JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Meijun Liu,Fengzhi Qiao,Shaolei Wang,Wenhao Ding,Shichao Xuan,Cristabelle De Souza,Muhammad Asif Javaid,Zhe Zhang,Huaxi Yi,Lanwei Zhang,Kai Lin
This study presents a novel oral delivery system for food-derived angiotensin I-converting enzyme (ACE) inhibitory peptides by integrating β-glucan-functionalized liposomes with microfluidic encapsulation and receptor-mediated targeting. Two peptides, RADHPFL and YAEERYPIL derived from egg white proteins, were encapsulated into liposomes (composed of lecithin, cholesterol, and DSPE-β-glucan) via a controlled microfluidic self-assembly process. Encapsulation significantly improved the gastrointestinal stability of the peptides and preserved their ACE inhibitory activity compared to free peptides. β-Glucan was grafted onto the liposomal surface to enable specific targeting of intestinal microfold (M) cells through interaction with the Dectin-1 receptor, thereby facilitating enhanced uptake in Peyer’s patches. In spontaneously hypertensive rats, both single-dose and continuous administration of β-glucan-functionalized liposomes resulted in superior antihypertensive effects compared to free peptides and unmodified liposomes. Interestingly, the antihypertensive efficacy was primarily attributed to modulation of the renin-angiotensin system, improved renal and cardiac function, and amelioration of endothelial dysfunction. These findings underscore the potential of the natural polysaccharide β-glucan as a targeting ligand in liposomal systems and highlight the utility of carbohydrate-based materials for enhancing the oral bioavailability and physiological efficacy of bioactive peptides. The proposed strategy offers a promising platform for the development of functional foods or nutraceuticals for hypertension management.
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高影响因子
Science China-Materials
·
2021
·Vol. 65
·期 4
·1000-1011
·
IF 8.273
Luo Mingwei,Lu Chunhui,Liu Yuqi,Han Taotao,Ge Yanqing,Zhou Yixuan,Xu Xinlong
Heterostructures based on new advanced materials offer a cornerstone for future optoelectronic devices with improved photoelectric performance. Band alignment is crucial for understanding the mechanism of charge carrier transportation and interface dynamics in heterostructures. Herein, we grew SnS 2 /Bi 2 X 3 (X = Se, Te) van der Waals heterostructures by combining physical vapor deposition with chemical vapor deposition. The band alignment, measured by high-resolution X-ray photoelectron spectroscopy, suggested the successful design of type-I SnS 2 /Bi 2 Se 3 and type-II SnS 2 /Bi 2 Te 3 heterostructures. The SnS 2 /Bi 2 X 3 heterostructure greatly improved the photoelectric response of a photoelectrochemical-type photodetector. The photocurrent densities in the type-I SnS 2 /Bi 2 Se 3 and type-II SnS 2 /Bi 2 Te 3 heterostructure-based devices were more than one order of magnitude higher than those of SnS 2 , Bi 2 Se 3 , and Bi 2 Te 3 . The improved photoelectric properties of the SnS 2 /Bi 2 X 3 heterostructures can be explained as follows: (i) the photoexcited electrons and holes are effectively separated in the heterostructures; (ii) the charge-transfer efficiency and carrier density at the interface between the SnS 2 /Bi 2 X 3 heterostructures and the electrolyte are greatly improved; (iii) the formed heterostructures expand the light absorption range. The photoelectric performance was further enhanced by efficient light trapping in the upright SnS 2 . The photoelectric response is higher in the type-I SnS 2 /Bi 2 Se 3 heterostructure than in the type-II SnS 2 /Bi 2 Te 3 heterostructure due to more efficient charge transportation at the type-I SnS 2 /Bi 2 Se 3 heterostructure/electrolyte interface. These results suggest that suitable type-I and type-II heterostructures can be developed for high-performance photodetectors and other optoelectronic devices.
