JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Wenjun Zhu,Yuanyu Wang,Yongzhi Yu,Yuehui Hu,Yichuan Chen
In this paper, core-shell structured α-Fe 2 O 3 @Li 4 Ti 5 O 12 composite has been reported based on the design of structure and heterogeneous composite. Compared with pure α-Fe 2 O 3 and α-Fe 2 O 3 @TiO 2 composite, the core-shell structured α-Fe 2 O 3 @Li 4 Ti 5 O 12 composite can deliver a favorable reversible capacity of 898 mAh g −1 at 0.2 A g −1 (642 mAh g −1 at 2 A g −1 ) after 200 cycles and the reversible capacity still maintain 482 mAh g −1 at 3.2 A g −1 . The improved electrochemical property of the composite is attributed to its heterogeneous composite and unique structural advantages: high specific capacity and outstanding rate capability can be guaranteed by the synergistic effect between the inner core of α-Fe 2 O 3 and outer shell of spinel Li 4 Ti 5 O 12 , the large volume variation of α-Fe 2 O 3 can be effectively relieved by spinel Li 4 Ti 5 O 12 with unexceptionable structure stability, and the extra lithium ions storage as well as enhanced kinetics can be contributed by abundant grain boundaries and heterogeneous phase interfaces .
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APPLIED SURFACE SCIENCE
·
2019
·
IF 5.155
Yang Sun,Qiang Xie,Yangyang Zhu,Lu Wang,Qiang Sun,Lijuan Wang
In order to achieve high recovery for low concentration NO 2 gas detection, the α-6T OTFT gas sensors were fabricated by inducing growth method. The effect of interface inducing layer and active layer thickness on the sensor performance was studied. It was found that the p -6P inducing layer improved the surface properties of SiO 2 substrates and the α-6T films were manipulated to favorable film formation on p -6P interface layer. The α-6T crystal grains can be fused well and the large-area continuous crystal films were obtained. By the thickness modulation of α-6T active films, the sensors can achieve the detection to the low concentration of 1 ppm to NO 2 gas and exhibit the rapid recovery of 28 s. And the sensitivity was as high as 998% / ppm and the responsivity was up to 2645% for 1 ppm NO 2 gas. The formation of ultra-thin films on surface substrates is an effective method, which can induce the growth of organic semiconductor films and obtain the high-property devices.
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RSC Advances
·
2016
·Vol. 6
·期 56
·51247-51256
·
IF 3.289
Chuanping Gao,Ga Zhang,Tingmei Wang,Qihua Wang
The formation of a tribo-film on the counterface plays an important role on the tribological performances of polymer subjected to mixed and boundary lubrication conditions. However, when freshwater is used as a lubricant, the formation of a tribo-film usually is hindered. In order to overcome this disadvantage, PEEK/α-FeOOH nanocomposites were developed and their tribological performances were studied under water lubrication conditions in the present work. It was demonstrated that the inclusion of α-FeOOH nanoparticles (NPs) into the PEEK matrix improves significantly the tribological performance of the matrix. The nanostructures and properties of the tribo-films formed on the steel counterface were comprehensively studied. It was identified that the addition of α-FeOOH NPs promotes the formation of a lubricating tribo-film which covers the entire counterface. Based on the investigations on tribo-films, we deem that the α-FeOOH NPs act as precursors for the dehydration reaction promoting the formation of a tribo-film which consists of α-Fe2O3 and transferred PEEK. It is assumed that the enhanced tribological performance is related to the possibly high load-bearing capability and “easy-to-shear” characteristic of the tribo-film.
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CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Jie Liang,Xia Dong,Chang Wei,Guilei Ma,Tianjun Liu,Deling Kong,Feng Lv
The real-time controlling and tracking of the evolution and status of the hydrogel are important challenges for accurate and precise assessments. In this article, a visible and controllable hydrogel nanocomposites system for photo response was designed and developed based on a thermosensitive porphyrin-poly(ethylene glycol)/α-cyclodextrin hydrogel loaded with multi-walled carbon nanotubes (PPEG-MWNTs/α-CD). The PPEG-MWNTs/α-CD hydrogel was simply self-assembled with a carbon nanotubes dispersed porphyrin-poly(ethylene glycol) solution and an aqueous solution of α-cyclodextrin by homogeneous stirring. The structure and the optical and photothermal abilities of the hydrogel nanocomposites system were characterized in vitro. Moreover, the controlled disassembly of the hydrogel was monitored in real time by in vivo fluorescence imaging after subcutaneous injection using mice as models. The results demonstrated that the hydrogel disassembly can be efficiently accelerated under laser irradiation with the loading of carbon nanotubes by fluorescence imaging visualization. With the advantages of the photo response, fluorescence imaging tracking and photothermal remote controlling were combined into the hydrogel nanocomposites system.
