ANALYTICAL CHEMISTRY
·
2016
·
IF 5.886
Lingshan Gong,Hong Dai,Shupei Zhang,Yanyu Lin
In this work, we first exposed that the application of p-type semiconductor, silver iodide-chitosan nanoparticle (SICNP), acted as peroxidase mimetic to catalyze the bioprecipitation reaction for signal-amplification photocathodic immunosensing of human interleukin-6 (IL-6). After immobilization of captured antibody onto a polyethylenimine-functionalized carbon nitride (CN) matrix, SICNPs as photoactive tags and peroxidase mimetics were labeled on secondary antibodies, which were subsequently introduced onto the sensing interface to construct sandwich immunoassay platform through antigen–antibody specific recognition. Due to the matched energy levels between CN and AgI, the photocurrent intensity and photostability of SICNP were dramatically improved with rapid separation and transportation of photogenerated carriers. Moreover, the insoluble product in effective biocatalytic precipitation reaction served as electron acceptor to scavenge the photoexcited electron, leading to great amplification of the photocurrent signal of SICNP again. With the help of multiamplification processes, this photocathodic immunosensor presented a turn-on photoelectrochemical performance for IL-6, which showed wide linear dynamic range from 10–6 to 10 pg/mL with the ultralow detection limit of 0.737 ag/mL. This work also performed the promising application of SICNP in developing an ultrasensitive, cost-effective, and enzyme-free photocathodic immunosensor for biomarkers.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Yali Zhao,Jiayue Chen,BingXi Wang,Li Wei
An ideal and highly desired wound dressing for the repair of infectious wounds should provide a moist environment, close adhesion to the wound site, and self-healing and antibacterial properties. Thus, in the present study, we manufactured multifunctional, mussel-inspired hydrogels CACS-Fe 3+ -CYCS and CACS-Fe 3+ using catechol-grafted-chitosan (CACS) and cysteine-modified-chitosan (CYCS) as raw materials and ferric chloride as a cross-linking agent. The CACS-Fe 3+ -CYCS hydrogel exhibited excellent adhesion because of metal coordination between the ferric ion (Fe 3+ ) and catechol groups and a strong covalent bond between the catechol groups and the amino and sulfhydryl groups. Its self-healing quality was attributed to the dynamic and reversible properties of metal coordination. The loading of the total flavones of Resina Draconis (RDF) provided the hydrogel with good antibacterial properties. The antibacterial rates of the CACS-Fe 3+ -CYCS and RDF-CACS-Fe 3+ -CYCS hydrogels for Escherichia coli and Staphylococcus aureus were 90.62% and 96.45% and 99.98% and 100.00%, respectively. The RDF-CACS-Fe 3+ -CYCS hydrogel at pH 5.0, 6.8, and 8.0 in phosphate-buffered saline exhibited slow, sustained cumulative release rates of 53.94%, 71.97%, and 85.13% at 60 h, respectively. Complete wound healing was observed by day 12 in the CACS-Fe 3+ -CYCS hydrogel group (healing ratio = 96.59%). In the RDF-CACS-Fe 3+ -CYCS hydrogel group, complete healing was achieved by day 9 (healing rate = 94.46%; highest value at all treatment times). Thus, both hydrogels can be used as an ideal dressing for treating infectious wounds. The combination of traditional Chinese medicine and novel wound dressings can work synergistically, providing a novel strategy for designing biomimetic hydrogels for potential applications in wound healing.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Yongjian Xu,Hao Chen,Lan Zhang,Yang Xu
In this study, the formation of clove essential oil loaded chitosan nanocapsules (CEO/CS-NCs) was achieved by the ionotropic gelation technology. The spherical shape and core-shell structure of CEO/CS-NCs were characterized by SEM, TEM , and FT-IR. CEO/CS-NCs have a reasonable encapsulation efficiency rate of 39 % and an average size of 253.63 nm. The simulated release of CEO/CS-NCs in a citric acid buffer solution shows that the nano-encapsulation technology could control the sustained release of clove essential oil (CEO). The shelf life of untreated blueberries at room temperature is only about 3 days, while CEO/CS-NCs combined with low-temperature storage can extend the shelf life to about 12 days. The quality characteristic of blueberries, including fruit firmness and moisture content, were effectively maintained, and the rotting rate of blueberries was significantly reduced with CEO/CS-NCs. As a natural preservative, CEO/CS-NCs have a good antioxidant activity close to the commercial antioxidant butylated hydroxytoluene (BHT) and a high antibacterial activity against pathogenic bacteria (PB) isolated from naturally occurring blueberries. Therefore, this study not only gives a theoretical basis for the development of CEO as a commercial preservative but also provides a practical solution to solve the protection challenge of preserving blueberries.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Sizhao Zhang,Yanrong Liao,Kunming Lu,Zhao Wang,Jing Wang,Linzhe Lai,Wangwang Xin,Yunyun Xiao,Shixian Xiong,Feng Ding
