Drug Delivery and Translational Research
·
2022
·Vol. 13
·期 4
·983-993
·
IF 5.671
Tong Le,Zhou ZeYang,Wang Gang,Wu Chao
Oral absorption of docetaxel was limited by drug efflux pump p-glycoprotein (P-gp) and cytochrome P450 enzyme (CYP 450). Therefore, co-loading agent that inhibits P-gp and CYP450 in self-nanoemulsifying drug delivery systems (SMEs) is considered a promising strategy for oral delivery of docetaxel. In this study, curcumin was selected as an inhibitor of P-gp and CYP450, and it was co-encapsuled in SMEs to improve the oral bioavailability of docetaxel. SMEs quickly dispersed in water within 20 s, and the droplet size was 32.23 ± 2.21 nm. The release rate of curcumin from DC-SMEs was higher than that of docetaxel in vitro. Compared with free docetaxel, SMEs significantly increased the permeability of docetaxel by 4.6 times. And competitive experiments showed that the increased permeability was the result of inhibition of p-gp. The half-life and oral bioavailabilty of DC-SMEs increased about 1.7 times and 1.6 times than docetaxel SMEs, which indicated that its good pharmacokinetic behavior was related to the restriction of hepatic first-pass metabolism. In conclusion, DC-SME was an ideal platform to facilitate oral delivery of docetaxel through inhibited P-gp and CYP 450. Graphical Abstract
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International Journal of Electrochemical Science
·
2023
·
IF 1.5
Yu Zhang,Qiang Xie,Zhi Xia,Guofeng Gui,Ping Zhang,Lifen Meng,Ling Pan
In this study, a rapid and sensitive electrochemical sensor based on amino β-cyclodextrins (NH 2 -β-CD) functionalized graphene and multi-walled carbon nanotubes (MWCNTs) nanohybrids was successfully constructed for the simultaneous determination of p -aminophenol ( p -AP) and acetaminophen (AC). Graphene and MWCNTs were oxidized with strong acid to give carboxyl groups (COOH-f-GS/MWCNTs). Then, the NH 2 -β-CD was immobilized on its surface by EDC and NHS to prepare a porous hybrid nanocomposite (β-CD-NHCO-f-GS/MWCNTs). The composite material displays a well synergistic effect of high electrocatalytic activity and excellent conductivity of COOH-f-GS/MWCNTs and high supramolecular recognition capability of NH 2 -β-CD. The electrocatalytic mechanism and catalytic process are discussed. Under the optimum conditions, the detection limits of the as-prepared electrochemical sensor are 0.11 mM and 0.15 mM for p -AP and AC, respectively. The linear ranges are 1.0 mM to 1.32 mM for p -AP and 0.6 mM to 0.44 mM for AC. More importantly, this result was measured in the presence of each other. The electrochemical sensor can simultaneously display obvious and accurate response to p -AP and AC at different potentials with high sensitivity and less interferences.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Sun Zuyou,Zhou Jiali,Zhang Hui,Liu Zufan,Tao Shiyong,Xu Jing
The widespread used organoarsenicals have drawn attention for decades due to their potential environment risks. In this study, a heterogeneous system of goethite/oxalate irradiated using UVA light ( λ = 365 nm) was applied for the removal of ASA, a kind of organoarsenicals used in animal feeding operations as additives, from the aqueous phase through photodegradation. Results showed that the presence of 5 mM of oxalate significantly enhanced the photodegradation efficiency of ASA in the 0.1 g/L of goethite suspended system from 28 to ~100% within 180 min reaction at pH 5. Acid conditions favored the photoreaction rate, compared with neutral and basic conditions. This reaction process was also influenced by the initial concentration of oxalate and ASA. Furthermore, the mechanism study was conducted by quenching experiments and revealed the important roles of ·OH in the degradation of ASA in the goethite/oxalate/UVA system. By analyzing the reaction products, both inorganic arsenic (As(III) and As(V)) and ammonia were detected during the photodegradation of ASA. These findings help to gain a better understanding of the geochemical behavior of ASA in surface water and can also provide a potential treatment method for the organoarsenicals contaminated water.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 22
