JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2024
·
IF 1.9
Haoda Zhang,Peng Deng,Zhou Wang,Yuxuan Bai,Yongjin Li
A facile rapid-combustion process was introduced for preparing magnetic CoxMgyCu(1-x-y)Fe2O4 nanoparticles, and to enhance their specific surface area and saturation magnetization, the optimization involved adjusting the element proportion, calcination temperature, and solvent amount. The optimal element proportion of x:y:(1-x-y) for CoxMgyCu(1-x-y)Fe2O4 nanoparticles was 0.1:0.7:0.2, and the effects of solvent amount, and calcination temperature were also investigated. The average particle size and specific surface area of Co0.1Mg0.7Cu0.2Fe2O4 nanoparticles calcined at 400 °C with 25 mL absolute alcohol were 17.9 nm and 56.96 m2/g, respectively; while demonstrating a saturation magnetization of 8.5 emu/g. To solve the increasingly severe issue of water pollution, these nanoparticles were employed to efficiently treat dye wastewater containing methyl blue (MB). After fitting kinetic and isotherm models, the adsorption process of magnetic Co0.1Mg0.7Cu0.2Fe2O4 nanoparticles for MB dominated by chemisorption and was a multilayer adsorption process. The adsorption isotherm experiments revealed a remarkable maximum adsorption capacity of methyl blue, reaching 2255.7 mg/g, within the concentration range of MB from 400 to 4000 mg/L. The thermodynamic analysis indicated the spontaneity of the exothermic adsorption process. The studies on the effect of pH also led to satisfying results; while the residual adsorption capacity could still remain 91.2% initial adsorbance after 12 times recycle. The outstanding recycling ability, resistance to ionic strength, and pH resistance distinguished the magnetic Co0.1Mg0.7Cu0.2Fe2O4 nanoparticles among vast adsorbents. These results highlight the significant potential of these nanoparticles for treating dye wastewater.
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APPLIED CATALYSIS A-GENERAL
·
2024
·
IF 4.7
Cong Wang,Gang Li,Zheng Huang,Anfeng Peng
Alkyl-aluminum, which is sensitive to air, has been a major obstacle to the development of ethylene oligomerization. Herein, LiAlH 4 is used as an effective alkyl-aluminum substitute. The performance of LiAlH 4 itself in the reaction is investigated, proving that it possesses moderate activity. Further addition of Versailles/Santa Barbara-1 (VSB-1) catalysts with different morphologies can effectively improve the reaction, in which VSB-1/LiAlH 4 presents the activity of 32.1 g ‧ g LiAlH4 −1 ·h −1 (154.1 g ‧ g VSB-1 −1 ‧h −1 ) and the selectivity of 1-butene, 1-hexene and 1-octene in all products could reach 51.4 %, 18.9 % and 7.9 %, respectively. The co-catalytic system is stable and the VSB-1 catalyst therein can be effectively reused at least three times under the suitable treatment conditions. In addition, the product analysis of the co-catalyzed system reveals that the addition of VSB-1 catalyst tended to produce 1-butene, 1-hexene and 1-octene at 20 bar. Based on above result, a possible reaction mechanism is proposed.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Haonan Zhang,Changhe Lu,Shuai Wang,Qinhua Zhang,Qiang Zhou,Shuxu Zhu,Chong Qi,Mingbo Wu,Wenting Wu
The utilization of O 2 for propylene epoxidation is a highly desirable reaction due to its 100 % atom economy. However, achieving this reaction under mild conditions presents a significant challenge. In this paper, we present a tandem reaction system that combines 4,4′-dibromobenzophenone (BP) modified carbon nitride (g-C 3 N 4 ) with titanium silicalite zeolite (TS-1) to enable the selective photooxidation of propylene into propylene oxide at room temperature, using O 2 as the oxygen source. The achieved production rate of propylene oxide was an impressive 1195 μmol/g cat. /h, with a selectivity exceeding 99 %. Furthermore, the catalyst exhibited no significant deactivation after 5 cycles. Spectra and in-situ capture experiments revealed that the reaction involved a two-step system, with photocatalytic production of H 2 O 2 and propylene epoxidation facilitated by H 2 O 2 ·H 2 O 2 was generated through O 2− and 1 O 2 pathways, with an in-situ utilization efficiency of H 2 O 2 reaching 82 %. This work presents a novel approach for the direct epoxidation of propylene using O 2 .
