JOURNAL OF ENVIRONMENTAL MANAGEMENT
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2026
·
IF 9.2
Maolin Wang,Haoyang Fu,Yanchun Fan,Gang Zhao,Tianwen Liu,Yi Liu,Qingqing Wu,Ying Huang
Persulfate (PS)-based advanced oxidation of polycyclic aromatic hydrocarbons (PAHs) in carbonate-rich water is severely constrained by radical scavenging and surface passivation of iron-based activators. Here, a dithionite–zerovalent iron–copper (DTN–ZVI–Cu) ternary system was developed to promote persulfate activation toward predominantly non-radical oxidation under bicarbonate-rich conditions. DTN and ZVI accelerated Cu(II)-to-Cu(I) reduction while simultaneously regenerating the ZVI surface, thereby sustaining Cu-centered redox turnover and facilitating the formation of Cu(III)-like oxidizing species. In parallel, DTN promoted sulfur-centered conversion pathways that favored 1 O 2 generation. These non-radical oxidizing pathways are generally less susceptible to inorganic-anion scavenging than conventional sulfate and hydroxyl radicals. Under standard conditions, the system achieved 91% acenaphthene removal within 60 min ( k obs = 0.039 min −1 ), an 8.7-fold kinetic enhancement over ZVI/PS alone. Moderate bicarbonate further promoted degradation, with k obs reaching 0.13 min −1 at 250 mg/L HCO 3 − , which is consistent with a plausible role of copper–carbonate complexation in stabilizing Cu redox cycling and favoring non-radical oxidation pathways. XPS analysis suggested that DTN–ZVI coupling elevated the reactive copper pool (Cu(I) + Cu(III)) to 57% of total surface copper. Applied to synthetic wastewaters, the system maintained 90–96% PAH removal at optimal dosages, indicating strong performance across complex saline matrices. This work demonstrates the feasibility of using coexisting Cu(II) as a catalytic resource for non-radical persulfate activation in carbonate-rich water.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2026
·
IF 4.1
Sang Fuming,Bai Yinglun,Hu Naixin,Li Menglin
A dual-ratiometric assay combining fluorescence and colorimetry is constructed based on a gold(I)-triggered in situ reaction between o -phenylenediamine (OPD) and ascorbic acid (AA). OPD is oxidized by gold(I) to form fluorescent 2,3-diaminophenazine (OPDox), which has an absorption peak centered at 445 nm and a fluorescence emission at 555 nm. When AA is introduced, AA can be oxidized to dehydroascorbic acid (DHAA) by gold(I), inhibiting the production of OPDox. Simultaneously, DHAA reacts with OPD to form a fluorescent quinoxaline derivative (DFQ), which exhibits an absorption peak around 340 nm and a fluorescence emission at 425 nm. Based on this redox-modulated strategy, a highly selective dual-mode sensing assay is established with ratiometric colorimetric ( A ₃₄₀/ A ₄₄₅) and ratiometric fluorescence ( F ₄₂₅/ F ₅₅₅) signals. This method enables the quantitative analysis of AA, with limits of detection (LOD) of 0.09 μmol/L and 0.04 μmol/L, respectively. Owing to its facile analytical procedure, this assay exhibits many merits including simplicity, excellent selectivity and good biocompatibility, and has been successfully applied to detect AA in human serum samples. Such an approach based on the in situ formation of fluorophores provides a valuable tool for AA detection in clinical diagnosis and drug screening. Graphical
The alternative text for this image may have been generated using AI.
