Journal of Materials Research and Technology-JMR&T
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2024
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IF 6.2
Qian Zhang,Jiawei Li,Qingdi Qu,Shuang Pan,Kunyang Yu,Yushi Liu
The challenge of precisely regulating temperature during the photo-thermal bone promotion remains unresolved. Phase change material (PCM), capable of undergoing a phase transition at a specific temperature, offers a solution by photothermal temperature regulation through the storage and release of heat. This study incorporated biocompatible polyethylene glycol (PEG) with specific phase transition points as PCM. A phase change hydrogel scaffold was then synthesized through semi-crosslinking PEG with calcium-ion-chelated sodium alginate (SA) acting as the structural framework. Additionally, the newly developed graphene oxide (GO) modified composite scaffolds (GO-PHSC), featuring 0.5 wt% GO, not only demonstrated outstanding photothermal conversion efficiency and an optimal phase change temperature (42.2 °C) but also exhibited desirable values for latent enthalpy (100 J/g) and latent heat recovered (LHR) (93.3%). Moreover, the form-stability test demonstrated the PCM scaffolds' exceptional resistance to leakage and maintenance of shape stability even at elevated temperatures (70 °C). Beyond achieving passive temperature control in photothermal therapy, experimental findings highlighted that the phase change hydrogel, incorporating calcium ions and GO, met various requirements such as physicochemical properties, microstructure, mechanics, mineralization, biocompatibility, and cell affinity. These collective attributes suggest that GO-PHSC emerges as a promising scaffold composite candidate for temperature-controlled photothermal therapy in bone regeneration.
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APPLIED SURFACE SCIENCE
·
2025
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IF 6.9
Songfeng E,Yuan Wang,Yuanming Wang,Jiaming Yang,Junli Ma,Kaiyue Huang,Zhangzi Li,Zhaoqing Lu,Lejia Wang
We discovered that incorporating the Ca 2+ into sodium alginate (SA) solution as ball-milling medium of hexagonal boron nitride ( h -BN) could increase the lateral size of the exfoliated h -BN nanosheets (BNNSs) at least twice those of pure SA solution obtained, which can be owing to the Ca 2+ −induced crosslinking of SA and enhancement of interfacial adhesion forces between SA and h -BN that not only boost the impacting resistance to milling balls but also the exfoliation energy to h -BN. Based on the crucial role of Ca 2+ in h -BN exfoliation, the large-area and small-thickness BNNSs are produced simultaneously with the increased milling speed and Ca 2+ concentration, which can be assembled into highly compact and horizontal oriented structures with aramid nanofibers (ANFs) due to the favorable compatibility, dispersity, and interfacial binding force. This kind of compact and ordered structure enables ANF/BNNS film with high thermal conductivity (TC) since the connective and high-efficiency heat conduction paths, of which the highest TC is 27.57 W⋅m −1 ⋅K -1 . Compared with soft and molecular SA chains, the ANFs show an incredible ability to guide the horizontal orientation of BNNSs for the superior TCs of their composites.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Xiangyan Xie,Xue Ao,Ruijuan Xu,Hongyi Lv,Shiqiao Tan,Jinrong Wu,Lijuan Zhao,Yi Wang
The combination of pharmacological and physical barrier therapy is a highly promising strategy for treating intrauterine adhesions (IUAs), but there lacks a suitable scaffold that integrates good injectability, proper mechanical stability and degradability, excellent biocompatibility, and non-toxic, non-rejection therapeutic agents. To address this, a novel injectable, degradable hydrogel composed of poly(ethylene glycol) diacrylate (PEGDA), sodium alginate (SA), and l -serine, and loaded with platelet-rich plasma (PRP) (referred to as PSL-PRP) is developed for treating IUAs. l -Serine induces rapid gelation within 1 min and enhances the mechanical properties of the hydrogel, while degradable SA provides the hydrogel with strength, toughness, and appropriate degradation capabilities. As a result, the hydrogel exhibits an excellent scaffold for sustained release of growth factors in PRP and serves as an effective physical barrier. In vivo testing using a rat model of IUAs demonstrates that in situ injection of the PSL-PRP hydrogel significantly reduces fibrosis and promotes endometrial regeneration, ultimately leading to fertility restoration. The combined advantages make the PSL-PRP hydrogel very promising in IUAs therapy and in preventing adhesions in other internal tissue wounds.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Guanqun Peng,Jia Hu,Jinnan Guo,Jiahui Dong,Yuanyuan Zhao,Tong Ye,Fengjun Xiao,Zhiyun Meng,Hui Gan,Ruolan Gu,Peng Han,Wenzhong Sun,Guifang Dou,Yunbo Sun,Shuchen Liu
