SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Haonan Zhang,Changhe Lu,Shuai Wang,Qinhua Zhang,Qiang Zhou,Shuxu Zhu,Chong Qi,Mingbo Wu,Wenting Wu
The utilization of O 2 for propylene epoxidation is a highly desirable reaction due to its 100 % atom economy. However, achieving this reaction under mild conditions presents a significant challenge. In this paper, we present a tandem reaction system that combines 4,4′-dibromobenzophenone (BP) modified carbon nitride (g-C 3 N 4 ) with titanium silicalite zeolite (TS-1) to enable the selective photooxidation of propylene into propylene oxide at room temperature, using O 2 as the oxygen source. The achieved production rate of propylene oxide was an impressive 1195 μmol/g cat. /h, with a selectivity exceeding 99 %. Furthermore, the catalyst exhibited no significant deactivation after 5 cycles. Spectra and in-situ capture experiments revealed that the reaction involved a two-step system, with photocatalytic production of H 2 O 2 and propylene epoxidation facilitated by H 2 O 2 ·H 2 O 2 was generated through O 2− and 1 O 2 pathways, with an in-situ utilization efficiency of H 2 O 2 reaching 82 %. This work presents a novel approach for the direct epoxidation of propylene using O 2 .
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Kaifang Wang,Danlin Chen,Jiali Tang,Zihao Hong,Zhongtai Zhu,Ziyi Yuan,Zhihong Lin,Yuqi Liu,Raphael Semiat,Xuezhong He
Membrane gas separation technologies have emerged as highly prospective avenues for the selective separation of CO 2 . In this research, a novel array of mixed-matrix membranes (MMMs) was engineered, integrating two-dimensional nanosheets of MXene, specifically Ti 3 C 2 T x , into polymers of intrinsic microporosity (PIMs) to selectively separate CO 2 from N 2 . The inclusion of Ti 3 C 2 T x nanosheets, rich in polar functional groups, significantly increases the affinity between CO 2 molecules and the fabricated MMMs. Additionally, the precise modulation of the molecular diffusion channels for CO 2 and N 2 is achievable due to the interlayer spacing between MXene layers (∼0.35 nm) within the PIM-1 matrix. This innovation is predicated on the synergistic effect of solution-diffusion and molecular sieving mechanisms that underpin the gas separation process, leading to a marked improvement in both selectivity for CO 2 over N 2 and the permeability of CO 2 . Among the series, the MMMs with a 0.5 wt% MXene display exceptional separation efficiency, achieving a CO 2 permeability of 12475.3 barrer and a CO 2 /N 2 selectivity of 32.7. Notably, all the PIM-1/MXene membranes prepared with different compositions in this study exceed the Robeson upper bound defined in 2019, indicating their substantial promise for CO 2 separation and capture in industrial applications.
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LIFE SCIENCES
·
2024
·
IF 5.2
Kai Yang,Xiaoxiao Yu,Zihao Guo,Zhihao Fang,Hongyu Zhang,Wanyangchuan Zhang,Changxu Liu,Yanchao Ji,Zhichao Dong,Qiang Gu,Jiahao Yao,Chang Liu
Aims Non-alcoholic fatty liver disease (NAFLD) has risen as a significant global public health issue, for which vertical sleeve gastrectomy (VSG) has become an effective treatment method. The study sought to elucidate the processes through which PIM1 mitigates the advancement of NAFLD. The Pro-viral integration site for Moloney murine leukemia virus 1 (PIM1) functions as a serine/threonine kinase. Bioinformatics analysis revealed that reduced PIM1 expression in NAFLD. Methods To further prove the role of PIM1 in NAFLD, an in-depth in vivo experiment was performed, in which male C57BL/6 mice were randomly grouped to receive a normal or high-fat diet for 19 weeks. They were operated or delivered the loaded adeno-associated virus which the PIM1 was overexpressed (AAV-PIM1). In an in vitro experiment, AML12 cells were treated with palmitic acid to induce hepatic steatosis. Key findings The results revealed that the VSG surgery and virus delivery of mice alleviated oxidative stress, and apoptosis in vivo. For AML12 cells, the levels of oxidative stress, apoptosis, and lipid metabolism were reduced via PIM1 upregulation. Moreover, ML385 treatment resulted in the downregulation of the NRF2/HO-1/NQO1 signaling cascade, indicating that PIM1 mitigates NAFLD by targeting this pathway. Significance PIM1 alleviated mice liver oxidative stress and NAFLD induced by High-fat diet by regulating the NRF2/HO-1/NQO1 signaling Pathway.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2024
·
IF 1.9
Haoda Zhang,Peng Deng,Zhou Wang,Yuxuan Bai,Yongjin Li