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JOURNAL OF LUMINESCENCE
·
2019
·
IF 2.961
Yanchun Yang,Song Wei,Xiaojiao Kang,O. Tegus,Daocheng Pan
Employing the short-chain C 4 H 9 NH 3 X (X = Cl, Br, I) compound as the unique capping agent, highly quality CH 3 NH 3 PbX 3 (X = Cl, Br, I) perovskite quantum dots can be synthesized at room temperature in the open air, which possess high photoluminescence quantum yields and tunable emission in the range of 440–660 nm. Besides, C 4 H 9 NH 3 Br can also improve the morphology of CH 3 NH 3 PbBr 3 thin films by spin-coating the N, N -dimerthylformamide solution of CH 3 NH 3 Br, C 4 H 9 NH 3 Br and PbBr 2 , making the thin film dense and compact, and improving its optical properties .
研究领域:
材料科学
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纳米科技
·
光电功能材料
·
半导体物理
·
凝聚态物理
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Science China-Materials
·
2026
·
IF 7.4
Wang Qianqian,Pan Shifeng,Li Haibo,Zhang Menghuan,Zhou Zhennan,Liu Wei,Ouyang Gangfeng
Organic-inorganic hybrid copper(I) halide semiconductors have attracted extensive attention for applications in phosphor-converted white light-emitting diodes (pc-WLEDs), X-ray imaging, and photodetectors because of their superior photo/radioluminescence, structural diversity, and eco-friendliness. In our previous work, we proposed a novel strategy for synthesizing highly efficient blue-emitting copper(I) halide hybrids by combining coordinated anionic inorganic modules with cationic derivatives. However, the complexity of the synthesis process has limited the practical application of this approach. To address this challenge, we report a facile, efficient, and rapid solution-based ultrasonic treatment method for synthesizing high-performance blue-emitting phosphors with this structural motif using inexpensive and commercially available tetraethylammonium halides (TEAX, X = Cl, Br, and I). The synergistic interplay of ionic and covalent bonds in these compounds endows them with a high photoluminescence quantum yield (PLQY) of 70% and excellent stability. These materials exhibit a thermally activated delayed fluorescence (TADF) mechanism, delivering outstanding performance in pc-WLEDs and X-ray imaging. Their exceptional properties highlight their significant potential for use in optoelectronic devices and X-ray scintillators. This work provides an important reference for the rapid synthesis of high-performance copper(I) halide hybrid phosphors and paves the way for their commercial application.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Sang Fuming,Bai Yinglun,Hu Naixin,Li Menglin
A dual-ratiometric assay combining fluorescence and colorimetry is constructed based on a gold(I)-triggered in situ reaction between o -phenylenediamine (OPD) and ascorbic acid (AA). OPD is oxidized by gold(I) to form fluorescent 2,3-diaminophenazine (OPDox), which has an absorption peak centered at 445 nm and a fluorescence emission at 555 nm. When AA is introduced, AA can be oxidized to dehydroascorbic acid (DHAA) by gold(I), inhibiting the production of OPDox. Simultaneously, DHAA reacts with OPD to form a fluorescent quinoxaline derivative (DFQ), which exhibits an absorption peak around 340 nm and a fluorescence emission at 425 nm. Based on this redox-modulated strategy, a highly selective dual-mode sensing assay is established with ratiometric colorimetric ( A ₃₄₀/ A ₄₄₅) and ratiometric fluorescence ( F ₄₂₅/ F ₅₅₅) signals. This method enables the quantitative analysis of AA, with limits of detection (LOD) of 0.09 μmol/L and 0.04 μmol/L, respectively. Owing to its facile analytical procedure, this assay exhibits many merits including simplicity, excellent selectivity and good biocompatibility, and has been successfully applied to detect AA in human serum samples. Such an approach based on the in situ formation of fluorophores provides a valuable tool for AA detection in clinical diagnosis and drug screening. Graphical
The alternative text for this image may have been generated using AI.