Chitosan aerogels could be applied potentially in thermal insulation for energy-saving buildings, separation/adsorption, and catalysis. However, disadvantages of chitosan aerogels include their hydrophilicity and low insufficient mechanical strength. Here we propose a silica-phase hybriding route to create chitosan/silica hybrid aerogels with a synergistic capability for favourable hydrophobicity and superior mechanical strength, demonstrating an emergent finding (hydrophobicity optimised with the improved mechanical strength). The aerogels exhibit low drying shrinkage (as low as 13.41 %), lightweight (lowest to 0.149 g cm −1 ), high-efficient thermal insulation (thermal conductivity as low as to 0.024 W m −1 K −1 at room temperature and normal pressure) either under cryogenic (−196 °C) or high-temperature conditions, exceptional fire-retardancy (self-extinguishing in 1.8 s) and environmentally friendly characteristic (initial mineralisation after 10 d). High hydrophobic property (water contact angle up to 142°) of the aerogels were achieved depending upon 1H, 1H, 2H, 2H-perfluorodecyltriethoxysilane of vapor deposition, presenting a discovery concerning substantial improvement of mechanical properties (up to 0.188 MPa at 5 % strain, increased by 25 %). Furthermore, we demonstrate that a plausible mechanism for simultaneous hydrophobic and mechanical enhancement is depending upon the modulation of networking skeletons at the nanoscale.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Wenjie Ye,Jianfeng Xi,Yan Sun,Liucheng Meng,Huiyang Bian,Huining Xiao,Weibing Wu
Elastic and hydrophobic aerogels have received a lot of attention in dealing with the increasing oil pollution due to their recyclable properties. Herein, we present an ultralight and superelastic aerogel with highly oriented polygon structure based on chitin nanofibril (ChNF) and chitosan (CS) by directional freezing. The chemical cross-linking enables good mechanical strength at low aerogel density. After 500 compression-release cycles, the aerogel can retain the deformation recovery rate of 88 % in air, demonstrating the excellent resilience. The bio-based aerogel has high absorption capacity (52-114 g/g) for various oils and organic solvents , and it is able to achieve the absorption retention of 90 % even after 20 absorption-extrusion cycles. Moreover, owing to the good elasticity, the pore size of the aerogel can be adjusted by compression to selectively separate water-in-oil emulsions of different particle sizes with separation efficiencies higher than 99.5 %. The bio-based aerogel with good cycle performance has broad application prospects in the field of oil-water separation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2023
·
IF 8.2
Lin Huang,Wantao Wang,Yiwen Xian,Lei Liu,Jinghao Fan,Hongmei Liu,Zhaomin Zheng,Decheng Wu
Intervertebral disc (IVD) degeneration occurred with the increasing age or accidents has puzzled peoples in daily life. To seal IVD defect by injectable hydrogels is a promising method for slowing down IVD degeneration. Herein, we reported a rapidly in situ forming injectable chitosan/PEG hydrogel (CSMA-PEGDA-L) through integrating photo-crosslink of methacrylate chitosan (CSMA) with Schiff base reaction between CSMA and aldehyde polyethylene glycol (PEGDA). The CSMA-PEGDA-L possessed a stronger compressive strength than the photo-crosslinked CSMA-L hydrogel and Schiff-base-crosslinked CSMA-PEGDA hydrogel. This chitosan/PEG hydrogel showed low cytotoxicity from incubation experiments of nucleus pulpous cells. When implanted on the punctured IVD of rat's tail, the CSMA-PEGDA-L hydrogel could well retard the progression of IVD degeneration through physical plugging, powerfully proven by radiological and histological evaluations. This work demonstrated the strategy of in situ injectable glue may be a potential solution for prevention of IVD degeneration.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2023