A facile rapid-combustion process was introduced for preparing magnetic CoxMgyCu(1-x-y)Fe2O4 nanoparticles, and to enhance their specific surface area and saturation magnetization, the optimization involved adjusting the element proportion, calcination temperature, and solvent amount. The optimal element proportion of x:y:(1-x-y) for CoxMgyCu(1-x-y)Fe2O4 nanoparticles was 0.1:0.7:0.2, and the effects of solvent amount, and calcination temperature were also investigated. The average particle size and specific surface area of Co0.1Mg0.7Cu0.2Fe2O4 nanoparticles calcined at 400 °C with 25 mL absolute alcohol were 17.9 nm and 56.96 m2/g, respectively; while demonstrating a saturation magnetization of 8.5 emu/g. To solve the increasingly severe issue of water pollution, these nanoparticles were employed to efficiently treat dye wastewater containing methyl blue (MB). After fitting kinetic and isotherm models, the adsorption process of magnetic Co0.1Mg0.7Cu0.2Fe2O4 nanoparticles for MB dominated by chemisorption and was a multilayer adsorption process. The adsorption isotherm experiments revealed a remarkable maximum adsorption capacity of methyl blue, reaching 2255.7 mg/g, within the concentration range of MB from 400 to 4000 mg/L. The thermodynamic analysis indicated the spontaneity of the exothermic adsorption process. The studies on the effect of pH also led to satisfying results; while the residual adsorption capacity could still remain 91.2% initial adsorbance after 12 times recycle. The outstanding recycling ability, resistance to ionic strength, and pH resistance distinguished the magnetic Co0.1Mg0.7Cu0.2Fe2O4 nanoparticles among vast adsorbents. These results highlight the significant potential of these nanoparticles for treating dye wastewater.
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CHEMICAL PAPERS
·
2024
·Vol. 78
·期 14
·7943-7950
·
IF 2.1
Li Zhigang,Liu Xuzhuo,Wang Chunlong,Song Hanbing,Zhang Jie
In this study, we synthesized zinc selenide (ZnSe)-polyacrylamide (PAM) nanomaterials for their potential application in treating knee osteoarthritis (KOA). Initially, we characterized the newly prepared material through various techniques including Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and nitrogen adsorption–desorption to confirm its identity as the desired product. The results demonstrated that ZnSe-PAM nanomaterial exhibited excellent water solubility, biocompatibility, and stability, along with a large surface area, making it suitable for use as a drug carrier. Subsequently, the material was loaded with the drug 1 to obtain ZnSe-PAM@1. Cellular and thermosensitive experiments were then conducted, revealing that this nanomaterial could facilitate drug release by generating heat, thereby reducing the level of microRNA-146a-5P and blocking the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/extracellular (PI3K/Akt/mTOR/ERK) signal-regulated kinase signaling pathway, thus alleviating the symptoms of KOA. These findings present a new direction for drug intervention in KOA and highlight the potential of developing ZnSe-PAM nanomaterials as novel drug carriers.
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Reaction Chemistry & Engineering
·
2024
·Vol. 9
·期 3
·728-739
·
IF 3.4
Tongtong Wu,Weili Gao,Jiehe Zhang,Mingxu Hao,Shiyu Zhang,Haisheng Tao
As a typical antibiotic, tetracycline is ecotoxic and prone to bacterial resistance, producing superbugs and causing a public ecological crisis, thus raising the need to eliminate tetracycline from the aqueous environment. In this work, magnetic catalyst Fe3O4@HKUST-1 was prepared for catalyzing the degradation of tetracycline by persulfate. X-ray diffraction, scanning electron microscopy, and vibrating sample magnetometry were used to characterize the catalyst, and the results show that the catalyst had good crystallinity and magnetic properties. Tetracycline removal in the Fe3O4@HKUST-1/persulfate system reached 84.80%, and the catalyst was easily recovered from the solution due to its good magnetic properties. Mechanism analysis revealed that the non-radical pathway was the main degradation channel in the Fe3O4@HKUST-1/persulfate system, and 1O2 was the main reactive oxygen species generated from Ov on the surface of the Fe3O4@HKUST-1 catalyst. Tetracycline degradation was achieved by hydroxylation, demethylation, decarbonylation, dehydroxylation and the cleavage of C–N bonds. This finding holds significant value in further comprehension of the catalytic activation mechanism of metal–organic frameworks derivatives on persulfate and provides novel ideas for efficient water treatment technology development.
