REACTIVE & FUNCTIONAL POLYMERS
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2023
·
IF 5.1
Wei Zhang,Bingtao Wang,Yan Xia,Wei Wang,Zhenghong Guo,Zhengping Fang,Juan Li
It is a great challenge to prepare polyamide 6 (PA6) compounds with outstanding fire safety and mechanical properties. In this research, a flame retardant containing P/N/S elements (SNDP) was synthesized using 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO), 2-thiophene-carboxaldehyde and 4-aminobenzonitrile. The PA6/SNDP compounds were prepared using a melt blending method. Two chain extenders were incorporated into PA6/SNDP compounds to adjust their mechanical properties. The results suggest that PA6 compound with 10 wt% SNDP obtains a UL-94 V-0 rating (1.6 mm) and a limiting oxygen index (LOI) value of 27.4 vol%. SNDP induces the degradation of PA6 and decreases its mechanical properties. While the two chain extenders have reinforced effects on PA6/SNDP and this effect of 1,3-phenylene-bis-oxazoline is superior to another one. Moreover, the main flame-retardant mode of actions for SNDP in PA6 is gas-phase effect, including scavenging free radicals and diluting flammable gases.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2021
·
IF 4.432
Fujing Wang,Rong Hu,Jiaxing Zhang,Tingting Pei,Zhuo'en He,Liliang Ju,Zhongxiao Han,Mingqing Wang,Wei Xiao
Renal fibrosis is the pathological consequence of progressive chronic kidney disease . Although it has been reported that vitamin D3 exerts antifibrotic effects, the underlying mechanisms remain unclear. This study is aimed at investigating the effects and molecular mechanisms in high-dose vitamin D3 treatment on renal fibrosis. A model of chronic kidney disease was established by 5/6 nephrectomy in rats characterised by high levels of serum creatine, urea nitrogen, and urinary protein. Serum 25-dihydroxyvitamin D3, calcium and parathormone levels were measured to evaluate vitamin D levels. Hematoxylin and eosin , periodic acid Schiff and Mallory's Trichrome staining were used to evaluate histopathological changes in rats. Moreover, the expression of vimentin , collagen I, α-smooth muscle actin and E-cadherin were analyzed at molecular and histopathological levels. Our results showed that exposure to vitamin D3 decreased the levels of serum creatine, urea nitrogen and urine protein and restored the homeostasis of calcium and parathormone. Vitamin D3 also downregulated the expression of vimentin, collagen I and α-smooth muscle actin and attenuated renal fibrosis and epithelial to mesenchymal transition in the kidney. Importantly, vitamin D3 treatment increased the expression of the vitamin D receptor and inhibited Transforming growth factor-β1 (TGF-β1)/Smad3 signaling pathway in rats kidneys with chronic kidney disease. Mechanistically, the upregulation of TGF-β1 and phosphorylation of Smad3 induced by vitamin D3 was reversed by activation of the vitamin D receptor. Our findings indicated that vitamin D3 is a potential antifibrotic drug in chronic kidney disease via the vitmin D receptor and inhibiting TGF-β1/Smad3 signaling pathway.
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PubMed
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BMC Veterinary Research
·
2016
·Vol. 12
·期 1
·1-10
·
IF 1.643
Ma Ning,Liu Xi-Wang,Yang Ya-Jun,Shen Dong-Shuai,Zhao Xiao-Le,Mohamed Isam,Kong Xiao-Jun,Li Jian-Yong
Background Based on the prodrug principle, aspirin and eugenol, as starting precursors, were esterified to synthesize aspirin eugenol ester (AEE). The aim of the present study was to evaluate the antithrombotic effect of AEE in an animal disease model. In order to compare the therapeutic effects of AEE and its precursors, aspirin, eugenol and a combination of aspirin and eugenol were designed at the same molar quantities as the AEE medium dose in the control group.Methods After oral administration of AEE (dosed at 18, 36 and 72 mg/kg) for seven days, rats were treated with k-carrageenan to induce tail thrombosis. Following the same method, aspirin (20 mg/kg), eugenol (18 mg/kg) and 0.5 % CMC-Na (30 mg/kg) were administered as control drug. Different drug effects on platelet aggregation, hemorheology, TXB2/6-keto-PGF1α ratio and blood biochemistry were studied.Results AEE significantly inhibited ADP and AA-induced platelet aggregation in vivo. AEE also significantly reduced blood and plasma viscosity. Moreover, AEE down-regulated TXB2 and up-regulated 6-keto-PGF1α, normalizing the TXB2/6-keto-PGF1α ratio and blood biochemical profile. In comparison with aspirin and eugenol, AEE produced more positive therapeutic effects than its precursors under the same molar quantity.Conclusion It may be concluded that AEE was a good candidate for new antithrombotic and antiplatelet medicine. Additionally, this study may help to understand how AEE works on antithrombosis in different ways.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2017