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ACS Nano
·
2025
·
IF 16
Yang Chu,Xiaoxiong Jin,Guonan Ji,Pengfei Li,Shanshan Xiao,Wanying Wang,Ziyuan Song
Thermally activated delayed fluorescence (TADF)-based nanoprobes are promising candidates as bioimaging agents, yet the fine-tuning of their photophysical properties through the modulation of the surrounding matrices remains largely unexplored. Herein, we report the development of polypeptide–TADF nanoprobes, where the rigid, α-helical polypeptide scaffold plays a critical role in enhancing the emission intensity and lifetime of the TADF fluorophore for bioimaging. The α-helical scaffolds not only spatially separated TADF molecules to avoid self-quenching but also anchored the dyes with minimized rotation and vibration. The nanoprobes thus exhibited >600 nm microsecond emission even in the presence of oxygen, facilitating cellular and animal imaging with a high signal-to-background ratio (SBR) by minimizing the interferences from autofluorescence signals. We believe that this work highlights the impact of the supporting polymeric conformation on the TADF performance, offering insights for the future design of time-resolved imaging probes.
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PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Kexin Zhang,Zhen Xu,Zexiu Xiao,Fei Cao,Jing Wang,Yuandong Xu,Winson M.J. Ma,Sihui Long,Gao-Feng Zha
Lipid nanoparticles (LNPs) have emerged as a clinically validated platform for cancer immunotherapy; however, challenges remain in optimizing RNA delivery and promoting synergistic immune activation. To address these issues, we developed a modified LNP system that incorporates α-galactosylceramide (α-GalCer), a CD1d-binding glycolipid known to activate invariant natural killer T (iNKT) cells. Through structural optimization, we created the α-GalCer-LNP (G-LNP), which offers three primary advantages over conventional four-component LNPs: (1) enhanced mRNA transfection efficiency due to improved endosomal/lysosomal escape, (2) increased capacity for in vivo DC transfection, leading to robust activation of tumor-specific CD8 + T cells via MHC-I and iNKT cells via the CD1d pathway, and (3) reprogramming of the tumor microenvironment, resulting in a 1.5-fold increase in iNKT cell infiltration and sustained elevation of IFN-γ (>24 h) in lymph nodes. In a TC-1 cervical carcinoma model, G-LNP induced complete tumor regression in 100 % of treated mice (compared to 42.85 % for standard LNP) and provided long-term protection against tumor rechallenge (lasting >100 days). Mechanistic studies showed that G-LNP preferentially targets CD11c + DC in the lymph nodes, facilitating coordinated antigen presentation and innate immune activation. This five-component engineering strategy establishes a versatile platform to enhance the functionality of LNPs for the development of next-generation cancer vaccines.
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产品关联
DOI
PubMed
高影响因子
MATERIALS CHARACTERIZATION
·
2022
·
IF 4.537
Yahui He,Shihong Zhang,Yi He,Hongjie Li,Teng He,Ruxia Song,Bo Liu,Zhifei Zhang,Yi Fan
Ni-P/α-ZrP composite coatings were successfully prepared by electroless plating, in which α-ZrP nanosheets were synthesized by reflow method. The surface morphology, element composition, structure and valence composition of the composite coating were analyzed by SEM, EDS, XRD and XPS, respectively. In the reciprocating friction experiment and electrochemical test, the corrosion and wear behaviour of the composite coatings were analyzed. The results show that α-ZrP nanosheets can significantly improve the corrosion and wear resistance of Ni P alloys. With the enrichment of α-ZrP nanosheets, the properties of coatings showed a tendency of increasing first and then slightly decreasing. Ni-P/α-ZrP (1.00 g/L) coating has the lowest porosity and the best corrosion resistance, and its corrosion rate (6.01 × 10 −3 mm/a) is about 1/5 of that of pure Ni P coating (3.12 × 10 −2 mm/a). Ni-P/α-ZrP (1.50 g/L) coating has the best wear performance, its average coefficient of friction (COF) is reduced from 0.568 to 0.167, and the specific wear rate is reduced from 7.13 ± 0.42 (× 10 −6 ) to 0.36 ± 0.06 (× 10 −6 ) (about 1/20 of pure Ni P coating).
