CERAMICS INTERNATIONAL
·
2024
·Vol. 50
·期 17
·31589-31597
·
IF 5.1
Yi Zhang,Zhexuan Gao,Yinyan Li,Huanping Wang,Shilong Zhao,Yang Shen,Degang Deng,Shiqing Xu
A novel near-infrared emitting Ga 2 O 3 : Ni 2+ phosphor was prepared, and its emission characteristics were improved through melting aid and charge balance. Under 410 nm excitation, the Ga 2 O 3 : Ni 2+ phosphor exhibits broadband near-infrared emission in the second region, with a peak at 1455 nm and a half maximum width of up to 300 nm. At the same time, the crystallinity of the sample was improved and the charge imbalance during substitution between Ga 3+ and Ni 2+ was eliminated through melting assistance and charge compensation. The results show that the emission intensity of Ga 1.97 O 3 : 0.015Ni 2+ , 0.015Ge 4+ phosphor (with added flux H 3 BO 3 ) is 10 times higher than that of Ga 1.985 O 3 : 0.015Ni 2+ sample. Its quantum yield is as high as 31.2 %, significantly higher than the reported Ni 2+ ion doped phosphors. According to the distinct absorptions of C–H, O–H as well as N–H bonds in the shortwave near-infrared range, samples of ethanol, n-hexanol, water and ammonia demonstrated different absorption peaks under the penetration of the constructed phosphor conversion light-emitting diode, which proved the potential application of Ga 2 O 3 : Ni 2+ , Ge 4+ -H 3 BO 3 phosphor in composition analysis and detection.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Xuan Hu,Ziyan Shen,Huahua Hao,Ke Ma,Aihua Zhen,Yibo Yang,Kai Liang,Zelong Chen,Jiaxuan Li,Yinghua Lv,Shuang Chao,Yuxin Pei,Zhican Qu,Zhichao Pei
Melanoma is a highly invasive and metastatic malignant skin tumor. Recently, immunogenic cell death (ICD) has attracted great attention as a promising approach to immunotherapy. However, efficiently and comprehensively activating ICD throughout the dense tumor tissue is a key challenge. Herein, we designed a NIR II light-driven asymmetric nanomotor drug delivery system (Sor@CS-ZIF-8@MO1) to achieve deep penetration into the tumor tissue. By combining photothermal therapy (PTT) and chemodynamic therapy (CDT) to synergistically induce ICD, the immunotherapeutic efficacy against melanoma is enhanced. The research results showed that Sor@CS-ZIF-8@MO1 exhibited good photothermal performance and motor-driven performance, and was able to effectively penetrate 3D tumor cell spheroids deeply. Sor@CS-ZIF-8@MO1 targeted tumor tissues through mannose and controllably released sorafenib under the low pH conditions in tumor tissues and photothermal stimulation, thereby promoting tumor tissue angiogenesis to improve its hypoxic microenvironment and effectively enhancing the CDT effect induced by Cu +/2+ . This could synergistically enhance the ICD of tumor cells with the PTT. Meanwhile, the tumor-associated antigens released by ICD, together with ovalbumin and mannose, stimulated immune response, reshaped the tumor immune microenvironment, enhanced tumor immunity, and ultimately effectively inhibited the growth and metastasis of melanoma tumors. In this work, a nanomotor delivery system that integrates multiple modalities and is capable of deeply penetrating tumor tissues to efficiently and comprehensively induce immunogenic cell death (ICD) has been designed, providing a new strategy to address the problem of insufficient induction of ICD in melanoma immunotherapy.
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PubMed
高影响因子
Nanoscale
·
2024
·
IF 5.8
Jingjing Jiang,Qiong Zhang,Yue Zhang,Lintong Gao,Yan Feng,Xianshun Sun,Junjun Wang,Xiao-Jiao Zhu,Xingxing Chen,Hong-Ping Zhou
Currently, cuproptosis mainly focuses on the Cu2+ induced morphology of mitochondria (Mito), the observation of endoplasmic reticulum (ER)-related Cu2+ content in cuproptosis is relatively lacking. Herein, we develop a hydroxyflavone (HF) based NIR excited fluorescent probe, BHCO, for exhibiting specific recognition of Cu2+. BHCO can accurately locate in ER and detect Cu2+ content in cuproptosis process. The two-photon fluorescence nature of BHCO enables to track both ferroptosis and cuproptosis processes with high resolution. Furthermore, BHCO can upgrade reactive oxygen species (ROS) under 720 nm excitation, which facilitates ferroptosis occurrence. We firmly convince the nonlinear optical (NLO) small molecules could provide a valid tool for rapid tumors elimination through synergistic ferroptosis and cuproptosis.
