INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Zengsheng Wang,Lijian Xu,Weiling Liu,Yi Chen,Qiannian Yang,Zengmin Tang,Haihu Tan,Na Li,Jingjing Du,Maolin Yu,Jianxiong Xu
Pursuing high-performance conductive hydrogels is still hot topic in development of advanced flexible wearable devices. Herein, a tough, self-healing, adhesive double network (DN) conductive hydrogel (named as OSA-(Gelatin/PAM)-Ca, O-(G/P)-Ca) was prepared by bridging gelatin and polyacrylamide network with functionalized polysaccharide (oxidized sodium alginate, OSA) through Schiff base reaction. Thanks to the presence of multiple interactions (Schiff base bond, hydrogen bond, and metal coordination) within the network, the prepared hydrogel showed outstanding mechanical properties (tensile strain of 2800 % and stress of 630 kPa), high conductivity (0.72 S/m), repeatable adhesion performance and excellent self-healing ability (83.6 %/79.0 % of the original tensile strain/stress after self-healing). Moreover, the hydrogel-based sensor exhibited high strain sensitivity (GF = 3.66) and fast response time (<0.5 s), which can be used to monitor a wide range of human physiological signals. Based on this, excellent compression sensitivity (GF = 0.41 kPa −1 in the range of 90–120 kPa), a three-dimensional (3D) array of flexible sensor was designed to monitor the intensity of pressure and spatial force distribution. In addition, a gel-based wearable sensor was accurately classified and recognized ten types of gestures, achieving an accuracy rate of >96.33 % both before and after self-healing under three machine learning models (the decision tree, SVM, and KNN). This paper provides a simple method to prepare tough and self-healing conductive hydrogel as flexible multifunctional sensor devices for versatile applications in fields such as healthcare monitoring, human-computer interaction, and artificial intelligence.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Xiaole Gong,Jingquan Liu,Changbin Zhang,Mengyu Cao,Yuru Min,Chenyao Yuan,Xiaoxia Hu,Jiangtao Xu,Honglei Liu
Indoor formaldehyde pollution can cause inestimable harm to human health and even cancers, thus studies on the removal of formaldehyde attract extensive attentions. In this paper, an environmentally friendly and low-cost biomass material, sodium alginate (SA) was utilized to prepare pyrene functionalized amido-amine-alginic acid (AmAA-Py) by acidification and two-step amidation, which is subsequently self-assembled on reduced graphene oxide (rGO) by π-π stacking interaction, and the final composites were acidified to afford a highly porous composite material for chemical removal of formaldehyde. The formaldehyde chemical removal performance of composite is evaluated at different conditions and find that 1.0 g of acidified alginate derivatives and graphene composites (HCl·AmAA-Py-rGO) can adsorb 69.2 mg of HCHO . Simultaneously, amino groups in amido-amine derivative of acidified sodium alginate (AmAA) can react with acidic pollutants such as H 2 S and HCl via forming ionic bonding without generating any other by-products, which enables efficient and environment-friendly removal of acidic pollutants. The subtle design of the highly porous composite material utilizing low-cost SA and rGO with large specific surface area opens up a new methodology for fabricating highly porous materials for efficient removal of formaldehyde and other indoor hazardous pollutants.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Muhammad Yawar Younis,Wenting Li,Javed Khan,Yun Wei
A cost-effective and environmentally friendly composite hydrogel for the adsorption of Cd 2+ was fabricated by combining sodium alginate with lotus carbon dots (SA@lotus CDs). The impact of many factors, including doping amount, dose, pH, initial solution concentration, adsorption period, and temperature, on the process of Cd 2+ adsorption was studied. The adsorption isotherm was fitted well to the Langmuir isotherm model with high accuracy (R 2 = 0.9604). The adsorption kinetics conformed to the Pseudo-Second-Order kinetic model, demonstrating a high coefficient of determination (R 2 = 0.9238). The Langmuir model predicted that the adsorbent had adsorption capacity of 179.35 mg/g for Cd 2+ . After undergoing five cycles, the SA@lotus CDs continued to exhibit a removal effectiveness of 85.1 %. The SA@lotus