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IF 3.154
Yehong Han,Chunliu Yang,Yang Zhou,Dandan Han,Hongyuan Yan
A new method involving ionic liquid–hybrid molecularly imprinted material–filter solid-phase extraction coupled to high-performance liquid chromatography (IL–HIM–FSPE–HPLC) was developed for the simultaneous isolation and determination of 6-benzyladenine (6-BA) and 4-chlorophenoxyacetic acid (4-CPA) in bean sprouts. Sample preconcentration was performed using a modified filter, with the new IL–HIM as the adsorbent, which shows double adsorption. The first adsorption involves special recognition of molecular imprinting, and the second involves ion exchange and electrostatic attraction caused by the ionic liquid. This method combines the advantages of ionic liquids, hybrid materials, and molecularly imprinted polymers and was successfully applied to determine 6-BA and 4-CPA in bean sprouts. The adsorption of 6-BA to IL–HIM is based on selective imprinted recognition, whereas the adsorption of 4-CPA is mainly dependent on ion-exchange interactions.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-9
·
IF 3.8
Yuan Fang-Fang,Wang Pei,Han Xiao-Jie,Qin Ting-Ting,Lu Xin,Bai Hai-Jiao
The microreactor with two types of immobilized enzymes, exhibiting excellent orthogonal performance, represents an effective approach to counteract the reduced digestion efficiency resulting from the absence of a single enzyme cleavage site, thereby impacting protein identification. In this study, we developed a hydrophilic dual-enzyme microreactor characterized by rapid mass transfer and superior enzymatic activity. Initially, we selected KIT-6 molecular sieve as the carrier for the dual-IMER due to its three-dimensional network pore structure. Modification involved co-deposition of polyethyleneimine (PEI) and acrylamide (AM) as amine donors, along with dopamine to enhance material hydrophilicity. Remaining amino and double bond functional groups facilitated stepwise immobilization of trypsin and Glu-C. Digestion times for bovine serum albumin (BSA) and bovine hemoglobin (BHb) on the dual-IMER were significantly reduced compared to solution-based digestion (1 min vs. 36 h), resulting in improved sequence coverage (91.30% vs. 82.7% for BSA; 90.24% vs. 89.20% for BHb). Additionally, the dual-IMER demonstrated excellent durability, retaining 96.08% relative activity after 29 reuse cycles. Enhanced protein digestion efficiency can be attributed to several factors: (1) KIT-6’s large specific surface area, enabling higher enzyme loading capacity; (2) Its three-dimensional network pore structure, facilitating faster mass transfer and substance diffusion; (3) Orthogonality of trypsin and Glu-C enzyme cleavage sites; (4) The spatial effect introduced by the chain structure of PEI and glutaraldehyde’s spacing arm, reducing spatial hindrance and enhancing enzyme–substrate interactions; (5) Mild and stable enzyme immobilization. The KIT-6-based dual-IMER offers a promising technical tool for protein digestion, while the PDA/PEI/AM-KIT-6 platform holds potential for immobilizing other proteins or active substances.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Qi Zhao,Zhencheng Chen,Chen-Wei Shan,Tao Zhan,Chen-Yang Han,Guo-Cheng Han,Xiao-Zhen Feng,Heinz-Bernhard Kraatz
Human chorionic gonadotropin (HCG), a vital protein for pregnancy determination and a marker for trophoblastic diseases , finds application in monitoring early pregnancy and ectopic pregnancy . This study presents an innovative approach employing electrochemical immunosensors for enhanced HCG detection, utilizing Anti-HCG antibodies and gold nanoparticles (AuNPs) in the sensor platform. Two sensor configurations were optimized: BSA/Anti-HCG/c-AuNPs/MEL/e-AuNPs/SPCE with [Fe(CN) 6 ] 3−/4− as a redox probe (1) and BSA/Anti-HCG/PPy/e-AuNPs/SPCE using polypyrrole (PPy) as a redox probe (2). The first sensor offers linear correlation in the 0.10–500.00 pg∙mL −1 HCG range, with a limit of detection (LOD) of 0.06 pg∙mL −1 , sensitivity of 32.25 μA∙pg −1 ∙mL∙cm −2 , RSD <2.47 %, and a recovery rate of 101.03–104.81 %. The second sensor widens the HCG detection range (40.00 fg∙mL −1 -5.00 pg∙mL −1 ) with a LOD of 16.53 fg∙mL −1 , ensuring precision (RSD <1.04 %) and a recovery range of 94.61–106.07 % in serum samples. These electrochemical immunosensors have transformative potential in biomarker detection, offering enhanced sensitivity, selectivity , and stability for advanced healthcare diagnostics.
