APPLIED SURFACE SCIENCE
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2026
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IF 6.6
Han Zhang,Lingui Li,Jianing Zhang,Yinxing Xu,Lijuan Li,Xiang Li
A TpPa-1@CS/β-CD aerogel is fabricated via freeze-drying and in-situ self-assembly. • The composite aerogel exhibits exceptional BPA adsorption capacity of 163.40 mg/g. • The TpPa-1@CS/β-CD aerogel is ultra-lightweight, elastic and regenerable. • After treatment with the aerogel, the COD of BPA meets the emission standard. The presence of bisphenol A (BPA), a significant industrial chemical, in aquatic environments poses persistent ecological risks and requires effective mitigation. Herein, a novel composite aerogel, TpPa-1@CS/β-CD, was fabricated by integrating freeze-drying and in-situ self-assembly. The TpPa-1 COF and chitosan/β-cyclodextrin (CS/β-CD) matrix provide abundant sites for synergistic BPA removal. The adsorption mechanism involves hydrogen bonding between the composite’s N- and O-containing groups and BPA hydroxyls, π-π stacking between BPA benzene rings and TpPa-1 conjugated frameworks, and hydrophobic inclusion in β-CD and TpPa-1 cavities. The aerogel exhibits a high BPA adsorption capacity of 163.40 mg/g, with kinetics and isotherm fitting the pseudo-second-order and Freundlich models, respectively. It also demonstrates ultra-lightweight, mechanical elasticity, and satisfactory regeneration. In dynamic filtration, the aerogel achieved 95.85% BPA removal at 20 mg/L. When applied to raw sewage, the aerogel achieved a BPA removal efficiency of 79.49% and reduced the COD from 174.18 to 55.99 mg/L, meeting the GB 31572–2015 emission standard. This study presents a valuable strategy for in-situ preparation of COF-based composite aerogels as high-performance adsorbents for advanced wastewater treatment. Download: Download high-res image (243KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Jin Liu,Tianhao Wang,Qilin Lv,Yunshan Meng,Zideng Gao,Shuwen Hu,Xueqin Ren
Chitosan is widely used in reactive oxygen species (ROS)-responsive films but remains great challenges owing to its weak mechanical strength and strong hydrophilicity . Herein, we synthesized novel hydrophobic crosslinked CS films with ROS-responsive properties and excellent physicochemical properties. A novel crosslinker, 2-((10-carboxydecyl)thio)succinic acid, with long-chain alkanes, three carboxyl groups, and sulfhydryl groups was synthesized and then used to produce thioether-containing crosslinked CS membranes. The results suggested that crosslinking could significantly increase the tensile strength of the film from 15.67 MPa to 24.32 MPa. The compact structure of crosslinked chitosan film improved the hydrophobicity and degradability, reduced the thermal stability and swelling rates, exhibited excellent non- cytotoxicity. The in vitro release studies revealed that crosslinked chitosan films could displayed the highest flux about 1.40 mg/ (cm 2 h) and significant NR fluorescence change over 80 %. Collectively, our results demonstrate the applicability of these films as ROS-responsive drug delivery systems.
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Progress in Natural Science-Materials International
·
2023
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IF 4.7
Kaiting Cheng,Yiming Fang,Liang Bai,Feng Gui,Junchi Ma,Huimin Gao,Yadong Zhao,Xingtao Xu
In everyday life, traditional dressings such as band-aid and gauze are used for dealing with small wounds. However, these dressings have shortcomings such as pain caused by tearing, inapplicability to joints, single functionality, and adverse reactions. Therefore, there is a great need for an inexpensive, comfortable, and multi-functional wound dressing. In this study, quaternized chitosan (QCS) with a high degree of substitution (107.84 %) was successfully prepared and characterized using ultraviolet–visible (UV–vis) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), and proton nuclear magnetic resonance ( 1 H NMR). A series of QCS/F127 thermosensitive hydrogels were prepared by physical cross-linking and used as potential wound dressings. Then the temperature sensitivity, hemostatic ability, antibacterial activity, and sustained drug release effect of the hydrogels were investigated to evaluate their multifunctionality as wound dressings. Finally, the effect of QCS concentration on hydrogel properties was explored. The results show that the composite hydrogels have significant hemostatic, antibacterial, and sustained drug release abilities, and they can be rapidly transformed into a gel state and adhere to skin upon reaching body temperature. In addition, the properties of the hydrogels can be adjusted by varying the concentration of QCS, which allows for the preparation of wound dressings that are responsive to needs. Therefore, multifunctional QCS/F127 hydrogels with temperature-response characteristics are of great clinical research value as wound dressings.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Xinyue Zhao,Dingyang Chen,Nan Zhang,Minsi Shi,Wei Hu,Guangli Yu,Rui Zhao
