Journal of Water Process Engineering
·
2026
·
IF 6.6
Lang Liu,Yanqing Zhao,Jianyi Zhang,Yuanyuan Liu,Jingwen Zeng,Shengtao Ma,Meiqing Lin,Xunan Ning
Apparent aqueous removal overestimates net 4-NPs attenuation in textile dyeing wastewater treatment. • Stage-dependent NP rebound occurs via precursor transformation and interphase redistribution. • 4-NPs exhibit stage-dependent rebound due to precursor transformation and sludge-water redistribution. • Low-branched 4-NP isomers attenuate more readily than highly branched, persistent isomers. • Highly branched isomers enrich in final effluents and sludge, raising environmental concern. Nonylphenols (NPs) are ubiquitous endocrine disruptors in textile wastewater, yet their removal is typically evaluated using bulk concentrations, ignoring isomer-specific behaviors. To address this, we investigated eight textile dyeing treatment plants (TDPs) in the Pearl River Delta, using SPE–GC–MS to track the occurrence, attenuation, and sludge–water partitioning of ten major 4-NP isomers. Although apparent aqueous removal was high (61.1%–99.5%), NP concentrations did not decrease monotonically, instead showing a pattern of initial reduction, intermediate rebound, and final decline. Mass-balance analysis revealed wide variations in apparent net attenuation (−30.5% to 63.8%), indicating that simple aqueous removal does not guarantee actual biological degradation. Crucially, attenuation was highly isomer dependent. Low-branched 4-NP isomers showed stronger apparent attenuation during biological treatment, while highly branched isomers often became enriched in the final effluent. Additionally, sludge–water distribution coefficients (logKd) consistently decreased as side-chain complexity increased. Overall, these results suggest that the fate of 4-NPs in TDPs is strongly isomer-dependent and that reliance on bulk aqueous concentrations alone may not adequately represent the isomer-resolved fate and residual environmental implications of NPs in textile dyeing wastewater treatment systems. Download: Download high-res image (191KB) Download: Download full-size image
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高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-24
·
IF 15.7
Liu Chuqi,Liu Dexiang,Zheng Xiang,Guan Jiali,Zhou Xinyan,Zhang Haikun,Wang Shen,Li Qiubai,Lu Gan,He Jun,Ma Cong
Tumor-derived exosomes carry programmed death-ligand 1 (PD-L1), which binds programmed cell death protein 1 (PD-1) on T cells, suppressing immune responses locally and systemically. However, the mechanisms governing exosomal PD-L1 sorting and secretion remain elusive. Here, we identify Munc13-4 as a crucial regulator of this process. Deletion of Munc13-4 in breast tumors enhances T cell-mediated anti-tumor immunity, suppresses tumor growth, and improves the efficacy of immune checkpoint inhibitors. Mechanistically, Munc13-4 collaborates with hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), Rab27, and SNAREs to facilitate PD-L1 sorting and secretion via exosomes. Cryogenic electron microscopy (cryo-EM) analysis of the Munc13-4–Rab27a complex provide structural insights into exosome secretion. Importantly, PD-L1 sorting relies on a ternary complex composed of Munc13-4, PD-L1 and HRS, which is regulated by interferon gamma (IFNγ) signaling. A designed peptide that disrupts Munc13-4–PD-L1 interaction impedes PD-L1 sorting, enhances antitumor immunity, and suppresses tumor growth, highlighting the therapeutic potential of targeting this pathway.
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DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Siting Wei,Youdan Ning,Deming Gong,Peng Zhang,Guowen Zhang,Xing Hu
Excessive inflammatory response is an important cause of various diseases. Toll-like receptor 4 (TLR4), a central innate immune receptor, represents a promising target for treating inflammatory diseases. Therefore, the search for natural inhibitors of TLR4 is essential for the prevention and treatment of inflammatory diseases. Luteolin (Lut), a dietary flavonoid with significant anti-inflammatory effects, is a highly promising functional food ingredient. Through integrated spectroscopic characterization and computational simulations, the molecular interaction dynamics between Lut and TLR4 were elucidated in this work. It was found that Lut exhibited concentration-dependent TLR4 fluorescence quenching through static quenching, forming a stable complex spontaneously, speculating that it may bind to the amino acid residues Arg264, Tyr292, Asp294 and Thr319 in TLR4 mainly through electrostatic and hydrogen-bonding interactions. Lut decreased the content of α-helix of TLR4, increased the content of random coil, and decreased its protein compactness and structural instability, thereby inhibiting TLR4 activation. The binding constant between the mutant protein and Lut was significantly decreased by alanine mutagenesis, confirming that Arg264 and Tyr292 are critical residues for the interaction between Lut and TLR4. These findings revealed the molecular mechanism by which Lut regulated the conformational changes of TLR4 and inhibited its activation, providing an important theoretical foundation for exploiting Lut as a natural TLR4-targeted therapeutic agent.
