ACS Photonics
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2017
·
IF 6.756
Haiting Zhang,Yating Zhang,Xiaoxian Song,Yu Yu,Mingxuan Cao,Yongli Che,Zhang Zhang,Haitao Dai,Junbo Yang,Guizhong Zhang,Jianquan Yao
We fabricated a vertical field effect phototransistor with Au/Ag nanowires as the transparent source electrode and with vertically stacked layers of poly(3-hexylthiophene) (120 nm) and lead sulfide quantum dots (380 nm), which formed heterojunctions. The built-in electric field in the layered heterojunction aids the separation of photoinduced excitons, while the short channel enables efficient carrier transport across the active region. Both of these benefits enable a high photoperformance and fast photoresponse. This vertical phototransistor can be operated at room temperature with a low operation voltage of −1 V and is therefore energy-efficient. Further, it has a wide response spectrum from 400 to 2100 nm, a high photoresponsivity of more than 9 × 104 AW–1, and a high detectivity of up to 2 × 1013 Jones (cm Hz1/2 W–1) under infrared illumination. Additionally, this vertical phototransistor had a response time of 9 ms, which is faster than a previously reported lateral field effect phototransistor based on poly(3-hexylthiophene)/lead sulfide quantum dots. The vertical architecture combined with the layered heterojunction approach provides a new, facile way of fabricating high performance devices.
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APPLIED SURFACE SCIENCE
·
2015
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IF 2.711
Yixuan Song,Tingting Qiang,Ming Ye,Qiuyang Ma,Zhen Fang
Design an effective absorbent that has high surface area, and perfect recyclable is imperative for pollution elimination. Herein, we report a facile two-step strategy to fabricate magnetically separable 3-dimensional (3D) hierarchical carbon-coated nickel (Ni@C) nanocomposites by calcinating nickel based metal organic framework (Ni 3 (OH) 2 (C 8 H 4 O 4 ) 2 (H 2 O) 4 ). SEM and TEM images illuminate that the nanocomposites were constructed by 8 nm nickel nanoparticle encapsulated in 3D flake like carbon. The specific surface area of the obtained nanocomposites is up to 120.38 m 2 g −1 . Room temperature magnetic measurement indicates the nanocomposites show soft magnetism property, which endows the nanocomposites with an ideal fast magnetic separable property. The maximum adsorption capacity of the nanocomposites for rhodamine B is 84.5 mg g −1 . Furthermore, the nanocomposites also exhibit a high adsorption capacity for heavy metal ions. The adsorbent can be very easily separated from the solution by using a common magnet without exterior energy. The as-prepared Ni@C nanocomposites can apply in waste water treatment on a large-scale as a new adsorbent with high efficiency and excellent recyclability.
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CATALYSIS TODAY
·
2017
·
IF 4.636
Zhijie Wu,Min Zhang,Yirong Yao,Jingtuo Wang,Danhong Wang,Minghui Zhang,Yongfeng Li
1,3-propanediol (1,3-PDO) and γ-valerolactone (GVL) were simultaneously obtained via the hydrogenolysis of glycerol in levulinic acid (LA) using Ru/C catalysts. Ru/C catalyst exhibited a high LA conversion (∼99%) and a high GVL selectivity (∼99%) for the hydrogenation of LA; while a low conversion (∼11%) and little selectivity of 1,3-PDO for the hydrogenolysis of glycerol. LA promoted the hydrogenolysis of glycerol over Ru/C catalyst, in which LA catalyzed dehydration of glycerol into acetol (precursor of 1,2-propanediol (1,2-PDO)), and glycerol acetalization with the hydrogenated GVL into cyclic acetals, resulting in the formation of 1,3-PDO. A reaction scheme involves the formation of cyclic acetal ethers between GVL and glycerol was proposed to explain the product distributions in the one-pot synthesis of 1,3-PDO and GVL. 64.5% conversion of glycerol and 35.8% selectivity of 1,3-PDO together with 99.1% conversion of LA and 85.8% selectivity of GVL were obtained during one-pot converting glycerol and LA with 3.0 MPa H 2 at 200 °C for 6 h. We reported an effective strategy for the preparation of 1,3-PDO by selective hydrogenolysis of dioxan originated from glycerol with aldehydes or ketones.