CDs hydrogel composite was also used for the removal of Pb 2+ by 291.23 mg/g. The adsorption capability of the hydrogel was improved due to the addition of CDs. Pb 2+ was adsorbed by SA beads at 275.5 mg/g, while SA@lotus CDs had a slight increase to 291.23 mg/g (5.7 %). However, there was a 40.2 % increase in Cd 2+ adsorption from 127.89 mg/g by SA beads to 179.35 mg/g by SA@lotus CDs beads. The results of the adsorption tests showed the different removal efficiency of Pb 2+ and Cd 2+ by SA@lotus CDs. These findings suggested that SA@lotus CDs were more effective for removing Cd 2+ than Pb 2+ . The interaction mechanism between materials and metal ions was studied by using density functional theory. The interactions between CDs sites or SA sites and metal ions were calculated respectively. The results showed that the adsorption energy of CDs sites for metal ions was Cd 2+ < Cu 2+ < Pb 2+ < Fe 2+ < Co 2+ < Mg 2+ , while the adsorption energy of SA for Pb 2+ was much lower than that for Cd 2+ . Therefore, the affinity order of SA@lotus CDs for metal ions was Pb 2+ > Cd 2+ > Cu 2+ > Fe 2+ > Co 2+ > Mg 2+ , which was consistent with the experimental results.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Jin Fang,Zhiwei Zhao,Zhenzhen Xu,Qingqing Ni
Moisture electricity generator (MEG) is a green and environmental-friendly energy harvesting technology, and the ubiquitous presence of moisture makes it a strong competitor for mobile power. Among the available structural forms, fibrous MEG with engineered tunability and high integrality are perhaps one of the most promising solutions. However, the continuous preparation of fibrous MEG limits their scale-up production and commercial application. Herein, we utilized sodium alginate (SA) and multi-walled carbon nanotubes (MWCNTs) in combination with microfluidic sequential wet spinning to continuously fabricate axial heterogeneous structure fiber, where the gradient of oxygen-containing functional groups is critical for electricity generation. A single unit (1 cm) can produce an open-circuit voltage (V oc ) of 0.26 V, a short-circuit current (I sc ) of 2.59 μA, and a power density of 0.80 μW/cm 2 under moisture stimulation. The energy output can be easily increased by a simple series/parallel connection. Benefiting from the axial heterogeneous structure, the fibrous MEG can continuously output 0.2–0.25 V for more than 168 h. Furthermore, we extended the functionality and practicality of the fibrous MEG by incorporating materials with pH-responsive functions, which enables visual monitoring of acid/alkali gases. Overall, this work creates a new strategy for the structural design and large-scale continuous production of multifunctional fiber-based electronics.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Si Shi,Junjie Tang,Yanyan Zhou,Hongyan Huang,Jianxi Zhang,Wenhao Liu,Zhiwen Hu,Hongwei Wang,Jie Pang,Chunhua Wu
Maintaining the safety and quality of minimally processed agricultural products is a significant challenge in modern food supply chains. This study developed multifunctional sodium alginate (SA)-based films incorporating high internal phase Pickering emulsions (HIPPEs) stabilized by curcumin/β-cyclodextrin inclusion complexes (CUR/β-CD). The HIPPEs demonstrated excellent colloidal stability (>21 days) with a mean droplet diameter of 12.76 ± 0.32 μm. Through solvent casting, HIPPEs were uniformly integrated into SA matrices (0.5–2 % w/w). Based on a comprehensive characterization of the films, the optimum concentration of 1.5 % for doping with HIPPEs was determined. The SA/HIPPEs1.5 films exhibited excellent tensile strength (14.21 MPa), elongation at break (26.28 %), and adequate water vapor (6.5 × 10 −11 g/(m·s·Pa)) and oxygen permeability (1.06 × 10 −3 g/m 2 ·s). Furthermore, they demonstrated dual antimicrobial-antioxidant functionality, with inhibition zones of 19.30 ± 0.70 mm ( Staphylococcus aureus ) and 20.53 ± 0.40 mm ( Escherichia coli ), along with 70.63 % DPPH radical scavenging activity. Compared to polyethylene packaging, SA/HIPPEs1.5 films effectively preserved blueberry quality at 25 °C for 18 days, showing lower weight loss (30.6 % vs. 42.2 %) and a favorable pH (3.43 vs. 4.22). These findings support the potential of SA/HIPPEs composite films as an effective active packaging solution for extending blueberry shelf life.