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Foods
·
2024
·Vol. 13
·期 23
·3797
·
IF 4.7
Chenmeng Song,Wei Zheng,Chengyi Song,Houfeng Zhou,Jengyuan Yao
Background: Kaempferol (KPF), a flavonoid abundant in edible plants, possesses potent anti-inflammatory and antioxidant properties beneficial with notable health benefits. Objective: To evaluate the protective effects of KPF on metabolic disturbances and pancreatic damage in a Type 1 diabetes mellitus (T1DM) mouse model. Methods: Male C57BL/6 mice were divided into normal, T1DM, T1DM + KPF 25 mg/kg, and T1DM + KPF 50 mg/kg groups. T1DM was induced by streptozotocin (STZ). KPF was administered via intraperitoneal injection for 2 weeks. After 4 weeks from the start, metabolic parameters, pancreatic histology, and plasma metabolites were analyzed. Network pharmacology and molecular docking identified key targets and pathways. In vitro, INS-1 cells were used to assess reactive oxygen species (ROS) production and apoptosis. Results: KPF significantly reduced blood glucose (GLU) and triglyceride (TG) levels, increased high-density lipoprotein (HDL) levels, and preserved pancreatic β-cell structure. Metabolomics revealed changes in energy metabolism and oxidative stress-related metabolites. Network analysis highlighted the PI3K/AKT/mTOR pathway, with strong binding affinities to targets such as AKT1. In vitro, KPF decreased ROS production in INS-1 cells; this effect was reversed by a PI3K/AKT inhibitor. KPF also reduced apoptosis in INS-1 cells. Conclusions: KPF ameliorates metabolic disturbances and pancreatic damage in T1DM mice, suggesting potential as a functional food ingredient for diabetes management.
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Particuology
·
2025
·
IF 4.3
Liping Zhao,Chun Shen,Guangsheng Luo
Supported small TS-1 particles are important catalysts in the ammoximation of ketones, but still facing challenges such as agglomeration in the reaction system and long synthesis time. In this work, we report the fast synthesis of small TS-1 particles supported on porous glass beads in a microreactor. Short crystallization time of only 1.5 h is needed for the synthesis of TS-1 particles with the mean size of ∼200 nm. Effects of aging time, size of the microchannel, sol/support mass ratio, crystallization temperature, and surface areas of the porous glass beads on the morphology and catalytic performance for ammoximation of cyclohexanone have been studied systematically. The as-synthesized supported TS-1 catalyst achieved 82.4% cyclohexanone conversion and > 99% selectivity to cyclohexanone oxime after reaction at 353 K for only 20 min, and the conversion rises to 97.6% if the duration prolongs to 40 min, outperforming the commercial TS-1 catalyst and supported TS-1 catalyst synthesized in an autoclave (crystallized for 48 h).
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ACS Nano
·
2025
·
IF 16
Lingzhu Zhao,Guoqing Zhao,Jiaxin Fu,Yan Liu,Jinteng Feng,Guangjian Zhang,Feng Xu,Hui Guo,Min Lin
Programmed cell death protein 1 (PD-1) is a critical immune checkpoint that suppresses T cell activation and cytotoxicity, yet its mechanistic role in regulating T cell mechanotransduction remains unclear. Here, we reveal that PD-1 engagement attenuates T cell activation by impairing cytoskeletal force generation and nuclear mechanotransduction in a mechanically defined microenvironment. Using tunable poly(ethylene glycol) (PEG)-based hydrogels that mimic the stiffness of target cells, we show that PD-1 suppresses T cell receptor (TCR)-mediated activation in a stiffness-dependent manner, requiring immobilized ligand presentation. Mechanistically, PD-1 ligation disrupts actin polymerization, reduces traction forces, and prevents nuclear deformation, thereby impairing the nuclear translocation of mechanosensitive transcription factors yes-associated protein (YAP) and nuclear factor 1 of activated T cells (NFAT1). This inhibition is mediated by the dephosphorylation of cofilin, an actin-severing protein that restricts actin assembly and downstream mechanotransduction. Consequently, PD-1 engagement diminishes the cytokine production and effector cytotoxicity of T cells. Pharmacological or genetic restoration of actin polymerization or nuclear transport rescues nuclear YAP/NFAT1 localization and partially restores T cell activation and function. Our findings suggest PD-1 as a mechanical checkpoint that suppresses T cell immunity by dampening cytoskeletal dynamics and nuclear mechanotransduction, offering insights into the biophysical regulation of immune suppression.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Guojun Lv,Linfang Jiang,Yan Chen,Xuyang Zou,Xubin Zhang,Fumin Wang