The management of combined radiation-wound injury (CRWI) is a major clinical challenge owing to the delayed and prolonged wound-healing process. Moreover, the mechanisms underlying the healing of CRWI are complex, and chronic wounds can increase vulnerability to multidrug-resistant bacterial infections, vascular disease, and other adverse conditions. Although exosomes from iPSC-derived mesenchymal stem cells (iMSCs) can promote injury repair, the feasibility of encapsulating them within polysaccharide-based hydrogels to treat CRWI remains to be explored. Here, iMSC-derived exosomes were encapsulated within an injectable hydrogel (HACC/OSA) consisting of quaternized chitosan (HACC) and oxidized sodium alginate (OSA). The HACC/OSA hydrogel exhibited good self-healing properties, excellent injectability, and good biocompatibility. In mouse models of CRWI, the HACC/OSA hydrogel could form a protective barrier covering the wound. Due to the presence of quaternary ammonium salts, the hydrogel could provide long-term antimicrobial protection to the wound, which was favorable for wound healing. In addition, the hydrogel could also promote CRWI repair by stabilizing exosome release. The exosome-loaded hydrogel (HACC/OSA@Exos) significantly inhibited bacterial growth and promoted the repair of CRWI, as indicated by enhanced wound healing efficiency, rapid re-epithelialization, favorable collagen deposition, and abundant angiogenesis at the wound site. Together, the in vivo and in vitro results indicated that the exosome-loaded polysaccharide-based hydrogel (HACC/OSA@Exos) can promote the healing of CRWI and potentially serve as a valuable clinical agent for CRWI management.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Haixin Chen,Ziyun Zhou,Bingde Zheng,Hongjie Yang,Yi Chen,Yayan Huang,Na Zhang,Xueqin Zhang,Meitian Xiao,Jing Ye,Yucheng Yang
As environmental awareness grows, developing non-toxic, environmentally friendly, and biodegradable water- and oil-resistant coating layers using bio-based materials for paper-based packaging has become a key field of research. In this work, sodium alginate (SA) and sodium carboxymethyl cellulose (CMC) were used as the oil-resistant coating layer, while shellac (LAC) and ethyl cellulose (EC) formed the water-resistant coating layer, to produce a water- and oil-resistant coated paper. The effect of the mass ratio of these materials on performance was analyzed, demonstrating that the interaction between SA and CMC enhances the compactness of coating, thereby improving oil resistance. Similarly, the addition of LAC to EC increases coating compactness, which improves water resistance. The resulting coated paper has excellent water resistance (Cobb value: 3.42 g/m 2 ) and oil resistance (Kit rating: 12/12) and shows no leakage after holding hot water and hot oil for 30 min, indicating good resistance to both. Additionally, the coated paper demonstrates good mechanical properties, thermal stability, biodegradability and recyclability. The materials used are widely available and low-cost, and the preparation method is straightforward, making this research highly valuable for advancing paper-based packaging materials.
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高影响因子
MOLECULES
·
2024
·Vol. 29
·期 19
·4518
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IF 4.2
Pengbo Chang,Shuyang Zhou,Tongchao Wang,Dangling Hua,Shiliang Liu,Oseweuba Valentine Okoro,Armin Shavandi,Lei Nie
This study investigates the removal efficiency of Cu2+from wastewater using a composite hydrogel made of carbon nanotubes (CNTs), sodium alginate (SA), and polyacrylic acid (PAA) prepared by free radical polymerization. The CNTs@SA/PAA hydrogel’s structure and properties were characterized using SEM, TEM, FTIR, XRD, rheology, DSC, EDS, elemental mapping analysis, and swelling. The adsorption performance for Cu2+was tested in batch adsorption experiments, considering the pH, dosage, initial concentration, and contact time. The optimal conditions for Cu2+removal were pH 5.0, an adsorbent dosage of 500 mg/L, and a contact time of 360 min. The adsorption followed pseudo-second order kinetics. Isotherm analyses (Langmuir, Freundlich, Temkin, Dubinin–Radushkevich, Sips, Toth, and Khan) revealed that the Freundlich isotherm best described the adsorption, with a maximum capacity of 358.52 mg/g. A thermodynamic analysis indicated that physical adsorption was the main interaction, with the spontaneity of the process also demonstrated. This study highlights the high efficiency and environmental friendliness of CNT@SA/PAA composites for Cu2+removal from wastewater, offering a promising approach for water treatment.
