Materials Today Bio
·
2025
·
IF 10.2
Yaozhi He,Siyuan Zou,Jiawei Wang,Wenbin Zhang,Sheng Lu,Mengxian Jia,Yumin Wu,Xiaowu Lin,Ziwei Fan,Qishun Liang,Yizhe Sheng,Qichuan Zhuge,Bi Chen,Minyu Zhu,Honglin Teng
Spinal cord injury (SCI) causes devastating neurological deficits, and cellular senescence critically contributes to the pathogenesis of various diseases. Notably, endothelial cells (ECs) senescence exerts a pivotal effect on the pathogenesis following SCI. In this study, we found that the number of senescent ECs increased by 18.87% ± 5.91%, and the disruption of the blood-spinal cord barrier (BSCB) was aggravated with an 18% increase in Evans Blue dye extravasation in diabetic mice with spinal cord injury (DM-SCI). To address this pathological process, a bioinspired nanotherapeutic platform utilizing milk-derived small extracellular vesicles with platelet membrane fusion (PM-sEVs) was developed for the targeted delivery of curcumin (Cur). In vitro , PM-sEVs-Cur effectively mitigated HG/IL-1β-induced HUVECs senescence by 54.19% ± 5.39% and increased expression of the tight junction protein ZO-1 by 4.33-fold. Mechanistically, Cur attenuated HUVECs senescence by activating the NRF2/HO-1 pathway. In vivo , platelet membrane modification enhanced the lesion targeting of sEVs. Treatment with PM-sEVs-Cur attenuated ECs senescence by 34.96% ± 6.59%, preserved BSCB integrity with a 17% reduction in Evans Blue dye extravasation, promoted axonal regeneration with a 6.36-fold increase in neurofilament expression, and improved motor function recovery with an increase of 2.4 ± 0.55 points in Basso Mouse Scale score in DM-SCI. This study highlights PM-sEVs-Cur as a promising therapeutic delivery platform for DM-SCI treatment.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Ran Wei,Shuyi Zhao,Chuandong Fang,Long Jiao,Xiaoye Zhang,Xiang Chen,Soottawat Benjakul,Bin Zhang
To improve the water solubility and photodynamic inactivation (PDI) activity of curcumin (Cur), a novel methoxy polyethylene glycol amine (mPEG-NH 2 )-modified Cur derivative, mPEG-NH-Cur, was synthesized and characterized. The results showed that mPEG-NH-Cur had extremely high water solubility with a saturated solubility of 6.71 mg/mL, which was 15-fold that of Cur. Theoretical calculations revealed that the introduction of PEG markedly enhanced hydrogen bonding, electrostatic interactions, and van der Waals interactions between mPEG-NH-Cur and H 2 O while simultaneously reducing the energy gap to its excited state. These effects contributed to its enhanced stability and resistance to aggregation in aqueous solutions, thereby significantly improving its capacity for singlet oxygen ( 1 O 2 ) generation (achieving 100 % degradation of 1,3-diphenylisobenzofuran within 30 s). In the PDI preservation experiments, the peeled Pacific white shrimp ( Litopenaeus vannamei ) treated with mPEG-NH-Cur showed the greatest sensory acceptability after eight days of storage at 4 °C compared to the control group. Moreover, the inhibitory effects of mPEG-NH-Cur-mediated PDI treatment on the total volatile basic nitrogen content, pH, thiobarbituric acid value, and total viable count were significantly higher than those of the control group. Ultimately, the use of mPEG-NH-Cur increased the refrigerated shelf life of the peeled L . vannamei by 8 days. Further, the weak interaction analysis demonstrated that PEG effectively suppressed molecular aggregation through enhanced hydrogen bonding and steric hindrance over an extended duration (40,000 ps), thereby improving aqueous solubility and dispersion stability. Overall, the findings of this study provide novel insights into the potential application of Cur derivatives in PDI preservation.