·1-21
·
IF 2.8
Nazir Ahsan,Huo Pengwei,Jagirani Muhammad Saqaf,Akram Muhammad Yasir,Wang Huijie
In this study, a plasmonic p–n heterojunction Ag@Ag 2 O–BiVO 4 photocatalyst was successfully prepared by a simple chemical precipitation-reduction process. The obtained samples were tested by various measurements and the photocatalytic behavior in the decomposition of tetracycline (TC) under irradiation with visible light was studied. The photodegradation study exhibits that Ag@Ag 2 O–BiVO 4 has the optimum activity and can efficiently degrade 83.52% of TC in 60 min by irradiation with visible light. Furthermore, the Ag@Ag 2 O–BiVO 4 exhibited more pronounced visible light absorption and the best performances than the BiVO 4 and Ag 2 O–BiVO 4 , which was mainly due to the LSPR of plasmonic Ag. The experimental radical trapping proved that the active species of the photocatalytic process act in the following order: ·O 2 − > h + > · OH. To find intermediates, the possible TC degradation pathways via HPLC–MS were also investigated. This research provides a successful method to develop a plasmonic photocatalyst with p–n heterojunction for wastewater treatment.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Ze Yu,Wei Ting Gao,Ying Jie Liu,Qiu Gen Zhang,Ai Mei Zhu,Qing Lin Liu
Anion exchange membrane fuel cells (AEMFCs), which are more economical than proton exchange membrane fuel cells (PEMFCs), stand out in the context of the rapid development of renewable energy. Superacid-catalyzed ether-free aromatic polymers have recently received a lot of attention due to their exceptional performance, but their development has been hampered by the trade-off between the dimensional stability and ionic conductivity of anion exchange membranes (AEMs). Here, we introduced fluoroketones containing different numbers of fluorinated groups (x = 0, 3 and 6) in the main chain of p-terphenyl piperidine because of the favorable hydrophobic properties of fluorinated groups. The results show that fluorinated AEMs can enhance OH − conductivity by building more aggregated hydrophilic channels while ensuring dimensional stability. The PTF6-QAPTP AEM with more fluorinated groups has the most excellent performance at 80 °C with an OH − conductivity of 142.7 mS cm −1 and a swelling ratio (SR) of only 4.55 %. Additionally, it exhibits good alkali durability, with the OH − conductivity and quaternary ammonium (QA) cation retaining at 93.45% and 92.6%, respectively, after immersion in a 2 M NaOH solution at 80 °C for 1200 h. In addition, the power density of the PTF6-QAPTP based single cell reaches 849 mW cm −2 when the current density is 1600 mA cm −2 . The PTF6-QAPTP based cell has a voltage retention of 88% after 80 h of stability testing at a constant current density of 300 mA cm −2 at 80 °C.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Yangsen Zeng,Feng Wei,Qingyun Liu,Yaojie Gao,Shengtao Gao,Yaohui Lv
As one of the energy storage devices, aqueous zinc ion hybrid capacitors (AZHCs) have been intensively investigated because of their characteristics of high gravimetric capacity, excellent safety and environmental compatibility. Yet, the preparation of highly active electrode materials for AZHCs is still a huge defiance. Herein, the superior energy density and anti-self-discharge AZHCs are achieved based on the P doped honeycomb-like carbons (PHCs) with high surface area, total pore volume and O/P functionalities, which prepared from the triphenyl phosphate by the salt template strategy. The unique structural characteristics of the PHC cathodes not only offer abundant active sites for Zn 2+ ion storage, but also supply lots of channels for ion transfer, resulting in rapid ion transport kinetics. Interestingly, the PHC 3 cathode presents high capacity of 150.1 mAh g −1 at 0.1 A g −1 , big energy and power output of 126.8 Wh kg −1 and 12.19 kW kg −1 and excellent cycle stability with capacity retention of 98.56% after 30,000 cycles. Moreover, the capacity keeps 87.77% of the initial capacity after rested for 250 h. This study offers a facile strategy to prepared carbon cathodes with the heteroatoms for high performance AZHCs.