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高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.1
Hongyi Li,Changjin Zhou,Jiadong Chen,Junlun Zhu,Yunxia Jin,Yingxi Wang,Zhengfang Tian,Shengfu Wang,Wei Wen
Metallene, as a new type of metal material, has unique structure and properties, which brings new research directions and application prospects for environmental wastewater treatment, catalysis, energy storage and conversion. Here, we developed copper doped palladium metallene (Cu-doped Pd metallene) by reasonable and effective interface design for electrochemical detection of 4-nitrophenol (4-NP) and degrading 4-NP in presence of sodium borohydride. The synergistic interaction both the catalytic activity sites of copper and the high conductive properties of Pd metallene exhibited, transforming into an ideal candidate for the electrochemical detection and catalytic reduction of 4-NP. Inspired by these advantages, electrochemical detection of 4-NP was exhibited better analytical performance, which displayed the detection range from 10 to 1000 μM. In addition, the Cu-doped Pd metallene showed the best activity with k app = 0.54 s −1 . Notably, the Cu-doped Pd metallene exhibited outstanding catalytic efficiency for the degradation of 4-NP that was three times greater than that of pure Pd metallene. Under the condition of high temperature and high concentration of salt, Cu-doped Pd metallene still maintained high catalytic activity. Those results indicated that Cu-doped Pd metallene exhibited superior catalytic activity, considerable stability, elevated turnover frequency, and improved green sustainability for the detection and degradation of 4-NP. This will be of immense importance to the realization of metallene toward potential high-value applications and the advancement of nanocatalyst research.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9
Wei Shao,Xiuling Liu,Zhaojing Jing,Ziyang Guo,Xiaowen Huo,Weihao Zhang,Haitao Wang,Na Chang
The selective separation of lithium and magnesium by conventional nanofiltration (NF) membranes remains a major challenge for lithium extraction from salt-lake brine. This difficulty results from the extremely fast and disordered nature of the interfacial polymerization process, which hampers precise control over the pore size of the separation layer. In this study, to utilize the hollow internal cavity of the macrocycle, calix[4]arene was directly sulfonated to prepare hydrophilic sulfonated calix[4]arene (SC[4]A), which was incorporated as an aqueous-phase additive into the piperazine (PIP) solution. NF membranes were then fabricated via interfacial polymerization (IP) on a self-made polysulfone (PSf) substrate. The results demonstrated that SC[4]A effectively accelerated the kinetics of the IP reaction. More importantly, SC[4]A, which was ionically bonded into the polyamide (PA), served as the additional mass transfer channel and formed a separation layer with a smaller free volume, narrower pore size distribution, and enhanced negative surface charge. The prepared TFC-0.5 membrane exhibited a Li + /Mg 2+ separation factor as high as 28.90, a 2.19-fold increase over the pristine membrane. Additionally, the incorporation of SC[4]A improved the hydrophilicity of the membrane surface, imparting superior antifouling properties to the modified membrane. By precisely regulating the IP process and tailoring the free volume of the separation layer, this study provides a new strategy for developing high-performance lithium‑magnesium separation NF membranes.
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高影响因子
Clinical and Experimental Obstetrics & Gynecology
·
2026
·Vol. 53
·期 1
·
IF 0.6
Caiqun Huang,Ying Lyu,E Fen Cheng
Background:Although multiple factors contribute to recurrent spontaneous abortion (RSA), recent studies have highlighted a role for regulatory T cells (Tregs) in maintaining immune tolerance during pregnancy. Understanding the intricate relationship between RSA and Tregs offers promising avenues for diagnosis and therapeutic strategies in reproductive medicine.Methods:We successfully established a mouse model of RSA, and all animals were euthanized on gestational day 13. Uterine horns were examined upon dissection to determine the number of viable fetuses and resorption sites, after which the post-implantation loss rate (abortion rate) was calculated. Placental morphology was evaluated via hematoxylin and eosin staining, whereas gene expression was analysed by immunohistochemistry. Treg abundance was determined by flow cytometry. Gene expression and cytokine levels in EL4 cells and patient samples were evaluated by quantitative real-time polymerase chain reaction (qPCR) and Western blotting.Results:The abortion rate of RSA mice was 31.64%. In addition, Treg numbers were reduced in both RSA mice and patients, while the expression of Toll-like receptor 4 (TLR4) and p65 was upregulated, further suppressing forkhead box protein P3 (FOXP3) expression. Blocking p65 expression with small interfering RNA (siRNA) targeting p65 prevented the lipopolysaccharide (LPS)-induced downregulation of FOXP3 in EL4 cells. The TLR4 inhibitor IAXO102 was ineffective at increasing FOXP3 expression in EL4 cells following p65 overexpression p65.Conclusions:The results of this study suggest that activation of the TLR4/p65 signalling in RSA inhibits FOXP3 expression and contributes to abortion. Importantly, the findings indicate that Treg suppression in RSA is p65-dependent.
