JOURNAL OF ALLOYS AND COMPOUNDS
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2020
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IF 4.65
Bingxin Xie,Lei Lei,Jinghua Xu,Shiqing Xu
An pH-sensitive citric acid coated Ce/Tb:KGd 2 F 7 nanocrystals with a broad detection range from 3 to 10 is established. Under the 254 nm excitation, the Tb 3+ emission intensity originated from Ce 3+ → Gd 3+ →Tb 3+ decreases gradually with the increase of pH, while its intensity almost keeps unchanged in pH 3 to 6 and increases in pH 6 to 10 under the 311 nm excitation, which activates the ratiometric pH sensing with high sensitivity.
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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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2019
·
IF 4.708
Siyu Guan,Qianqian Zhang,Jianwei Bao,Tijie Duan,Rongfeng Hu,Tori Czech,Jihui Tang
In recent decades, targeted drug delivery systems (TDDS) have been widely used as an ideal method of improving therapeutic effects and reducing systemic side effects of chemotherapeutic agents. Historically, a handful of methods have been developed to further improve the targeting ability of delivery systems. Thus, in this study, two methods, taking advantage of tumor characteristics, were used for the creation of a multi-targeted delivery system. The first was the fabrication of pH-sensitive micelles , lending the ability to increase drug release by exploiting the acidic tumor environment. The second method was through utilization of the surface-exposed phosphatidylserine (PS) of tumors, which is normally found in the inner leaflet in healthy cells. Using PS as a target site, PS binding peptide (PSBP-6) was conjugated to pH-sensitive mixed micelles, (consisting of poly (ethylene glycol)-b-poly (D, L-lactide) (PEG-PDLLA) and poly (ethylene glycol)-b-poly (L-histidine) (PEG-PHIS)). After successful preparation of micelles, paclitaxel (PTX), a common chemotherapeutic agent, was selected to measure drug loading capacity and encapsulation efficiency, showing 7.9% and 83.5%, respectively. The in vitro release of PTX from mixed micelles at pH 5.0, 6.5, and 7.4 was 78.1, 56.8, and 51.4%, respectively, indicating acid-triggered drug release. The PSBP-6-modified, mixed micelles exhibited significantly enhanced in vitro cytotoxicity and demonstrated more efficient cellular uptake compared to unmodified mixed micelles in the HeLa cell line. Moreover, pharmacokinetic , in vivo biodistribution , and fluorescence imaging studies showed that PSBP-6-PEG-PDLLA/PEG-PHIS mixed micelles provide prolonged time in blood circulation and enhanced tumor accumulation. These results suggest that the use of PS as a novel targeting site is advantageous, and that these new multi-targeted mixed micelles show great potential for realization of broad prospects in the targeted treatment of tumors for chemotherapeutic delivery.
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Materials Science & Engineering C-Materials for Biological Applications
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2019
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IF 4.959
Xiangping Hao,Shougang Chen,Dong Qin,Mutian Zhang,Wen Li,Jincheng Fan,Chao Wang,Mengyao Dong,Jiaoxia Zhang,Frank Cheng,Zhanhu Guo
Antifouling biocides releasing restricts the longevity of antifouling coatings. Compared with the anchoring state, the releasing behavior of agents is much faster on the voyage, while the biofouling process is tougher. In this work, a series of capsaicin-based pH-triggered polyethylene glycol/capsaicin@chitosan (PEG/CAP@CS), polyvinyl alcohol (PVA)/CAP@CS and alginate (ALG)/CAP@CS multilayer films are prepared with controlling antimicrobial properties in marine environments. There are 23.70, 23.35 and 22.06 ppb CAP releasing from (PVA/CAP@CS) 20 , (PEG/CAP@CS) 20 and (ALG/CAP@CS) 20 films after immersing in pH 4 solutions for 60 days, while only 13.07, 12.95 and 11.55 ppb CAP have been found in alkaline solutions after immersing for the same time, respectively. All these three types of films exhibit extraordinary pH responsive properties. They can control the CAP release at a low level in alkaline solutions, and make the CAP release fast in acid solutions. Moreover, the antibacterial properties against P.aeruginosa are outstanding about 95.84%, 95.0% and 96.91% for (PVA/CAP@CS) 20 , (PEG/CAP@CS) 20 and (ALG/CAP@CS) 20 films, respectively. The bacteriostasis of (ALG/CAP@CS) 20 film keeps 92.73% after 60 days in alkaline solution, which means it is steadily controlled in the marine environment. Although with similar antibacterial properties to those of (PEG/CAP@CS) 20 film, (PVA/CAP@CS) 20 film displays the maximum decrease with about 92% in acid solution after 60 days. The ALG/CAP@CS film with the best-controlled release performance and long-term antibacterial properties provides novel guidance for developing new antifouling coatings application in the marine environment.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2019
