MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 12
·1-9
·
IF 5.833
Zhao Peng,Sun Jingyi,Zhao Shijun,Song Yanan,Gao Feng,Wang Hongbin,Ni Qingbin,Wang Ying,Sun Baoliang
A surface-enhanced Raman scattering (SERS)–based immunoassay with gold nanostars (GNSs) is utilized for determination of the subarachnoid hemorrhage (SAH) biomarker glial fibrillary acidic protein (GFAP) at very low concentration levels, which allows for early diagnosis and guides clinical decision-making to treat SAH-induced complications. The Raman reporter 5,5′-dithiobis-2-nitrobenzoic acid (DTNB) modified on GNSs was selected as the SERS tags. The SERS immunoassay was assembled by SERS tag and GFAP probe-immobilized ITO substrate. Therefore, the level of GFAP can be detected by monitoring the characteristic Raman peak intensity of GFAP-conjugated GNSs at 1332 cm −1 with a very low detection limit. Under optimized conditions, the assay can work in the GFAP concentration range from 1 pg⋅mL −1 to 1 μg⋅mL −1 , with a detection limit as low as 0.54 fg⋅mL −1 . The performance of the SERS immunoassay proven by the detection of GFAP is equivalent to that of the conventional enzyme-linked immunosorbent assay (ELISA). Graphical abstract Scheme 1. Schematic illustration of GNSs SERS immunoassay for ultrasensitive dynamic change detection of GFAP. (SAH: Subarachnoid hemorrhage, SCF: Cerebrospinal fluid; GNSs: gold nanostars; SERS: surface-enhanced Raman scattering; GFAP: glial fibrillary acidic protein)
✓ 已验证
产品关联
DOI
PubMed
高影响因子
IONICS
·
2021
·Vol. 28
·期 2
·635-645
·
IF 2.817
Zhao Wei,Feng Wangjun,Chen Jingzhou,Huang Zhaoyu
Lithium-sulfur batteries (LSBs) are considered the most likely replacement for conventional lithium–ion batteries in next-generation high-energy output solutions based on their high specific capacity (1675 mAh g −1 ) and high-energy density (2600 Wh kg −1 ). But, there are some problems that need to be solved urgently. In this work, an environmentally friendly, green, and low-cost ZIF-67-derived cobalt-based sulfate material (CoSO 4 ) combined with carbon nanotubes was proposed as a sulfur host material. Experiments show that the addition of CoSO 4 can significantly enhance the transformation of polysulfide and suppress the shuttle effect. The best performance is the CNT-CoSO 4 -2/S, which has an initial capacity of 1356.9 mAh g −1 at 0.1 C current density. Furthermore, long-term cycle test was carried out at a current density of 0.2 C; the coulombic efficiency was above 98.63% after 200 cycles. This work demonstrates the potential of cobalt-based sulfates as cathode materials for lithium–sulfur batteries.
✓ 已验证
产品关联
DOI
高影响因子
CATALYSIS LETTERS
·
2021
·Vol. 152
·期 9
·2607-2624
·
IF 3.186
Zhang Qian,Chen Si,Yu Yong Bo,Hong Jun-ming
Simultaneous pollution degradation and disinfection were seldom discussed in the field of electrocatalytic oxidation. In this work, N-doped graphene (N-GN) was selected as anode to ensure the high performance of paracetamol (APAP) degradation. With N doping, the activity of N-GN is evidently improved because of the better surface area, active defects, and conductivity compared with graphene. The generation of active chlorine and O 2 . − on the N-GN surface played an important role in APAP degradation. Compared with other operation parameters (such as pH and current density), environmental microorganisms exhibited more negative interference for APAP degradation. However, evident disinfection effects can be observed because of the release of fulvic and humic acids from microorganisms. In particular, active chlorine is evidently more effective than O 2 . − for disinfection. The simultaneous APAP degradation and disinfection observed in this research provided the possible technology of electrocatalytic oxidation via N-GN for practical application. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
Optoelectronics Letters
·
2021
·Vol. 17
·期 12
·751-756
·
IF 0
Yang Chen,Gu Weiyuan,Yu Shuguo,Zhang Hongyan
In this study, using surfactant monoethanolamine (MEA), zinc oxide (ZnO)-MEA humidity sensor based on ZnO was successfully prepared by hydrothermal method. MEA makes the surface of the ZnO-MEA have more oxygen vacancy and hydrophilic functional groups, which improves the performance of ZnO humidity sensor. ZnO-MEA achieved a change of 4 orders of magnitude at room temperature in the relative humidity (RH) from 11% to 95%, and it shows better linearity, shorter response/recovery time (20 s/15.9 s), smaller humidity lag and long-term stability. In addition, the distribution of ZnO-MEA particles is more uniform and provides more active sites for adsorption of water molecules to enhance humidity sensing performance.