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RSC Advances
·
2026
·Vol. 16
·期 19
·17393-17400
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IF 6.1
Lihua Zhang,Jiang Li,Tengyan Gao,Wei Liu,Zirui Zhang,Zezhong Chen,Feng Feng
Heavy metal ion contamination poses a serious threat to human health and ecological balance, emphasizing the need for sensitive detection methods to maintain water quality and safeguard public safety. To meet this challenge, an integrated quantitative detection platform based on smartphone image capture and a built-in RGB color analysis app, following a “one-stone-three-birds” strategy, was developed. It allows for rapid, sensitive, and on-site detection of silver ions (Ag(I)) in actual water samples. In the presence of Ag(I) ions, the aggregation of AuNPs with ammonium thioglycolate (ATG), which acts as a multifunctional agent (an aggregation inducer, charge modulator, and recognition unit), is inhibited, resulting in a notable hypsochromic shift in the surface plasmon resonance (SPR) spectrum of AuNPs and a color change from gray-blue to pink-red, depending on the target level. Quantitative analysis is performed by measuring the color signal intensity of AuNPs after adding Ag(I) ions with a smartphone equipped with an RGB color detector. The detection mechanism was verified further through transmission electron microscopy (TEM), dynamic light scattering (DLS), and UV-Vis spectrophotometry (UV-Vis). The smartphone-integrated detection method exhibited a linear range of 0.1 to 8 µM and a detection limit of 10.4 nM. Results from this platform, paired with a smartphone, were validated against data from atomic absorption spectrometry (AAS). This smartphone-based detection approach offers the benefits of simplicity, speed, and low cost, making it suitable for environmental monitoring of Ag(I) ions.
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ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Huiyu Zou,Yuying Zheng,Erkang Bian,Chenyang Li,Zhengwu Yang,Zhiyu He,Jingjing Zhou,Chunyan Deng
Early diagnosis of cardiovascular diseases requires precise detection of multiple biomarkers, yet simultaneous analysis of these biomarkers without cross-talk remains a major challenge. To overcome this limitation, we developed a novel dual-zone biosensing platform capable of generating independent multimode signals for the parallel detection of cardiac troponin I (cTnI, the gold-standard biomarker) and interleukin-6 (IL-6, a key inflammatory marker). This platform features two spatially resolved zones, Zone I integrates rhodamine B (RhB) with a cadmium sulfide@bismuth tungstate (CdS@Bi2WO6) composite, allowing dual-signal detection of cTnI via photoelectrochemical (PEC) and smartphone-based fluorescent (FL) methods. Zone II is functionalized with dsDNA/methylene blue (MB), enabling dual-signal detection of IL-6 through PEC and electrochemical (EC) techniques. The biosensor exhibits excellent analytical performance, including high specificity against interfering species, a broad dynamic range covering clinically relevant concentrations, and high detection sensitivity (cTnI: 1 ∼ 50,000 pg mL–1 for PEC, 10 ∼ 50,000 pg mL–1 for FL; IL-6:1 ∼ 20,000 pg mL–1 for PEC, 1 ∼ 20,000 pg mL–1 for EC.) with low limits of detection (cTnI: 0.27 pg mL–1 for PEC, 0.86 pg mL–1 for FL; IL-6:0.57 pg mL–1 for PEC, 0.65 pg mL–1 for EC.). Importantly, it maintains robust functionality in human serum and shows strong correlation with established clinical methods. This work provides a generalizable framework for developing multiplexed biosensors that combine orthogonal detection principles, effectively addressing key challenges in multicomponent bioanalysis, which is a significant advancement in the field of clinical diagnostics.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Zhang Xiangxiang,Zhao Jingjing,Li Chao,Li Shubin,Tang Xuefeng,Zhao Wan,Liu Fukai,Han Xiaojun
A large population suffers from diabetes worldwide. Type I diabetes mellitus results in insulin-deficient hyperglycemia, causing serious health issues. Pancreatic islet transplantation is a promising way to treat type I diabetes. It remains a challenge to obtain the islet spheroid with a core–mantle architecture similar to that of rodent pancreatic islets in vivo. We demonstrate a methodology to produce islet spheroids composed of β and α cells with a core–mantle architecture based on the magneto-Archimedes effect in a high-throughput manner. The core–mantle islet spheroid (CMIS) shows a more sensitive glucose stimulation response and better insulin secretion performance than the mixed islet spheroid at high-glucose conditions, as indicated by the relative mRNA expression levels. The high-throughput toxicity tests on immunosuppressive drugs using CMIS (β:α = 7:3) indicate that mycophenolate mofetil exhibits a less negative effect on cell viability and insulin secretion than rapamycin and tacrolimus. The CMIS (β:α = 7:3) exhibits a better therapeutic effect in treating diabetic mice after transplantation than the other types of islet spheroids, which holds great potential in the clinical treatment of diabetes. The proposed versatile methodology for core–mantle islet spheroids paves the path for fabricating spatially coded tissues with a complicated architecture in the organoid field.