Combining adsorption with other technologies holds great potential in fast and deep arsenic ion removal. Herein, chitosan‑zirconium composite adsorptive membranes (CS-Zr CM) were successfully prepared using simple casting and sodium hydroxide coagulation strategies, which was demonstrated the use in arsenic ion-capture electrodialysis based on their good adsorption performance. In the batch adsorption tests, the maximum adsorption capacities of CS-Zr CM for As(III) and As( V ) were 134.2 mg/g and 119.5 mg/g, respectively. CS-Zr CM also exhibited satisfying adsorption selectivity and good reusability toward As(III) and As(V). However, the adsorption kinetics showed that they needed 48 h to reach the adsorption equilibrium and the adsorption ability toward trace arsenic ion was ineffective. Furthermore, CS-Zr CM was applied as the adsorptive membrane in the electrodialysis process. Under the influence of electric field, the As(III) and As( V ) removal equilibrium time was shortened to 12 h and the concentrations of As(III) and As(V) ions could be efficiently reduced to below the WHO limit in drinking water (10 μg/L), which far surpassed the physicochemical adsorption method. Such good arsenic ion removal ability of CS-Zr CM together with the ease scalable fabrication, low cost, and biodegradable properties shows its huge prospects in arsenic-containing wastewater treatment.
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COMPOSITES COMMUNICATIONS
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2023
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IF 8
Jiangjuan Yuan,Huan Kan,Han Wang,Ningli Wang,Yun Liu,Dong Pei,Qingli Qu
Enzymatic microreactors have gradually become a research hotspot as they can provide an ideal environment for the enzymatic reaction to ensure that the enzymatic reaction can be carried out in an organized manner. Here, inspired by the cellular structure of eukaryotic organisms, we developed Alginate@Chitosan (Alg@CS) microparticles for enzymatic reactions by oil-free gas-shearing method, allowing free access to substrate and product while shielding the enzyme from its surroundings. With the interpenetrating network crosslinked by Alg, CS and Ca 2+ as the substrate, XOD can be encapsulated in particles at the same time of crosslinking. The microreactors are more stable and could provide more active sites for XOD with the addition of CS. The microreactors show excellent recyclability and 4 °C storage stability. This work opens up an intriguing avenue for enzyme microreactor preparation, which is important for the construction of artificial biomimetic catalytic systems.
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ACS Applied Nano Materials
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2023
·
IF 5.9
Naijian Hu,Xiucai Wang,Jia Yang,Meng Liu,Jianwen Chen,Xinmei Yu,Wenbo Zhu,Minggao Zhang
Owing to their degradability, environmental friendliness, and low cost, natural polymers have been widely utilized in the fabrication of triboelectric nanogenerators (TENGs). Chitosan is a natural polymer containing long chains of n-acetylamino glucose. However, the low dielectric constant of pure chitosan films affects their electrical properties. Therefore, in this study, to improve their electrical output performance, the dielectric constant of the films was increased by the incorporation of conductive nanoparticles. Highly transparent Ag/Chitosan films were successfully constructed, and the output performance was improved by varying the concentration of Ag nanoparticles (100–200 nm). At a concentration of 6 wt %, the open-circuit voltage, short-circuit current, and transferred charge reached 74 V, 4.6 μA, and 23.8 nC, respectively, with a maximum output power of 83 μW. Besides, the fabricated friction-based nanogenerator (AC-TENG) lit 20 blue light-emitting diodes (LEDs) and successfully drove a commercial calculator, which verified its practical application potential. Finally, the AC-TENG was used to transmit Morse code, successfully sending the signals “HELP” and “SOS”, which might open opportunities in the field of communication application.