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Materials Today Communications
·
2025
·
IF 4.5
Gengsheng Shi,Wenqin Yin,Jing Luo,Song Lin,Linluo Zhang,Yuan He,Hui Ding
This study developed transferrin (Tf) -functionalized magnetic nanoparticles (Tf-MNP-PEG-PLGA-Cur) to enhance curcumin (Cur)’s therapeutic potential for lung cancer. Tf-MNP-PEG-PLGA-Cur was synthesized by chemically coupling Tf (tumor-targeting ligand) to the surface of MNP-PEG-PLGA-Cur. Its size and morphology were measured, in vitro drug release was evaluated via dialysis, oral bioavailability and tissue distribution were studied in rats and mice. Cytotoxicity to normal cells was tested by CCK-8, A549 cell uptake was observed by confocal laser microscopy, and in vitro anti-lung cancer activity was studied using MTT assay. In vivo, its distribution in tumor-bearing nude mice was detected by near-infrared imaging, followed by measuring tumor growth and histopathological observation. Tf-MNP-PEG-PLGA-Cur nanoparticles had a small size (137.39 ± 3.72 nm, PDI 0.224 ± 0.010) with a biphasic release pattern, longer half-life (P<0.05), and 186% relative oral bioavailability. It promoted Cur accumulation in tissues, especially liver and spleen. Both Tf-MNP-PEG-PLGA-Cur and Cur showed good cytocompatibility. Tf-MNP-PEG-PLGA-Cur enhanced curcumin's anti-lung cancer activity in vitro and in vivo, indicating good tumor-targeting. H&E staining showed it protected nude mice's vital organs and inhibited tumor growth. Tf-MNP-PEG-PLGA-Cur is a promising polymeric sustained-release curcumin preparation, improving oral bioavailability and anti-lung cancer activity.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Qiongrui Jiang,Junxian Guo,Xiaoxian Wu,Xiyan Shen,Xiaoyun Li,Chengjun Fang,Zhuohong Yang,Zhuangzhuang Chu,Yang Hu
Bio-based waterborne polyurethane (WPU) films have attracted much attention to replacing plastic films in food packaging fields. Despite recent clear progress in constructing bio-based WPU films, it is still a challenge to fulfill suitable mechanical property, high water and gas-resistant behavior, outstanding UV-blocking performance, favourable antioxidant and antibacterial activities at the same time in a bio-based WPU film. Herein, curcumin (Cur)-loaded soybean oil-derived WPU multifunctional films are developed by an in-situ emulsion encapsulation method. The results indicate that Cur is homogeneously embedded in WPU film matrix, and interacts with WPU chain through hydrogen bonds to compactify film structure. And the incorporation of Cur can significantly enhance the overall performances of WPU films. The optimal WPU film displays favourable mechanical property with the tensile strength of 10.95 MPa and strain at break of 1511.02 %, high water barrier performance with water contact angle of 100.9° and water vapor permeability rate of 0.77 × 10 −10 g·m −1 ·s −1 ·Pa −1 , favorable gas barrier behavior with the oxygen and carbon dioxide permeabilities of 1.24 × 10 −10 g·m⁻¹ ·s⁻¹ ·Pa⁻¹ and 2.49 × 10 −10 g·m⁻¹ ·s⁻¹ ·Pa⁻¹ , and the nearly complete UV-blocking capability. Furthermore, the optimal WPU film demonstrates remarkable antioxidant activity with ABTS radical scavenging rate as high as 98.02 %, clear antibacterial ability with the inhibition rates of 89.35 % against E. coli and 98.33 % against S. aureus . Interestingly, the results of litchi preservation tests imply that Cur-loaded WPU films effectively delay litchis deterioration and extend litchis shelf life. This study provides a robust strategy for designing high-performance, bio-based active packaging films for fruit preservation application fields.