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JOURNAL OF CONTROLLED RELEASE
·
2026
·
IF 12.4
Kexin Wen,Chenxi Zhang,Qin Fan,Jinqiao Zhang,Yuhan Mo,Junjun Huang,Songling Liu,Xin Wang,Ziliang Dong
PANoptosis, an inflammatory cell death integrating pyroptosis, apoptosis, and necroptosis, has emerged as a promising approach for tumor immunotherapy. Reactive oxygen species (ROS) generation is the predominant strategy for triggering PANoptosis. However, in solid tumors, the hypoxic microenvironment suppresses ROS production, thereby limiting PANoptosis induction. Herein, we present an in situ-formed pH-responsive injectable hydrogel enabling sequential delivery of 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) and Type I sonodynamic nanoparticles for hypoxic tumor immunotherapy. Upon intratumoral injection, the hydrogel gradually degrades in acidic conditions. DMXAA is released first, inducing vascular shutdown and aggravating tumor hypoxia. Subsequently, nanoparticles are liberated and, under ultrasound, generate abundant ROS via a Type I sonodynamic process, bypassing oxygen dependence. The ROS burst triggers tumor cell PANoptosis, leading to immunogenic cell death, promoting antigen release and dendritic cell maturation. In multiple hypoxic tumor models, this sequential approach achieved significant tumor regression, suppressed metastasis, and induced durable immune memory to prevent recurrence. Overall, our work presents an injectable hydrogel platform that integrates controlled drug release, Type I sonodynamic PANoptosis, and immune activation for enhanced antitumor immunotherapy.
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MOLECULES
·
2025
·Vol. 30
·期 12
·2560
·
IF 4.6
Zihao Wang,Xiao Liu,Yifan Ma,Jiaxin Zheng,Ke Xu,Yingxue Chang,Zhaoyan Ye,Yong Ling,Lei Wang
To address the clinical challenges posed by symbiotic drug-resistant bacterial infections and tumor microenvironments, this study designed and synthesized novel carbazole/benzindole-based photosensitizersA1–A4, systematically evaluating their antitumor and antibacterial therapeutic potential through chemo-photodynamic therapy. Especially, compoundA4demonstrated potent Type I/II reactive oxygen species (ROS) generation capabilities. In vitro experiments revealed thatA4concentration-dependently inhibited HT-29 cells under hypoxic conditions (IC50= 0.89 μM) with a prominent photodynamic index (PI > 9.23), and substantially promoted cancer cell programmed death. In antibacterial evaluations,A4achieved the complete eradication of dermal MRSA infections within 7 days through ROS-mediated membrane disruption under illumination. In the HT-29 xenograft model, the PDT–chemotherapy synergy strategy achieved a tumor suppression rate of 96%. This work establishes an innovative strategy for the combinatorial management of multidrug-resistant infections and solid tumors.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
·
IF 6.2
Meijun Liu,Fengzhi Qiao,Shaolei Wang,Wenhao Ding,Shichao Xuan,Cristabelle De Souza,Muhammad Asif Javaid,Zhe Zhang,Huaxi Yi,Lanwei Zhang,Kai Lin
This study presents a novel oral delivery system for food-derived angiotensin I-converting enzyme (ACE) inhibitory peptides by integrating β-glucan-functionalized liposomes with microfluidic encapsulation and receptor-mediated targeting. Two peptides, RADHPFL and YAEERYPIL derived from egg white proteins, were encapsulated into liposomes (composed of lecithin, cholesterol, and DSPE-β-glucan) via a controlled microfluidic self-assembly process. Encapsulation significantly improved the gastrointestinal stability of the peptides and preserved their ACE inhibitory activity compared to free peptides. β-Glucan was grafted onto the liposomal surface to enable specific targeting of intestinal microfold (M) cells through interaction with the Dectin-1 receptor, thereby facilitating enhanced uptake in Peyer’s patches. In spontaneously hypertensive rats, both single-dose and continuous administration of β-glucan-functionalized liposomes resulted in superior antihypertensive effects compared to free peptides and unmodified liposomes. Interestingly, the antihypertensive efficacy was primarily attributed to modulation of the renin-angiotensin system, improved renal and cardiac function, and amelioration of endothelial dysfunction. These findings underscore the potential of the natural polysaccharide β-glucan as a targeting ligand in liposomal systems and highlight the utility of carbohydrate-based materials for enhancing the oral bioavailability and physiological efficacy of bioactive peptides. The proposed strategy offers a promising platform for the development of functional foods or nutraceuticals for hypertension management.