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ACS Applied Nano Materials
·
2023
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IF 5.9
Ting-Ting Li,Kelei Zang,Xiaomeng Wang,Ching-Wen Lou,Jia-Horng Lin
In this paper, zinc borate nanoparticles were synthesized by in situ synthesis using zinc nitrate and sodium tetraborate as raw materials, and zinc borate nanoparticles were loaded onto carboxymethyl chitosan aerogel prepared by directional freezing in combination with a freeze-drying technique, and zinc borate (ZB)/carboxymethyl chitosan composite aerogels (ZBAs) with excellent multifunctionality have been successfully prepared. The thermal behavior of carboxymethyl chitosan aerogel (CCSA) and ZBAs was analyzed using TG and DTG, and the flame retardancy of the composite aerogel was explored by simple vertical combustion experiments, where the introduction of ZB significantly improved the flame retardancy of CCSA. Meanwhile, the presence of ZB did not affect the porous structure of the aerogels, and the average acoustic absorption coefficient of the ZBA was the lowest at 0.58, and the maximum value of the thermal conductivity was 0.069 W·m–1·k–1, which indicated that the aerogels were loaded with zinc borate nanoparticles for effective thermal insulation and acoustic absorption. Moreover, the composite aerogel maintained excellent antimicrobial properties after the addition of zinc borate nanoparticles. The results of this study provide ideas for the comprehensive application of carboxymethyl chitosan aerogels in different fields.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Haoran Cui,Junjie Cai,Hanjiao He,Sheng Ding,Yi Long,Song Lin
Wound infection control is a primary clinical concern nowadays. Various innovative solutions have been developed to fabricate adaptable wound dressings with better control of infected wound healing. This work presents a facile approach by leveraging 3D printing to fabricate chitosan/glycerol into composite dressings with tailored micropatterns to improve wound healing. The bioinks of chitosan/glycerol were investigated as suitable for 3D printing. Then, three tailored micropatterns ( i.e. , sheet, strip, and mesh) with precise geometry control were 3D printed onto a commercial dressing to fabricate the micropatterned composite dressings. In vitro and in vivo studies indicate that these micropatterned dressings could speed up wound healing due to their increased water uptake capacity (up to ca. 16-fold@2 min), benign cytotoxicity (76.7 % to 90.4 % of cell viability), minor hemolytic activity (<1 %), faster blood coagulation effects (within 76.3 s), low blood coagulation index (14.5 % to 18.7 % @ 6 min), enhanced antibacterial properties (81.0 % to 86.1 % against S. aureus , 83.7 % to 96.5 % against E. coli ), and effective inhibition of wound inflammation of IL-1β and TNF-α factors. Such tailored micropatterned composite dressing is facile to obtain, highly reproducible, and cost-efficient, making it a promising implication for improved and personalized contaminated wound healing.
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CHEMOSPHERE
·
2023
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IF 8.8
Jiaqi Shen,Yuxin Gu,Yue Yang,Jiaojie He,Chuanliang Zhao,Yan Sun,Junfeng Li,Liwei Yang
The metal organic frameworks (MOFs) are considered as the effective adsorbents for phosphate removal , while their ultrafine powders limit their practical application. In this study, we fabricate two chitosan (CS) gel beads added with different cerium-based MOFs and coated with PDA for phosphate adsorption. The MOFs doped in beads are CM1 and CM2, in which the Ce(III)/Ce(IV) ratio is 0.36 and 1.46, indicating CM2 is Ce(III) dominated and more suitable for phosphate removal. However, during the process of preparing gel beads, the mixture of chitosan and CM1/CM2 are added drop-by-drop to NaOH solution, leading to the decrease of Ce(III) contents in both of the two beads on account of oxidization. On this basis, in order to improve the phosphate uptake performance and enhance the mechanical strength, polydopamine (PDA) is applied to be coated on the outside. The adsorption capacities of CS-CM1 and CS-CM2 are no more than 20 mg/g higher than that of pure CS, which is also quite equal with the phosphate uptake of CS@PDA (63 mg/g). Due to the reduction of PDA, the content of Ce(III) increasing evidently in the two adsorbents. The maximum phosphate adsorption capacities are 146.8 mg/g and 114.8 mg/g for CS-CM1@PDA and CS-CM2@PDA, respectively. CS-CM2@PDA exhibits the largest treatment volume of ∼1166 BV in the fix-bed column study, much higher than that of CS-CM1@PDA (976 BV). The main reason is that Ce(III) could form binding with phosphate through ligand exchange and precipitation. Those inner-sphere interactions are much stronger than the electrostatic attraction between Ce(IV) and phosphate. Thus, due to this strong affinity, CS-CM2@PDA possessing a higher content of Ce(III) can capture phosphate more easier at low concentration. In summary, owing to reduction of PDA, the Cerium-based MOFs are successfully introduced in CS to realize excellent phosphate removal and exhibit a great prospect in application.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
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IF 5.2
Xiuwu Liu,Chen Chen,Youhua Cao,Chengqiang Peng,Jing Fang,Haoyang Wang,Wei Wu,Gaojin Lyu,Hao Li
Chitosan is a desirable alternative for petroleum-derived packaging materials, but the unsatisfactory performance of most chitosan composites drastically impedes their practical application. In this work, a facile physical blending strategy was selected to prepare chitosan-based composite films with good properties utilizing sodium lignosulfonate as a reinforcing agent. The effects of sodium lignosulfonate addition on the barrier performance, antioxidant activity , UV-blocking, and mechanical properties of the composite films were evaluated. The enhancement mechanism of sodium lignosulfonate on the structural and functional properties of the membranes was also investigated. The results show that chitosan mixed with sodium lignosulfonate exhibited a higher tensile strength (∼75Mpa), improved barrier property (OTR and WVTR are 4.8 g·m −2 ·d −1 and 415 g·m −2 ·d −1 , respectively), increased free radical scavenging activity (29.9 %), and enhanced UV-blocking ability (95 %) compared to pure chitosan film. Strong electrostatic interaction and hydrogen bonding between monodispersed sodium lignosulfonate and chitosan have an essential effect on the performance of composite films. The application of sodium lignosulfonate as a reinforcing material is both environmentally friendly and economically viable, showing promising potential for use in food packaging applications.
