Journal of Materials Chemistry A
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2018
·Vol. 6
·期 19
·8930-8939
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IF 9.931
Yu-Xia Li,Shuai-Shuai Li,Ding-Ming Xue,Xiao-Qin Liu,Meng-Meng Jin,Lin-Bing Sun
Cu(I)-containing materials have great potential in various applications such as in CO adsorption; however, development of an efficient and controllable method to produce Cu(I) sites remains a significant challenge; herein, a two-step double-solvent (DS) strategy is reported for the first time to fabricate Cu(I) sites in a representative metal–organic framework, MIL-101(Cr); this strategy ensures that both introduction of the Cu(II) precursor and its reduction to Cu(I) occur inside the pores and significantly minimizes the aggregation of Cu species. This is difficult to realize through conventional methods used for Cu(II) introduction (wet impregnation) or reduction (liquid-phase reduction). The two-step DS strategy involves selective reduction of Cu(II) to form Cu(I) without the formation of any Cu(0). The obtained Cu(I)-containing materials exhibit an excellent CO adsorption capacity (up to 2.42 mmol g−1) at 298 K and 1 bar, much better than that of the benchmark adsorbents including CuCl/γ-Al2O3 (1.0 mmol g−1), CuCl/MCM-41 (0.57 mmol g−1), and CuZSM-5 (0.11 mmol g−1).
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FOOD HYDROCOLLOIDS
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2022
·
IF 11.504
Weiwei Hu,Huan Cheng,Dongmei Wu,Jianle Chen,Xingqian Ye,Shiguo Chen
The rhamnogalacturonan I (RG-I) region of pectin shows health benefits and novel gel applications. Commercial pectin is extracted from citrus peel in most instances, whereas they are homogalacturonan (HG)-dominated productions and the methods to extract pectin targeting RG-I are limited. To take full advantage of citrus wastes and upgrading this pectin resources, a new extraction method based on a diluted NaOH assisted by a combination of ultrasound (US) and pressure, namely manosonication (MS), was established for RG-I enriched pectin extraction. MS significantly enhanced the pectin yield (21.47 ± 0.11%) while reducing the use of NaOH reagents (50 mmol/L) and processing time (50 min). Structurally, the MS (300 kPa) resulting products achieved nearly a 2-fold greater RG-I content (58.61 mol%) than that of commercial pectin (30.12 mol%). Moreover, for the investigation of the extraction mechanism, external pressure enhanced the cavitation effect, as the calorimetric intensity increased from 1.28 W/mL (100 kPa) to 3.3 W/mL (350 kPa). A sufficient ultrasonic mechanical action allowed for obtaining RG-I enriched products with large molecular weight (9.506 × 10 4 –2.813 × 10 5 ) and low degree of methoxylation. Transmission electron microscopy (TEM) and scanning electron microscopies (SEM) verified the increased disintegration of the cell wall tissue by MS. Raman imaging and immunofluorescence labeling suggested the synergistic effect of pressure and ultrasound on enhancing the yields and RG-I content. This new method provided alternations in functional polysaccharides extraction, and the yield and structure of citrus RG-I enriched pectin strongly indicates the potentials of MS in other RG-I rich vegetables applications.
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Molecular Catalysis
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2018
·
IF 0
Xia Chen,Xu Ye,Wen-Yu Liang,Qing Zhou,Giang Vo-Thanh,Ye Liu
The unique amphiphilic Zwitterionic P,O-hybrid ligand ( L1 ) containing phosphino-fragment and −SO 3 − group was synthesized and firstly applied in Au-catalyzed hydration of alkynes. Without the aid of any auxiliary additive such as acid or silver salt, L1 -based Au-catalyst exhibited excellent activity towards hydration of alkynes to yield ketones with 100% selectivity according to Markovnikov’s rule. On the other hand, L1 -based Au-catalyst could be recycled for 4 runs in room temperature ionic liquid of [Bmim]PF 6 without obvious activity loss, and also exhibited wide generality to the hydration of different alkynes.