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ACS Applied Materials & Interfaces
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2024
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IF 8.3
Guohua Wang,Yicheng Wang,Guoqiang Lu,Shiyu Dong,Ruifen Tang,Yingying Zhao,Jun Nie,Xiaoqun Zhu
Hydrogel tubes made of sodium alginate (SA) have potential applications in drug delivery, soft robots, biomimetic blood vessels, tissue stents, and other fields. However, the continuous preparation of hollow SA hydrogel tubes with good stability and size control remains a huge challenge for chemists, material scientists, and medical practitioners. Inspired by the plant apical growth strategy, a new method named soft cap-guided growth was proposed to produce SA hydrogel tubes. Due to the introduction of inert low gravity substances, such as air and heptane, into the extrusion needle in front of calcium chloride solution to form a soft cap, the SA hydrogel tubes with controllable sizes were fabricated rapidly and continuously without using a template through a negative gravitropism mechanism. The SA hydrogel tubes had good tensile strength, high burst pressure, and good cell compatibility. In addition, hydrogel tubes with complex patterns were conveniently created by controlling the motion path of a soft cap, such as a rotating SA bath or magnetic force. Our research provided a simple innovative technique to steer the growth of hydrogel tubes, which made it possible to mass produce hydrogel tubes with controllable sizes and programmable patterns.
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Biomaterials Advances
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2025
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IF 6
Lei Wang,Huainian Wang,Haoming Dang,Baolong Niu,Hong Yan,Ruijie Guo,Huifang Wang,Pucha Zhou
Effective wound dressings play an important role in preventing infections and promoting wound healing. Most polysaccharide-based hydrogel dressings have the drawbacks of weak tissue adhesion and poor antibacterial properties. Herein, a multifunctional dopamine-grafted oxidized sodium alginate-methacrylated carboxymethyl chitosan/gallic acid‑copper(II) complex (OD-CM/GA-Cu II UV ) hydrogel was fabricated through Schiff base bonds and photo-crosslinked polymerization between dopamine-grafted oxidized sodium alginate (OSA-DA) and methacrylated carboxymethyl chitosan (CMC-MA), with the integration of gallic acid‑copper(II) complexes (GA-Cu II ). The double cross-linked network and mussel-inspired adhesion mechanism endowed the hydrogel with attractive physicochemical properties, including excellent self-healing properties, pH-responsive biodegradability, robust toughness, and a maximum adhesion strength of 15.06 kPa. Moreover, the composite hydrogel exhibited an antibacterial ratio of > 99 % against Escherichia coli and Staphylococcus aureus , as well as good antioxidant activity. The MTT assay showed that the cell viability of the composite hydrogel reached > 85 %. The in vivo full-thickness skin defect healing assays in rats demonstrated that the composite hydrogel remarkably accelerated wound repair by attenuating the inflammatory response and promoting epithelial tissue remodeling. Therefore, this novel multifunctional hydrogel has potential applications in biomedical wound dressing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Shuxin Wang,Chenxia Guan,Pu Wang,Donghui Wang,Hanqi Wang,Ryan Chak Sang Yip,Hao Chen
Probiotics offer numerous beneficial functions for human bodies, while the low survival rate under gastric acid and short retention time in the intestine are the major obstacles to their utilization. To address these issues, we designed a novel dual-network hydrogel microsphere that combines gastric acid resistance with enhanced mucoadhesion, aiming for the targeted delivery of probiotics. Thiolated oxidized guar gum (SOGG) was disulfide-linked to form the first network, and sodium alginate (SA) was cross-linked with Ca 2+ to form the second network. Under the protection of the interpenetrating dual network microspheres, a much higher viability of Lactobacillus rhamnosus (LGG) (8.73 log CFU/mL) was achieved in simulated gastric fluid, compared to the zero-survival rate of free LGG. Mucoadhesion tests showed that the adhesion rate of SOGG/SA microspheres to the intestinal mucosa was 1.75 times higher than that of thiol-free microspheres. In vivo studies revealed that LGG-loaded microspheres significantly enhanced intestinal barrier function, remodeled the gut microbiome, and alleviated DSS-induced colitis in mice. Overall, SOGG/SA microspheres provide an effective strategy to the challenges of probiotic reduction in the stomach and rapid expulsion from the intestines, enhancing their health benefits.