✓ 已验证
产品关联
DOI
Nature Sustainability
·
2021
·Vol. 5
·期 3
·205-213
·
IF 19.346
Han Daliang,Cui Changjun,Zhang Kangyu,Wang Zhenxing,Gao Jiachen,Guo Yong,Zhang Zhicheng,Wu Shichao,Yin Lichang,Weng Zhe,Kang Feiyu,Yang Quan-Hong
Aqueous zinc (Zn) batteries have long been considered a potentially more sustainable alternative to lithium-ion batteries because of their better environmental compatibility, enhanced safety and cost advantage. However, in the presence of an aqueous electrolyte, the Zn anode is poised to undergo dendrite failure, corrosion and hydrogen evolution, all of which resonate with each other leading to fast performance degradation. Here, in a break from the current aqueous battery path, we report a low-cost hydrous organic electrolyte involving a hydrated Zn(BF 4 ) 2 salt and an ethylene glycol solvent, which not only promotes the in situ formation of a favourable ZnF 2 passivation layer to protect Zn from dendrite growth and side reactions but also embraces excellent non-flammability. Remarkably, the present Zn anode sustains a long-term cycling over 4,000 h at a current density of 0.5 mA cm −2 with a high Coulombic efficiency of 99.4% and shows an areal capacity as high as 5 mAh cm − 2 . Equally intriguingly, the electrolyte can run across a wide temperature range from −30 °C to 40 °C without seriously compromising performance. The Zn//V 2 O 5 full cells with our electrolyte also perform much better in terms of capacity retention than a device with an aqueous ZnSO 4 electrolyte. Our findings suggest a promising direction for developing electrolyte solutions for practical Zn batteries which combine safety, performance and sustainability.
✓ 已验证
产品关联
DOI
高影响因子
Nano Research
·
2021
·Vol. 15
·期 4
·3367-3375
·
IF 8.897
Wang Xin,Li Lingxiao,Wang Danping,Zuo Shiyi,Liu Tian,Dong Fudan,Zhang Xuanbo,He Zhonggui,Sun Bingjun,Sun Jin
Prodrug-based nanoassembly emerges as a hopeful way for the efficient delivery of antitumor drugs, with carrier-free structure and ultra-high drug loading. Carbon chains are widely used to design self-assembling prodrugs. The impacts of the length of carbon chains on the self-assembly stability, drug delivery efficiency and antitumor effect of prodrugs have not been fully elucidated. Here, three paclitaxel prodrugs were synthesized by conjugating paclitaxel with octanol (C 8 ), decanol (C 10 ) or dodecanol (C 12 ) through disulfide bond. The three prodrugs could form homogeneous nanoparticles, with over 50% drug loading and redox dual-responsivity. Interestingly, the length extension of carbon chains ameliorates the self-assembly and the colloidal stability of prodrugs, thus improving the drug delivery efficiency. The optimal paclitaxel-dodecanol prodrug nanoassemblies exhibit better antitumor efficacy than Taxol and Abraxane. These findings are meaningful for the rational design of advanced nanomedicines in cancer therapy.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 414
·期 4
·1553-1561
·
IF 4.157
Zhang Wenjuan,Hu Haoyun,Ruan Guihua,Huang Yipeng,Du Fuyou,Chen Zhengyi