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DYES AND PIGMENTS
·
2025
·
IF 4.2
Binbin Wu,Qin Zhang,Min Chen,Hongchen Zhang,Lulu Zheng,Xingyu Peng,Shihua Wang,Yun-Yun Quan,Lingtian Wang,Zu-Sheng Huang,Xiaoxia Ye
Photothermal therapy (PTT) has gained significant attention as a promising cancer treatment due to its low systemic toxicity, minimal invasiveness, and other advantages. Aggregation-induced emission luminogens (AIEgens) with second near-infrared (NIR-II) fluorescence have emerged as ideal photothermal agents (PTAs), offering key benefits such as high biosafety, excellent biocompatibility, and precise tumor theranostics. Nevertheless, achieving an optimal balance between radiation-mediated NIR-II fluorescence imaging and non-radiation NIR-PTT poses a considerable challenge in designing efficient NIR-II AIEgens. In this work, we employed side chain engineering by strategically grafting n -hexyl onto the π-bridge of a conjugated D-π-A-π-D structure, leading to the development of four new AIEgens ( BQ1 ∼ BQ4 ). These compounds feature 6,7-diphenyl- [1,2,5] thiadiazolo [3,4- g ] quinoxaline as the acceptor, thiophene as the π-bridge, and phenothiazine as the donor. This molecular design enables precise regulation of backbone distortion, effectively balancing fluorescence emission and photothermal conversion. Among them, BQ1 , BQ3 , and BQ4 exhibited strong fluorescence, longer emission wavelengths, and superior photothermal conversion efficiencies (PCEs) (59.2%, 57.8%, 52% respectively), whereas BQ2 , with greater molecular distortion, showed a lower PCE of 33.4%. Notably, BQ1 nanoparticles demonstrated outstanding photothermal conversion, prolonged tumor retention, strong resistance to photobleaching in vitro and in vivo , and NIR-II imaging capability at 1055 nm. This study introduces a novel strategy for optimizing NIR-II/AIE PTAs through precise conformational control via strategic n -hexyl positioning, which remains unreported to date.
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Journal of Materials Chemistry C
·
2025
·Vol. 13
·期 18
·9382-9391
·
IF 5.1
Zaidong Chen,Yuefei Xiang,Xinghui Qin,Lei Zhong,Hong Liao,Shiwen Liu,Jiaqi Wang,Kezhi Zheng,Dejian Hou,Lei Zhou,Mingmei Wu
The challenges of low blue light absorption, reduced luminous efficiency, and low thermal stability are critical issues confronting near-infrared II (NIR-II) phosphors, which significantly hinder their applications in food testing, medical imaging, and various other fields. Herein, an energy transfer strategy was adopted to enhance blue light absorption by introducing Cr3+ into Lu2CaMg2Si3O12:Ni2+, thereby enhancing their luminescence properties, including quantum efficiency and thermal stability. Given the superior energy transfer efficiency of Cr3+ → Ni2+, the quantum efficiency of Lu2CaMg2Si3O12:Cr3+,Ni2+ was increased from 23.0% to 32.6%, and the thermal stability improved by 18%, as compared to Lu2CaMg2Si3O12:Ni2+. Furthermore, the Dexter's model was employed to systematically analyze the energy transfer mechanism of transition metal ions. In addition, due to the difference in the temperature response of Cr3+ and Ni2+, the thermometry performance of this phosphor was studied. Importantly, a pioneering method for food components detection based on the convolutional neural network model was proposed, demonstrating a 100% detection success rate. This research not only propels the development of novel blue-light-excitable NIR-II phosphors but also contributes to the advancement of intelligent lighting technologies.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Muqun Wang,Shaofeng Liang,Shuangliang Zhao,Wei Gao,Zequan Li
High-performance interlayer materials have garnered considerable interest owing to their low manufacturing costs and applicability in smart windows. In this study, a novel smart-window interlayer material capable of selective shielding against both near-infrared (NIR) and ultraviolet (UV) radiation is developed based on the light transmittance control mechanism. An excellent thermoresponsive liquid, denoted as CDs@TRL (viz., carbon quantum dots at thermal-responsive liquid), is synthesized by compositing biomass-based fluorescent carbon quantum dots (CDs) and poly(N-isopropylacrylamide) (pNIPAM) at natural ambient temperature and in an aqueous phase. Due to the characteristics of CDs and synergistic effect of hydrogen bonds, CDs@TRL exhibits a high specific heat capacity (4.41 kJ kg–1 K–1), large thermal storage capacity (264.6 kJ kg–1), and better UV–NIR-blocking properties, compared to pure pNIPAM, as well as improves the sensitivity of thermal response. When injected into a window as a liquid interlayer, CDs@TRL can intelligently adjust the light transmittance according to ambient light intensity to achieve an intelligent response. The shielding rate of a 10 mm-thick CDs@TRL composite liquid against UV radiation (200–400 nm) was more than 95% in an overcast environment with insufficient light and close to 100% in a well-lighted environment. In addition, CDs@TRL is a cost-effective material that can be prepared from a wide range of raw material sources using a simple preparation process and exhibits excellent mobility and recyclability. Because of these features, it is considered to be a promising candidate for developing energy-saving and climate-adapted smart windows.