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Annals of Dermatology
·
2024
·
IF 1.5
Lin-Xia Liu,Zhi-Kai Liao,Bing-Qi Dong,Shan Jiang,Tie-Chi Lei
Background Although reports suggest that tranexamic acid (TXA) has clinical benefits for melasma patients by oral, intralesional and topical treatment, the optimal route of TXA therapy and the underlying mechanism involved remain poorly defined. Objective To compare the skin lightening effect between oral TXA and topical TXA and to dissect the molecular mechanisms using ultraviolet B (UVB)-induced hyperpigmentation mouse model, ex vivo cultured human skin explant, and cultured melanocytes (MCs) and endothelial cells. Methods Melanin content and cluster of differentiation 31 (CD31)-positive cell numbers were measured in tail skins from UVB-irradiated mice treated by intragastral or topical TXA using immunofluorescent and Fontana-Masson staining. The conditioned medium (CM) was harvested from human umbilical vein endothelial cells treated with or without 3 mM TXA and was used to treat MCs for 48 hours. mRNA and protein levels of tyrosinase and microphthalmia-associated transcription factor were measured using quantitative real-time reverse transcription polymerase chain reaction and western blotting assays. HMB45- and CD31-positive cell numbers as well as melanin content were also examined in ex vivo cultured human skin explants. Results The hyperpigmented phenotype were significantly mitigated in UVB-irradiated tail skin plus intragastral TXA-treated mice compared with mice treated with UVB only or with UVB plus topical TXA. CD31-positive cell numbers correlated with the anti-melanogenic activity of TXA therapy. The data from cultured cells and skin tissues showed that suppression of endothelin-1 (ET-1) in vascular endothelial cells by TXA reduced melanogenesis and MC proliferation. Conclusion Oral TXA outperforms topical TXA treatment in skin lightening, which contributes to suppression of ET-1 in dermal microvascular endothelial cells by TXA.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Zhixian Du,Yuan Gao,Zhuanzhuan Liang,Yanqing Yang,Weike Zhang
In this work, the Bi 2 WO 6 /KCC-1 photocatalytic composite was prepared by hydrothermal method using Bi 2 WO 6 as photocatalyst and KCC-1 as cocatalyst, for degradation of Rhodamine B (RhB). The result shows that when the mass percentage of KCC-1 in the composite is 7 % (BK-3), the photocatalytic degradation efficiency is the highest, reaching 90.63 %. Furthermore, the BK-3 composite shows a well degradation activity (83.90 %) even after four consecutive cycles of photocatalysis. Characterization of the photocatalyst by various testing techniques show that the BK-3 composite presents high visible light response, narrow energy band, and strong separation of photogenerated carriers. The results of free radical capture experiments indicate that the main active substance in the degradation of RhB under visible light is h + and ·O 2 − also plays a certain auxiliary role. This study offers promising prospects for the preparation of highly efficient photocatalysts through the modification of bismuth-based materials.
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CHEMICAL PAPERS
·
2024
·Vol. 78
·期 14
·7943-7950
·
IF 2.1
Li Zhigang,Liu Xuzhuo,Wang Chunlong,Song Hanbing,Zhang Jie
In this study, we synthesized zinc selenide (ZnSe)-polyacrylamide (PAM) nanomaterials for their potential application in treating knee osteoarthritis (KOA). Initially, we characterized the newly prepared material through various techniques including Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and nitrogen adsorption–desorption to confirm its identity as the desired product. The results demonstrated that ZnSe-PAM nanomaterial exhibited excellent water solubility, biocompatibility, and stability, along with a large surface area, making it suitable for use as a drug carrier. Subsequently, the material was loaded with the drug 1 to obtain ZnSe-PAM@1. Cellular and thermosensitive experiments were then conducted, revealing that this nanomaterial could facilitate drug release by generating heat, thereby reducing the level of microRNA-146a-5P and blocking the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/extracellular (PI3K/Akt/mTOR/ERK) signal-regulated kinase signaling pathway, thus alleviating the symptoms of KOA. These findings present a new direction for drug intervention in KOA and highlight the potential of developing ZnSe-PAM nanomaterials as novel drug carriers.