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JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2026
·
IF 9.2
Maolin Wang,Haoyang Fu,Yanchun Fan,Gang Zhao,Tianwen Liu,Yi Liu,Qingqing Wu,Ying Huang
Persulfate (PS)-based advanced oxidation of polycyclic aromatic hydrocarbons (PAHs) in carbonate-rich water is severely constrained by radical scavenging and surface passivation of iron-based activators. Here, a dithionite–zerovalent iron–copper (DTN–ZVI–Cu) ternary system was developed to promote persulfate activation toward predominantly non-radical oxidation under bicarbonate-rich conditions. DTN and ZVI accelerated Cu(II)-to-Cu(I) reduction while simultaneously regenerating the ZVI surface, thereby sustaining Cu-centered redox turnover and facilitating the formation of Cu(III)-like oxidizing species. In parallel, DTN promoted sulfur-centered conversion pathways that favored 1 O 2 generation. These non-radical oxidizing pathways are generally less susceptible to inorganic-anion scavenging than conventional sulfate and hydroxyl radicals. Under standard conditions, the system achieved 91% acenaphthene removal within 60 min ( k obs = 0.039 min −1 ), an 8.7-fold kinetic enhancement over ZVI/PS alone. Moderate bicarbonate further promoted degradation, with k obs reaching 0.13 min −1 at 250 mg/L HCO 3 − , which is consistent with a plausible role of copper–carbonate complexation in stabilizing Cu redox cycling and favoring non-radical oxidation pathways. XPS analysis suggested that DTN–ZVI coupling elevated the reactive copper pool (Cu(I) + Cu(III)) to 57% of total surface copper. Applied to synthetic wastewaters, the system maintained 90–96% PAH removal at optimal dosages, indicating strong performance across complex saline matrices. This work demonstrates the feasibility of using coexisting Cu(II) as a catalytic resource for non-radical persulfate activation in carbonate-rich water.
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Journal of Functional Foods
·
2026
·
IF 3.9
Lin Zhang,Zi-Li Chen,Ding-Tao Wu,Qin Yuan,Shengpeng Wang,Mei-Lin Feng,Yi-Chen Hu,Mao-Ling Tan,Jing-Wei Huang,Liang Zou,Ya-Nan Cao
Tartary buckwheat leaf is a promising sustainable source of rhamnogalacturonan-I-rich pectic polysaccharides (TBP) with marked in vitro immunostimulatory activity. However, their in vivo efficacy and structure-activity relationships remain unknown. Here, we investigated TBP fractions differing in esterification degree, molecular mass, and branching in a murine immunosuppression model. All TBP fractions attenuated immunosuppression, an effect associated with modulating gut microbial homeostasis, enhancing levels of short-chain fatty acids (SCFAs), reinforcing gut barrier integrity, and improving systemic immune markers. Structural modifications augmented bioactivity; low-esterified TBP-D and low-molecular-mass, low-branching TBP-F outperformed native TBP. TBP-F had the strongest effects, significantly improving immune organ indices, cytokines, immunoglobulins, SCFAs, and tight-junction proteins. Microbiota analysis revealed that all TBPs enriched Muribaculaceae and decreased dysbiosis-associated taxa, with TBP-F most strongly suppressing detrimental bacteria. These results imply that TBPs with lower molecular mass, less branching, or reduced esterification possess superior immunostimulatory potency, supporting their development as immune-enhancing functional foods.