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Catalysis Science & Technology
·
2019
·Vol. 9
·期 9
·2103-2110
·
IF 5.726
Shuhui Liang,Yukun Chang,Yue Wang,Dafeng Zhang,Xipeng Pu
A simple combustion method was reported to prepare a novel BiOBr:Yb3+,Er3+/AgBr (BYE/AgBr) heterojunction photocatalyst. Phase composition, morphology and optical properties of samples were characterized. The diffuse reflectance and photoluminescence spectra showed that the as-synthesized BYE/AgBr can be activated under both visible (vis) and near-infrared (NIR) light. Notably, BYE/AgBr composites exhibited enhanced photocatalytic activity for RhB degradation under vis/NIR irradiation. The degradation rate constants of BYE/AgBr-1 : 1.5 for RhB were 0.0220 min−1 and 0.01368 h−1 under visible and NIR irradiation, which are about 2.6 and 4.9 times higher than that of pure BYE, respectively. The upconversion effect of Er3+ can convert the NIR light (∼980 nm) to visible light which was then absorbed by BYE/AgBr to generate e− and h+. Moreover, the formation of the heterojunction also plays a role in the enhanced vis/NIR photocatalytic abilities; and a corresponding plausible photocatalytic mechanism was proposed.
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Small
·
2023
·
IF 13.3
Min Hou,Rui Guo,Tianyu Ren,Tao Wang,Jian-Hui Jiang,Jianjun He
Dysfunctional transcription factors that activate abnormal expressions of specific proteins are often associated with the progression of various diseases. Despite being attractive drug targets, the lack of druggable sites has dramatically hindered their drug development. The emergence of proteolysis targeting chimeras (PROTACs) has revitalized the drug development of many conventional hard-to-drug protein targets. Here, the use of a palindromic double-strand DNA thalidomide conjugate (PASTE) to selectively bind and induce proteolysis of targeted activated transcription factor (PROTAF) is reported. The selective proteolysis of the dimerized phosphorylated receptor-regulated Smad2/3 and inhibition of the canonical Smad pathway validates PASTE-mediated PROTAF. Further aptamer-guided active delivery of PASTE and near-infrared light-triggered PROTAF are demonstrated. Great potential in using PASTE for the selective degradation of the activated transcription factor is seen, providing a powerful tool for studying signaling pathways and developing precision medicines.
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CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Jie Ding,Zi Qiao,Yusheng Zhang,Danrui Wei,Suping Chen,Jiajia Tang,Lu Chen,Dan Wei,Jing Sun,Hongsong Fan
Conductive and self-healing hydrogel sensor is perspective in human-machine interaction applications. However, the design of ideal self-healing hydrogels are always challenging. Herein, by introducing disulfide modified Ag nanowires (AgNWs), we show a novel self-healing hydrogel strain sensor with superior mechanics, conductivity, antibacterial property , and firstly realizing of self-healing with both recovery of mechanics and sensing properties. We demonstrate that the covalent and reversible non-covalent hydrophobic blocks in hydrophobic modified polyacrylamide (HMPAM) achieves the basic self-healing network; dextran with plentiful hydroxyl groups synergistic helps the self-healing by hydrogen bonds ; disulfide on the AgNWs surface forms a NIR-responsive and dynamic Ag-S coordination bridge between HMPAM and AgNWs. The resulted hydrogel sensor exhibits comprehensive electromechanical properties, and precisely monitors human motion and subtle electromyography (EMG) signals. Importantly, we firstly achieved the recovery of sensing properties on human motion detection and EMG signal detection after self-healing. This work provides a promising exploration to manufacture bionic strain sensors for potential applications in wearable electronics.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Zengyue Li,Nan Kang,Yixun Jin,Weiyan Yao,Jin Cheng,Zimei Liu,Xiaoqing Qian,Qian Zhang