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Journal of Materials Chemistry B
·
2024
·
IF 6.1
Gong Chen,Yuan Yuan,Ying Li,Zushun Xu,Qianyuan He,Zizhen Qin,Han Hu,Congcong Gao,Qi Xu,Qinglei Gao,Fei Li
Oncolytic virus ablation of tumor cells has the advantages of high tumor selectivity, strong immunogenicity and low side effects. However, the recognition and clearance of oncolytic viruses by the immune system is the main reason that limits their anti-tumor efficiency. As a highly biosafe and highly modifiable oncolytic virus vector, acrylamide can improve the long-term circulation of oncolytic viruses, but it is limited in its uptake efficiency by tumor cells. Herein, we constructed a N- hydroxymethyl acrylamide -b-(N-3- aminopropyl methacrylamide) -b-DMC block copolymers (NMA-b-APMA-b-DMA, NAD) as an oncolytic virus carrier, which not only improves the long-term circulation of oncolytic viruses in the body but also has excellent loading oncolytic virus stability. The data shows that no obvious difference in the transfection effect of the NAD/Ad complex with or without neutralizing antibody in the medium, which meant that the cationic carrier mediated by NAD/Ad had good serum stability. Only 10 micrograms of NAD carrier are needed to load the oncolytic virus, which can increase the transfection efficiency by 50 times. Cell experiments and mouse animal experiments show that NAD vector can significantly enhance the anti-tumor effect of oncolytic viruses. We hope that this work will promote the application of acrylamide as an oncolytic virus vector and provide new ideas for modification methods of acrylamide for biomedical applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Bin Ma,Jiafeng Niu,Hao Zhu,Huibing Chi,Zhaoxin Lu,Fengxia Lu,Ping Zhu
The oxidative reaction of Fusarium mycotoxin deoxynivalenol (DON) using the dehydrogenase is a desirable strategy and environmentally friendly to mitigate its toxicity. However, a critical issue for these dehydrogenases shows widespread substrate promiscuity. In this study, we conducted pocket reshaping of Devosia strain A6-243 pyrroloquinoline quinone (PQQ)-dependent dehydrogenase (DADH) on the basis of protein structure and kinetic analysis of substrate libraries to improve preference for particular substrate DON (10a). The variant presented an increased preference for substrate 10a and enhanced catalytic efficiency. A 4.7-fold increase in preference for substrate 10a was observed. Kinetic profiling and molecular dynamics (MD) simulations provided insights into the enhanced substrate specificity and activity. Moreover, the variant exhibited stronger conversion of substrate 10a to 3-keto-DON compared to the wild DADH. Overall, this study provides a feasible protocol for the redesign of PQQ-dependent dehydrogenases with favourable substrate specificity and catalytic activity, which is desperately needed for DON antidote development.
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ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Caixia Li,Shuping Pu,Jiapin Liu,Yun Huang,Jiepeng Chen,Xinyan Xiang,Lei Fu,Chao Zou,Xing Li,Mingshan Wang,Yuanhua Lin,Haijun Cao
Sodium (Na) super ion conductor (NASICON) structure Na3MnTi(PO4)3 (NMTP) is considered a promising cathode for sodium-ion batteries due to its reversible three-electron reaction. However, the inferior electronic conductivity and sluggish reaction kinetics limit its practical applications. Herein, we successfully constructed a three-dimensional cross-linked porous architecture NMTP material (AsN@NMTP/C) by a natural microbe of Aspergillus niger (AsN), and the structure of different NMTP cathodes was optimized by adjusting different transition metal Mn/Ti ratios. Both approaches effectively altered the three-dimensional NMTP structure, not only improving electronic conductivity and controlling Na+ diffusion pathways but also enhancing the electrochemical kinetics of the material. The resultant AsN@NMTP/C-650, sintered at 650 °C, exhibits better electrochemical performance with higher reversible three-electron reactions corresponding to the voltage platforms of Ti4+/3+, Mn3+/2+, and Mn4+/3+ around 2.1, 3.6, and 4.1 V (vs Na+/Na), respectively. The capacity retention rate is up to 89.3% after 1000 cycles at a 2C rate. Moreover, a series of results confirms that the Na3.4Mn1.2Ti0.8(PO4)3 cathode has the most excellent electrochemical performance when the Mn/Ti ratio is 1.2/0.8, with a high capacity of 96.59 mAh g–1 and 97.1% capacity retention after 500 cycles.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 10