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MOLECULES
·
2023
·Vol. 28
·期 3
·1321
·
IF 4.6
Lingyun Tu,Yifeng Fan,Yongfei Deng,Lu Hu,Huaiqing Sun,Bisheng Zheng,Dengjun Lu,Chaowan Guo,Lin Zhou
Amphiphilic polysaccharides can be used as wall materials and applied to encapsulate hydrophobic active chemicals; moreover, there is significant demand for novel medical high-molecular-weight materials with various functions. In order to prepare amphiphilic schizophyllan (SPG), octenyl succinic anhydride (OSA) was chosen to synthesize OSA-modified schizophyllan (OSSPG) using an esterified reaction. The modification of OSSPG was demonstrated through FT-IR and thermal analysis. Moreover, it was found that OSSPG has a better capacity for loading curcumin, and the loading amount was 20 μg/mg, which was 2.6 times higher than that of SPG. In addition, a hydrogel made up of PVA, borax, and C-OSSPG (OSSPG loaded with curcumin) was prepared by means of the one-pot method, based on the biological effects of curcumin and the immune-activating properties of SPG. The mechanical properties and biological activity of the hydrogel were investigated. The experimental results show that the dynamic cross-linking of PVA and borax provided the C-OSSPG/BP hydrogel dressing with exceptional self-healing properties, and it was discovered that the C-OSSPG content increased the hydrogel’s swelling and moisturizing properties. In fibroblast cell tests, the cells treated with hydrogel had survival rates of 80% or above. Furthermore, a hydrogel containing C-OSSPG could effectively promote cell migration. Due to the excellent anti-inflammatory properties of curcumin, the hydrogel also significantly reduces the generation of inflammatory factors, such as TNF-α and IL-6, and thus has a potential application as a wound dressing medicinal material.Keywords:schizophyllan;octenyl succinic anhydride;curcumin;PVA;hydrogel;wound-healing
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
·
2022
·
IF 5.112
Nan Jin,Ruotong Chen,Yuling Li,Ziyi Zhang,Baomei Zhang,Jianmin Chen
The aim is to achieve the targeting function of Aptamer 21-2 (Apt) by modifying glycyrrhizic acid (GA) to obtain Apt-GA and by delivering it through mesoporous silica in μm-size (μmS). Moreover, it is planned to induce synergistic effects of the novel amorphous preparation of Apt-GA with curcumin (Cur) in the treatment of psoriasis. UV/vis spectrophotometric analysis and Fourier transform infrared spectroscopy were performed to demonstrate the linkage of Apt and GA. The replacement of GA with Apt-GA in GA-Cur-μmS did not make a difference in the amorphous state, but showed superior fluorescence of Cur in the inflamed dermis similar to psoriatic induced by imiquimod. Consequently, compared to GA-Cur-μmS and Apt, Apt-GA-Cur-μmS exhibited less pronounced psoriatic characteristics in vivo , including Psoriasis Area and Severity Index, histological image, immunohistochemistry and immuno-fluorescence labeling neutrophils. The enzyme-linked immunosorbent assay showed a similar phenomenon that less IL-17A was observed after treatment with Apt-GA-Cur-μmS than with GA-Cur-μmS or Apt. Our finding suggests that this novel Apt delivery system achieved the Apt targeting function in the dermis by taking advantage of GA and μmS, and exhibited synergistic anti-psoriatic effect by co-delivering curcumin .