·
IF 6.4
Yahong Xie,Ke Zhao,Haobin Wang,Ying Qi,Peng Wei,Jian Cheng
SnO2 is considered as a promising electron transport material for carbon-based perovskite solar cells (C-PSCs) due to its excellent electron mobility, stability over TiO2, and low-temperature processing. However, the lattice mismatch and poor contact quality of the SnO2/CH3NH3PbI3 interface, as well as oxygen vacancies, usually lead to nonradiative recombination and limit the further improvement of photovoltaic performance. In this paper, two chitosan derivatives, chitosan quaternary ammonium salt (HACC) and carboxymethyl chitosan (CMCS), were used as additives for SnO2 to adjust the energy level and improve the contact performance of the SnO2/CH3NH3PbI3 interface. These two additives have suitable terminal active functional groups, amino group and hydroxyl group, which can interact with SnO2 and CH3NH3PbI3 at the interface, induce the crystal growth of the perovskite, and play a good role in passivating interfacial defects. Therefore, the interfacial contact and the charge-transfer ability were effectively enhanced. As a result, the addition of HACC and CMCS increased the PCE of C-PSCs from 10.17 to 12.42 and 13.39%, and the repeatability and long-term stability of the corresponding unencapsulated C-PSCs were also significantly improved. This work expands the vision for the future interface modification strategies to improve the device performance and is conducive to promote the further commercialization of C-PSCs.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Ying Li,Xiu-Er Luo,Ming-Jun Tan,Fu-Hao Yue,Run-Yu Yao,Xin-An Zeng,Meng-Wai Woo,Qing-Hui Wen,Zhong Han
In this study, a novel carboxymethylcellulose / ZnO / chitosan (CMC / ZnO / Cs) hydrogel microbeads loaded with crosslinked porous starch / curcumin (CPS / Cur) were designed and prepared to improve the encapsulation efficiency of curcumin for drug delivery to specific sites. It was found that the total pore volume of crosslinked porous starch (CPS) was increased by 1150 % when compared to the native starch (NS), and the adsorption ratio of curcumin by CPS was enhanced by 27 % when compared to NS. Secondly, the swelling ratio of composite hydrogel microbeads was within 25 % in an acidic environment at pH 1.2, and the swelling ratio of hydrogel microbeads sharply increased to 320 % ~ 370 % at pH 6.8 and 7.4. In addition, the results of in vitro simulated release experiments showed that the released amount of hydrogel microbeads loaded with NS/Cur and CPS/Cur in SGF were within 7 % in simulated gastric fluid (SGF). The highest released amount of curcumin was 65.26 % for hydrogel beads loaded with CPS/Cur, which was 26 % lower than that of hydrogel microbeads loaded with Cur in simulated intestinal fluid (SIF). In simulated colonic fluid (SCF), the released amount of hydrogel microbeads loaded with CPS/Cur and Cur were 73.96 % and 91.69 %, respectively. In conclusion, pH-sensitive drug delivery system with good drug stability and bioavailability were successfully prepared with carboxymethylcellulose / ZnO / chitosan bead, suitable targeting drug delivery to the small intestine .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2023
·
IF 3.9
Qianwen Xue,Jiangqin Wu,Zaosheng Lv,Yang Lei,Xuegang Liu,Yanfen Huang
Superhydrophobic cotton fabrics have a lot of potential for use in practical settings. The majority of superhydrophobic cotton fabrics, however, only serve one purpose and are made from fluoride or silane chemicals. Therefore, it remains a challenge to develop multifunctional superhydrophobic cotton fabrics using environmentally friendly raw materials. In this study, chitosan (CS), amino carbon nanotubes (ACNTs), and octadecylamine (ODA) were used as raw materials to create CS-ACNTs-ODA photothermal superhydrophobic cotton fabrics. The cotton fabric that was created showed a remarkable superhydrophobic property with a water contact angle of 160.3°. The surface temperature of CS-ACNTs-ODA cotton fabric can rise by up to 70 °C when exposed to simulated sunlight, demonstrating the fabric’s remarkable photothermal capabilities. Additionally, the coated cotton fabric is capable of quick deicing. Ice particles (10 μL) melted and began to roll down in 180 s under the light of “1 sun”. The cotton fabric exhibits good durability and adaptability in terms of mechanical qualities and washing tests. Moreover, the CS-ACNTs-ODA cotton fabric displays a separation efficacy of more than 91% when used to treat various oil and water mixtures. We also impregnate the coating on polyurethane sponges, which can quickly absorb and separate oil and water mixtures.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Pan Wu,Yaru Fang,Kezhou Chen,Mi Wu,Wenchang Zhang,Shiyu Wang,Dongwen Liu,Junqing Gao,Huaiguo Li,Jianhua Lv,Yan Zhao