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JOURNAL OF MEDICINAL CHEMISTRY
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2024
·
IF 6.8
Yi Huang,Fengling Liu,Shuhua Ren,Yuanqing Ding,Man Chi,Weiwei Huang,Wenjing Gu,Hewen Qian,Yaxia Yuan,Shurong Hou,Xiabin Chen,Lei Ma
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease with an elusive etiology. Aberrant activation of c-Jun N-terminal kinase 1 (JNK1) has been implicated in its pathogenesis. Through a combination of structure-based drug design and structure–activity relationship (SAR) optimization, a series of pyrimidine-2,4-diamine scaffold derivatives have been developed as potent JNK1 inhibitors. Compound E1 was identified with low nanomolar JNK1 inhibitory potency (IC50 = 2.7 nM). The introduction of a dimethylamine side chain has significantly enhanced the ability of E1 to inhibit c-Jun phosphorylation, surpassing the clinical candidate CC-90001. Molecular dynamics simulations revealed a binding free energy of −50.46 kcal/mol for E1. Moreover, E1 displayed satisfactory pharmacokinetic properties, with a bioavailability of 69% in rats. Furthermore, compound E1 exerted significant antifibrotic effects in a bleomycin-induced IPF mouse model and prevented a TGF-β-induced epithelial-to-mesenchymal transition in vitro. These findings position E1 as a promising lead for further drug development targeting IPF.
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TALANTA
·
2025
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IF 6.1
Mengyu Du,Fangfang Sun,Yilin Sun,Zhenzhen Ma,Chenshuo Wang,Mengyu Liu,Ling Zhu,Hanchun Yao
Acute kidney injury (AKI) is a swiftly advancing condition that may result in kidney failure and pose a significant threat to life. Therefore, diagnosis of AKI is crucial for treating AKI and preventing the worsening of the condition. We developed a near-infrared fluorescent probe, CyO@CD-Ser, designed for the diagnosis of AKI. This probe targets kidney injury molecule-1 (KIM-1) and is activated by ONOO − . It consists of L-serine-modified β-cyclodextrin and compound CyO. In this system, ONOO − , a novel biomarker for AKI, triggers the oxidation of CyO to produce compound CyOH, resulting in a pronounced enhancement of near infrared fluorescence, offering a clear, visual signal for the detection of AKI. Through its modification with L-serine, β-cyclodextrin is able to efficiently penetrate cells by targeting KIM-1 receptors, thereby enhancing its specificity and effectiveness. In vitro and in vivo experiments demonstrate the probe's high sensitivity and biocompatibility, with a detection limit of 42.7 nM for ONOO − . Fluorescence is detectable in cisplatin-induced AKI after 12 hours, becoming significant at 24 hours. This suggests that CyO@CD-Ser can identify AKI earlier than traditional methods, offering a valuable tool for studying and diagnosing drug-induced AKI. Consequently, the probes we constructed can detect AKI early by precisely targeting and identifying biomarkers, preventing the deterioration of the condition, and providing an opportunity for early treatment for patients.
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CHEMICAL ENGINEERING JOURNAL
·
2025
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IF 13.2
Jihan Yang,Airong Li,Junping Guo,Zhihong Wang
The control of sulfur dioxide (SO 2 ) emissions from natural gas purification processes has become an urgent environmental priority due to increasing regulatory pressures and public concerns over air pollution. In this study, a series of 1-methylimidazolium-based ionic liquids ([MIM]-ILs) were synthesized and structurally characterized, followed by systematic evaluation of their SO 2 absorption capacities under simulated flue gas conditions (2000 ppm SO 2 ). Among them, [MIM]Lac showed the relatively better absorption performance, reaching a saturated capacity of 1.986 mol SO 2 per mol IL at a low concentration of 2000 ppm SO 2 . The regeneration experimental results demonstrated that [MIM]Lac achieved an optimal SO 2 removal efficiency of 99.71 % at 85 °C, indicating excellent thermal responsiveness. Even after 10 consecutive absorption-desorption cycles, [MIM]Lac retained 92.52 % of its initial absorption capacity, highlighting its outstanding cyclic stability and thermal durability. The insights based on FT-IR and 1 H NMR analyses revealed that SO 2 absorption by [MIM]Lac primarily involved the reversible chemical interactions between SO 2 and the lactate anion, particularly at the S O and S−O sites. This study provides a practical strategy for designing efficient SO 2 absorbents and the development of ionic liquid-based desulfurization systems.