In this study, reduced graphene oxide (rGO) hybridized high internal phase emulsions were developed and polymerized as porous carriers for aptamer (5’/5AmMC6/-AGT CCG TGG TAG GGC AGG TTG GGG TGA CT-3’) modification to enrich human α-thrombin from serum. The structure and properties of the materials were confirmed by scanning electron microscope (SEM), Fourier transform infrared spectroscope (FT-IR), and X-ray photoelectron spectra (XPS). The adsorption ability and selectivity were studied and the thrombin was detected with liquid chromatography-mass spectrometry (LC–MS). The adsorption of thrombin onto the sorbent was achieved within 30 min and the desorption was realized using 5.0 mL of acetonitrile/water (80/20, v/v). The thrombin was quantified by LC–MS according to its characteristic peptide sequence of ELLESYIDGR. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOM
·
2021
·Vol. 73
·期 12
·3710-3717
·
IF 2.474
Hu Sanyuan,Yan Youwei,Zhou Zheng,Lu Jianquan,Chi Guoming
Commercial indium tin oxide (ITO) has been limited in utility due to its brittleness and high cost. Here, a flexible Sn-Cu hybrid metallic network with a low sheet resistance of 3.71 Ω sq −1 at 90% transparency was synthesized by a facile solution electro-writing method, exceeding the performance of ITO film. By incorporating Sn nanoparticles into a Cu microfiber network matrix, a heating-induced self-healing recoverable metallic network was obtained. The Sn-Cu microfiber transparent conductive electrode (TCE) endured a sheet resistance increase of ~ 2.6% after 1000 bending cycles, and a decrease of ~ 2.0% was found after a heating-induced self-healing process was subsequently conducted on the TCE. These results indicate that the proposed Sn nanoparticle incorporated self-healing copper metallic network can be expected to be a potential replacement for conventional ITO film and could be widely used in flexible and recoverable electronics.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2021
·Vol. 30
·期 5
·1995-2006
·
IF 3.667
Shen Jian,Xu Xinyi,Ouyang Xiao-kun,Jin Mi-cong
Based on the excellent performances of nanocrystalline cellulose, sodium alginate, or K-carrageenan in Pb 2+ adsorption, nanocrystalline cellulose/sodium alginate/K-carrageenan composite hydrogel beads were prepared to adsorb Pb(II) from aqueous solutions. The objective of this study was to demonstrate the excellent potential of the composite hydrogel beads for heavy metal ion adsorption. We successfully prepared ecofriendly Fe-modified nanocrystalline cellulose/sodium alginate/K-carrageenan composite hydrogel beads and characterized them. The structure and adsorption mechanism were investigated using scanning electron microscopy, Fourier-transform infrared spectroscopy, and X-ray photoelectron spectroscopy, and the optimal adsorption conditions were determined. The tricomponent hydrogel beads were robust and exhibited improved adsorption capacity for Pb 2+ and good reusability. The adsorption results could be fitted well with a pseudo-second-order kinetic model and the Langmuir adsorption model. The maximum adsorption capacity obtained by fitting was 351.04 mg g −1 . Recycling experiments revealed that the adsorption capacity of the adsorbent remained high after five cycles of reuse.