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Materials Today Bio
·
2026
·
IF 11
Shanlingzi Huang,Lu Gao,Yujun Chen,Zhaoming Fu,Ziyou Wang,Yifan Liu,Zhicheng Zhou,Ru Huang,Wen Song,Feifan Zhou
Triple-negative breast cancer (TNBC), characterized by low immunogenicity, is a challenging issue in clinical treatment due to its poor response to various therapies. The transformation of TNBC from a “cold tumor” with low immunogenicity into a “hot tumor” that elicits stronger immune responses is a key research focus. Photodynamic therapy (PDT) has emerged as a promising solution for TNBC treatment because it can effectively induce immunogenic cell death (ICD), which prompts the release of damage-associated molecular patterns (DAMPs) and activates immune responses. The role of MHC-I molecules in antigen presentation is crucial, but TNBC cells often evade immune surveillance by downregulating or losing MHC-I expression. Recent studies have shown that inhibiting the activity of complex II (CII) in the mitochondrial electron transport chain of tumor cells can promote MHC-I expression. Based on this finding, the combination of the PDT photosensitizer PCN-224 with the CII inhibitor 3-nitropropionic acid (3NPA) to form PCN@3NPA has been innovatively developed. Furthermore, modification with hyaluronic acid (HA) enables targeted delivery to TNBC cells that overexpress CD44. PDT induces ICD in tumor cells, releasing large amounts of DAMPs, while the sustained release of 3NPA effectively inhibits CII activity, significantly enhances MHC-I expression, thereby boosting tumor cell immunogenicity. This process significantly improves the recognition and killing of tumor cells by CD8 + T cells, markedly strengthening the body's anti-tumor immune response. This approach offers a novel and promising strategy for efficiently treating not only low-immunogenic TNBC but also other similar tumors, bringing new hope for future clinical treatments.
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WATER SCIENCE AND TECHNOLOGY
·
2018
·Vol. 78
·期 6
·1390-1399
·
IF 1.247
Li Wenshu,Zhou Peng,Zhang Jing,Zhang Yongli,Zhang Gucheng,Liu Yang,Cheng Xin
This study investigated the generation of reactive oxygen species (ROS) (O 2 − •, H 2 O 2 , and HO•) by promoting the Cu(II)/Cu(I) redox cycle with certain reducing agents (RAs) in aerobic aqueous solution, and benzoic acid (BA) was employed as indicator for the hydroxyl radical (HO•). Hydroxylamine (HA) can reduce Cu(II) to Cu(I) to induce chain reactions of copper species resulting in the generation of the superoxide radical (O 2 − •) and hydrogen peroxide (H 2 O 2 ), and the intermediate Cu(I) can further activate H 2 O 2 via a Fenton-like reaction to produce HO•, creating the remarkable BA degradation. O 2 is indispensable, and unprotonated HA is the motive power in the O 2 /Cu/HA system. Moreover, pH is a crucial factor of the O 2 /Cu/HA system due to the protonated HA not being able to reduce Cu(II) into Cu(I). The oxidation of HA can be effectively induced by trace amounts of Cu(II), and both a higher HA dosage and a higher Cu(II) dosage can enhance H 2 O 2 generation and BA degradation. In addition, some other RAs that can reduce Cu(II) into Cu(I) could replace HA in the O 2 /Cu/HA system to induce the generation of these ROS in aerobic aqueous solution.