·1-9
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IF 5.3
Cheng Ye,Tian Dong-Yang,Chen Cui-Li,Bao Ning,Wu Zeng-Qiang
Stainless steel sheets were coated with carbon ink to obtain disposable carbon electrodes, which were used as supports for moleculary imprinted polymer (MIP) electrochemical sensors by electropolymerizing o-phenylenediamine and o-aminophenol along with indole-3-acetic acid (IAA) as the template. After optimization, the MIP biosensors could be used for sensitive and selective detection of IAA with the limit of quantification of 0.1 µM. Our experimental results showed that stable and reproducible electrochemical responses could be achieved for the disposable MIP biosensors. This approach was successfully used for detection of IAA in different tissues of pea sprouts. This study reveals the potential of MIP electrochemical sensors in practical applications and shrinks the trench between the research and the real world. Graphical Abstract
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LANGMUIR
·
2024
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IF 3.7
Chang Liu,Yang Hu,Lin Zhang,Wensheng Yang
Amino-functionalized silica has attracted a great deal of interest due to its high surface reactivity and potential for diverse applications across various fields. While the classical co-condensation method is commonly used to synthesize amino-functionalized silica particles, the mechanism of the reaction between (3-aminopropyl)triethoxysilane (APTES) and tetraethoxysilane under different conditions remains unclear, leading to unexpected self-nucleation or cross-linking between silica particles and consequently hindering rational control over the extent of functionalization. To address this issue, we systematically explored the co-condensation growth mechanism of amino-functionalized silica particles in the Stöber method by investigating the effects of APTES concentration and water content on the hydrolysis and condensation of silanes. The experimental results revealed that APTES could decrease the rate of hydrolysis/condensation, while the moderate water content promoted both the rate of hydrolysis/condensation and the overall quality of the silica particles. Consequently, we successfully demonstrated the rational synthesis of amino-functionalized silica particles with diameters ranging from 213 to 670 nm and a nitrogen content of ≤2.8 wt %. The relationship between the APTES concentration and particle properties exhibited a biphasic trend. At low APTES concentrations (≤2.0 mM), the particle size remained stable while the isoelectric point increased rapidly. Further increasing the APTES concentration from 2.0 to 100.0 mM induced a decrease in particle size due to APTES’s inhibitory effect on silica growth, with nitrogen content continuing to increase even after the isoelectric point remained unchanged. These silica particles, featuring varying surface amino group densities, were utilized as matrices for loading Au nanoparticles. The resulting functionalized particles exhibited distinctive catalytic ability in the reduction of 4-nitroaniline, demonstrating significant potential for applications across various fields.
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COMPOSITES COMMUNICATIONS
·
2025
·
IF 7.7
Jiashi Chen,Xiyue Cao,Wen Fan,Huijuan Ma,Xuanfeng Jiang,Zhengguang Sun,Yuan Zhan
Organosilicon-coated carbon dots (OSiCDs) microspheres were synthesized by one-step solvothermal method in which phenylenediamine-derived CDs were encapsulated by organosilicon network structure to achieve blue, yellow and red emissive solid-state fluorescent powder. The influence of the three isomers of phenylenediamine on the solid-state fluorescence of OSiCDs microspheres were characterized in detail. Furthermore, the fluorescence stability of three kinds of OSiCDs microspheres were measured and exhibited excellent stability, which facilitate the acquisition and preservation of fingerprint patterns. The OSiCDs microspheres used as a fluorescence developer were further applied to capture the latent fingerprints (LFPs) on different substrate surfaces. The results indicate that the OSiCDs microspheres can efficiently eliminate background interferences of challenging surfaces, such as multicolored or patterned substrates, and the identified LFPs have clear patterns with high-resolution fluorescence, enabling fluorescent fingerprint recognition at three levels (core, hole, island, and fork). The as-prepared OSiCDs microspheres show great promise in practical application scenarios for fingerprint development.
