JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
·
IF 9.6
Jiarui Qu,Hongyao Gu,Dong-Feng Chai,Di Wu,Yutong Wang,Yingyi Liu,Xinhui Yu,Guohua Dong,Dongxuan Guo
A metallic salt solution quenching strategy enables lattice-confined Ce doping in Fe 9 S 10 /FeS nanoflowers, overcoming surface adsorption limitations. • Quenching-induced grain boundaries and lattice strain narrow the Fe d -band width and downshift the d -band center, optimizing oxygen intermediate adsorption. • The optimized electronic structure lowers the OER rate-determining energy barrier from 2.22 eV to 1.82 eV, achieving an overpotential of 274 mV and 300 h AEMWE stability. Lattice confinement of large-radius cerium enables atomic-level electronic modulation for oxygen evolution reaction (OER) electrocatalysts in anion exchange membrane water electrolyzer (AEMWE) applications but remains challenging. Herein, a metallic salt solution quenching strategy achieves lattice-confined cerium doping in iron sulfide composite nanoflowers (Fe 9 S 10 /FeS). The ultrafast cooling generates abundant grain boundaries and lattice strain, which collectively reduce Fe Fe orbital overlap, narrow the Fe d -band width, and shift the d -band center upward. These electronic modifications consequently optimize the adsorption energetics of oxygen-containing intermediates on the pristine Fe 9 S 10 /FeS surface, mitigating their excessively strong binding. According to density functional theory (DFT) calculations, the energy barrier for the rate-determining step is reduced from 2.22 eV to 1.82 eV. Consequently, the cerium-doped iron sulfide catalyst (Ce-FeS-4th) exhibits a low overpotential of 274 mV at 10 mA cm −2 and a Tafel slope of 68 mV dec −1 . An AEMWE using this anode achieves 1.0 A cm −2 at 2.48 V and operates stably for over 300 h. Overall, this work establishes quenching-induced lattice confinement as a versatile paradigm for d -band center engineering in advanced electrocatalysts. Download: Download high-res image (81KB) Download: Download full-size image
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ChemSusChem
·
2025
·Vol. 18
·期 16
·e202500950
·
IF 6.6
Shuai Wang,Yihu Ke,Fei Jin,Youji Li,Zhiliang Jin
Noble metal nanoparticle co-catalysts offer high photocatalytic activity but are costly and scarce, driving the search for efficient, economical alternatives. We constructed a FeCo 2 O 4 /ZnCdS composite catalyst using electrostatic self-assembly. Optimizing the FeCo 2 O 4 loading to 10 wt% achieved a remarkable hydrogen production rate of 9080 μmol g −1 h −1 −3.49 times higher than pristine ZnCdS and exceeding precious metal co-catalysts like Au. Kelvin probe force microscopy, X-ray photoelectron spectroscopy, and density functional theory (DFT) calculations reveal an S-scheme heterojunction forms between FeCo 2 O 4 and ZnCdS. The resulting internal electric field efficiently drives directional charge migration and significantly suppresses electron-hole recombination. DFT further shows the interface electric field shifts the d-band center, optimizing reactant molecule adsorption. This avoids catalyst deactivation from strong adsorption while overcoming the energy barrier from weak adsorption, creating an ideal moderate-strength activated state. This work deepens understanding of S-scheme mechanisms and provides a new strategy for economical photocatalytic hydrogen production. Graphical The built-in electric field in FeCo 2 O 4 /ZnCdS heterojunctions regulates the d-band center to optimize hydrogen adsorption energy. An S-scheme charge transfer mechanism achieves a photocatalytic hydrogen evolution rate of 9080 μmol g − 1 h − 1 , surpassing noble-metal cocatalysts. Density functional theory and Kelvin probe force microscope studies confirm that interfacial electric field engineering enhances carrier separation and reaction kinetics, providing an efficient noble-metal-free strategy.