Accurate diagnosis and effective treatment of pancreatic cancer are essential to improving survival rates, yet current strategies are highly limited by toxicity of therapeutic drugs and efficacy challenges. Herein, we proposed a biodegradable nanosystem (denoted as MnCO3–BSA@DOX/IR820) based on manganese carbonate (MnCO3) loaded with doxorubicin (DOX) and photothermal agent IR820. This platform integrates chemotherapy with photothermal/photodynamic therapy (PTT/PDT) under 808 nm laser irradiation, achieving synergistic antitumor efficacy against pancreatic cancer. Specifically, the MnCO3-based nanosystem can enhance tumor accumulation, while the hydrogen peroxide (H2O2)-enriched acidic tumor microenvironment (TME) triggers oxidative stress pathways to generate reactive oxygen species (ROS). Upon 808 nm laser irradiation, IR820 is activated to exert a combined therapeutic effect. It mediates PDT to generate ROS, while the localized hyperthermia induced by PTT causes direct cellular apoptosis and facilitates DOX release, thereby enhancing therapeutic efficacy. Additionally, the nanosystems integrate magnetic resonance imaging (MRI) and near-infrared fluorescence (NIR) imaging capabilities, enabling real-time treatment monitoring and precise diagnosis. In vivo studies demonstrated that MnCO3–BSA@DOX/IR820 nanosystems effectively inhibit tumor growth without causing notable damage to normal tissues. Therefore, this pH-responsive and MRI/NIR imaging-guided nanoplatform represents a targeted theranostic system for pancreatic cancer, enabling chemo-PTT/PDT synergy.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yixin Wang,Ye Zhang,Mengshu Xu,Zhuoran Yang,Wei Guo,Chunyu Yang
Breast cancer is one of the most prevalent malignant tumors worldwide and a leading cause of cancer-related mortality, underscoring the urgent need for innovative therapeutic strategies. In this study, we developed an injectable hydrogel-based system, in which polyvinylpyrrolidone (PVP)-modified NiS 2-x @PVP nanospheres were incorporated with metformin hydrochloride (MH) and dispersed in a hyaluronic acid (HA) hydrogel matrix to form the NiS 2-x @PVP@HA tumor treatment platform. This system exhibits excellent photothermal performance under near-infrared (NIR) light irradiation and can be employed for tumor photothermal therapy (PTT). The Ni 2+ released from the degradation of NiS 2-x @PVP nanospheres can catalyze the decomposition of endogenous hydrogen peroxide in tumor cells, thereby generating toxic hydroxyl radicals for chemodynamic therapy (CDT). By altering the HA concentration, the internal pore structure, mechanical properties, drug release behavior, and swelling capacity of the hydrogel can be modulated. The loaded antitumor drug MH further enhances the therapeutic efficacy. Under NIR and ultrasound stimulation, this platform enables controlled drug release. In vitro and in vivo experiments have demonstrated that the NiS 2-x @PVP@HA hydrogel achieves the synergistic treatment of PTT/CDT/chemotherapy for tumor tissues. Kyoto Encyclopedia of Genes and Genomes pathway analysis suggested that activation of the MAPK signaling pathway was a key mechanism underlying tumor cell death. This work presents a rational design strategy that addresses the related challenges in breast cancer and promotes precise cancer therapy.
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Nano Today
·
2024
·
IF 13.2
Fapu Wu,Senyao Liu,Bingbing Zheng,Wenwen Cao,Yu Zhu,Jieyu Yang,Hu Xiong
Real-time monitoring of intestinal movement is critical for the clinical diagnosis of bowel diseases, however, the application of organic fluorophores in non-invasive imaging of the intestinal tract via systemic administration is still challenging. We herein report a series of albumin-chaperoned chloro-cyanine dyes for high spatiotemporal tracking of intestinal peristalsis and bowel disease in vivo. By adjusting the size of the central rings, Cy7–5 , with a five-membered ring and meso-chlorine, could covalently bind with circulating endogenous albumin in the blood, generating a bright and stable cyanine-albumin fluorescent complex with ∼1055 nm fluorescence in the near-infrared-II window in situ. Notably, Cy7–5 was able to clearly view intestinal peristalsis by harnessing the inherent intestine tropism of Cy7–5 -albumin complex following intravenous (i.v.) administration. Furthermore, a hydroxyl radical (·OH)-activatable fluorophore ( Hydro-Cy7–5 ) was created, allowing for the selective detection of overproduced ·OH in bowel disease as well as the successful visualization of the inflammatory intestinal tract in vivo after i.v. injection. This work provides a facile strategy for the investigation of intestinal movement and related diseases.
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