MICROPOROUS AND MESOPOROUS MATERIALS
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2022
·
IF 5.876
Xiaofeng You,Yan Wang,Lin Han,Qing Liu,Zhaoyang Fei,Xian Chen,Zhuxiu Zhang,Jihai Tang,Mifen Cui,Xu Qiao
Hyper-cross-linked resin has enormous potential in the removal of organic dyes from aqueous solutions due to its adjustable porous structure and designable chemical properties, whereas its poor adsorption capacity limits the application. In this study, the co-modified hyper-cross-linked resin (HCP-x) with tunable porosity was synthesized by adjusting the dosages of 4-vinylpyridine (4-VP) and 4-vinylbenzoic acid (4-VA) in the polymerization process. The results indicated that pores in the range of 4–12 nm show up in HCP-x resin with the addition of 4-VP and 4-VA. Particularly, the polymer containing 10% by weight of monomer (HCP-90) had the highest specific surface area, the largest micropore volume and a bigger mesoporous volume in the terpolymer . The adsorption experiment results demonstrated that HCP-90 showed 4 times increased Rhodamine B adsorption than the original resin. This study described a simple method to co-modify the hyper-cross-linked resin by introducing two functional monomers, and the modified material was potential for Rhodamine B adsorption.
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INVESTIGATIONAL NEW DRUGS
·
2023
·Vol. 41
·期 1
·134-141
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IF 3.4
Yan Gaobo,Zhang Hongyan,Li Yan,Miao Guoqiang,Liu Xiaolei,Lv Qifan
Lysine-specific demethylase 1 (LSD1) has been a promising target to treat prostate cancer, and discovery of novel LSD1 inhibitors would have great clinical significance. In this work, viscosalactone B was first identified as a novel LSD1 inhibitor. Viscosalactone B isolated from Withania Somnifera displayed antiproliferative activity against PC3, DU145, C42B, PC3/MDVR, DU145/MDVR, and C42B/MDVR cells with IC 50 values of 1.17, 0.72, 3.86, 2.06, 0.96 and 1.15 μM, respectively. In comparison, it was a selective LSD1 inhibitor with an IC 50 value of 970.27 nM and could induce a significant accumulation of LSD1 substrates H3K9me1, H3K9me2, and H3K4me1 in a concentration-dependent manner in DU145 cells. According to docking studies, it formed hydrogen bonds with the Thr11, Lys14, and Arg8 residues of LSD1. Importantly, while it displayed potent antitumor efficacy in vivo, it did not show obvious cytotoxicity on the major organs of nude mice. Therefore, viscosalactone B, as a novel LSD1 inhibitor, is a potential candidate that can be used for the treatment of prostate cancer in clinics.
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PubMed
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Xianlong Zhang,Yiheng Shi,Panpan Wang,Di Wu,Jianghua Liu,Rui Huang,Yongning Wu,Guoliang Li
Inspired by a biomineralization behavior, we prepared a nanoflower-like artificial clickase (namely LCN clickase) for portable and sensitive click SERS immunoassay of foodborne bacterial pathogen. Encouraged by its high click catalytic activity to trigger Cu(I)-catalyzed azide-alkyne cycloaddition reaction, LCN clickase was successfully used for establishing a novel click SERS immunoassay by combining the clickase-mediated SERS signal variation at Raman-silent region. The developed method not only effectively eliminated the interferences between Raman reporter and biological species, but also reduced the complex sample matrix interference. Compared with traditional CuAAC-based immunoassays, the established method avoided the superfluous dissolution process of nanocatalysts and eliminated the requirement of reducing agent during detection, thereby shortening detection time and improving detection reliability. Impressively, the proposed method showed high selectivity and sensitivity for detection of Salmonella enterica serovar Paratyphi B with a low LOD of 20 CFU/mL, exhibiting a great potential in detection of foodborne bacterial pathogen in food samples.