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EMBO Molecular Medicine
·
2026
·Vol. 18
·期 5
·1679
·
IF 7.9
Yufei Wu,Xiaomei Yang,Yu Bai,Chenze Li,Peng Wang,Qing Xu,Hui Li,Xiaoli Rao,Yangkai Xu,Jie Chen,Huanhuan Cao,Qi Zhang,Mingming Zhao,Rui Zhan,Xue Fan,Yuedong Hou,Jie Liu,Hong S Lu,Tianyun Wang,Wei Dong Gao,Linzhang Huang,Han Xiao,Lingyun Zu,Alan Daugherty,Mingguo Xu,Lemin Zheng
Cardiac microvascular endothelial cells (CMECs) dysfunction is a well-recognized mediator of heart failure with preserved ejection fraction (HFpEF), but the underlying mechanism remains unclear. Here we find that scavenger receptor class B type I (SR-B1) is predominantly expressed in CMECs and decreased significantly in HFpEF. Endothelial-specific SR-B1 deficiency exacerbates cardiac pathological remodeling and diastolic dysfunction in HFpEF, which can be prevented by endothelial SR-B1 reconstitution through adeno-associated virus serotype 1 (AAV1)-mediated delivery in endothelial-specific SR-B1-deficient mice. Single-cardiac-endothelial-cell transcriptomics and lineage-tracing system reveal that inflammatory CMECs subcluster activation is responsible for the deteriorating HFpEF progression induced by endothelial SR-B1 loss, rather than endothelial-to-mesenchymal transition. Mechanistically, SR-B1 loss drives increased CXCL10 secretion, which orchestrates CMECs activation and CXCR3-positive T-cell cardiotropism to promote diastolic dysfunction—a process associated with endothelial IRF1 activation. Most importantly, the SR-B1-CXCL10-CXCR3 axis is activated in human HFpEF cardiac tissue, and the elevated CXCL10 level in plasma is independently associated with a higher HFpEF prevalence. This study uncovers that activation of the SR-B1–CXCL10-CXCR3 axis in CMECs aggravates HFpEF pathogenesis through the accumulation of CXCR3-positive T-cells in hearts. This study demonstrates that SR-B1 deficiency in cardiac microvascular endothelial cells (CMECs) exacerbates heart failure with preserved ejection fraction (HFpEF) by driving the CXCL10-CXCR3 signaling, thereby linking inflammatory CMEC activation to CXCR3 + T-cell recruitment. This study demonstrates that SR-B1 deficiency in cardiac microvascular endothelial cells (CMECs) exacerbates heart failure with preserved ejection fraction (HFpEF) by driving the CXCL10-CXCR3 signaling, thereby linking inflammatory CMEC activation to CXCR3 + T-cell recruitment.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yueyang Li,Jingde Luan,Haibin Yan,Yu Zhang,Qingyu Chi,Wengang Liu,Jian Liu,Zheng Yan
Integrating dual functional sites in the crystal lattice is a promising strategy to fabricate novel hetero nuclear-hetero polar dual-atom catalyst. However, the synergy between the dual active sites is governed by the local coordination environment, shaped by doping configuration of hetero atoms in the crystal lattice. Herein, engineering cobalt–iodine dual-site on anatase-TiO2 (Co-I-a-TiO2) was conducted by coupling in-situ cross-linking-assisted hydrothermal synthesis with electrostatic self-assembly. The optimal Co-I-a-TiO2 exhibits a H2 production rate of 20.8 mmol g−1 h−1, approximately 8.32 fold higher than that of pristine a-TiO2. Experimental and theoretical analysis reveal that the Co3+-for-Ti4+ substitution and vacancy-doped I ions in the lattice alter the electron density distribution, establishing a built-in electric field oriented from bulk to surface in the near-surface region. This redistribution empowers Co atom to function as an electron-rich center and I atom as a proton-trapping site. These findings emphasize the importance of constructing asymmetric coordination via anion-cation dual-site modification to promote photogenerated charge separation, as well as the enhanced probability of electron-proton binding.