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JOURNAL OF MOLECULAR STRUCTURE
·
2021
·
IF 3.196
Ting-Hong Huang,Cheng Luo,Dan Zheng,Jing-Yang Tan,Yong Liu,Jing Tang
Based on α- and β-naphthylamine, two new diphosphines, N,N-bis((diphenylphos phino)methyl)naphthalen-1-amine ( 1 ) and N,N-bis((diphenylphosphino)methyl)naphthalene -2-amine ( 2 ), have been prepared and characterized by IR, 1 H NMR, 31 P NMR, TG, UV-Vis, XRD and X-ray crystal structure analysis. Structural analysis shows that the two Ph 2 PCH 2 - groups in 1 and 2 are disposed in an anti configuration, and the change of the position of the (Ph 2 PCH 2 ) 2 N-group on the naphthalene moiety results in different spatial configurations of the two Ph 2 P- groups and different weak interactions, such as C-H … π and π–π interactions. DFT studies show that the composition of the HOMOs for 1 and 2 are almost the same (the naphthyl group with admixed N and P atoms), but the ingredients of the LUMOs for 1 are different from that for 2, coinciding with the change of Mülliken atomic charges . Moreover, the emission spectra show that the emissions of complexes 1 and 2 in acetonitrile solution are not similar to those of solid-state samples.
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JOURNAL OF ORGANIC CHEMISTRY
·
2021
·
IF 4.354
Yuxiu Li,Xiangqian Li,Xiaowei Li,Dayong Shi
The straightforward synthesis of α-fluoro-β-arylalkenyl sulfones under transition-metal- and base-free conditions has been described, which displays broad functional group compatibility and high stereoselectivity. In particular, the strategy is also applied to the late-stage modification of complex natural products and drugs.
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DOI
PubMed
高影响因子
Journal of Nanostructure in Chemistry
·
2022
·Vol. 13
·期 6
·577-589
·
IF 8
Tian Ruonan,Gao Zeyuan,Lang Ruifeng,Li Na,Gu Huilin,Chen Gang,Guan Hongtao,Comini Elisabetta,Dong Chengjun
Lately novel strategies to enhance the sensing properties on iron oxide have been proposed to achieve high performance gas sensors for acetone detection. In this working report, the synthesis of iron-glycerate (Fe-Gly) using glycerol to combine with Fe 3+ is first presented. Depending on the thermal treatment, this compound can evolve into γ-Fe 2 O 3 , α/γ-Fe 2 O 3 and α-Fe 2 O 3 . α/γ-Fe 2 O 3 shows better sensing performance as far as acetone detection is concerned. Using the dual phases of α/γ-Fe 2 O 3 as a fundamental building block, their sensing properties were further improved using Ni doping and Ru nanoparticles functionalization. The high response and selectivity to acetone detection was ascribed to the synergistic effects of unique nanosheets, mixed phases, rich oxygen vacancies and excellent catalytic activity of Ru nanoparticles. Graphical abstract
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JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
·
2019
·Vol. 93
·期 3
·289-299
·
IF 1.429
Li Zhendong,Liu Huijun,Qi Caixia,Yang Aohui,Deng Shanxia
Using ethylenediamine-β-cyclodextrin and α-naphthylacetic acid as raw material, a novel inclusion complex (en-β-CD@NAA) was synthesized. The inclusion complex structures and properties were analyzed by reliable spectroscopic and physicochemical techniques. The stoichiometry of the inclusion complex was 1:1 and the stability constant ( K S ) value was found to be 2511 M −1 at 293 K. Molecular thermodynamic parameters indicated that the spontaneous and exothermic nature of the process. The inclusion form was foreseen by Chem 3D program combined with 1 H-NMR experimental data. The solubilization curves ( K 1 = 2.05) and in-vitro dissolution data demonstrated that the en-β-CD@NAA inclusion complex has satisfactory water solubility.
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Crystals
·
2021
·Vol. 11
·期 9
·1049
·
IF 2.589
Jia Xiang,Bo Wang,Le Fu,Chuanpin Chen,Wenjie Liu,Songwen Tan
Lactose is a commonly used excipient with two isomers. Different isomers have different properties, especially in terms of solubility. This work is mainly to explore the influence of different a/β ratio lactose on drug dissolution. This work has developed novel mesoporous pollen-like lactose anhydrous with tailored α/β ratios as ingredient carriers for controlled dissolution rate. The produced lactose carriers are pollen-like with a particle size of ~15 μm and a mean pore width of ~30 nm. β-lactose anhydrous has a unique FTIR-peak at 948 cm−1, whereas α-lactose anhydrous shows a unique FTIR-peak at 855 cm−1. DSC analysis suggests that the pollen-like α/β-lactose crystals are polymorphs with unique peaks of melting points. XRD analysis suggests that (5:5)α/β-lactose polymorph has high crystalline purity. The loading efficiency (30.6–33.4%w/w) of acetamidophenol within the nanoporous lactose particles is dependent on the surface structure and pore volumes—the pore volumes were found to be 0.0209–0.0380 cm3/g. The release rates of acetamidophenol are lower for lactose with high α/β ratios. The lactose solubility and the first-order release constant can be tailored by changing the proportion of β-lactose in the pollen-like lactose carriers.Keywords:pollen-like anhydrous lactose;α/β ratio;solubility;controlled release
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