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Journal of Water Process Engineering
·
2023
·
IF 7
Guanfeng Lin,Yongzhi Xiong,Guilong Wang,Simin Li,Rongyuan Jiang,Beili Lu,Yandan Chen,Biao Huang
Adsorption and selective adsorption are effective means of separating rare earths (REs) from aqueous solutions and reducing heavy metal contamination. In this work, bagasse was used as carbon source and phytic acid as phosphorus source and activator, and a simple synthesis strategy was applied to prepare the effective adsorbent P-doped porous carbon (PC) of lanthanum ions (La 3+ ). Doping of P was helpful to enhance the adsorption and selectivity of porous carbon to La 3+ . Compared with the samples without P-doping, the adsorption capacity of PC on La 3+ was increased by >4 times, and the theoretical maximum adsorption capacity is as high as 342.2 mg g −1 , which was greater than that of other reported carbon-based materials. In addition, the selective adsorption of PC on La 3+ was as high as 96.07 % and 71.07 % not only in the multi-ion coexistence system of La 3+ , Ni 2+ , Zn 2+ , Co 2+ , Ca 2+ , and Na + , but also in the La 3+ /Na + (1:50) coexistence system with very low La 3+ content, respectively. The adsorption of La 3+ on PC-800 is mainly chemisorption , where C-P-O, C/P=O and C-O-P groups are the main active sites for adsorption and improves the selectivity. This work can furnish some useful message on designing and synthesizing of carbon-based adsorbent, which has excellent adsorption selectivity in polyionic and low La 3+ coexistence systems.
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Catalysts
·
2023
·Vol. 13
·期 6
·1002
·
IF 3.9
Qi Wu,Dejin Zhang,Shu Sun,Chengcheng Liu,Cong Wang
The synthesis 2-tert-butyl-4-methylphenol is of great significance because of its wide application in industry, and the development of a highly efficient catalyst is necessary for the alkylation of p-cresol and tert-butyl alcohol. Here, an efficient and mild method was established. Caprolactam was chosen as the hydrogen-bonding acceptor; p-toluenesulfonic acid was employed as the hydrogen-bonding donor, and a deep eutectic solvent (DES) was prepared to catalyze the alkylation reaction. The structure of the deep eutectic solvent catalyst was characterized by1H NMR spectra, thermogravimetric analysis, and Fourier transform infrared spectra (FT-IR). In addition, response surface design based on the Box–Behnken method was employed to optimize the alkylation reaction process parameters, and the study of reaction kinetics was also carried out subsequently. The recycle performance of the catalyst was evaluated by recovery experiments, and a good result was obtained. By drawing comparisons with the literature reported, we provide a mild method for the synthesis of 2-tert-butyl-4-methylphenol.
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Advanced Science
·
2022
·Vol. 9
·期 32
·2203111
·
IF 17.521
Jing Guo,Ying Liu,Ping-An Chen,Xinhao Wang,Yanpei Wang,Jing Guo,Xincan Qiu,Zebing Zeng,Lang Jiang,Yuanping Yi,Shun Watanabe,Lei Liao,Yugang Bai,Thuc-Quyen Nguyen,Yuanyuan Hu
Doping is of great importance to tailor the electrical properties of semiconductors. However, the present doping methodologies for organic semiconductors (OSCs) are either inefficient or can only apply to some OSCs conditionally, seriously limiting their general applications. Herein, a novel p-doping mechanism is revealed by investigating the interactions between the dopant trityl tetrakis(pentafluorophenyl) borate (TrTPFB) and poly(3-hexylthiophene) (P3HT). It is found that electrophilic attack of the trityl cations on thiophenes results in the formation of tritylated thiophenium ions, which subsequently induce electron transfer from neighboring P3HT chains to realize p-doping. This unique p-doping mechanism enables TrTPFB to p-dope various OSCs including those with high ionization energy (IE ≈ 5.8 eV). Moreover, this doping mechanism endows TrTPFB with strong doping capability, leading to doping efficiency of over 80% in P3HT. The discovery and elucidation of this novel doping mechanism not only points out that strong electrophiles are a class of efficient p-dopants for OSCs, but also provides new opportunities toward highly efficient doping of various OSCs.