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高影响因子
Small
·
2025
·
IF 12.1
Qing Sun,Xiangjun Zhou,Yanfeng Zhang,Chunlin Qin,Jiahui Wang,Yaman Cui,Hongyu Gong,Xuecheng Cao,Xiangjun Zheng
Designing efficient bifunctional electrocatalysts for the kinetically divergent hydrogen and oxygen evolution reactions (HER/OER) is challenging due to their conflicting interfacial requirements. Herein, precisely engineered RuS 2 /(FeNi)S 1.03 heterointerfaces are constructed via homogeneous chelation-coupled in situ sulfidation, enabling distinct interfacial mechanisms that independently enhance HER and OER. For HER, the RuS 2 component exclusively optimizes HER through static electronic modulation, where interfacial electron transfer at RuS 2 /(FeNi)S 1.03 interface downshifts the Ru d-band center to −1.99 eV and weakens hydrogen adsorption ( 0.51 eV). This yields superior HER activity with an overpotential of 270 mV@ at 50 mA cm −2 . Conversely, for OER, the (FeNi)S 1.03 phase undergoes dynamic reconstruction, transforming into an OER-catalytically active Fe-NiO oxide with stable RuS 2 (RuS 2 /Fe-NiO interfaces) that reduce intermediate energy barriers and delivers an overpotential of 300 mV at 50 mA cm −2 . This dual-interface synergy enables outstanding bifunctional performance with low cell voltages (1.68 V alkaline water; 1.76 V seawater) and industrial stability (>250 h at 1000 mA cm − 2 ), resolving the mechanistic conflict in bifunctional catalyst design.
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高影响因子
DALTON TRANSACTIONS
·
2012
·Vol. 42
·期 10
·3402-3409
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IF 3.838
Bo Chai,Tianyou Peng,Xiaohu Zhang,Jing Mao,Kan Li,Xungao Zhang
A novel nanostructured carbon/TiO2 nanocomposite photocatalyst is firstly fabricated via a facile hydrothermal process by using fullerene (C60) decorated single-walled carbon nanotubes (SWCNTs) as carbon source, which is denoted as C60-d-CNTs. The obtained nanostructured carbon/TiO2 nanocomposites are characterized by X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), UV-vis diffuse reflectance spectra (DRS), Raman spectra, X-ray photoelectron spectroscopy (XPS) and photoluminescence spectra (PL), and then are used as catalysts for photocatalytic hydrogen production. It is found that the kinds and contents of various carbon nanostructured materials (such as SWCNTs, C60 and C60-d-CNTs) coupled with TiO2 can significantly enhance the photoactivity for hydrogen production, and the 5 wt% C60-d-CNTs/TiO2 nanocomposite exhibits the best performance. Experimental results suggest that the C60-d-CNTs as a novel carbon nanostructured material could be more beneficial for the photogenerated carrier separation than SWCNTs and C60 when these carbon nanostructured materials are coupled with TiO2.
研究领域:
材料科学
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纳米技术
·
光催化
·
氢能
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高影响因子
Scientific Reports
·
2026
·
IF 4.9
Zhou Kun,Yuan Wei,Zhang Fan
Radix Bupleuri-Radix Paeoniae Alba (RB-RPA) has the potential to ameliorate the immune microenvironment in hepatocellular carcinoma (HCC). The interactions between various cells influence the immune microenvironment. However, the effects of the active components (saikosaponin D (SSD) and paeoniflorin) of RB-RPA on HCC and the cell interactions within its microenvironment warrant further investigations. We established orthotopic mouse models of HCC using Hepa 1–6 cells (a hepatoma cell line) to investigate the infiltration of cancer-associated fibroblasts (CAFs). Following this, we knocked down CLCF1 in the CAFs to explore their interactions with Hepa 1–6 cells. We subsequently treated CAFs with SSD-paeoniflorin. In T-cell activation assays, we overexpressed PD-L1 in Hepa 1–6 cells and co-cultured these cells with T cells. Additionally, we treated HCC mice with SSD-paeoniflorin and induced the overexpression of CLCF1 in vivo. In mice with HCC, tumors were characterized by substantial infiltration of CAFs, which displayed elevated levels of the protein CLCF1. These CAFs play a role in suppressing the HCC immune microenvironment and elevating PD-L1 levels through the production of CLCF1. At the cellular level, SSD-paeoniflorin inhibited the growth of CAFs and the expression of CLCF1 and also suppressed the PD-L1 level in Hepa 1–6 cells through CAF-derived CLCF1. Mechanistically, CLCF1 may promote PD-L1 expression via the JAK/STAT3 signaling pathway. Furthermore, the overexpression of PD-L1 in Hepa 1–6 cells suppressed T cell proliferation and activation. In animal studies, SSD-paeoniflorin improved the HCC immune microenvironment by enhancing the interaction between CAFs and Hepa 1–6 cells through CLCF1. Collectively, SSD-paeoniflorin inhibits CLCF1 secretion in CAFs to downregulate PD-L1 expression in Hepa 1–6 cells and may reactivate the anti-tumor immune microenvironment in HCC.