·Vol. 137
·期 18
·48640
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IF 2.188
Song Gao,Gang Wei,Qiang Liu,Qinze Liu,Tingting Gao,Jinshui Yao
Lignosulfonate-based polycatecholamine (PCEA-LS) was synthesized by a two-stage approach involving Mannich and catechol–amine reactions, and it was directly used to adsorb Congo red (CR) from the pH-unadjusted aqueous solution. PCEA-LS was characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS). Various factors affecting on removal of CR by PCEA-LS were investigated in depth, including contact time, adsorbent dosage, and initial concentration of CR and adsorption temperature. The adsorption kinetics, isotherm, and thermodynamics of PCEA-LS for CR were explored in detail, and then its adsorption mechanism was systematically elucidated. Results indicated that the removal process of CR followed the pseudo-second-order kinetic model, and the isotherm data fitted the Langmuir model well. The maximum adsorption capacity reached 972.6 mg g −1 at 30°C in the pH-unadjusted (pH = 6.25) solution possibly due to the hydrogen bond, π–π stacking, and electrostatic interaction between PCEA-LS and CR. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020 , 137 , 48640.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
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IF 4.784
Xinxin Yang,Zhaoshuang Li,He Liu,Lina Ma,Xujuan Huang,Zhaosheng Cai,Xu Xu,Shibin Shang,Zhanqian Song
N-vinylcaprolactam (NVCL) is a temperature-responsive monomer, which is widely used for preparing responsive hydrogels. However, poor water solubility of NVCL necessitates the use of emulsifiers for better dispersion. Hydrolyzed epoxy soybean oil-grafted hydroxyethyl cellulose (H-ESO-HEC) polymeric emulsifier has excellent emulsifying properties, and the carboxyl groups afford pH-responsiveness to the hydrogels. A novel temperature- and pH-responsive cellulose-based hydrogel was prepared by combining NVCL and H-ESO-HEC. The hydrogel morphology, thermal stability , and swelling capacity were characterized, and it was also used as a dual-responsive drug preservative carrier. Scanning electron microscopy and thermogravimetric analysis confirmed the porous structure and good thermal stability, respectively, of the hydrogel. The hydrogel displayed a temperature- and pH-dependent swelling behavior and improved swelling capacity. The swelling behavior agreed well with the Korsmeyer-Peppas model and Schott's second-order kinetic model. The dual-responsive hydrogel has significant potential in the drug delivery systems owing to its biocompatibility and temperature and pH sensitivity.
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LANGMUIR
·
2019
·
IF 3.683
Sihui He,Jiantao Yu,Fangfang Wang,Leilei Tian
Intracellular pH is a vital parameter which can reflect the physiological process, and the detection of intracellular pH with a high signal-to-noise ratio (SNR) remains a challenge. Compared to pH biosensors based on a single-wavelength signal, it is much easier to obtain better sensitivity and higher SNR from the biosensors by two-wavelength ratiometric signals. In this study, we used DNA-grafted graphene oxide (GO) to ratiometrically detect intracellular pH ranging from basic to acidic. A high SNR with a 35-fold difference in the ratiometric output has been achieved through careful optimization: (1) A high DNA conjugation yield of 45% has been gained through utilizing the partial double-stranded assembly strategy. (2) Herring sperm DNA (HSD) plays an important role in improving the sensitivity of the nanosystem by purifying and passivating the surface of GO; therefore, the concentration of HSD has been optimized to pursue the most sensitive ratiometric response. Apart from the ultrahigh SNR, fabricated GO-AR-Cy5/IFO-Cy3 exhibited excellent stability and biocompatibility in biological environments. Further experiments demonstrated that the nanosystem worked well in live cells in response to pH changes. It is possible to distinguish small pH differences and realize quantitative detection based on ratiometric fluorescence imaging by laser scanning confocal microscope analysis, which makes the nanosystem a promising candidate for further biological study and clinical applications.