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APPLIED OPTICS
·
2016
·Vol. 55
·期 35
·9907-9916
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IF 1.598
Hongpeng Liu,Dan Yu,Ke Zhou,Dongyao Mao,Langbo Liu,Hui Wang,Weibo Wang,Qinggong Song
Temperature-induced diffraction spectrum responses of holographic
gratings are characterized for exploring the temperature-sensing
capability of a holographic sensor. Linear blue shift of peak
wavelength and linear diffraction reduction are observed. It provides
quantitative expressions for sensing applications. Inorganic
nanoparticles are dispersed into the binder to improve sensing
properties. Obvious improvement of sensing parameters, including
wavelength shift and diffraction change, is confirmed. The
sensitivity, response rate, and linear response region of holographic
sensors are determined to evaluate sensing capacity. Influence of
relative humidity on holographic sensing response is discussed.
Expansion of humidity range provides a probability for extending the
range of wavelength shift. Finally, the temperature response
reversibility of a holographic sensor is evaluated. These experimental
results can expand the practical application field of holographic
sensing strategy and accelerate the development of holographic
sensors.© 2016 Optical Society of
America
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
·
IF 6.3
Zizhao Fu,Jie Zhao,Rui Jiang,Shiliang Mei,Wanlu Zhang,Ruiqian Guo
I-III-VI alloyed quantum dots (QDs) have shown great application potential in many fields. At present, Al-based alloyed QDs have become a kind of ideal material of the color conversion layer of WLEDs because of their blue-emission, abundant raw material content, and the strong stability of Aluminum oxides. In this study, we synthesized blue-emitting CuAlSe 2 /ZnSe QDs and dual-emitting CuAlGaSe/ZnSe QDs by using hot-injection and one-pot method respectively, with a photoluminescence quantum yield (PL QY) of 46.75% and 68.79%. Their spectral tuning effect and the luminescence mechanism were investigated and discussed by changing the elemental molar ratios and nucleation temperature. By changing the Cu/(Al+Ga) and Al/Ga molar ratio, the emission wavelength of CuAlGaSe/ZnSe QDs was adjustable from 456 nm to 631 nm, with the Al and Ga competition mechanism in CuAlGaSe/ZnSe was also proposed. Finally, a single-component dual-emission CuAlGaSe/ZnSe WLED with a color rendering index (Ra) of 91.4 was prepared. This work demonstrated the superior fluorescence performance of multi-component QDs and the potential application of Al-based QDs in WLEDs.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2024
·
IF 2
Xiaofang Luo,Yuntian Xiao,Linlin Shi,Lingli Hou,Yongkang Liu,Ling Zhou,Qiuxiang Yin
Prednisolone (PDL), a corticosteroid extensively used in the treatment of allergic and autoimmune inflammatory diseases, faces limitations in clinical application due to its poor water solubility. Consequently, grasping the solid–liquid equilibrium behavior across diverse solvents is imperative for advancing the development of solid formulations with improved bioavailability. This study measured the solubility of PDL Form I in 13 pure solvents using gravimetric analysis and employed molecular dynamics, including molecular electrostatic potential surface analysis, Hirshfeld surface analysis, the independent gradient model based on Hirshfeld partitioning, radial distribution function, and solute–solvent interaction energy calculations, to explore the solid–liquid equilibrium behavior. The solubility of PDL Form I across various solvents exhibited a temperature-dependent increase, showing the largest variation in acetone. Radial distribution function analysis indicated multiple hydrogen-bonding interactions between the PDL molecule and the solvents tested. The calculations of solute–solvent interaction energy revealed that ethanol had the highest interaction energy with PDL, correlating with its the highest solubility. The validity of the solid–liquid equilibrium data was confirmed by fitting to the Apelblat equation, λh model, van’t Hoff equation, and NRTL equation, with an average relative deviation below 2.5, indicating good correlation.