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REGULATORY TOXICOLOGY AND PHARMACOLOGY
·
2023
·
IF 3.4
Lang Yan,Jingjing Mao,Wenjing Shi,Lijun Ren,Jinfeng Li,Bijiang Geng,Haoneng Wang,Jiqianzhu Zhang,Yijun Tian,Bin Zhang,Fangyuan Gao,Xiaofang Zhang,Jikuai Chen,Jiangbo Zhu
In this study, the toxicity of ferric oxide nanoparticles (Fe 2 O 3 NPs) administered through gavage to Sprague Dawley (SD) rats for 94 d, consecutively and the recovery after Fe 2 O 3 NPs withdrawal for 30 d were evaluated. The vehicle control group, low-, medium-, and high-dose groups were administered with the vehicle (0.5% sodium carboxymethyl cellulose [CMC-Na]), 125, 250, and 500 mg/kg of Fe 2 O 3 NPs, respectively, administered every morning for 94 d. There was no significant difference in the body weight, food intake, hematological, blood biochemical, and urine indices of SD rats in each administration group and the control group (P > 0.05). There was no significant difference in organ weight, organ indices, and the coefficient of the visceral brain between the SD rats in the different dosage groups and the SD rats in the vehicle control group (P > 0.05). Histopathological observations showed that there was no correlation between the pathological lesions of the organs observed in this study and the dose of Fe 2 O 3 NPs (P > 0.05). The no-observed-adverse-effect level (NOAEL) dose of Fe 2 O 3 NPs was initially determined to be 500 mg/kg administered to SD rats through oral gavage for 94 d, consecutively, followed by recovery after Fe 2 O 3 NPs withdrawal for 30 d.
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Small
·
2023
·Vol. 19
·期 37
·2301085
·
IF 13.3
Guo Liu,Qi Zeng,Xinyi Sui,Shuhao Tian,Xiao Sun,Qingfeng Wu,Xijuan Li,Yuhao Zhang,Kun Tao,Erqing Xie,Zhenxing Zhang
Polysulfide shuttle effect and sluggish sulfur reaction kinetics severely impede the cycling stability and sulfur utilization of lithium-sulfur (Li-S) batteries. Modulating d-band electronic structures of molybdenum disulfide electrocatalysts via p/n doping is promising to boost polysulfide conversion and suppress polysulfide migration in lithium-sulfur batteries. Herein, p-type V-doped MoS 2 (V-MoS 2 ) and n-type Mn-doped MoS 2 (Mn-MoS 2 ) catalysts are well-designed. Experimental results and theoretical analyses reveal that both of them significantly increase the binding energy of polysulfides on the catalysts’ surface and accelerate the sluggish conversion kinetics of sulfur species. Particularly, the p-type V-MoS 2 catalyst exhibits a more obvious bidirectional catalytic effect. Electronic structure analysis further demonstrates that the superior anchoring and electrocatalytic activities are originated from the upward shift of the d-band center and the optimized electronic structure induced by duplex metal coupling. As a result, the Li-S batteries with V-MoS 2 modified separator exhibit a high initial capacity of 1607.2 mAh g −1 at 0.2 C and excellent rate and cycling performance. Moreover, even at a high sulfur loading of 6.84 mg cm −2 , a favorable initial areal capacity of 8.98 mAh cm −2 is achieved at 0.1 C. This work may bring widespread attention to atomic engineering in catalyst design for high-performance Li-S batteries.