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Journal of the American Heart Association
·
2025
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IF 5.3
Siyao Chen,Xiaodong Zeng,Meifeng Wu,Jiade Zhu,Yijin Wu
BackgroundMyocardial fibrosis is a pathological hallmark of heart failure post infarction, emphasizing the need for innovative treatment strategies. This research assesses the antifibrotic potential of a sodium alginate (SA) hydrogel loaded with extracellular vesicles (EVs) from bone marrow mesenchymal stem cells and PAP (p38α antagonistic peptides), aiming to interfere with fibrosis‐inducing pathways in myocardial tissue after infarction.MethodsWe induced fibrosis in mouse cardiac fibroblasts through hypoxia and disrupted the Mapk14 gene to study its contribution to fibrosis. Mesenchymal stem cell‐derived EVs, loaded with PAP, were encapsulated in the SA hydrogel (EVs‐PAP@SA). The formulation was tested in vitro for its effect on fibrotic marker expression and cell behavior, and in vivo in a murine model of myocardial infarction for its therapeutic efficacy.ResultsMap k14 silencing showed a decrease in the fibrotic response of cardiac fibroblasts. Treatment with the EVs‐PAP@SA hydrogel notably reduced profibrotic signaling, increased cell proliferation and migration, and lowered apoptosis rates. The in vivo treatment with the hydrogel post myocardial infarction significantly diminished myocardial fibrosis and improved cardiac performance.ConclusionsThe study endorses the SA hydrogel as an effective vehicle for delivering mesenchymal stem cell‐derived EVs and PAP to the heart post myocardial infarction, providing a novel approach for modulating myocardial fibrosis and promoting cardiac healing.
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BIOMEDICINE & PHARMACOTHERAPY
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2024
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IF 6.9
Qin Lihao,Liu Tingting,Zhang Jiawei,Bai Yifei,Tang Zheyu,Li Jingyan,Xue Tongqing,Jia Zhongzhi
In patients with diabetic wounds, wound healing is impaired due to the presence of persistent oxidative stress, an altered inflammatory response, and impaired angiogenesis and epithelization. Salvianolic acid B (SAB), which is derived from the Chinese medicinal plant Salvia miltiorrhiza , has been found to exhibit antioxidant, anti-inflammatory, and proangiogenic effects. Previous studies have used 3D bioprinting technology incorporating sodium alginate (SA) and gelatin (Gel) as basic biomaterials to successfully produce artificial skin. In the current study, 3D bioprinting technology was used to incorporate SAB into SA-Gel to form a novel SAB-SA-Gel composite porous scaffold. The morphological characteristics, physicochemical characteristics, biocompatibility, and SAB release profile of the SAB-SA-Gel scaffolds were evaluated in vitro. In addition, the antioxidant, anti-inflammatory, and proangiogenic abilities of the SAB-SA-Gel scaffolds were evaluated in cells and in a rat model. Analysis demonstrated that 1.0 wt% (the percentage of SAB in the total weight of the solution containing SA and Gel) SAB-SA-Gel scaffolds had strong antioxidant, anti-inflammatory, and proangiogenic properties both in cells and in the rat model. The 1.0% SAB-SA-Gel scaffold reduced the expression of tumor necrosis factor-α, interleukin-6, and interluekin-1β and increased the expression of transforming growth factor-β. In addition, this scaffold removed excessive reactive oxygen species by increasing the expression of superoxide dismutase, thereby protecting fibroblasts from injury. The scaffold increased the expression of vascular endothelial growth factor and platelet/endothelial cell adhesion molecule-1, accelerated granulation tissue regeneration and collagen deposition, and promoted wound healing. These findings suggest that this innovative scaffold may have promise as a simple and efficient approach to managing diabetic wound repair.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Zhuang-Zhuang Li,Peng Ren,Qing He,Si-Wen Li,Zheng-wen Wei,Rong-Xi Li,Xiang-Fei Lv,Wei Wang,Giuseppe Mele,Jian-She Zhao