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高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 11
·877
·
IF 3.504
Guangyu Lei,Jingwen Ma,Zhen Li,Xiaobin Fan,Wenchao Peng,Guoliang Zhang,Fengbao Zhang,Yang Li
In this paper, a facile route has been developed to prepare magnetic trimetallic Au-Ag-γ-Fe2O3/rGO nanocomposites. The impact of the preparation method (the intensity of reductant) on the catalytic performance was investigated. The nanocomposites were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). The prepared nanocomposites show fine catalytic activity towards the reduction reaction of 4-nitrophenol (4-NP). The nanocomposites also have superparamagnetism at room temperature, which can be easily separated from the reaction systems by applying an external magnetic field.
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高影响因子
DALTON TRANSACTIONS
·
2019
·Vol. 48
·期 27
·10320-10326
·
IF 4.052
Ying-Jie Jia,Yi-Gang Chen,Ting Wang,Yao Guo,Xiao-Fang Guan,Xian-Ming Zhang
Two new alkali–metal bismuth iodates KBi(IO3)3(OH) (1) and NaBi(IO3)4 (2) have been synthesized by a hydrothermal method via tuning of alkali–metal ions. Compound 1 crystallizes in the space group P and features a [Bi(IO3)3(OH)]n chain with eight-membered Bi–O–I–O–Bi–O–I–O rings. The [Bi(IO3)3(OH)]n chain consists of paddlewheel-like dimeric Bi2(OH)2(IO3)4 units linked by IO3 pairs. Compound 2 in the polar space group Cc features a [Bi(IO3)4]− double layer with Bi4I4 eight-membered rings (8-MRs). NaBi(IO3)4 exhibits a strong second harmonic generation (SHG) response of ∼5.0 × KDP (KH2PO4) and a wide transmittance window (0.4–12 μm), and structure analyses and theoretical calculations reveal that polarization results mainly from the proper alignment of the IO3 groups. The calculated electronic structure based on the DFT method indicates that the BiOn and IO3 groups dominate their optical properties.
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高影响因子
CATALYSIS COMMUNICATIONS
·
2016
·
IF 3.389
Wenhuan Dong,Saisai Cheng,Cheng Feng,Ningzhao Shang,Shutao Gao,Chun Wang
Well-dispersed and ultrafine metal nanoparticles can significantly improve the catalytic performance of heterogeneous catalyst. In this paper, highly dispersed Pd nanoparticles were successful anchored on reduced graphene oxide using a co-deposition and sacrificial method, in which cobalt was used as the sacrificial agent. This method can effectively prevent the Pd nanoparticles from aggregation, and the resulted catalyst exhibited exceedingly high catalytic activity for the reduction of 4-nitrophenol at room temperature with NaBH 4 as hydrogen resource. The turnover frequency reaches 9900 h − 1 at 298 K, which is among the highest values ever reported thus far for heterogeneously catalyzed reduction of 4-nitrophenol under ambient conditions.
