JOURNAL OF MEDICINAL CHEMISTRY
·
2016
·
IF 5.589
Zhao Ma,Yuxing Lin,Yanna Cheng,Wenxiao Wu,Rong Cai,Shouzhen Chen,Benkang Shi,Bo Han,Xiaodong Shi,Yubin Zhou,Lupei Du,Minyong Li
Fluorescent ligands are gaining popularity as tools to aid GPCR research. Nonetheless, in vivo application of such tools is hampered due to their short excitation wavelengths in the visible range and lack of fluorogenic switch. Here we report the discovery of fluorescent ligands (3a–f) for α1-adrenergic receptors (α1-ARs) by conjugating the environment-sensitive fluorophore cyane 5 (Cy5) with the quinazoline pharmacophore. Among them, the conjugated compound 3a, with acylated piperazine and the shortest carbon chain spacer, exhibited potent binding and remarkable changes in fluorescence (10-fold) upon binding to α1-AR. Furthermore, it could be employed to selectively and specifically label α1-ARs with no washing procedures in single cells, prostate tissue slices, intact tumor xenografts and organs in living mice. Especially, the slice imaging results gave direct and visual evidence that there is a close relationship between α1-ARs and pathological prostate. It is anticipated that our fluorescent tools will find broad applications in the study of α1-AR pharmacology and physiology to aid development of novel therapeutics.
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Cell Reports Physical Science
·
2025
·
IF 7.3
Junrong Lin,Zetao Dang,Yijing Du,Yanli Gao,Jia Li,Yuewei Zhang,Shoujun Zhu
Assessing the integrity of the blood-testis barrier (BTB) is critical, as it serves to protect developing sperm cells by creating a protective environment against toxins and pathogens. Here, we optimize a near-infrared (NIR) dye for in situ binding of endogenous albumin or constructing NIR-II fluorescent proteins (FPs) based on exogenous albumin, affording non-invasive in vivo imaging of BTB disruption with tunable time windows. To further enhance the targeting capability of FPs, we employ a site-directed mutagenesis (SDM) strategy to develop the mutant albumin with increased binding efficiency to CO-1080 at room temperature, which serves as a specialized exogenous albumin for accelerating the imaging window of BTB disruption. Given the common drawbacks of traditional modalities for assessing BTB integrity, non-invasive and real-time NIR-II imaging is an effective method for investigating the testicular microenvironment as well as understanding testicular physiology and pathology.
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RARE METALS
·
2025
·
IF 11
Liao Yin-Han,Liao Hai-Qing,Wu Xing-Mou,Liang Xu-Zhi,Zhang Shi-Yu,Liu Yan,Mo Wei-Jiu,Li Sui-Hua,Jiang Ming-Yang,Gao Zhi-Wei,Wang Jia-Xi,Gao Ming,Li Hao,Li Cui-Ping
Maxillofacial trauma is an infection and oxidative stress-induced damage to maxillofacial area related cells. Increasing evidences have suggested that therapeutic strategies with controllable anti-infective and anti-inflammatory capabilities hold great potentials in the clinical treatment of maxillofacial trauma. Herein, we reported an infectious microenvironment responsive bimetallic sulfide (FeCuS x , FCS) combining with near infrared (NIR) irradiation for maxillofacial trauma therapy. In cellular levels, FCS exhibited the most efficient antioxidant and anti-inflammatory, cell migration, and angiogenesis behaviors through down-regulating the inflammatory factor (iNOS) expression level, up-regulating anti-inflammatory factors (Arg-1 and TGF-β) expression level, inducing macrophages M2 polarization (CD86 down-regulation and CD206 up-regulation), and promoting tissue repair factors (CD31) expression level. Besides, it presented the excellent antibacterial ability of Escherichia coli (99.74%) and MRSA (99.78%) for FCS + NIR. Significantly, it also confirmed that FCS + NIR presented the excellent functions of inhibiting wound infections, decreasing wound inflammation, as well as promoting trauma tissue repairing. Altogether, it had developed the strategy of FCS + NIR for the synergistic enhancement of infectious maxillofacial trauma healing, could also serve as a promising therapeutic strategy for the treatment of infectious diseases. Graphical abstract
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Materials
·
2025
·Vol. 18
·期 17
·4165
·
IF 3.2
Heng Zhang,Yiping Yang,Shengchao Yang,Yuchang Qin,Xuan Lv,Lin Cui,Wei Jia,Zhiyong Liu
The impact of encapsulating gemcitabine (GEM) into nanoparticles on its delivery remains underexplored, with the potential benefits of targeted drug delivery and stimuli-responsive release yet to be fully clarified. Herein, we designed a near-infrared (NIR) light-responsive polymeric nanoparticle, ZnPc@P(PEG-CMA-TKGEM), which integrates reactive oxygen species (ROS) generation and cell imaging capabilities. The self-assembled polymeric micelles exhibit a hydrodynamic size of ~134 nm. Under NIR irradiation, the cumulative drug release rate reaches 51% within 48 h, which is three times higher than that of the non-irradiated control group. In cytotoxicity assays, the cell viability of the NIR-irradiated drug-loaded group is approximately 17%, while that of the NIR-irradiated blank group (without drug loading) remains above 80%. These results confirm that the nanocarriers successfully deliver GEM to target cells and achieve controlled drug release via NIR stimulation.