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Reaction Chemistry & Engineering
·
2024
·Vol. 9
·期 3
·728-739
·
IF 3.4
Tongtong Wu,Weili Gao,Jiehe Zhang,Mingxu Hao,Shiyu Zhang,Haisheng Tao
As a typical antibiotic, tetracycline is ecotoxic and prone to bacterial resistance, producing superbugs and causing a public ecological crisis, thus raising the need to eliminate tetracycline from the aqueous environment. In this work, magnetic catalyst Fe3O4@HKUST-1 was prepared for catalyzing the degradation of tetracycline by persulfate. X-ray diffraction, scanning electron microscopy, and vibrating sample magnetometry were used to characterize the catalyst, and the results show that the catalyst had good crystallinity and magnetic properties. Tetracycline removal in the Fe3O4@HKUST-1/persulfate system reached 84.80%, and the catalyst was easily recovered from the solution due to its good magnetic properties. Mechanism analysis revealed that the non-radical pathway was the main degradation channel in the Fe3O4@HKUST-1/persulfate system, and 1O2 was the main reactive oxygen species generated from Ov on the surface of the Fe3O4@HKUST-1 catalyst. Tetracycline degradation was achieved by hydroxylation, demethylation, decarbonylation, dehydroxylation and the cleavage of C–N bonds. This finding holds significant value in further comprehension of the catalytic activation mechanism of metal–organic frameworks derivatives on persulfate and provides novel ideas for efficient water treatment technology development.
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CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Kai An,Hongyan Jia,Ruobing Cheng,Yong Guo,Xiaohui Liu,Yanqin Wang
Pt-based bimetallic catalysts have gained more and more attention in propane dehydrogenation (PDH), but still suffer from the high cost and poor stability. In this work, a PtCu@S-1 catalyst with an extremely low loading of Pt (0.047 wt%) is prepared by in-situ hydrothermal synthesis and employed in PDH. An excellent productivity (propylene yield: 471.8 molC 3 H 8 ⋅ g Pt -1 ⋅ h −1 ) is achieved at 600 °C with a weight hour space velocity of 25.80 h −1 . After 50 h of reaction at 600 ℃, 0.047Pt0.19Cu@S-1 catalyst still remains sinter-free, with a deactivation rate of only 0.006 h −1 . Various characterizations show that Cu 0 co-existed with Pt 0 in PtCu@S-1 catalyst plays an important role, greatly improved catalyst reactivity and stability. At high weight hour space velocity (44.5 h −1 ), the propylene productivity can reach 1056.4 molC 3 H 8 ⋅ g Pt -1 ⋅ h −1 . This work provides a new way for the design of extremely low Pt-loaded PDH catalysts with excellent performance at high temperatures.
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MOLECULES
·
2024
·Vol. 29
·期 19
·4564
·
IF 4.2
Yanglan Luo,Naixin Cao,Liling Huang,Lanlan Tang,Xuzhou Liu,Wenlong Zhang,Shilv Huang,Xiuchao Xie,Yong Yan
Sanghuang as a medicinal fungus in China has a history of more than 2000 years, and is known as the “forest gold”. Most notably, the polysaccharides of Sanghuangporus sp. have attracted widespread attention due to their significant bioactivity in recent years. At present, extensive studies are being carried out on the extraction methods, structural characterization, and activity evaluation of polysaccharides. Here, we aimed to evaluate the structure and bioactivity of LEPS-1, an exopolysaccharide derived from the S. sanghuang JM-1 strain. The structure was elucidated by chromatography/spectral methods and hydrolyzation, and the solubility, the antioxidant activity, hypoglycemic activity and immunomodulatory activity were investigated. Results showed that LEPS-1 contained a →2)-α-Manp(1→6)-α-Galp(1→[2)-α-Manp(1→] n →2,6)-α-Manp(1→6,2)-α-Manp(1→3)-α-Manp(1→ backbone substituted at the O -6 and O -2 positions with side chains. These two branching fragments were β-Manp(1→. The molecular weight of LEPS-1 is 36.131 kDa. The results of biological activity analysis suggested that LEPS-1 was easily soluble in water, with reducing capability and DPPH radical scavenging capability. Furthermore, the IC 50 values of LEPS-1 against α-amylase and α-glucosidase were 0.96 mg/mL and 1.92 mg/mL. LEPS-1 stimulated RAW264.7 cells to release NO, TNF-α and IL-6 with no cytotoxicity, showing potent potential for immunomodulatory activity. These findings describe a potential natural exopolysaccharide with medicinal value and a basis for the development of S. sanghuang exopolysaccharides.
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