✓ 已验证
产品关联
DOI
高影响因子
Nature Biomedical Engineering
·
2021
·Vol. 6
·期 1
·32-43
·
IF 25.671
Zheng Di-Wei,Deng Wei-Wei,Song Wen-Fang,Wu Cong-Cong,Liu Jie,Hong Sheng,Zhuang Ze-Nan,Cheng Han,Sun Zhi-Jun,Zhang Xian-Zheng
Because a host’s immune system is affected by host–microbiota interactions, means of modulating the microbiota could be leveraged to augment the effectiveness of cancer therapies. Here we report that patients with oral squamous cell carcinoma (OSCC) whose tumours contained higher levels of bacteria of the genus Peptostreptococcus had higher probability of long-term survival. We then show that in mice with murine OSCC tumours injected with oral microbiota from patients with OSCCs, antitumour responses were enhanced by the subcutaneous delivery of an adhesive hydrogel incorporating silver nanoparticles (which inhibited the growth of bacteria competing with Peptostreptococcus ) alongside the intratumoural delivery of the bacterium P. anaerobius (which upregulated the levels of Peptostreptococcus ). We also show that in mice with subcutaneous or orthotopic murine OSCC tumours, combination therapy with the two components (nanoparticle-incorporating hydrogel and exogenous P. anaerobius ) synergized with checkpoint inhibition with programmed death-1. Our findings suggest that biomaterials can be designed to modulate human microbiota to augment antitumour immune responses.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 29
·期 17
·24612-24622
·
IF 4.223
Li Zhansheng,Zhao Hongxia,Li Xintong,Bekele Tadiyose Girma
Environmentally persistent free radicals (EPFRs) are an emerging class of environmental hazardous contaminants that extensively, stably exist in airborne particulate matter and pose harmful effects on human health. However, there was little research about the sources of EPFRs in actual atmospheric conditions. This study reported the occurrence, characteristics, and sources of EPFRs and polycyclic aromatic hydrocarbons (PAHs) in PM 2.5 collected in Dalian, China. The concentrations of PM 2.5 -bound EPFRs ranged from 1.13 × 10 13 to 8.97 × 10 15 spins/m 3 (mean value: 1.14 × 10 15 spins/m 3 ). Carbon-centered radicals and carbon-centered radicals with adjacent oxygen atoms were detected. The concentration of ∑PAHs ranged from 1.09 to 76.24 ng/m 3 , and PAHs with high molecular weight (HMW) were predominant species in PM 2.5 . Correlation of EPFRs with SO 2 , NO 2 , O 3 , and 12 kinds of PAHs indicated that both fuel (coal and biomass) combustion and photoreaction in atmosphere influenced the concentrations of EPFR. The positive matrix factorization (PMF) model results have shown that the primary sources contributed most of the EPFRs and those of secondary sources had a little proportion. Coal combustion (52.4%) was the primary contributor of EPFRs, followed by traffic emission (22.6%), industrial sources (9.6%), and secondary sources (9.2%) during the heating period, whereas industrial emission (39.2%) was the primary contributor, followed by coal combustion (38.1%), vehicular exhaust (23.5%), and secondary sources (9.6%) during the non-heating period. The finding of the present study provides an important evidence for further study on the formation mechanism of EPFRs in actual atmospheric to control the air pollution.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2021
·Vol. 12
·期 1
·1-11
·
IF 14.919
Sun Hao,Chen Ling,Xiong Likun,Feng Kun,Chen Yufeng,Zhang Xiang,Yuan Xuzhou,Yang Baiyu,Deng Zhao,Liu Yu,Rümmeli Mark H.,Zhong Jun,Jiao Yan,Peng Yang
Electrochemical CO 2 reduction (CO 2 RR) in a product-orientated and energy-efficient manner relies on rational catalyst design guided by mechanistic understandings. In this study, the effect of conducting support on the CO 2 RR behaviors of semi-conductive metal-organic framework (MOF) — Cu 3 (HITP) 2 are carefully investigated. Compared to the stand-alone MOF, adding Ketjen Black greatly promotes C 2 H 4 production with a stabilized Faradaic efficiency between 60-70% in a wide potential range and prolonged period. Multicrystalline Cu nano-crystallites in the reconstructed MOF are induced and stabilized by the conducting support via current shock and charge delocalization, which is analogous to the mechanism of dendrite prevention through conductive scaffolds in metal ion batteries. Density functional theory calculations elucidate that the contained multi-facets and rich grain boundaries promote C–C coupling while suppressing HER. This study underlines the key role of substrate-catalyst interaction, and the regulation of Cu crystalline states via conditioning the charge transport, in steering the CO 2 RR pathway.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）