xunan Ning
Apparent aqueous removal overestimates net 4-NPs attenuation in textile dyeing wastewater treatment. • Stage-dependent NP rebound occurs via precursor transformation and interphase redistribution. • 4-NPs exhibit stage-dependent rebound due to precursor transformation and sludge-water redistribution. • Low-branched 4-NP isomers attenuate more readily than highly branched, persistent isomers. • Highly branched isomers enrich in final effluents and sludge, raising environmental concern. Nonylphenols (NPs) are ubiquitous endocrine disruptors in textile wastewater, yet their removal is typically evaluated using bulk concentrations, ignoring isomer-specific behaviors. To address this, we investigated eight textile dyeing treatment plants (TDPs) in the Pearl River Delta, using SPE–GC–MS to track the occurrence, attenuation, and sludge–water partitioning of ten major 4-NP isomers. Although apparent aqueous removal was high (61.1%–99.5%), NP concentrations did not decrease monotonically, instead showing a pattern of initial reduction, intermediate rebound, and final decline. Mass-balance analysis revealed wide variations in apparent net attenuation (−30.5% to 63.8%), indicating that simple aqueous removal does not guarantee actual biological degradation. Crucially, attenuation was highly isomer dependent. Low-branched 4-NP isomers showed stronger apparent attenuation during biological treatment, while highly branched isomers often became enriched in the final effluent. Additionally, sludge–water distribution coefficients (logKd) consistently decreased as side-chain complexity increased. Overall, these results suggest that the fate of 4-NPs in TDPs is strongly isomer-dependent and that reliance on bulk aqueous concentrations alone may not adequately represent the isomer-resolved fate and residual environmental implications of NPs in textile dyeing wastewater treatment systems. Download: Download high-res image (191KB) Download: Download full-size image
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高影响因子
Food Bioscience
·
2025
·
IF 5.9
Siting Wei,Youdan Ning,Deming Gong,Peng Zhang,Guowen Zhang,Xing Hu
Excessive inflammatory response is an important cause of various diseases. Toll-like receptor 4 (TLR4), a central innate immune receptor, represents a promising target for treating inflammatory diseases. Therefore, the search for natural inhibitors of TLR4 is essential for the prevention and treatment of inflammatory diseases. Luteolin (Lut), a dietary flavonoid with significant anti-inflammatory effects, is a highly promising functional food ingredient. Through integrated spectroscopic characterization and computational simulations, the molecular interaction dynamics between Lut and TLR4 were elucidated in this work. It was found that Lut exhibited concentration-dependent TLR4 fluorescence quenching through static quenching, forming a stable complex spontaneously, speculating that it may bind to the amino acid residues Arg264, Tyr292, Asp294 and Thr319 in TLR4 mainly through electrostatic and hydrogen-bonding interactions. Lut decreased the content of α-helix of TLR4, increased the content of random coil, and decreased its protein compactness and structural instability, thereby inhibiting TLR4 activation. The binding constant between the mutant protein and Lut was significantly decreased by alanine mutagenesis, confirming that Arg264 and Tyr292 are critical residues for the interaction between Lut and TLR4. These findings revealed the molecular mechanism by which Lut regulated the conformational changes of TLR4 and inhibited its activation, providing an important theoretical foundation for exploiting Lut as a natural TLR4-targeted therapeutic agent.
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产品关联
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高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-24
·
IF 15.7
Liu Chuqi,Liu Dexiang,Zheng Xiang,Guan Jiali,Zhou Xinyan,Zhang Haikun,Wang Shen,Li Qiubai,Lu Gan,He Jun,Ma Cong
Tumor-derived exosomes carry programmed death-ligand 1 (PD-L1), which binds programmed cell death protein 1 (PD-1) on T cells, suppressing immune responses locally and systemically. However, the mechanisms governing exosomal PD-L1 sorting and secretion remain elusive. Here, we identify Munc13-4 as a crucial regulator of this process. Deletion of Munc13-4 in breast tumors enhances T cell-mediated anti-tumor immunity, suppresses tumor growth, and improves the efficacy of immune checkpoint inhibitors. Mechanistically, Munc13-4 collaborates with hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), Rab27, and SNAREs to facilitate PD-L1 sorting and secretion via exosomes. Cryogenic electron microscopy (cryo-EM) analysis of the Munc13-4–Rab27a complex provide structural insights into exosome secretion. Importantly, PD-L1 sorting relies on a ternary complex composed of Munc13-4, PD-L1 and HRS, which is regulated by interferon gamma (IFNγ) signaling. A designed peptide that disrupts Munc13-4–PD-L1 interaction impedes PD-L1 sorting, enhances antitumor immunity, and suppresses tumor growth, highlighting the therapeutic potential of targeting this pathway.
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PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Qing Kang,Yidi Liu,Xiubing Cui,Jianming Chu,Tong Lin,Jingbo Jiao,Xinjun Du,Shuo Wang
Herein, we developed a novel “4 + 1” biosensing platform based on cascaded nucleic acid amplification and nanozyme activity, enabling fluorescence-colorimetric dual-mode detection and efficient inactivation of Salmonella Typhimurium (S. typhimurium). The “4 + 1” system incorporates a multi-component strategy featuring multivalent aptamers for enhanced target recognition, coupled with a quadruple signal amplification strategy involving exponential amplification reaction (EXPAR), hybridization chain reaction (HCR), multivalent aptamers, and functional nanozymes (Fe3O4 and Fe-PDs), thereby achieving synergistic antibacterial effects. It achieves a wide linear range of 3 × 101–3 × 107 CFU/mL, with detection limits of 7.7 CFU/mL for fluorescence and 8.7 CFU/mL for colorimetry. Furthermore, the system exhibits antibacterial capability by catalytically generating reactive oxygen species (ROS), reducing the risk of secondary contamination. When applied to spiked milk samples, the biosensor showed satisfactory recovery rates and reproducibility. The study provides a high-precision, low-cost analytical solution for detecting and inactivating foodborne pathogens, demonstrating significant potential for rapid on-site food safety monitoring.
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PubMed
高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 11
·877
·
IF 3.504
Guangyu Lei,Jingwen Ma,Zhen Li,Xiaobin Fan,Wenchao Peng,Guoliang Zhang,Fengbao Zhang,Yang Li
In this paper, a facile route has been developed to prepare magnetic trimetallic Au-Ag-γ-Fe2O3/rGO nanocomposites. The impact of the preparation method (the intensity of reductant) on the catalytic performance was investigated. The nanocomposites were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The prepared nanocomposites show fine catalytic activity towards the reduction reaction of 4-nitrophenol (4-NP). The nanocomposites also have superparamagnetism at room temperature, which can be easily separated from the reaction systems by applying an external magnetic field.
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高影响因子
危险品化学品经营许可证（带存储）