This study innovatively synthesizes a bio-based poly(ionic liquid), namely GH.ALG, from renewable sodium alginate-an abundant, biodegradable marine biomass-thus avoiding reliance on petrochemical feedstocks. A heterogeneous catalyst, GH.ALG@POM, is fabricated by anchoring polyoxometalates (POMs) onto the GH.ALG, integrating POMs， robust oxidative capacity with the desulfurization and self-demulsuification properties of GH.ALG. Under optimized conditions (0.2 g catalyst, O/S molar ratio 7, 70 °C), GH.ALG@POM demonstrates exceptional desulfurization performance without the need for adding auxiliary extractants during the reaction stage: the desulfurization rate reaches 99.72 % for DBT, 85.79 % for 4,6- 4,6-DMDBT, and 55.35 % for BT. Notably, the catalyst retains over 95 % activity after five consecutive cycles. Applied to real diesel, it reduces sulfur content from 2.172 wt% to 0.1983 wt%, with a 90.87 % removal rate. Mechanistic studies reveal superoxide radicals (·O₂ − ) as the main reactive species driving the desulfurization process. This study pioneers a new approach for biomass-based catalyst design, offering a sustainable and scalable deep desulfurization solution-one that aligns with green chemistry principles by minimizing toxicity, utilizing renewable feedstocks, and integrating oxidation and extraction into a single step without the need for additional chemical additives.
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ChemistrySelect
·
2024
·Vol. 9
·期 14
·e202400566
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IF 1.9
Zicheng Yang,Rongyu Li,Ruonan Wang,Senhe Qian
Graphical An SA/SS/GI/PSP@AgNP composite film was developed, and its physicochemical properties, cytocompatibility, antioxidant activity, and antibacterial properties were investigated. The composite film released PSP@AgNPs in a sustained way, and the film demonstrated favorable mechanical properties, excellent cytocompatibility, and high antioxidant and antibacterial activities in both in vitro and in vivo models. As a result, we conclude that this composite film has potential for application as a medical material. A sodium alginate/silk sericin (SA/SS) film was modified with glycerin (GI) and Polygonatum sibiricum polysaccharide@silver nanoparticles (PSP@AgNPs) to create a SA/SS/GI/PSP@AgNP composite film with antibacterial and antioxidant properties. The physicochemical properties of the SA/SS/GI/PSP@AgNP composite film were analyzed, and its cytocompatibility, antioxidant activity, and antibacterial properties were investigated. The optimum conditions for the preparation of the SA/SS/GI/PSP@AgNP composite film were 2 % SA, 2 % SS, 20 % GI, and 40 μg/mL of PSP@AgNPs. The addition of GI improved the surface smoothness of the composite films, while the presence of PSP@AgNPs did not significantly alter it. Spectroscopic characterization demonstrated that GI and PSP@AgNPs were physically bound to SA/SS. Approximately 53 % of the PSP@AgNP was released from the SA/SS/GI/PSP@AgNP composite film over 24 h of soaking in aqueous solution. The resulting leaching solution did not cause hemolysis or cytotoxicity, indicating its biocompatibility. Additionally, the SA/SS/GI/PSP@AgNP composite film exhibited strong antioxidant and antibacterial properties, and it promoted healing of mouse wounds infected with Staphylococcus aureus .