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CARBOHYDRATE POLYMERS
·
2024
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IF 10.7
Hongyang Zhou,Qi He,Xuran Liu,Qianqian Jiang,Dawang Chu,Qiong Wang,Xuan Yang,Tongling Zhang,Hongkun Wang,Zhenglong Li
Cellulose has outstanding potential for application in energy storage batteries due to its high temperature resistance, high electrolyte affinity, renewability, and suppression of the shuttle effect, but single cellulose membranes still suffer from problems such as inhomogeneous pore distribution and unstable three-dimensional network structure. In this study, a green and sustainable regenerative cellulose (RC)/sodium alginate (SA) gel electrolyte membrane is developed by sol-gel process, the double crosslinked network scaffold centered on Zn 2+ was constructed by the synergistic hydrogen-bonding and metal ion- coordination network, the stable and uniform pore structure was also formed. The obtained RC-SA gel electrolyte membrane exhibits outstanding performance, featuring a dual crosslinked network with abundant pore structure and numerous polar groups that effectively enhance Zn 2+ transport, significantly improving battery cycling performance. The corresponding RC-SA gel electrolyte membrane demonstrates high ionic conductivity (6.30 mS·cm −1 ) and Zn 2+ transference number (0.66), leading to excellent reversible capacity (159 mA·h·g −1 ) and self-discharge suppression capability (maintaining 99.2 % of capacity after a 24 h standstill) in Zn//V 2 O 5 full-cell. The coulombic efficiency and cycling stability of the Zn//Cu half-cell and Zn//Zn symmetric cell using RC-SA gel electrolyte membrane outperforms that of the glass fiber separator, highlighting its multifunctionality and potential applications.
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Analytical Methods
·
2024
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IF 2.7
Wenjuan Wang,Danrong Chen,Yujiao Cai,Zijing Liu,Hongfen Yang,Hongbin Xie,Jinquan Liu,Shengyuan Yang
Herein, we presented a paper-based POCT sensor based on lactate dehydrogenase-mediated alginate gelation combined with visual distance reading and smartphone-assisted colorimetric analysis dual-signal to determine the concentrations of L-lactate in yogurt samples. In this research, L-lactate was transformed to pyruvate by lactate dehydrogenase. The pyruvate then triggered the gelation of the sol mixture, increasing the viscosity (ηs) of the mixture, which showed a decrease in diffusion diameter on the paper-based sensor. Also, protons from pyruvate accelerated the degradation of Rhodamine B, causing color fading of the mixture, which could be analyzed by a RGB analysis application software. Under the optimal experimental conditions, the linear ranges of the visual distance reading and smartphone-assisted colorimetric analysis were 0.1-15 μM for the former and 0.3-15 μM for the latter, and the detection limits were 0.03 μM and 0.07 μM, respectively. As a proof-of-concept application, we then exploited the paper-based sensor to determine the concentrations of L-lactate in yogurt samples. The results from the dual-signal paper-based sensor are consistent with the ones from HPLC analysis. In short, this study developed a simple, convenient, cost-effective and feasible method for the quantitative detection of L-lactate in real samples.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Song Lv,Xiaojie Lian,Haonan Feng,Bo Yang,Zehua Liu,Tong Fu,Liqin Zhao,Di Huang
Although 3D printed scaffolds are widely used in irregularly shaped bone defects, additional steps often need to be introduced when fabricating structures with curvature. In contrast, 4D printing has a unique advantage in the fabrication of scaffolding with a curved structure. Bone defects such as skull is generally curved, so a self-bending scaffold would be more appropriate for the cranial defect site. This paper presents a novel self-bending SAGMA hydrogel was loaded with nano-spherical mineralized collagen, then fabricated by a 4D printing method, which achieves adjustable self-bending through three-step crosslinking. When subjected to UV light irradiation, variations in gradient of photo-crosslinking are induced within the scaffold. This gradient of photo-crosslinking serves as the foundation for the scaffold's self-bending. The scaffold exhibited self-bending after crosslinking with calcium ions and chitosan, respectively, with curvature ranging from 0.05 mm −1 to 0.446 mm −1 . In vivo experiments demonstrated the efficacy of the scaffold in enhancing the repair of cranial bone defects and promoting new bone formation in rats, as evidenced by microcomputed tomography and histochemical analysis. Therefore, this self-bending scaffold provides a potentially effective method for the clinical treatment of skull defects with curvature.
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