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TALANTA
·
2024
·
IF 5.6
Jizhong Shi,Manshan Liang,Yiting Qiu,Jin Zhang,Shihua Wang,Heng Fang,Yongsheng Jiang,Xiaoxia Ye,Yanshu Luo,Zu-Sheng Huang,Yun-Yun Quan
Multifunctional type-I photosensitizers (PSs) for hydrogen sulfide (H 2 S) detection and photodynamic therapy (PDT) of hypoxia tumors exhibits attractive curative effect but remains a challenging task. Herein, a mitochondria targeted aggregation-induced emission (AIE) photosensitizer TSPy-SS-P was designed and synthesized, which could be used for H 2 S detection and simultaneously type I and type II PDT. TSPy-SS-P had excellent selectivity and anti-interference abilities for endogenous and exogenous H 2 S detection in tumor cells. TSPy-SS-P was able to distinguish tumor cells with high level of H 2 S from normal cells by fluorescence “turn off” response to H 2 S. In addition, TSPy-SS-P showed type Ⅰ and type Ⅱ reactive oxygen species (ROS) generation ability to effectively ablate hypoxic tumor cells. TSPy-SS-P showed mitochondria targeting capacity which could produce ROS in situ to disrupt mitochondria and promote cell apoptosis. In vivo PDT experiments showcased that TSPy-SS-P had excellent tumor retention capability, effective tumor ablation ability and good biocompatibility. This work provided a two-pronged strategy to design organelles targeted photosensitizers for H 2 S detection and effective PDT of tumors.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Xuedong Jia,Hongyuan Guo,Xiu Zhao,Ruining Liu,Xiayu Song,Zhuo Shi,Yingchun Zhu,Suozhu Wu
A novel electrochemical sensor based on gold nanoparticles-poly(phenylboronic acid)/glass carbon electrode (AuNPs-poly(PBA)/GCE) was successfully constructed for detecting nitrite (NO 2 − ) ions using the iodine/iodide (I 2 / I − ) mixed system as a probe. The AuNPs-poly(PBA) composites were firstly prepared on a bare GCE by one-step electrodeposition. By combining the specific enrichment ability of poly(PBA) to NO 2 − and I 2 / I − with the catalytic activity of AuNPs to the reaction between them, the response range of this sensor towards NO 2 − was 1.0 × 10 −11 M to 1.0 × 10 −4 M with a limit of detection (LOD) of 1.7 × 10 −12 M (S/N = 3). The sensor had the advantages of easy preparation, fast response, wide linear range, low LOD, and good selectivity, and could be applied to detect NO 2 − in beef and tap water samples with satisfactory results, which provided a highly sensitive and rapid analysis approach in the fields of food safety and environmental monitoring.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Chengren Ouyang,Jielin Yu,Haixin Teng,Guanrong Ou,Bingru Lu,Xu Zhang,Hao Xie,Chun-Qiong Zhou
The combination of type I photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted increased interest in the clinical treatment of tumors because of the suitability of oxygen-independent therapy for hypoxic tumors and the maintenance of high PTT efficacy by reactive oxygen species (ROS). Particularly, near-infrared (NIR) organic molecules have become a research hotspot because of their good reproducibility and low toxicity. However, the majority of them are still far from meeting the clinical requirements for phototherapeutic efficacy and biosafety. Herein, a croconium derivative, CR-497 , was synthesized with benzo[ e ]indole and (thiophen-2-yl)piperazine and complexed with Fe 3+ ( CR-497 -Fe 3+ ) and a tumor-targeting peptide to construct the CR-497 -Fe 3+ nanoparticle (NP) platform. At the breast tumor site, the released CR-497 exhibited pH activation for NIR fluorescence (NIRF) and photoacoustic (PA) imaging, type I PDT, and PTT. In the tumor microenvironment, where glutathione (GSH) and H 2 O 2 were overexpressed, the accumulated Fe 3+ induced ferroptosis and •OH generation. ROS from chemodynamic therapy (CDT) and PDT and lipid peroxidation from ferroptosis inhibited the expression of heat shock proteins (HSPs) and maintained the high efficacy of PTT. In a mouse model, CR-497 -Fe 3+ NPs accurately located the tumor by NIRF and PA bioimaging and exhibited the combined therapeutic effects of ferroptosis, CDT, PDT and PTT with good biosafety. This study presents an effective strategy for the design of tumor-targeted single-component croconium nanoplatforms that exhibit excellent biosafety and enhanced efficacy for type I PDT and PTT.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Baoling Tang,Jiance Jin,Kai Han,Tianrui Li,Haoran Zhang,Xuejie Zhang,Maxim Molokeev,Yuzhen Wang,Zhiguo Xia,Bingfu Lei
Exploring new types of scintillators, especially fabricating large-area scintillating screens, is essential in applications of life science, industry, and material science. However, the thickness and light scattering in composite scintillator film present a major challenge for balancing the spatial resolution and radioluminescence intensity. Herein, an in situ crystallization route is developed to innovate the preparation of the large-area scintillating screens based on the hybrid copper(I)-based C 6 H 8 N 2 OCuX (X = I and Br), in which carboxymethylcellulose sodium (CMC-Na) contribute to the “CMC-Na membrane” film formation and further increase absorption cross-section for X-ray radiation owing to the existence of Na elements. The choice of halogen can regulate the photoluminescence of C 6 H 8 N 2 OCuX (X = I, Br, and Cl) from cyan to green and then to yellow, and significant scintillation property can be achieved for C 6 H 8 N 2 OCuI with the light yield of 52 000 photons MeV −1 and detection limit of 43.14 nGy s −1 . Finally, the high X-ray absorption assisted by CMC-Na, as well as the thin thickness of the composite scintillator films help to realize remarkable spatial resolution above 14 lp mm −1 . This study provides a foundation for discovering high-performance copper(I)-based halides scintillators and offers a creative think film preparation method for X-ray imaging.