Based on sodium methacrylate alginate (MASA) and carboxymethyl chitosan (CMCS), double network (DN) hydrogels were formed by covalent crosslinking and physical crosslinking in succession. Covalent crosslinking was achieved by using poly(ethylene glycol) diacrylate (PEGDA) as the crosslinker and initiated by ammonium persulfates, while physical crosslinking was realized by the electrostatic interactions between the carboxyl group of MASA and the amino group of CMCS induced by acetic acid atmosphere. With the addition of PEGDA (1.25 wt% of mixture solution), the compressive strength of hydrogel was increased from 9.0 kPa to 73.3 kPa. Compared with the physically cross-linked hydrogels, the light transmittance of the DN hydrogels at 600 nm was significantly increased from 23.7% to 93.8%. The drug release studied by taking berberine hydrochloride hydrate (Ber) as the model drug showed that drug release behaviors of the DN hydrogels were pH sensitive and notably correlated with the content of PEGDA. In addition, DN hydrogels existed excellent water absorption rate (38.3-fold). Therefore, the enhanced mechanical properties, high transparency, excellent water absorption rate, and pH sensitivity of the DN hydrogel suggested the promising applications of the hydrogels as visual transdermal drug delivery systems.
✓ 已验证
产品关联
DOI
高影响因子
COMBUSTION SCIENCE AND TECHNOLOGY
·
2023
·
IF 1.9
Chunhui Lyu,Junqing Meng,Yanan Hou,Lijuan Wang,Jie Wang,Yingpei Lyu
Flame‐retardant silicone rubber foams (SRF) were prepared by dehydrogenation at room temperature with chitosan (CS) and cyclodextrin (CD) as flame retardants. The flame retardancy, smoke suppression, mechanical properties, and thermal stability of SRF with CS and CD were tested using the UL-94 test, limiting oxygen index (LOI), cone calorimeter test (CCT), compression test, field emission scanning electron microscope (FESEM), and thermogravimetry analysis (TGA). The results indicated that the fire behavior was good when the content of CS and CD was 1 wt%, and the CD had a flame-retardant efficiency better than CS. The combination of 0.6 wt% CS and 0.4 wt% CD had the best synergistic flame-retardant efficiency, smoke suppression, and excellent thermal stability. The 0.6%CS/0.4%CD/SRF achieved an LOI value of 30% and a UL-94 V-0 rating and did not drip. Compared with pure SRF, the peak heat release rate (pHRR), the total heat release (THR), the peak smoke production rate (pSPR), and the total smoke production (TSP) decreased by 60.00%, 55.52%, 53.82%, and 55.00%, and the char residue increased by 17.40%. However, the addition of CS and CD slightly worsened the mechanical properties of SRF, and the compressive strength of 0.6%CS/0.4%CD/SRF was reduced by 3.62%.
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Jia Wan,Yongzhi Liang,Xiaofeng Wei,Haiyi Liang,Xu-Lin Chen
Skin injuries are one of the most common clinical traumas worldwide, and wound dressings are considered to be one of key factors in wound healing. Natural polymer-based hydrogels have been developed as ideal materials for a new generation of dressings due to their excellent biocompatibility and wetting ability. However, the inadequate mechanical performances and lack of efficacy in promoting wound healing have limited the application of natural polymer-based hydrogels as wound dressings. In this work, a double network hydrogel based on natural chitosan molecules was constructed to enhance the mechanical properties, and emodin, a herbal natural product, was loaded into the hydrogel to improve the healing effect of the dressing. The structure of the chitosan–emodin network formed by Schiff base reaction and microcrystalline network of biocompatible polyvinyl alcohol endowed hydrogels with excellent mechanical properties and ensured its integrity as wound dressings. Moreover, the hydrogel showed excellent wound healing properties due to the loading of emodin. The hydrogel dressing could promote cell proliferation, cell migration, and secretion of growth factors. The animal experimental results also demonstrated that the hydrogel dressing facilitated the regeneration of blood vessels and collagen and accelerated wound healing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）