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Zewen Shi,Fang Yang,Qian Pang,Yiwei Hu,Haijian Wu,Xueqiang Yu,Xianjun Chen,Lin Shi,Bowen Wen,Rui Xu,Ruixia Hou,Dan Liu,Qingjiang Pang,Yabin Zhu
With the development of minimally invasive orthopedics, injectable materials for bone repair are attracted more attention, especially for those wound with a small external mouth and sizeable internal cavity. In this work, the hydrogel with features of thermo-responsiveness, degradability and injectability was designed and fabricated. The hydrogel, named as FHCS, is composed of Pluronic F-127 (F127) loaded with carboxymethyl chitosan/sodium alginate nanoparticles (nCS) and nanohydroxyapatite (nHA). The hydrogel FHCS was non-toxic and good hemocompatible. It can enhance the ALP activity and extracellular matrix calcification of MC3T3-E1 due to the chitosan-based nanoparticle components (nCS). Moreover, FHCS-5 (containing 5 mg/mL nCS) showed relative high expression of osteogenic genes and protein markers. Osteal regeneration was observed treated by FHCS-5 hydrogel in a critical-size rat calvarial bone defect model. CT scanning showed that the whole defect was basically covered by new bone after FHCS-5 hydrogel. The results of H&E staining and Masson's trichrome staining on histological sections further confirmed that FHCS-5 hydrogel promoted new osteal formation and maturation, which up regulated the osteogenic related genes and proteins of ALP, OCN, OPN through BMP/Smad signaling pathway. Hence, this study suggests that FHCS-5 hydrogels have a promising application for non-loading bone regeneration.
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Frontiers in Nutrition
·
2025
·
IF 5.1
Jinpeng Gong,Boya Liu,Tao Huang,Lu Wei,Yupeng Ma,Hao Chen,Jing Gan,Junbo Ge
Osteoporosis, a prevalent metabolic bone disease, poses a significant challenge for bone repair in aged populations. Soy-derived osteogenic peptide (SOP) holds promise but its clinical translation is hampered by rapid enzymatic degradation and poor oral bioavailability, representing a major challenge that necessitates the development of a protective delivery system. To address this, we developed a novel composite hydrogel based on fish gelatin and sodium alginate (SA/FG) as an oral delivery vehicle to overcome these limitations. Systematic characterization revealed that the SA/FG formulation offers distinct advantages: the incorporation of an optimal amount of SA significantly enhanced the mechanical strength and stability of the hydrogel, addressing the common weakness of single-network gelatin hydrogels, while maintaining a high water content (~90%) and a superior rehydration capacity (83.65% in distilled water). In a glucocorticoid-induced zebrafish osteoporosis model, the SOP-loaded SA/FG hydrogel significantly increased skull bone mass by 120.17% and improved larval swimming behavior, markedly outperforming the free SOP group. This study presents the first report of an SA/FG composite hydrogel for effective oral delivery of an osteogenic peptide. The system demonstrates great potential as a functional food or supplement for preventing and treating osteoporosis, offering an innovative strategy to enhance peptide stability and bioavailability through a biocompatible, double-network carrier.
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FOOD RESEARCH INTERNATIONAL
·
2020
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IF 4.972
Jian Gao,Chengzhi Liu,Jieyu Shi,Fangfang Ni,Qing Shen,Hujun Xie,Kuiwu Wang,Qunfang Lei,Wenjun Fang,Gerui Ren
The ovalbumin (OVA)-pectin (PEC)-sodium alginate (SA)-Vitamin D 3 (VD 3 ) complex nanoparticles were fabricated by antisolvent precipitation method, and the excellent encapsulation efficiency and loading capacity of VD 3 were obtained by 96.6% and 2.8%, respectively. Compared with ternary OVA-PEC-VD 3 complexes, the addition of SA with strong negative charge effectively regulated the OVA-PEC complexes and significantly improved the stability of OVA-PEC-SA-VD 3 complex nanoparticles with preferable size as small as 126 nm. The storage stability was also investigated after low temperature storage for 31 d, and the particle size of quaternary complexes was increased only 40 nm. In vitro digestion results elucidated that the complex nanoparticles had good stability in the simulated gastric fluid, and almost completely released in the simulated intestinal fluid confirmed by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) experiments and scanning electron microscope (SEM) images. The release kinetics study clarified that it was close to Fick release. Fluorescence and Fourier transform infrared spectroscopy (FTIR) experiments showed that quaternary complex nanoparticles were mainly combined by electrostatic, hydrophobic and hydrogen bonding interactions. The novel quaternary protein-polysaccharide complexes have excellent stability and great sustained-release performance for VD 3 , which may be helpful for the digestion and absorption of vitamin by human body, thus have potential applications in the food and drug industry.
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