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PubMed
高影响因子
OPTICAL MATERIALS
·
2023
·
IF 3.9
Han Kang,Ze Zhang,Wei Zhou
Rhodamine B(RhB) was encapsulated in Tb(btc) (btc = 1,2,4-benzene tricarboxylic acid) frameworks by “one-pot” method, and the complex RhB@Tb(btc) with host-guest dual fluorescence emissions was synthesized. Compared with the stability of Tb 3+ emission, the characteristic emission of RhB at 620 nm showed a more sensitive response to ambient temperature. By integrating the different temperature dependence of Tb 3+ and RhB emissions, the temperature sensing of RhB@Tb(btc) was determined with relative sensitivity ranging from 0.43 to 0.59% K −1 (temperature range 298–353 K). Among several common antibiotics, RhB@Tb(btc) showed fluorescence quenching response to metronidazole (MDZ) and color transition to levofloxacin (LOFX) respectively with stable reusability. The combination of photoinduced electron transfer and internal filtration effect was confirmed as the contributor to MDZ induced fluorescence quenching. Furthermore, hydrogels and milk, which were added antibiotics on purpose for simulating unsafe foods, were detected at in situ temperature by RhB@Tb(btc) test paper, which achieved highly sensitive and highly selective detection to MDZ and LOFX with limit of detection reaching 10 −6 M.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 34
·期 5
·1739-1751
·
IF 3.4
Na Ni,Tiantang Fan,Wuyou Ye,Qi Xia,Dongyang Liu,Jingwen Qin,Zhongyong Fan,Qing Liu
Poly( L -lactic acid) (PLLA) is a biocompatible material and has found its application in bioresorbable vascular stents (BVS). However, the crystallization of pure PLLA makes it brittle as a medical implant device. In this work, the biodegradable poly(1,3-trimethylene carbonate- b -( L -lactide- ran -glycolide acid)) (PTLG) terpolymers with improved mechanical performance were developed and processed into peripheral vascular stents by a novel 3D 4-axial printing technology. The PTLG terpolymers were successfully synthesized by ring-opening copolymerization of L -lactic acid (LLA), 1,3-trimethylene carbonate (PTMC) and glycolide acid (GA) units. The crystallinity and mechanical properties of the PTLG terpolymers with various degradation rate depends on the chain sequence structure and the component contents. Compared with the stent prepared by laser engraving, the peripheral vascular stent prepared by the 3D 4-axial printing technology exhibit a finer structure and smoother strut surface. It was found that both the strut diameters and the molecular weight of PTMC affect the radial force of the stents and that the apparent activation energy of thermal decomposition of the stents is mainly influenced by the molecular weight of PTMC and the component ratio. Therefore, the addition of the PTMC segment can effectively improve the flexibility of the PTLG terpolymer stent and the 3D printed PTLG terpolymer-based stent. Furthermore, CCK-8 and live/dead staining suggested that the stents have good biocompatibility.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Si Ye,Yufeng Wang,Bohao Du,Lei Cheng,Lixian Sun,Puxuan Yan
The design of an efficient and reusable monolithic catalyst is important for catalyzing the hydrolysis of NaBH 4 to generate H 2 . Herein, an aerogel catalyst was prepared by freeze-drying of hydrazine modified cellulose nanofibers (NH 2 NH-CNF), polyvinyl alcohol (PVA) and B-doped CoP loaded sepiolite nanofibers. Further chemical cross-linking using glutaraldehyde (GA) resulted in better mechanical properties and shape recovery. Among them, the catalytic active component B-CoP@aSep has a low activation energy of 35.7 KJ·mol −1 . In addition, the optimized composite aerogel catalyst can get hydrogen generation rate ( 3534 m L m i n - 1 g c a t a l y s t - 1 ), which was maintained at 79.4% even after 5 cycles of testing. The better mechanical and catalytic properties of aerogel catalysts are mainly attributed to the overall three-dimensional layered porous structure maintained by chemical bonds and the heterogeneous interface formed by B-doped CoP.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Zhong Dengjie,Liu Peng,Liu Yi,Xu Yunlan