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Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 43
·16283-16293
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IF 8.067
Jingjing Xu,Xiaojing Yang,Xianjiao Tang,Mei-Xia Zhao
Chemotherapy, despite being the most common and effective cancer treatment, can cause several toxic adverse effects. Multimodal combined antitumor therapy, which accounts for the deficiency of monotherapy, has become an effective strategy for clinical cancer treatment. In this study, we describe the development of pH-sensitive Cy7-PEG-CA-DOX micelles with antitumor activity for controlled drug release, tumor imaging, and their synergy with photothermal therapy (PTT) and chemotherapy. The cyanine dye Cy7 was used as a near infrared (NIR) fluorophore and photosensitizer, and polyethylene glycol (PEG) served as a biocompatible carrier. The anticancer drug doxorubicin (DOX) was loaded onto PEG via aconitic anhydride bonds to increase pH sensitivity. Cy7-PEG-CA-DOX molecules initiated self-assembly to form nanomicelles (∼64.21 ± 0.49 nm) in aqueous solution. In vitro the DOX release rate reached 78% after 48 h at pH 5.5 due to the amide bond between DOX and aconitic anhydride becoming readily broken at low pH. Moreover, intracellular uptake images showed that Cy7-PEG-CA-DOX micelles effectively released DOX in 4T1 tumor cells. In vivo fluorescence imaging revealed that Cy7-PEG-CA-DOX micelles aggregated at tumor sites with optimal tumor imaging properties. More importantly, Cy7-PEG-CA-DOX micelles facilitated the favorable anti-breast cancer properties elicited by PTT and chemotherapy in vivo. This study provides a novel platform for constructing responsive multifunctional anticancer nanoparticles, which have significant potential applicability in controlled drug release and synergistic cancer therapy.
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Materials Today Communications
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2022
·
IF 3.662
Hua Yuan,Liming Zhou,Zhiwen Qi,Changwei Zhang,Chengzhang Wang
This study focuses on the development of a new preparation method of solanesol derivatives for their effective use as drug carriers. The current preparation methods for solanesol derivatives generally suffer from poor accessibility and low yields of the target products, which affect the further development of their products. To address this issue, a solanesol-based poly (glutamic acid) (Sol-PEG-PGA) was first designed on the basis of the click reaction between alkynyl-functionalized solanesol and amino-polyethylene glycol (PEG)-azide, followed by a coupling reaction with poly (glutamic acid). The introduced polyethylene glycol and poly (glutamic acid) conferred amphipathic properties on solanesol. Sol-PEG-PGA possessed a suitable lipid-water partition coefficient of 1.01 and water contact angle of 55° and could self-assemble into spherical micelles with an average diameter of 74.0 ± 3.5 nm to load doxorubicin (DOX) via hydrophobic interaction, with a loading capacity of 27.7 ± 1.2 %. Besides, Sol-PEG-PGA micelle exhibited excellent stability before and after loading DOX under the dilution of 1000 times and could be stored stably at room temperature for 15 days. The DOX loaded into Sol-PEG-PGA could be released by acid induction, with a cumulative release of 84.8 ± 2.5 % at pH 5.0. Furthermore, in vitro cytotoxicity assay, the normal cells NIH/3T3 treated with Sol-PEG-PGA maintained relatively high viability of 95.0% compared to that of free DOX at 320 µg/mL, verifying its good biocompatibility. The DOX loaded into Sol-PEG-PGA possessed a high-efficiency anticancer activity compared to free DOX, with an inhibition rate of 99.2 ± 1.6 % against tumor cells 4T1, suggesting the potentials of Sol-PEG-PGA for drug delivery applications. This new preparation method is expected to provide a new strategy for constructing various functional carriers from solanesol derivatives.
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ACS Applied Nano Materials
·
2022
·
IF 6.14
Yongjun Luo,Xiaoping Zhu,Jun Qian,Yiyi Yu,Jing Li,Zhiyong He,Suyan Duan,Honglei Guo,Xiangchun Shen,Qianqian Guo
Overuse of antibiotics has led to an increased threat of drug-resistant pathogens and sustained chronic infections, suggesting an urgent need for effective strategies against drug-resistant bacterial infections. Herein, we developed au gold nanorods coated with pH-responsive polymers (GNR-DPArPEGMA) for photothermal therapy against multidrug-resistant bacteria. The size and zeta potential of GNR-DPArPEGMA was 78 nm and −37.96 mV, respectively. In subacidic conditions, the nanocomposite surface was positively (14.18 mV) charged, leading to better bacterial adhesion and antibacterial efficiency. The nanocomposites showed augmented in vitro photothermal efficiency up to 70 °C under 808 nm irradiation for 3 min, which further demonstrated an enhanced photothermal bacteria-killing efficiency. The in vivo assays showed that GNR-DPArPEGMA irradiated with near-infrared radiation could treat a drug-resistant Staphylococcus aureus-caused subcutaneous abscess and drug-resistant Pseudomonas aeruginosa-caused pneumonia while reducing the number of bacteria and attenuating inflammation in the infected sites. These results indicate that the nanocomposites could be used as a potential photothermal agent to combat drug-resistant bacterial infections in the future.