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ChemNanoMat
·
2022
·Vol. 9
·期 1
·e202200400
·
IF 3.82
Bo Zhu,Xu Lu,Jiadang Li,Wenhao Xie,Lifei Wang,Qiang Zhang,Jianfeng Fan,Yun Zheng
Graphical The substitution of iso-valent Bi for Sb is adopted to adjust the thermoelectric transport properties of the undoped Mg 3 Sb 2 compound. The improved power factor and figure of merit are obtained accordingly. Bismuth is the most common alloying element for high-performance Mg 3 Sb 2 -based thermoelectric compounds. However, the electrical and thermal transport data is lacking for undoped Mg 3 (Sb, Bi) 2 solid solutions. In this study, theoretical calculation results show that Bi alloying can reduce the band gap of Mg 3 Sb 2 , favoring the regulation of carrier concentration. Both Mg 3 Sb 2 and Mg 3 SbBi compounds present a single band structure on the valence band maximum at Γ of the Brillouin zone. Incorporating the Bi element can slightly increase the density of states (DOS) on the valence band maximum, which is beneficial for the Seebeck coefficient. Mg 3 Sb 2-x Bi x (0≤x≤0.8) compounds were experimentally prepared via ball milling (BM) combined with the spark plasma sintering (SPS) technique. The carrier concentration, electrical conductivity, and power factor of the samples tend to increase with the increasing Bi content. Bismuth alloying significantly reduces the total thermal conductivity in the low-temperature range, with the lowest value of 0.65 Wm −1 K −1 obtained at ∼400 K for the x=0.2 sample. The peak ZT value of 0.077 at 800 K and the average ZT of 0.051 in the temperature range of 450–800 K are obtained for the x=0.2 sample, which is 93% and 219% higher than those of the unalloyed sample, respectively. This work reveals the Bi-alloying induced transport mechanism and provides fundamental thermoelectric data regarding the undoped Mg 3 Sb 2-x Bi x (0≤x≤0.8) solid solutions.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Yue Wang,Jingrui Zhang,Xingwen Wang,Wei Meng,Dongmei Ren,Boran Tong,Chao Han
Electrocatalytic decomposition of water using bifunctional catalysts is a potential method for clean hydrogen energy production. In order to solve the weakness of present catalysts, this study rationally designed a novel iron-nickel bifunctional electrocatalyst of Fe x Ni 1−x @C, P composites prepared by pyrolysis and phosphorus doping of a FeNi-bimetal-organic framework (FeNi-MOF). The innovative combination of FeNi bimetallic co-doping, low-temperature curing and phosphating has bred an excellent electrocatalyst for the hydrogen evolution reaction (HER) in alkaline solution. When the mass ratio of phosphate to Fe x Ni 1−x @C 250–800 was 10:1, Fe x Ni 1−x @C 250–800 , P (10:1) showed the highest hydrogen evolution activity, obtaining a low 189 mV hydrogen evolution overpotential with a Tafel slope of 91.9 mV·dec −1 at 10 mA·cm −2 current density. Meanwhile, Fe x Ni 1−x @C 250–800 , P exhibited good stability during HER process. This work would open up a novel pathway for designing efficient and stable bifunctional electrocatalysts for water electrolysis as well as sustainable chemistry applications.
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ENVIRONMENTAL TECHNOLOGY
·
2022
·
IF 3.475
Yafang Zhang,Shuning Yang,Linsheng Wei,Xiaoyang Zhao,Xiangdong Lu
Photocatalysis is a promising technology for wastewater treatment. It is of great significance to find catalysts with high photoactivity. In this paper, a catalyst with high photocatalytic degradation efficiency to organic wastewater, carbon nitride modified by graphene quantum dots (SCN-GQDX), is prepared by supramolecular self-assembly thermal polycondensation method and doping graphene quantum dots (GQDs). The results show that SCN-GQD0.5 has the best catalytic performance, and its photocatalytic degradation efficiency to organic pollutants can reach 86% and still remains above 83% after five cycles, which shows the modified carbon nitride has high catalytic efficiency and stability. In a word, SCN-GQDX is a highly efficient, non-toxic and stable photocatalyst for organic pollutants in wastewater.
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