The Zn/Fe@N-doped porous graphitic carbon catalyst (Zn/Fe@PCN) was successfully produced through one-step pyrolysis of g-C 3 N 4 and Zn/Fe-MOF and was used for the activation of persulfate (PS) for the degradation of RhB. The Zn/Fe@PCN/PS system was able to degrade 95.92% of RhB in 30 min at a rate of 0.6453 min −1 when RhB was concentrated at 50 mg L −1 . The efficient degradation of RhB is primarily realized through the synergistic activation of PS by Zn, Fe, and N to produce reactive oxygen species 1 O 2 , \(\cdot{\mathrm{O}}_2^-\) , \(\cdot \mathrm{SO}_4^-\) , and ·OH. Zn 0 /Fe 0 in Zn/Fe@PCN forms a galvanic cell with carbon to release electrons to join in the activation of PS. The doping of Zn not only provides sufficient electrons for the activation of PS but also promotes the effective reduction of Fe 2+ and thus the Fe 2+ /Fe 3+ cycle. The N doping accelerates the electron transfer during the reaction progress.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2023
·
IF 4.5
Jinfei Hu,Hang Zhu,Min Lin,Duoer Wu,Jianguo Yao,Tianyu Sun,Xiangjuan Ma,Yijing Xia
The objective of this research is to develop an effective electrocatalytic filtration system using Ti/SnO 2 -Sb membrane anodes for eliminating Rhodamine B (RhB) from wasteater. Compared to Ti/SnO 2 -Sb plate anode, the prepared Ti/SnO 2 -Sb membrane anodes featured smaller particle size, bigger electrocatalytic active surface area, lower charge transfer resistance, and higher potential for oxygen evolution. The electrocatalytic filtration system obtained RhB removal of 90.29% with EE/O of 5.51 kWh m −3 after 90 min of electrolysis when initial pH value was 5, current density was 10 mA cm −2 , initial RhB concentration was 50 mg L −1 , and membrane flux was 2.17 m 3 (m 2 ·h) −1 , respectively. The flow-through electrocatalytic filtration system was found to be limited by kinetics under a high membrane flux and dominated by an indirect radical oxidation. Finally, the possible RhB degradation pathways were proposed based on the detected intermediates and density functional theory calculations.
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高影响因子
Journal of Water Process Engineering
·
2023
·
IF 7
Fuwang Zhao,Yanling Yang,Siyang Ji,Rui Yu,Xing Li,Zhiwei Zhou
A photo-Fenton catalyst Fe‑carbon nitride (g-C3N4)/reduced graphene oxide (rGO) (labeled as FNGO) was prepared via two-step calcination thermal polymerization. rGO as a carrier of Fe-g-C3N4 accelerated the charge transfer and improved the reduction of Fe (III) as compared those of the binary Fe-g-C3N4 catalyst. The FNGO catalyst maintained a high surface area of 264.7 m2/g and its charge transfer rate was 2.77 times higher than Fe-g-C3N4. The decreasing transient photocurrent and increasing electrode resistance of FNGO, Fe-g-C3N4 and g-C3N4 confirm the positive synergistic effect of Fe N coordination and rGO in charge transfer. Under the synergistic of visible light irradiation and H2O2, the excellent degradation performance of FNGO towards rhodamine B was achieved (95.3 % removal) at Fe-doping content of 10 wt%, rGO loading content of 0.5 % and H2O2 addition of 1.5 mM. Hydroxyl radicals played a dominant role in the photocatalysis-Fenton system, which was related to the coordination of Fe N, the carrier off-domain of rGO, and the Fe (III)/Fe (II) cycle promoted by photogenerated electron and superoxide radicals. The FNGO had a high stability, a wide pH adaptation (3– 11) and a low Fe-leaching. This novel ternary light-driven photo-Fenton catalyst of FNGO enabled efficient decontamination during advanced treatment of wastewater.