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JOURNAL OF FOOD SCIENCE
·
2023
·Vol. 88
·期 11
·4718-4730
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IF 3.9
Bin Wang,Yuke Zhao,Yufei Qu,Jingyu Lu,Hua Yan,Juan Gu,Qiqing Jiang,Yanshun Xu,Wenshui Xia
Alcoholism is a serious public health problem, and the abuse of drinking seriously damages the health of people. Chitosan oligosaccharides (COSs) are small-molecule oligosaccharides with amino groups that have many unique properties. The neuroprotective effect of COS on alcohol-induced hippocampal injury in Sprague–Dawley (SD) rats was investigated. The discrimination ratio of the COS group in the Y-maze experiment was 59.3% higher than that of the ETOH group. Meanwhile, the discrimination index was less than 0 in the ETOH group but greater than 0 in the COS group during the object recognition test. The cells in the COS group were more tightly arranged than those in the ETOH group. Proteomics was used to identify differentially expressed proteins in the hippocampus. There were 27 differentially expressed proteins in the COS and ETOH group for further bioinformatic analysis. There are three enriched pathway categories, namely, primary immunodeficiency, hedgehog signaling, and sulfur relay system. Next, sonic hedgehog signaling pathway-related proteins were verified through western blotting. The protein expression level of β-arrestin-2 in the COS group was 2.85 times higher than that in the ETOH group. This work may contribute to understanding the underlying mechanism of the neuroprotective effect of COS against alcohol-induced hippocampal injury in SD rats.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
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IF 8.2
Hehe Yang,Yao Liu,Fang Wen,Xu Yan,Yandong Zhang,Zhimei Zhong
The current study created three novel chitosan derivatives named BACS, PIBACS, and MHBACS by grafting benzoic acid (BA), p-isopropyl benzoic acid (PIBA), and m-hydroxybenzoic acid (MHBA) onto chitosan (CS). The structures of the derivatives were investigated using infrared spectroscopy (FT-IR) and nuclear magnetic resonance ( 13 C NMR). The derivatives were discovered to be 45.06 %–60.49 % substituted using elemental analysis (EA). Based on the findings of in vitro antioxidant experiments (hydroxyl radical scavenging activity, superoxide anion radical scavenging activity, and DPPH radical scavenging activity), all of the derivatives had a higher hydroxyl radical scavenging activity than the chitosan raw material. MHBACS scavenged (31.02 ± 0.90)% of hydroxyl radicals at 0.5 mg/mL, 28.69 % more than chitosan raw. The derivatives scavenged more superoxide anion radicals than the chitosan feedstock at a particular concentration. For instance, at a test dose of 0.2 mg/mL, the scavenging rate of MHBACS on superoxide anion radicals was 7.75 % greater than that of chitosan raw materials. DPPH radical scavenging activity, on the other hand, was not as competent as chitosan feedstock. The growth rate approach was used to assess the potential of the three derivatives to inhibit the development of four phytopathogenic fungi. Chitosan derivatives have better antifungal efficacy than chitosan raw materials. PIBACS, MHBACS, BACS, and Wuyiencin inhibited Phytophthora capsici by (98.03 ± 1.95)%, (81.73 ± 1.63)%, (66.38 ± 1.81)%, and (93.01 ± 2.69)%, respectively, at 1.0 mg/mL. PIBACS had a higher inhibitory impact on Phytophthora capsici than the positive control. Based on the evidence presented above, it is reasonable to conclude that the addition of benzoic acid molecules increased the antioxidant and antifungal capabilities of chitosan.
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