The addition of an additional mesoporous/macroporous templating agent inevitably has an adverse effect on the economy and greenness of the seed-assisted synthesis process for hierarchical zeolites; hence, the development of an efficient seed-assisted method for the synthesis of hierarchical zeolite without the addition of an additional additive is appealing. Herein, we reported the preparation of hierarchical TS-1 zeolite with a large amount of mesopores using a liquid–solid mixture seed-assisted method and its application as a heterogeneous catalyst in the oxidative desulfurization reactions. The characterization results disclosed that the liquid–solid mixture seed was more conducive to the formation of hierarchical TS-1 zeolite than liquid seed alone and solid seed alone. The formation process of hierarchical TS-1 zeolite with different crystallization times was investigated in detail, and accordingly, a possible two-stage crystallization mechanism was proposed. In addition, the synthesized hierarchical TS-1 zeolite showed remarkably enhanced catalytic activity in the oxidative desulfurization of dibenzothiophene (DBT) and 4,6-dimethyldibenzothiophene (4,6-DMDBT) in comparison to the conventional microporous TS-1 zeolite. This work provides some guidance for the development of a more efficient and greener seed-assisted synthesis method for hierarchical zeolites without the addition of any additional mesoporous/macroporous templating agent.
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npj Biofilms and Microbiomes
·
2025
·Vol. 11
·期 1
·1-17
·
IF 9.2
Yang Ruili,Xu Yi,Xu Jinchun,Huang Chengqing,Zhu Feng,Wang Tian,Kong Rui,Xiao Jie,He Biao,Gu Xiaozhen,Wang Hui-Li
As a prevalent neurodevelopmental disease, whether ASD (autism spectrum disorder) can be ameliorated by the early use of a single microbe remains unknown. Here we used a lactobacillus strain, Lacticaseibacillus rhamnosus GR-1 (LGR-1), for prenatal intervention in autism-like mice with either environmental or idiopathic origins by exclusively administering to the pregnant dams at a dose of 10 9 /mouse/day, followed by offspring behavioral assessment with 3-chamber trial and marble burying test. The results revealed that LGR-1 prevented the occurrence of autism-like symptoms, as evidenced by the improved behaviors and restored E/I (excitatory-inhibitory) balance in the prefrontal cortex of male pups. In parallel, the offspring microbiome was reshaped by LGR-1 treatment, probably mediated by the vertical transmission of maternal microbiome, with its roles further unraveled by fecal microbiota transplant and cross-fostering experiments. In addition to gut commensals, the LGR-1-shaping vaginal microbiota also contributed to the establishment of “beneficial” microbiome. Regarding key taxa in offspring, Akkermansia muciniphila was influenced by LGR-1 and exerted impact on behaviors via pathways related to IL-17-producing lymphocytes. Our findings demonstrate that prenatal microbial administration protects offspring against autism-like behavioral phenotypes through microbiome transmission, highlighting a potential microbe-based therapeutic avenue to mitigate ASD risk.
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Nanomaterials
·
2025
·Vol. 15
·期 21
·1661
·
IF 4.3
Bingqian Zu,Song Chen,Liping Bao,Yingjie Liu,Liang Wu
Phase and band gap engineering of (CdS)x(CuInS2)1−xnanomaterials is critical for their potential applications in photovoltaics and photocatalysis, yet it remains a challenge. Here, we report a precursor-mediated colloidal method for phase-control synthesis of alloyed (CdS)x(CuInS2)1−xnanocrystals with tunable band gap. When CuCl, InCl3, and Cd(AC)2·2H2O are used as the respective cation sources, wurtzite-structured alloyed (CdS)x(CuInS2)1−xnanocrystals can be synthesized with a tunable optical band gap ranging from 1.56 to 2.45 eV by directly controlling the molar ratio of the Cd precursor. Moreover, using Cu(S2CNEt2)2, In(S2CNEt2)3, and Cd(S2CNEt2)2as cation sources results in alloyed (CdS)x(CuInS2)1−xnanocrystals with a zinc-blende structure, demonstrating that the optical band gap of these nanocrystals can be compositionally tuned from 1.50 to 1.84 eV through precisely adjusting the molar ratio of Cd precursor. The results were validated through a comprehensive characterization approach employing XRD, TEM, HRTEM, STEM-EDS, XPS, UV-vis-NIR absorption spectroscopy, and Mott–Schottky analysis.
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