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RSC Advances
·
2026
·Vol. 16
·期 19
·17393-17400
·
IF 6.1
Lihua Zhang,Jiang Li,Tengyan Gao,Wei Liu,Zirui Zhang,Zezhong Chen,Feng Feng
Heavy metal ion contamination poses a serious threat to human health and ecological balance, emphasizing the need for sensitive detection methods to maintain water quality and safeguard public safety. To meet this challenge, an integrated quantitative detection platform based on smartphone image capture and a built-in RGB color analysis app, following a “one-stone-three-birds” strategy, was developed. It allows for rapid, sensitive, and on-site detection of silver ions (Ag(I)) in actual water samples. In the presence of Ag(I) ions, the aggregation of AuNPs with ammonium thioglycolate (ATG), which acts as a multifunctional agent (an aggregation inducer, charge modulator, and recognition unit), is inhibited, resulting in a notable hypsochromic shift in the surface plasmon resonance (SPR) spectrum of AuNPs and a color change from gray-blue to pink-red, depending on the target level. Quantitative analysis is performed by measuring the color signal intensity of AuNPs after adding Ag(I) ions with a smartphone equipped with an RGB color detector. The detection mechanism was verified further through transmission electron microscopy (TEM), dynamic light scattering (DLS), and UV-Vis spectrophotometry (UV-Vis). The smartphone-integrated detection method exhibited a linear range of 0.1 to 8 µM and a detection limit of 10.4 nM. Results from this platform, paired with a smartphone, were validated against data from atomic absorption spectrometry (AAS). This smartphone-based detection approach offers the benefits of simplicity, speed, and low cost, making it suitable for environmental monitoring of Ag(I) ions.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Zhang Xiangxiang,Zhao Jingjing,Li Chao,Li Shubin,Tang Xuefeng,Zhao Wan,Liu Fukai,Han Xiaojun
A large population suffers from diabetes worldwide. Type I diabetes mellitus results in insulin-deficient hyperglycemia, causing serious health issues. Pancreatic islet transplantation is a promising way to treat type I diabetes. It remains a challenge to obtain the islet spheroid with a core–mantle architecture similar to that of rodent pancreatic islets in vivo. We demonstrate a methodology to produce islet spheroids composed of β and α cells with a core–mantle architecture based on the magneto-Archimedes effect in a high-throughput manner. The core–mantle islet spheroid (CMIS) shows a more sensitive glucose stimulation response and better insulin secretion performance than the mixed islet spheroid at high-glucose conditions, as indicated by the relative mRNA expression levels. The high-throughput toxicity tests on immunosuppressive drugs using CMIS (β:α = 7:3) indicate that mycophenolate mofetil exhibits a less negative effect on cell viability and insulin secretion than rapamycin and tacrolimus. The CMIS (β:α = 7:3) exhibits a better therapeutic effect in treating diabetic mice after transplantation than the other types of islet spheroids, which holds great potential in the clinical treatment of diabetes. The proposed versatile methodology for core–mantle islet spheroids paves the path for fabricating spatially coded tissues with a complicated architecture in the organoid field.
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JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Kexin Wen,Chenxi Zhang,Qin Fan,Jinqiao Zhang,Yuhan Mo,Junjun Huang,Songling Liu,Xin Wang,Ziliang Dong
PANoptosis, an inflammatory cell death integrating pyroptosis, apoptosis, and necroptosis, has emerged as a promising approach for tumor immunotherapy. Reactive oxygen species (ROS) generation is the predominant strategy for triggering PANoptosis. However, in solid tumors, the hypoxic microenvironment suppresses ROS production, thereby limiting PANoptosis induction. Herein, we present an in situ-formed pH-responsive injectable hydrogel enabling sequential delivery of 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) and Type I sonodynamic nanoparticles for hypoxic tumor immunotherapy. Upon intratumoral injection, the hydrogel gradually degrades in acidic conditions. DMXAA is released first, inducing vascular shutdown and aggravating tumor hypoxia. Subsequently, nanoparticles are liberated and, under ultrasound, generate abundant ROS via a Type I sonodynamic process, bypassing oxygen dependence. The ROS burst triggers tumor cell PANoptosis, leading to immunogenic cell death, promoting antigen release and dendritic cell maturation. In multiple hypoxic tumor models, this sequential approach achieved significant tumor regression, suppressed metastasis, and induced durable immune memory to prevent recurrence. Overall, our work presents an injectable hydrogel platform that integrates controlled drug release, Type I sonodynamic PANoptosis, and immune activation for enhanced antitumor immunotherapy.
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