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JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Manman Liu,Luyao Wang,Chen Cheng,Zhaohui Qiu,Sheng Liu,Liu Yang,Guangyi Liu
To achieve an eco-friendly flotation separation of galena from pyrite under the low alkaline and depressant-free conditions, the triazine-dithione surfactants, such as 2-dimethylamino- s -triazine-4-thiol-6(1H)-thione sodium (DMN), 2-diethylamino- s -triazine-4-thiol-6(1H)-thione sodium (DEN) and 2-dibutylamino- s -triazine-4-thiol-6(1H)-thione sodium (DBN) were designed as the special collectors for galena. The micro-flotation results showed that the collecting capacity of these three collectors towards galena was in the order of DBN > DEN ≫ DMN, being consistent with their hydrophobization ability. In-situ AFM observed the aggregation of DBN on the whole surface of galena, which significantly enhanced the contact angle of galena. UV spectra and zeta potential recommended that the affinity of DBN towards lead ions and galena was much stronger than ferrous/ferric ions and pyrite. DFT (density functional theory) calculation revealed DBN’s two exo -S atoms were of its electron-donating center. And XPS confirmed the bonding interaction of the two exo -S atoms with Pb(Ⅱ) atoms on/in galena surface. DBN owned the mild electron-donating capacity and strong electron-accepting ability, and realized the eco-friendly flotation separation of galena from pyrite at pH ∼8.0.
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POLYMER DEGRADATION AND STABILITY
·
2024
·
IF 6.3
Bohan Liang,Ke Liu,Junming Dai,Wenxing Chen,Wangyang Lu
A polymer-type flame retardant (PFR) based on a 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derivative was synthesised here to improve the flame retardancy of polyamide 6 (PA6). The chemical structure and thermal property of the PFR were characterised by Fourier-transform infrared (FTIR) spectroscopy, nuclear magnetic resonance spectroscopy, gel permeation chromatography (GPC), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The PFR and PA6 were melt-blended to obtain a flame-retardant polyamide 6 (FRPA6). Its thermal property, mechanical property and flame retardancy were characterised via TGA, DSC and tensile, impact, vertical burning and limiting oxygen index (LOI) tests. Its flame-retardant mode of action was analysed by scanning electron microscopy, FTIR spectroscopy, cone calorimetry and pyrolysis-gas chromatography-mass spectrometry. The FRPA6 with a phosphorus content of 3000 ppm passed the UL-94 V-0 rating, and the LOI of the FRPA6 with a phosphorous content of 5000 ppm reached 28.8 %. Compared with pure PA6 , the peak heat release rate, total heat release and effective heat of FRPA6–5000 were reduced by 35.4 %, 21.9 % and 26.5 %, respectively. These results indicate that the flame-retardant mode of action of PFR mainly involved the quenching effect of phosphorus-containing radicals in the gas phase.
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ACS Omega
·
2024
·
IF 3.7
Jin Long Zhang,Xiao Wei Zhang,Bing Yuan,Heng Zhang,Xing Zhi Wang,Hao Wang,Hong Wei Zhao
Advances in chemotherapeutic strategies are urgently required to improve antitumor efficiency. Herein, a carboxylated pillar[6]arene (CP6A) was employed to load chemotherapy medication, nitrogen mustard (NM), via forming a direct host–guest complex, as this helps to decrease the cytotoxicity of NM on normal mammary epithelial cells. Attributed to the stronger complexation ability of CP6A for endogenous spermine (SPM) than for NM, the complexed NM could be competitively released from the CP6A cavity via replacement with SPM. This chemotherapy strategy performed well in vitro and in vivo for SPM-overexpressed cancers. In comparison with free NM, antitumor efficiency of NM/CP6A was significantly enhanced, which originated from the synergistic effect of competitive release of NM and simultaneous trapping of SPM. This strategy might guide expansion to other first-line antitumor agents to improve therapeutic efficacy and decrease side effects, thereby replenishing the possibilities of supramolecular chemotherapy.