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PubMed
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FOOD HYDROCOLLOIDS
·
2025
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IF 12.4
Qingqing Li,Zhiyi Wu,Longdong Qin,Liang Zhang,Linpin Luo,Guangjun Huang,Jianlong Wang
Food spoilage caused by microbial proliferation and moisture loss remains a critical challenge in postharvest management. This study proposes a smart hydrogel system integrating photothermal-responsive Pickering emulsions and thermo-sensitive biopolymers to achieve on-demand antimicrobial release and water retention. The Pickering emulsion, stabilized by indocyanine green (ICG)-loaded halloysite nanotubes (HNTs), serves as an antimicrobial depot of cinnamaldehyde (Cin). Under near-infrared (NIR) irradiation, ICG converts light energy into heat, triggering both thermal-enhanced Cin volatilization and sol-gel transition of the κ-carrageenan/gelatin (CG) hydrogel matrix. This dual-action mechanism enables: (i) Spatiotemporal control: NIR exposure achieves precise Cin release, with cumulative release increasing to 21.5 %; (ii) Dual-mode antibacterial efficacy: The system exhibits a 3.12 cm inhibition zone against S. aureus and complete suppression of Penicillium expansum growth through combined contact and vapor-phase antimicrobial activity. (iii) Superior preservation performance: Grapes packaged with the hydrogel maintain 98.92 % initial weight after 14 days, with retained firmness, stable pH, and minimal soluble solids loss. By synergizing photothermal conversion, thermal-responsive hydrogel dynamics, and natural antimicrobials, this work establishes a non-contact preservation platform that extends grape shelf life by 250 %, demonstrating significant potential for intelligent food packaging applications.
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JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Xiaojuan Hu,Xingwen Cheng,Liqiang Shao,Lan Yang,Gongning Chen,Zhangwei Yan,Mengdie Yu,Yehui Kang,Xiaozhou Mou,Xianghong Yang,Yu Cai
Acute kidney injury (AKI) causes renal tubular damage, driven primarily by mitochondrial dysfunction and reactive oxygen species (ROS)-mediated oxidative stress, leading to a cellular energy crisis. The physiological architecture of the kidney hampers targeted drug delivery, rendering metabolic restoration a therapeutic challenge. To address this, we developed a second near-infrared (NIR-II) light-driven, bioenergetic nanoplatform (UCTR) that leverages upconversion nanoparticle (UCNPs)-enhanced photosynthesis for energy replenishment and mitochondrial repair in AKI. The UCTR consists of thylakoid membrane (TM)-encapsulated UCNPs cloaked with activated renal tubular epithelial cell membranes (RECM), enabling targeted accumulation in injured tubules. The UCNPs convert deep-tissue-penetrating NIR-II light into visible wavelengths, activating photosynthetic adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide phosphate (NADPH) synthesis within the TM component under irradiation. This exogenous bioenergetic supply mitigates hypoxia-induced mitochondrial energy deficits, while the AMPK/PGC-1α pathway is simultaneously activated to restore the mitochondrial membrane potential. Moreover, UCTR synergizes the antioxidative and anti-inflammatory effects of plantain, accelerating tubular repair.