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Science China-Materials
·
2021
·Vol. 65
·期 4
·1000-1011
·
IF 8.273
Luo Mingwei,Lu Chunhui,Liu Yuqi,Han Taotao,Ge Yanqing,Zhou Yixuan,Xu Xinlong
Heterostructures based on new advanced materials offer a cornerstone for future optoelectronic devices with improved photoelectric performance. Band alignment is crucial for understanding the mechanism of charge carrier transportation and interface dynamics in heterostructures. Herein, we grew SnS 2 /Bi 2 X 3 (X = Se, Te) van der Waals heterostructures by combining physical vapor deposition with chemical vapor deposition. The band alignment, measured by high-resolution X-ray photoelectron spectroscopy, suggested the successful design of type-I SnS 2 /Bi 2 Se 3 and type-II SnS 2 /Bi 2 Te 3 heterostructures. The SnS 2 /Bi 2 X 3 heterostructure greatly improved the photoelectric response of a photoelectrochemical-type photodetector. The photocurrent densities in the type-I SnS 2 /Bi 2 Se 3 and type-II SnS 2 /Bi 2 Te 3 heterostructure-based devices were more than one order of magnitude higher than those of SnS 2 , Bi 2 Se 3 , and Bi 2 Te 3 . The improved photoelectric properties of the SnS 2 /Bi 2 X 3 heterostructures can be explained as follows: (i) the photoexcited electrons and holes are effectively separated in the heterostructures; (ii) the charge-transfer efficiency and carrier density at the interface between the SnS 2 /Bi 2 X 3 heterostructures and the electrolyte are greatly improved; (iii) the formed heterostructures expand the light absorption range. The photoelectric performance was further enhanced by efficient light trapping in the upright SnS 2 . The photoelectric response is higher in the type-I SnS 2 /Bi 2 Se 3 heterostructure than in the type-II SnS 2 /Bi 2 Te 3 heterostructure due to more efficient charge transportation at the type-I SnS 2 /Bi 2 Se 3 heterostructure/electrolyte interface. These results suggest that suitable type-I and type-II heterostructures can be developed for high-performance photodetectors and other optoelectronic devices.
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Science China-Materials
·
2026
·
IF 7.4
Wang Qianqian,Pan Shifeng,Li Haibo,Zhang Menghuan,Zhou Zhennan,Liu Wei,Ouyang Gangfeng
Organic-inorganic hybrid copper(I) halide semiconductors have attracted extensive attention for applications in phosphor-converted white light-emitting diodes (pc-WLEDs), X-ray imaging, and photodetectors because of their superior photo/radioluminescence, structural diversity, and eco-friendliness. In our previous work, we proposed a novel strategy for synthesizing highly efficient blue-emitting copper(I) halide hybrids by combining coordinated anionic inorganic modules with cationic derivatives. However, the complexity of the synthesis process has limited the practical application of this approach. To address this challenge, we report a facile, efficient, and rapid solution-based ultrasonic treatment method for synthesizing high-performance blue-emitting phosphors with this structural motif using inexpensive and commercially available tetraethylammonium halides (TEAX, X = Cl, Br, and I). The synergistic interplay of ionic and covalent bonds in these compounds endows them with a high photoluminescence quantum yield (PLQY) of 70% and excellent stability. These materials exhibit a thermally activated delayed fluorescence (TADF) mechanism, delivering outstanding performance in pc-WLEDs and X-ray imaging. Their exceptional properties highlight their significant potential for use in optoelectronic devices and X-ray scintillators. This work provides an important reference for the rapid synthesis of high-performance copper(I) halide hybrid phosphors and paves the way for their commercial application.
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