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RSC Advances
·
2025
·Vol. 15
·期 14
·10862-10872
·
IF 4.6
Muneera Alrasheedi,Salah M. El-Bahy,Refat El-Sayed,Khaled F. Debbabi,Alaa S. Amin
Although modern reported methods, such as AAS, ICP-AES, ICP-MS, have good sensitivity, the high cost of equipment, the need for sophisticated instruments, separation and preconcentration steps and experienced technicians along with lack of precise methods make them cumbersome. Solid phase extraction (SPE) emerges as an attractive technique that reduces solvent consumption, minimizes exposure, shortens extraction time, and lowers disposal costs. Herein, a pioneering methodology for the quantification of minute amounts of silver is introduced, using 2-nitro-6-(thiazol-2-yl-diazenyl)phenol (NTDP) as a complexing agent and Triton X-100 as a nonionic surfactant within a ternary surfactant system at a pH of 5.3. This novel extraction strategy demonstrated selective preconcentration. The enriched solution was subjected to spectrophotometric analysis for the quantification of the analyte. After refining extraction and complexation parameters, a remarkable 250-fold increase in the enrichment factor was attained, highlighting a sensitivity boost of 509 times compared with traditional extraction approaches relying solely on nonionic surfactants. The key parameters of molar absorptivity and Sandell sensitivity were determined to be 6.04 × 106 L mol−1 cm−1 and 0.0018 ng cm−2, respectively. The calibration plot was observed from 5.0–175 ng mL−1, whereas Ringbom optimum concentrations ranged from 15–160 ng mL−1. The detection and quantification limits were 1.63 and 4.95 ng mL−1, respectively. The relative standard deviation (RSD) of the complex was 2.27. The suggested method was efficiently utilized for assessing the Ag+ concentration in real samples, producing acceptable outcomes.
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Oncology Letters
·
2022
·Vol. 23
·期 6
·1-11
·
IF 3.111
Chi-Ming Liu,Lijie An,Zhengping Wu,Ai-Jun Ouyang,Mengqiao Su,Zichen Shao,Yi Lin,Xiaoyu Liu,Yinjie Jiang
6‑Gingerol is a bioactive compound isolated from Zingiber officinale. 6‑Gingerol has been shown to have anticancer effects in numerous types of cancer cell. The mechanisms underlying the anticancer effect of 6‑Gingerol in prostate cancer requires investigation. In the present study, the effect on cell viability of 6‑Gingerol on LNCaP, PC3 and DU145 prostate cancer cells were determined using the MTT and colony formation assays. 6‑Gingerol significantly inhibited cell migration, adhesion and invasion in LPS‑stimulated and LPS‑unstimulated prostate cancer cells. Furthermore, these changes were accompanied by alterations in the protein expression levels of epithelial‑mesenchymal transition biomarkers, including E‑cadherin, N‑cadherin, Vimentin and zonula occludens‑1. 6‑Gingerol also induced autophagy by significantly increasing LC3B‑Ⅱ and Beclin‑1 protein expression levels in prostate cancer cells. Combining 6‑Gingerol with LY294002, an autophagy inhibitor, significantly increased cell survival in DU145 cells. Furthermore, 6‑Gingerol significantly decreased the protein expression levels of glutathione (GSH) peroxidase 4 and nuclear factor erythroid 2‑related factor 2 in prostate cancer cells. Reactive oxygen species (ROS) levels were significantly increased but GSH levels were decreased following 6‑Gingerol treatment in prostate cancer cells. Co‑treatment with the ferroptosis inhibitor, ferrostatin‑1, significantly increased cell viability and significantly decreased ROS levels in 6‑Gingerol‑treated cells. These results suggested that 6‑Gingerol may have inhibited prostate cell cancer viability via the regulation of autophagy and ferroptosis. In addition, 6‑Gingerol inhibited cell migration, adhesion and invasion via the regulation of EMT‑related protein expression levels in LPS‑stimulated and LPS-unstimulated prostate cancer cells. In conclusion, 6‑Gingerol may induce protective autophagy, autophagic cell death and ferroptosis‑mediated cell death in prostate cancer cells. These findings may provide a strategy for the treatment and prevention of prostate cancer.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Tao-Tao Shi,Wei-Guo Hu,Guan-Jin Gao,Xin-Yu Jiang,Jin-Gang Yu
The presence of diverse pollutants in wastewater highlights critical opportunities and urgent needs to develop effective strategies and technologies for their removal. In the present study, a novel composite of per-6-amino-β-cyclodextrin (PACD) covalently modified graphene oxide (GO) was fabricated by a facile one-step procedure. The morphologies, composition and bonding modes of GO-PACD composite were investigated by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermalgravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS) and specific surface analysis by the Brunauer-Emmett-Teller (BET) method. The prepared GO-PACD composite was used as an efficient adsorbent for the removal of azo dyes (alizarin yellow R) from colored wastewater. The maximum adsorption capacity of GO-PACD was 130.92 mg g −1 at 298 K. The influencing factors such as contact time, solution pH, initial dye concentration and temperature were investigated and optimized by a batch adsorption experiment. Adsorption kinetics, isotherms and thermodynamics were also investigated to reveal the possible adsorbent-adsorbate mechanisms. GO-PACD composite could be regenerated by a facile acid-soaking process. The results showed that the GO-PACD composite exhibited high stability and excellent reusability during 10 cycles of consecutive loading and regeneration. In summary, the developed GO-PACD composite is highly-efficient, regenerable, stable and facile-to-synthesize, making it be a potential candidate for azo dyes removal by adsorption.
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