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高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2022
·Vol. 29
·期 16
·e202203524
·
IF 5.02
Liang Yan,Yongqi Ke,Yu Wang,Jingkui Yang,Yujian He,Li Wu
Graphical A series of mini-PEGs modified D-amino acid-containing peptides were synthesized. It was determined that the polyethylene glycol (PEG) modification promoted the enzymatic cleavage of the D-amino acid-containing peptides under the action of serine-like proteases. It was previously reported that D-amino acid-containing peptides exhibited the ability to resist enzymatic hydrolysis. This study investigated the influence of mini-PEGs modification on enzymatic hydrolysis ability of D-amino acid-containing peptides. The results showed that PEGylation promoted enzymatic hydrolysis of the D-amino acid-containing peptide, especially, the cleavage rate of the D-amino acid-containing peptide 6-w with PEG 3 modification at the N-ends was up to 17 times higher in the presence of proteinase K (PROK) compared to those without PEG 3 modification. Moreover, analysis of the enzymatic cleavage sites demonstrated a similar cleavage pattern of the PEGylated D-amino acid-containing peptide to that of the unmodified peptide. The computational simulations further showed that the enhanced enzymatic hydrolysis ability can be attributed to the strong interaction between PROK and the peptide after PEG 3 modification and the resulting formation of a mature catalytic triad structure.
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高影响因子
ACS Omega
·
2023
·
IF 4.1
Yue Zhao,Chaoyuan Tang,Jingyi Huang,Hongyan Zhang,Jingbin Shi,Shujun Xu,Lisha Ma,Chun Peng,Qi Liu,Yang Xiong
In this study, we established a simple and rapid in vitro method for screening multidrug resistance (MDR) reversal agents in traditional Chinese medicines (TCMs), which could better correspond to the MDR reversing effect in vivo. Here, D-luciferin, a substrate for the enzyme firefly luciferase and also a substrate for ATP-binding cassette transporters (ABC transporters), was used as the probe to detect its efflux kinetics caused by ABC transporters. First, we established a stable doxorubicin (DOX)-resistant cell line (MCF-7/DOXFluc) that overexpressed luciferase. Then, some kinds of TCMs were chosen for the MDR reversal agents to measure its effect on inhibiting the D-luciferin outflow from MCF-7/DOXFluc, and the ideal reversal agent with the least D-luciferin efflux from MCF-7/DOXFluc was selected to further investigate its effect combined with DOX on MCF-7/DOXFluc tumor-bearing mice. The results indicated that quercetin (Qu) could remarkably increase the retention of D-luciferin in MCF-7/DOXFlucin vitro and in vivo. Also, the combination of Qu and DOX could exceedingly inhibit the tumor growth, which proved the feasibility of this in vitro screening method. The study proposed a feasible method for mass screening of MDR agents from TCMs in vitro.
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高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Dan Zhao,Jingjing Huang,Juan Li,Xiao Ma,Fang Wang,Honglei Zhang,Jiaze Xie,Jian Sun,Chuanxia Chen
Dual-readout protocols with two signal transduction channels can significantly improve the detection precision and diversity. In contrast to the previous tedious and time-consuming preparation of two response materials, a convenient and commercially available small molecule o -Phenylenediamine (OPD)-based dual-mode system was developed for the ultrasensitive detection of D-penicillamine (D-PA). Fortunately and interestingly, it is demonstrated that chloride ions (Cl − ) could largely enhance the oxidative ability of copper ions (Cu 2+ ) and improve the reaction rate and efficiency of the Cu 2+ -OPD system, leading to the boosted colorimetric and fluorescent signals and shorter reaction time. Meanwhile, D-PA could strongly bind with Cu 2+ to form a stable Cu 2+ -D-PA complex, thereby inhibiting the aforementioned oxidation process and exhibiting decrease of absorbance values and fluorescence intensity. Inspired by the excellent analytical performance, an “INH” molecular logic gate was devised by employing Cl − and D-PA as the inputs, and the dual-mode strategy has been successfully employed to probe D-PA in tablets and human serum samples. Such cost-effective yet efficacious analytical tool not only improve the sensing performance of the Cu 2+ -OPD reaction system, but also enhance the detection sensitivity for D-PA and promote the application and development of OPD-based reactions.