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Materials Today Advances
·
2026
·
IF 8
Jiabao Xiong,Yuan Wang,Lijun Zhu,Zhong Du,Le Guo,Jiayi Ding,Chi Zhang,Siyiti Amuti,Junhua Hu,Chao Wang,Biao Dong,Nuernisha Alifu
Overcoming thermoresistance and achieving precise, efficient tumor therapy remain major challenges. Heat shock protein 70 (HSP70) expression and autophagy activation are two major cellular defense mechanisms associated with thermal resistance. However, strategies that target both mechanisms to improve tumor treatment efficacy remain limited. Herein, this study presents a novel type of near-infrared II (NIR-II)-responsive theranostic nanoplatform (IR-820@γ-PGA/Arg NPs, PIRA NPs) that integrates photothermal therapy (PTT), photodynamic therapy (PDT), nitric oxide (NO)-mediated gas therapy (GT), and dual-pathway inhibition mechanisms to overcome thermal resistance. The theranostic nanoplatform utilizes a γ-polyglutamic acid (γ-PGA) to encapsulate the NIR-II dye IR-820, which forms stable J-aggregates to improve NIR-II fluorescence emission and photothermal conversion efficiency. The nanoplatform adsorbs L-arginine (Arg) and releases NO under 808 nm laser excitation, exhibiting excellent photothermal properties and NIR-II fluorescence emission for precise tumor treatment. PIRA NPs overcome photothermal resistance via two pathways: suppressing HSP70-mediated thermoresistance and disrupting the autophagy-lysosomal degradation pathway (LC3B/p62 axis) through Arg-derived NO generation. This dual-pathway blockade effectively neutralizes tumor defenses, achieving a 92.7% tumor inhibition rate with minimal systemic toxicity. The γ-PGA framework enhances the stability of J-aggregates and their biocompatibility, further improving therapeutic efficacy. This work provides a versatile nanotherapeutic platform based on a promising strategy for reversing thermoresistance and achieving highly efficient cancer therapy.
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Advanced Optical Materials
·
2026
·
IF 7.2
Qian Zhu,Huilin Chen,Ruichan Lv,Yuzhen Wang,Zhiguo Xia
Near-infrared II (NIR-II) emissions are unique and selective for non-destructive detection owing to their specific response to temperature changes and the ability to cover the characteristic overtone absorption bands of molecular functional groups. However, cross-interference in the spectral responses occurs for simultaneous temperature sensing and chemical reagent identification, therefore it is necessary to realize reliable decoding. Herein, the Nd 3+ / Er 3+ co-doped Y 2 MgTiO 6 phosphors with NIR-II emissions under 808 nm excitation have been designed and prepared, and the temperature sensing properties have been evaluated, in which the distinctive thermally enhanced luminescence is attributed to the efficient energy transfer process from Nd 3+ to Er 3+ ions. Besides, NIR-II-emitting composite film based on the rationally designed phosphors has been fabricated as the sensing platform, and the concentration recognition of water and methanol is enabled by the overtone absorption of C─H and O─H bonds. Finally, a Large Scale Convolutional Neural Network model is constructed to synchronously decouple, which can accurately extract temperature and chemical concentration from complex spectral data. This work paves the way for constructing a feasible and compact platform for dual-function intelligent sensors.
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INORGANIC CHEMISTRY COMMUNICATIONS
·
2026
·
IF 5.9
Yichen Yang,Xiaojiao Kang,Qiwen Pan,Zhennan Zhu,Wei Lü
Broadband near-infrared (NIR) phosphor-converted light-emitting diodes (pc-LEDs) are gaining significant interest due to their potential in spectroscopic applications. NIR phosphors play a critical role in pc-LED devices by converting visible light into NIR emission with high stability and tunability. In this study, an efficient broadband NIR phosphor, Ca 3 TiTaGa 3 O 12 :Cr 3+ , is developed and systematically investigated. Ca 3 TiTaGa 3 O 12 :Cr 3+ exhibits a broad NIR emission band centered at 790 nm with a full width at half maximum (FWHM) of 202 nm upon 450 nm blue light excitation. The emission bandwidth is further expanded to 303 nm by introducing an optimal amount of Yb 3+ co-doping, which produces a merged ultra-broadband Cr 3+ –Yb 3+ emission. Luminescence and decay kinetic analysis reveal that the resultant ultra-broadband emission originates from effective energy transfer Cr 3+ to Yb 3+ . Moreover, the Yb 3+ co-doping enhances the internal quantum efficiency from 30.5% to 41.3%, and improves thermal stability with emission retention increasing from 42.6% to 57.4% at 150 °C. The Ca 3 TiTaGa 3 O 12 :Cr 3+ and Ca 3 TiTaGa 3 O 12 :Cr 3+ , Yb 3+ phosphors are successfully integrated with a 450 nm blue LED chip, demonstrating their potential for practical NIR pc-LED device applications in night vision and bioimaging.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Xinru Chen,Xiaoyan Wang,Jin Li