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FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Jiayuan Liu,Gongshuai Song,Like Zhou,Danli Wang,Tinglan Yuan,Ling Li,Guanghua He,Gongnian Xiao,Jinyan Gong
In this study, we systematically compared the differences in the interactions of β-lactoglobulin (LG) with three mono-caffeoylquinic acids (MCQAs: 3-CQA, 4-CQA, and 5-CQA) and three dicaffeoylquinic acids (DCQAs: 3,4-DCQA, 3,5-DCQA, and 4,5-DCQA). Based on molecular docking techniques, it was concluded that the non-covalent binding of all six caffeoylquinic acids to LG was dominated by hydrophobic forces, among which the binding ability of DCQAs was stronger. The antioxidant assay revealed that caffeoylquinic acid significantly improved the antioxidant properties of LG, and the best antioxidant properties were achieved with 4,5-DCQA. The DPPH radical scavenging ability was increased by approximately 54 μmol Trolox/g-sample, and the ABTS radical scavenging ability increased by 29.26 μmol Trolox/g-sample. Six non-covalent complexes were used to embed curcumin , and the stability of the formed solution was further investigated and compared.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Runan Zhao,Haocheng Guo,Tianyi Yan,Jiaheng Li,Weidong Xu,Yong Deng,Jianwei Zhou,Xingqian Ye,Donghong Liu,Wenjun Wang
A new multifunctional film with active and intelligent effects was developed by incorporating curcumin-clove oil emulsion into natural materials. The basic properties, functional characteristics, and pH/NH 3 -sensitivity of films were investigated, and then these films were applied to extend shelf-life and monitor freshness of meat. Curcumin solution and emulsion illustrated significant color variations at different pH values. The incorporation of emulsion improved the UV–vis barrier and water resistance properties of films, which blocked most of UV-light and its water contact angle reached 100.03°. Meanwhile, the films had stronger mechanical strength and higher thermal stability, with elongation at break reaching 79.18 % and the maximum degradation temperature rising to 316 °C. Moreover, emulsion made films have a slow-release effect on clove oil, which not only enhanced the antioxidant property but also significantly improved their antibacterial activity. Additionally, the multifunctional films presented a significant color response to acidic/alkaline environments over a short time interval and could be easily identified by naked eyes. Finally, the films effectively extended the shelf-life of fresh meat by 3 days at 4 °C and visually monitored freshness through color changes in real-time. This knowledge provides insights and ideas for the development of novel food packaging with both active and intelligent functions.
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FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Jianglan Yuan,Ping Yan,Xiaocui Liu,Xu Kang,Yongguo Jin,Long Sheng,Jianxin Xia
This study explored the feasibility of a novel solid-like fat stabilized by porcine plasma protein (PPP) and carrageenan (CG) coupling emulsifier as curcumin delivery vehicle. The combination of 2.0% (w/v) PPP and 0.3% (w/v) CG successfully stabilized the oil of 80% (v/v) volume fraction at solid-like state, and the increasing of oil phase led to the increase in droplet size , storage modulus (G′) and apparent viscosity. Compared with free oil, oxidation of PPP-CG-stabilized solid-like fat could be significantly inhibited. The results from in vitro simulated digestion showed that the release rate of free fatty acids and bioaccessibility of curcumin in the solid-like fat were significantly higher than those in free oil, and curcumin was almost not released in simulated gastric fluid, but mainly released in simulated intestinal fluid. Therefore, PPP-CG-stabilized solid-like fat could be used as an effective nutrient delivery vehicle for food and pharmaceuticals, and the work provided some new insights into the structure design of functional food.