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Frontiers in Microbiology
·
2023
·
IF 5.2
Zhou Ziyuan,Wang Baohong,Pan Xiaxia,Lv Jiawen,Lou Zhuoqi,Han Yuqiu,Yao Yuanyuan,Chen Jun,Wang Qiangqiang,Li Lanjuan
Introduction: Acute liver failure (ALF) is a clinical condition with many causes, fast progression, and a poor prognosis. Previous research has indicated that microbial factors have a role in ALF, but a clear picture has yet to emerge.Methods: To investigate the specific involvement of microbial metabolites in ALF development, we pretreated D-GalN/LPS-induced ALF mice with indole derivatives, an influential class of gut microbial metabolites.Results: Contrary to their typical role as anti-inflammatory agents in the host, indole-3-acetic acid (IAA), indole-3-lactic acid (ILA), and indolepropionic acid (IPA) gavage sensitize mice to D-GalN/LPS-induced-ALF with a rapid rise in serum transaminases and histologic lesion. For a clearer picture, we performed comprehensive analysis for the IAA therapy. IAA markedly amplified inflammatory response and cellular damage. The transcriptome analysis indicated the participation of the TNF-α/NF-κB signaling pathway. The structure of gut microbiota in ileum and the expression of Toll-like receptor 2 (Tlr2) in the liver were also significantly changed.Discussion: In conclusion, IAA pretreatment can exacerbate D-GalN/LPS-induced ALF via probable Tlr2/NF-κB pathway involvement and ileac dysbiosis characterized by enriched gram-positive genus with potential pathogenesis. Microbial metabolites IAA may aggravate individual susceptibility to D-GalN/LPS-induced ALF. Further investigation of the underlying mechanism is needed, and intervention with indole derivatives and related commensal species should be undertaken with caution.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Wan Liu,Meng Cheng,Fangying Yuan,Jiaying He,Yulin Feng,Yi Jin,Jianfang Feng,Shilin Yang,Liangxing Tu
Nanocrystal technology is a common strategy to enhance the oral bioavailability of poorly-soluble drugs, and how to enlarge the enhancing ability on oral absorption via nanocrystals has become a pharmaceutical research field. In this study, we selected andrographolide (ADR), a typical poorly-soluble drug, as the model drug, and employed sodium dodecyl sulfate and D-ɑ-Tocopherol polyethylene glycol 1000 succinate copolymer (SDS-TPGS) to construct novel SDS-TPGS modified andrographolide nanocrystals (S-TANs). We found that the particle sizes of SDS/TPGS physical mixture modified nanocrystals (STANs) were about 553.4 ± 4.1 nm , while that of SDS-TPGS modified nanocrystals (S-TANs) were 604.6 ± 5.7 nm. During the production process of nanocrystals, the crystallinity of ADR was slightly decreased. Nanocrystals enhanced the saturation solubility of ADR, and improved oral absorption, C max and AUC 0-∞ of S-TANs was about 2.10 and 1.24 fold increased, STAN about 2.63, 2.97 fold. In a Real-time distribution study, we found the distribution time of andrographolide, SDS and TPGS in SDS/TPGS physical mixture modified nanocrystals system varies widely, while the distribution times of these materials were similar in SDS-TPGS copolymer modified nanocrystals system. These results indicated that modified with functional stabilizer was an efficient strategy to enlarge the enhancing ability on oral absorption of nanocrystals, and synthesized copolymer containing different functional stabilizers showed higher ability on enhancing oral bioavailability than physical mixtures.
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