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ACS ES&T Water
·
2023
·
IF 5.3
Yansu Lan,Yicheng Huang,Die Zhou,Xi Zhang,Lei Xia,Raf Dewil,Bart Van der Bruggen,Yan Zhao
Carboxylates, which are considered high-value platform chemicals, are by-products produced during the fermentation of organic waste. There is a major challenge in effectively separating and recovering carboxylates from the fermentation broth. Electrodialysis (ED) has been considered a promising technology with its high selectivity in the absence of chemical additives. Here, a class of internally cross-linked anion exchange membranes (referred to as QPSF-n AEMs) were synthesized by using chloromethylated polysulfone (CMPSF) and varying amounts of 1,4-diazabicyclo [2.2.2] octane through quaternization and cross-linking reactions to recover carboxylates. The resulting membrane (QPSF-0.88) showed a high anion exchange capacity of 2.79 mmol g–1 but a low water content of 3.3% and an excellent swelling rate of 13.9%. To evaluate the separation efficiency of carboxylates, the membrane was tested with single solutions of acetate, oxalate, and citrate in 15.0 V (constant voltage) ED for 180 min. The removal efficiencies of QPSF-0.88 for acetate, oxalate, and citrate were 92.6, 87.9, and 85.9%, respectively, indicating a monocarboxylate selectivity for QPSF-0.88. After immersion in acidic or basic solutions, the change in the ion exchange capacity of QPSF-0.88 is less than 2%, indicating a high resistance to pH changes. This study presents innovative concepts in developing a membrane for the desalination of carboxylate.
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MOLECULES
·
2023
·Vol. 28
·期 23
·7703
·
IF 4.6
Hongda Cheng
Metal–organic frameworks (MOFs) are considered to be promising materials for drug delivery. In this work, a Zinc-based MOF nanocomposite IRMOF-3 was introduced as a drug carrier for 10-hydroxycamptothecine (HCPT). Without an extra drug-loading process, a nanoscale drug delivery material HCPT@IRMOF-3 was prepared via one-pot synthesis. The composition and structure of the material were investigated, and the drug release character was measured. Compared with preparing IRMOF-3 first and loading the drug, the one-pot-prepared HCPT@IRMOF-3 exhibited a higher drug-loading capacity. The material presented pH-responsive release. The HCPT release rate at pH 5.0 was significantly higher than that at pH 7.4. The cytotoxicity experiments showed that IRMOF-3 was non-toxic, and HCPT@IRMOF-3 exhibited notable cytotoxicity to Hela and SH-SY5Y cells. One-pot synthesis is a simple and rapid method for the preparation of an MOF drug delivery system, and IRMOF-3 can be potentially used in pH-responsive drug delivery systems.Keywords:IRMOF-3;drug delivery;one pot;pH response;HCPT
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Polymer Chemistry
·
2017
·Vol. 8
·期 39
·6150-6157
·
IF 5.375
Shuo Chen,Qing Bian,Panjun Wang,Xuewei Zheng,Le Lv,Zhimin Dang,Guojie Wang
Here a novel photo, pH, and redox triple-responsive nanogel of poly(acrylic acid-co-spiropyran methacrylate) crosslinked by disulfide-containing N,N-bis(acryloyl)cystamine was prepared. Upon UV light irradiation or at low pH, the hydrophobic spiropyran (SP) isomerized to the hydrophilic merocyanine (MC) and the nanogels swelled-up. Upon the addition of reductant agents, the nanogels were disrupted due to the oxidative scission of the disulfide crosslinkers. The anticancer drug doxorubicin (Dox) could be loaded into the nanogels based on electrostatic interactions with the acrylic acids on the NGs, which would be released upon the stimulation of light, pH and DTT. The in vitro cytotoxicity study indicates that the nanogels loaded with anticancer drugs could kill the cancer cells effectively and the effect would be enhanced when irradiated by UV light. Interestingly, the isomerized MC in nanogels could emit intensive green light even endocytosed into the nucleus of the cancer cells, which afforded great potential in fluorescence cell imaging.
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