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Pharmaceutics
·
2022
·Vol. 14
·期 6
·1166
·
IF 6.525
Chennan Liu,Fangyuan Jiang,Zifeng Xing,Lihong Fan,Yuan Li,Shaoning Wang,Junhong Ling,Xiao-Kun Ouyang
We designed and synthesized aminated mesoporous silica (MSN-NH2), and functionally grafted alginate oligosaccharides (AOS) on its surface to get MSN-NH2-AOS nanoparticles as a delivery vehicle for the fat-soluble model drug curcumin (Cur). Dynamic light scattering, thermogravimetric analysis, and X-ray photoelectron spectroscopy were used to characterize the structure and performance of MSN-NH2-AOS. The nano-MSN-NH2-AOS preparation process was optimized, and the drug loading and encapsulation efficiencies of nano-MSN-NH2-AOS were investigated. The encapsulation efficiency of the MSN-NH2-Cur-AOS nanoparticles was up to 91.24 ± 1.23%. The pH-sensitive AOS coating made the total release rate of Cur only 28.9 ± 1.6% under neutral conditions and 67.5 ± 1% under acidic conditions. According to the results of in vitro anti-tumor studies conducted by MTT and cellular uptake assays, the MSN-NH2-Cur-AOS nanoparticles were more easily absorbed by colon cancer cells than free Cur, achieving a high tumor cell targeting efficiency. Moreover, when the concentration of Cur reached 50 μg/mL, MSN-NH2-Cur-AOS nanoparticles showed strong cytotoxicity against tumor cells, indicating that MSN-NH2-AOS might be a promising tool as a novel fat-soluble anticancer drug carrier.Keywords:pH-sensitive drug release;silica;brown algae oligosaccharides;curcumin;colon cancer cells
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Food Biophysics
·
2022
·Vol. 17
·期 4
·575-585
·
IF 3.34
Zhang Shangwei,Xu Xiaofei,Yang Jiguo,Ren Jie
Polyglycerol fatty acid esters (PGFEs), a type of nonionic surfactants, have been widely used in food industry. However, the effects of the aliphatic chain lengths in PGFEs and the concentrations of PGFEs on digestive profiles in emulsion-based systems are poorly understood. The present study has investigated the physicochemical stability, lipolysis dynamics and curcumin bioaccessibility in the nanoemulsions stabilized by synthesized PGFEs with different aliphatic chains (C 10 -C 18 ) at various concentrations using an in vitro gastrointestinal tract (GIT) model. Shorter aliphatic chain or higher concentrations of PGFEs resulted in smaller droplets in the emulsions before and during digestion. PGFEs concentration had different impacts on lipolysis dynamics of nanoemulsions depending on the aliphatic chain lengths of PGFEs. Furthermore, long aliphatic chain of PGFEs contributed to a greater rate and extent of lipolysis, but a lower bioaccessibility of curcumin compared with medium ones, which was attributed to the formation of insoluble calcium soaps induced by calcium ions. These results are expected to facilitate the application of PGFEs for developing optimized nanoemulsions in encapsulating poorly water-soluble nutraceuticals in functional food industry.
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Materials Today Chemistry
·
2021
·
IF 8.301
X. Xia,J. Shi,Q. Deng,N. Xu,F. Huang,X. Xiang
Mesoporous organosilica as drug delivery carriers capable of achieving improved cargo release, enhanced biodegradation, and direct imaging with prolonged circulation time and tracking cargo distribution is highly in demand for biomedical applications. Herein, we report a ditelluride-bridged mesoporous organosilica nanoparticle (DTeMSN)/polyethylene glycol-curcumin (PEG-CCM) nanocomposite through coassembly with oxidative/redox and self-fluorescent response. Tellurium is introduced into the silica framework for the first time as a drug delivery vehicle. In this case, the DTeMSNs as an inner core enable disassembly under oxidative and redox conditions via the cleavage of ditelluride bond, facilitating the drug release of doxorubicin (DOX) in a matrix degradation controlled manner. Through the systematical comparison of diselenide-bridged MSNs and DTeMSNs, DTeMSNs exhibit remarkable advantages in loading capacity, drug release, and degradation behavior, thereby significantly affecting the cytotoxicity and antitumor efficacy. The self-fluorescent response of PEG-CCM shell coated on the surface of DTeMSNs can real-timely track the cellular uptake, DOX release, and biodistribution owing to the intrinsic and stable fluorescence of CCM. Moreover, PEG-CCM could prolong circulation time, provide preferable drug accumulation in tumors, and increase antitumor efficacy of DOX-loaded DTeMSNs. Our findings are likely to enrich the family of organosilica that served as fluorescence-guided drug delivery carriers.
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