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BIOELECTROCHEMISTRY
·
2024
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IF 4.8
Guiyin Li,Wenzhan Li,Yu Zhou,Xiaohong Tan,Qing Huang,Jintao Liang,Zhide Zhou
Glypican-3 (GPC3) is exclusively overexpressed in most Hepatocellular carcinoma (HCC) tissue but not in normal liver tissue, making it a promising biomarker for the precise detection of HCC. In this paper, a label-free light-addressable potentiometric sensor (LAPS) decorated by platinumpalladium-hemin-reduced graphene oxide nanocomposites (PtPd@H-rGO NCs) was constructed for determination of GPC3. The GPC3 aptamer (GPC3 Apt ) and PtPd@H-rGO NCs were modified on the surface of silicon-based LAPS chip to build sensitive unit of LAPS system. A readout photocurrent elicited from a modulated light source, registers the localized surface potential change. When a bias voltage is provided to the LAPS system, the GPC3-GPC3 Apt complexes formed by the specific reaction between GPC3 and GPC3 Apt at the sensing interface can cause the sensitive membrane surface potential to change, resulting in the photocurrent-voltage (I-V) curves generate a corresponding offset response. Therefore GPC3 concentration can be determined by monitoring the potential shifts (△V). Under optimal conditions, the potential shift is linearly related to the concentration of GPC3 in the range of 0.001–3.00 μg/mL with the limit of detection (LOD) of 0.0001 μg/mL. The LAPS has a good analytical performance with good specificity, reproducibility and stability, and can be used for the detection of GPC3 in actual serum samples, which provides a broad application prospect for the combined application of LAPS and aptamers in biooassay.
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
·
2025
·Vol. 29
·期 2
·e70358
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IF 4.2
Jiangfang Lian,Hui Lin,Zuoquan Zhong,Yongfei Song,Xian Shao,Jiedong Zhou,Lili Xu,Zhenzhu Sun,Yongyi Yang,Jufang Chi,Ping Wang,Liping Meng
The clinical application of doxorubicin (DOX) is limited due to its cardiotoxicity, which is primarily attributed to its interaction with iron in mitochondria, leading to lipid peroxidation and myocardial ferroptosis. This study aimed to investigate the role of the gut microbiota‐derived metabolite, indole‐3‐lactic acid (ILA), in mitigating DOX‐induced cardiotoxicity (DIC). Cardiac function, pathological changes, and myocardial ferroptosis were assessed in vivo. The cardioprotective effects and mechanisms of ILA were explored using multi‐omics approaches, including single‐nucleus RNA sequencing (snRNA‐seq) and bulk RNA‐seq, and were further validated in Nrf2 knockout mice. The findings revealed that DOX treatment disrupted gut microbiota, significantly reducing the levels of the tryptophan metabolite ILA. In DIC models, ILA supplementation markedly improved cardiac function, reduced collagen deposition, and mitigated cardiac atrophy. The bulk and snRNA‐seq analyses indicated that myocardial ferroptosis played a crucial role in the cardioprotective effects of ILA. Experimental data demonstrated that ILA decreased DOX‐induced ferroptosis in both DIC mice and DOX‐treated H9C2 cells, evidenced by restoration of GPX4 and SLC7A11 levels and reduction of ACSL4. Mechanistically, ILA functions as a ligand for the aryl hydrocarbon receptor (AhR), leading to the upregulation of Nrf2 expression. The protective effects of ILA against ferroptosis were abolished by silencing AhR. Moreover, the beneficial effects of ILA on DIC were eliminated in Nrf2‐deficient mice. In conclusion, ILA exerts therapeutic effects against DIC by inhibiting ferroptosis through activation of the AhR/Nrf2 signalling pathway. Identifying the cardioprotective role of the microbial metabolite ILA could offer viable therapeutic strategies for DIC.
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CRYSTAL GROWTH & DESIGN
·
2024
·
IF 3.2
Xianglin Li,Shenglai Wang,Bo Wang,Hui Liu,Tianci Wu,Kaiyu Wang,Shuai Wang,Yanhong Li,Taixin Zhang,Xiaoyang Dai
The effect of Na3(PO3)3 on the growth of KDP crystal (101) faces was studied by the Michelson interference technique and atomic force microscopy. The experimental results show that the growth rates were near zero at low supersaturation when Na3(PO3)3 was doped into solution, i.e., there was a supersaturation interval similar to the “growth dead zone”. The growth rates began to increase rapidly as the supersaturation crossed the “growth dead zone” and continued to increase. The “growth dead zone” increased as the doping concentration was increased. In addition, the anisotropy of growth hillocks decreased and the competition of growth hillocks became more intense when the doping concentration of Na3(PO3)3 was gradually increased in solution at confirmed supersaturation. The calculated surface free energies of three adjacent planes show that they increased with the increase of doping concentration and always αI, αII > αIII.
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