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高影响因子
ACS Omega
·
2023
·
IF 4.1
Long Liu,Jinhu Bai,Ze Su,Yuan Yao,Zhixiang Zhou,Yangfeng Xia,Yanqiang Zhang
In this paper, a series of energetic ionic liquid plasticizers of 1-methyl-4-methoxyethyl-1,2,4-triazolium chloride (1), 1-methyl-4-methoxyethyl-1,2,4-triazolium bis(trifluoromethylsulfonyl)imide (1a), 1-methyl-4-methoxyethyl-1,2,4-triazolium nitrate (1b), 1-methyl-4-ethyl acetate-1,2,4-triazolium chloride (2), 1-methyl-4-ethyl acetate-1,2,4-triazolium bis(trifluoromethylsulfonyl)imide (2a), and 1-methyl-4-ethyl acetate-1,2,4-triazolium nitrate (2b) were synthesized and characterized. The results show that compounds 1a, 1b, 2a, and 2b have lower melting points (Tm, −72.60 to −32.67 °C) and good thermal stability (Td, 161–348 °C) and are suitable as plasticizers for hydroxyl-terminated polybutadiene (HTPB) curing systems. Among these four ionic liquids, ester-functionalized cations can help to improve the tensile strength (2a, 0.943 MPa; 2b, 1.113 MPa) of the cured system, while ether-functionalized cations are more beneficial to improve elongation at break (1a, 522.90%; 1b, 484.45%). Ester-functionalized ionic liquids are more beneficial to reduce the glass transition temperature of HTPB elastomers. The storage modulus of HTPB elastomers containing NO3– is higher, while that of HTPB elastomers containing NTf2– is lower. The crosslink densities of HTPB/TDI/2a and HTPB/TDI/2b plasticized by ester-functionalized ionic liquids are larger, which are 9369 and 9616 mol/m3, respectively. There are hydrogen bond interactions between the ionic liquid and the HTPB elastomer, and these interactions changed the distribution of the hard and soft segments in the polymer molecules.
研究领域:
含能材料
·
高分子科学
·
推进剂化学
·
材料工程
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高影响因子
POLYMER
·
2026
·
IF 5.1
Wan Ting Cui,Pei Zhi Zheng,Qiu Xiang Wang,Peng Cheng Hu,Shu Feng Zhou,Ao Nan Lai
To develop high-performance anion exchange membranes (AEMs) with excellent alkaline stability and high hydroxide conductivity, a series of poly(styrene-co-4-vinylpyridine) (PSD-m/n) were rationally designed and synthesized. Based on mature synthetic strategies, this work optimized a superior molecular configuration. The prepared polymers possess a flexible all-carbon backbone and adopt a side-chain grafting strategy to anchor industrial ionic liquids. Such aryl ether-free membrane architecture can effectively suppress the alkaline degradation behavior of conventional AEMs under harsh working conditions. Target quaternized AEMs (QPSD-m/n) were successfully fabricated by reacting PSD-m/n with an industrial ionic liquid 3-Bromo-N,N,N-trimethylpropan-1-aminium bromide (abbreviated as BTPA, counterion: Br − ). The content of pyridine-functionalized segments in the polymer backbone was precisely tailored by adjusting the molar feed ratio of styrene to 4-vinylpyridine, enabling a systematic investigation of the membrane structure-property relationship. The optimized QPSD-m/n AEMs exhibit desirable ion exchange capacity (IEC) of 1.53-2.13 meq g −1 , show low water uptake (WU) (15.22-31.03%) and restrict swelling ratio (SR) (10.11-23.90%) at 80 °C. The membranes achieve a high hydroxide conductivity of 58.32-90.06 mS cm −1 at 80 °C under test conditions. Moreover, the QPSD-m/n AEMs possess excellent thermal stability and optimizable alkaline durability. This work demonstrates that the QPSD-m/n membranes exhibit favorable performance and hold promising application prospects.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 33
·26031-26042
·
IF 6.7
Luo Bo,Wu Yanbing,Zhang Qingsi,Liu Xinyi,Cui Huanxi,Gao Zhanghan,Niu Wenjing,Zhao Xiaoyang,Li Dan,Feng Xiaoyu,Hu Yihan,Chai Jianqi,Fang Kun,Zhu Dongyang
In this study, 30 tetrahydroquinoline-based pyrazole-4-carboxamide
derivatives were designed, synthesized, and screened for antifungal
activities. Among them, compound 6m displayed the strongest
inhibitory activity against Rhizoctonia solani , with a half-maximal effective concentration (EC 50 ) as
low as 0.03 μg/mL, superior to Boscalid (EC 50 = 0.40
μg/mL) and Fluxapyroxad (EC 50 = 0.06 μg/mL).
Further detached-leaf assays on rice verified that 6m could markedly suppress the growth of R. solani with strong protective and curative effects even at 50 μg/mL.
Follow-up mechanistic studies indicated that compound 6m might exert antifungal activity through SDH inhibition-related mechanisms.
These findings suggested that compound 6m might be a
potent candidate as a succinate dehydrogenase inhibitor (SDHI) against R. solani . Further research, including field trials
and biosafety assessment, was needed to realize the potential of compound 6m as an effective tool for rice protection.
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PubMed
高影响因子
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