Raman spectroscopy in the second near-infrared (NIR-II, 1000–1700 nm) window has received ever-increasing attention in intraoperative tumor imaging due to its high specificity and penetration depth. However, the overwhelming majority of existing NIR-II Raman probes are fabricated by SERS with substrate enhancement, which raises serious biosafety concerns. Herein, we present van der Waals (vdW) enhanced Raman scattering (vdW-ERS) effect based on intermolecular charge transfer of dithiolene to develop ultrabright metal-free NIR-II Raman probes. The intermolecular charge transfer within dithiolene through vdW stacking is well illustrated by independent gradient model and ultrafast spectroscopy, which significantly boosts the intrinsic Raman properties with ultrahigh scattering cross-section (1.59 × 10 −19 cm 2 ) as well as the photothermal conversion efficacy (60.4%) through an additional femtosecond-scale non-radiative decay channel. Moreover, the fluorescence-free property of dithiolene greatly inhibits the spectral backgrounds and improves the photostability. In the tumor models of triple-negative breast cancer, vdW-ERS probes enable intraoperative CXCR4-targeted Raman-guided surgical resection and postoperative hyperthermia ablation of the residual microscopic tumors, resulting in approximately 100% survival rate. Importantly, vdW-ERS probes are hepatically excreted (ca. 92% excretion within two months), in stark contrast to accumulation in the liver for typical gold substrate-enhanced counterparts. Free from fluorescence background and photobleaching, intermolecular vdW-ERS effect presents a new mechanism for fabricating charge transfer Raman probes with the potential for clinical translation.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·Vol. 24
·期 1
·150
·
IF 12.6
Li Bei,Chen Zhengqiang,Sun Yong,Gou Maling,Luo Yuting,Zhang Wenli,Ye Xiwen,Zhao Yaqin,Feng Lei,You Zhen
The deep-seated locations and hypoxic microenvironments of tumors critically hinder conventional phototherapies. To overcome these limitations, we engineered a novel Au@Cu 2 − x Se nanoprobe via precise aspect ratio control of gold nanorods for NIR-II plasmonic resonance and site-specific growth of Cu 2 − x Se domains, resulting in the formation of a unique “lollipop” nanostructure. This design enables single-wavelength NIR-II laser-activated photothermal therapy and dynamic dual-modal therapy with intrinsic hypoxia tolerance: the nanoprobes achieve exceptional photothermal stability while simultaneously driving photothermally enhanced chemodynamic activity through accelerated Fenton-like catalytic cycles. Crucially, this strategy not only eradicates deep tumors but also activates systemic antitumor immunity. Combined with real-time photoacoustic imaging guidance, the platform establishes an oxygen-independent paradigm for treating hypoxic solid tumors. Graphical
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Polymers
·
2026
·Vol. 18
·期 3
·378
·
IF 4.9
Lin Sun,Zihao Zhang,Bingxin Sun,Zhiheng Yu,Guoyong Wang
Vanadium carbide (V 2 C) MXene shows great potential for addressing challenging implant-associated infections in bone regeneration due to its strong photothermal conversion efficiency. However, its photothermal efficacy is restricted to the near-infrared I (NIR-I) region due to a limited absorption range. To address this, we designed platinum nanoparticle-decorated V 2 C heterostructures (Pt@V 2 C) via an in situ growth method, leveraging Pt’s plasmonic and catalytic properties to extend the photoresponse to the NIR-II window. Subsequently, Pt@V 2 C was integrated into poly-L-lactic acid (PLLA) to fabricate PLLA-Pt@V 2 C scaffolds with photothermal antibacterial function by selective laser sintering. The optimized PLLA-Pt@V 2 C scaffold achieves a record photothermal conversion efficiency (56.03% at 1064 nm), triggering simultaneous hyperthermia (>52 °C) and catalytic ·OH radical generation. In vitro studies demonstrate exceptional antibacterial efficacy against Staphylococcus aureus and Escherichia coli, achieving over 99% killing rates upon 1064 nm near-infrared irradiation. Furthermore, the scaffold demonstrated significant inhibition of biofilm formation, achieving over 90% reduction in biofilm biomass. Moreover, the scaffold demonstrated high cell viability, confirming its dual functionality of potent bactericidal activity and biocompatibility that supports tissue regeneration. This work provides a feasible strategy for combating implant-associated infections.
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