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Frontiers in Immunology
·
2025
·
IF 5.9
Huimin Xie,Lin Ma,Xiaoli He,Songsong Zhao,Jin Wang,Ao Zhu,Changming Liu,Olga Piskareva,Chao Deng,Fenghua Meng,Mi Liu
Introduction: Cancer vaccines work through activating tumor-specific T cells, which can specifically attack cancer cells by recognizing antigens binding with Major-Histocompatibility-Complex I (MHC I) molecules. The downregulation or loss of MHC I expression on tumor cells can affect the efficacy of cancer vaccines.Methods: Herein, to increase the MHC I expression on tumor cells, a nanovesicle-based strategy was developed to improve the efficacy of cancer vaccines. Several clinically applied medicines, such as tyrosine kinase inhibitors (TKIs), were screened for their capacity to upregulate MHC I.Results: Two TKIs, Sunitinib and Sorafenib, were found to be very effective in elevating MHC I expression, and they were encapsulated into redox-responsive nanovesicles respectively (SUN-KD10 or SOR-KD10), which demonstrated favourable tumor-targeting capabilities in the tumor microenvironment. Sunitinib or Sorafenib activates the IFNγ/STAT1 pathway, which improve the expression of MHC I. When combined with whole-tumor-antigen-loaded nanovaccines, these nanovesicle formulations elicited a synergistic antitumor effect in both breast cancer and melanoma mouse models. The tumors in the tumor-bearing mice treated with combined strategy grew more slowly and the survival times of such mice are significantly prolonged.Discussion: The studies demonstrated that more tumor-specific T cells were activated in the combined strategy treated mice, suggesting improved immune-mediated tumor clearance. This combinatorial approach provides a promising strategy to overcome immune evasion and to enhance the therapeutic outcomes of cancer vaccine-based immunotherapy by using clinical-applied medicines with cancer vaccines.
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BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
·
2023
·Vol. 41
·期 1
·325-337
·
IF 1.2
Li Juan,Chen Shuliang,Chen Yunlong,Hu Xianzhi,Zi Futing
The thiosulfate method is a cyanide-free hydrometallurgical method for gold extraction, but the existence of copper ion in Cu 2+ –NH 3 –S 2 O 3 2− system is not conducive to the subsequent gold(I) recovery. This paper describes a process for improving the gold(I) adsorption capacity of mercapto-functionalized silica gel (MP-SG) by using ethylenediamine (en) as an additive to mask copper(II). The effects of en/Cu 2+ molar ratio, contact time, and pH on adsorption were investigated. The results showed that the addition of en increased the adsorption capacity of MP-SG to gold by more than 70%. X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) confirmed that the valence states of gold and copper on the adsorbent were both + 1, which confirmed the occurrence of competitive copper(II) adsorption. This could be inhibited by the addition of en without affecting the interfacial properties of MP-SG. UV–vis spectroscopy and the distribution of copper species revealed that addition of en changed the composition of the solution, forming a more stable Cu(en) 2 2+ complex, the fraction of Cu(en) 2 2+ increased with en content, thus reducing the competitive adsorption of Cu(II) to gold (I). The recovery rate of gold in the actual thiosulfate leaching solution was up to 92.35%, and en has almost no influence on the recycling process of the recovered leaching liquor, which proves the feasibility of this method in practical application.
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