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Advanced Therapeutics
·
2022
·Vol. 6
·期 1
·2200086
·
IF 5.003
Yijing Lin,Qingqing Yin,Deli Zhuge,Yiqin Hu,Xuewei Yang,Dongyan Tian,Li Li,Haonan Wang,Shuangshuang Liu,Cuiye Weng,Xufei Zhang,Bin Wen,Fang Wang,Linzhi Yan,Mengchun Chen,Ledan Wang,Yijie Chen
An effective therapeutic strategy to treat vulvovaginal candidiasis (VVC) that is mainly caused by Candida albicans ( C. albicans ) infection is highly desirable. While Amphotericin B (AmB) has demonstrated promise, its precise localization to C. albicans burden at vaginal sites is oftentimes limited by the high fluidity microenvironment of the vagina, which can compromise treatment efficacy. To overcome this issue, a biomimetic AmB delivery system is developed, in which AmB preloaded polymeric cores are cloaked with vaginal epithelial cells membrane (VM-ANP). With its cell membrane coating, VM-ANP naturally targets and strongly binds with C. albicans , thus resisting the self-cleaning of vaginal fluid. Besides its long retention property, VM-ANP could penetrate deeply in vaginal tissue to achieve its full antifungal potential by attaching to hidden C. albicans . It is shown that both C. albicans suspension and biofilm biomass could be effectively inhibited by the VM-ANP in vitro. In a C. albicans intravaginal infection model, treatment with VM-ANP results in significantly decreased fungal challenges both in vaginal tissue and fluid. Overall, such biomimetic strategy adds the merit of natural cell membrane into the targeted delivery of drug in treating VVC, which also serves as a promising platform against vaginitis-related pathogens.
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高影响因子
APPLIED CATALYSIS A-GENERAL
·
2022
·
IF 5.723
Wen Lu,Chen Wang,Yanan Han,Yuxuan Bai,Siyi Wang,Wenke Xi,Jianjun Wang
Covalent organic frameworks (COFs) have been widely used based on their ordered pore structure, inherent porosity, high specific surface area and excellent stability. Herein, the active two-dimensional COF (named HDU-25) photocatalyst was preformed by the solvothermal method, and the structure and morphology were characterized and analyzed. The effects of key factors on rhodamine B (RhB) degradation by HDU-25 were evaluated. The results showed that under suitable conditions, HDU-25 exhibited an excellent photocatalytic degradation rate of 99.9% for persulfate-assisted photocatalytic degradation of RhB, and HDU-25 also had superior stability and reusability. In addition, the mechanism of RhB degradation was investigated using free radical capture experiments and electron spin resonance (ESR) experimental analysis. The intermediates were detected by high performance liquid chromatography-mass spectrometry (HPLC-MS), and possible degradation pathways were suggested. The results of this research highlight the potential of HDU-25 photocatalysts to degrade organic dyes in wastewater.
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POLYMER
·
2022
·
IF 4.432
Ze-Kun Zhang,Shi-Peng Ding,Ze Ye,Ding-Li Xia,Jun-Ting Xu
In this study, the poly(ionic liquid)s (PILs)-based block copolymers (BCPs) with a high charge density, poly(ethylene oxide)- b -quaternized poly(4-vinylpyridinium) with X − as counterion (PEO- b -QP4VP-X), were prepared by full quaternization of the poly(4-vinylpyridine) (P4VP) block in neutral PEO- b -P4VP BCP. The complete quaternization of P4VP block was confirmed by NMR and FT-IR. The phase separation behavior of PEO- b -QP4VP-X BCPs was examined, which was found to be strongly dependent on the counterion species. Specifically, as compared with the neutral PEO- b -P4VP, PEO- b -QP4VP-Br exhibits a stronger segregation strength , while the other three PEO- b -QP4VP-X (X = PF 6 , TFO and TFSI) BCPs show a weaker phase separation ability. The phase behavior of PEO- b -QP4VP-X was explained using the thermodynamic mechanism originally applied for salt-doped BCPs of low charge density. The variation of the Flory-Huggins parameter (Δ χ ) can be divided into three terms: Δ χ 1 due to the change in monomer identity after quaternization, Δ χ Born from the Born energy of counterions and χ Γ arising from the local charge cohesion. For PEO- b -QP4VP-X BCPs, both Δ χ 1 and Δ χ Born are negative, but χ Γ is positive, and they vary with counterion size in different ways. The competition of these three terms dominates the change tendency of phase behavior, among which Δ χ 1 plays an important role at high level of charge density. The rationality of the aforementioned thermodynamic mechanism of Δ χ was also verified by the phase behavior of salt-doped PEO- b -QP4VP-X.
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