ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Ruohan Li,Jingyi Zhang,Xinqi Zhao,Mingda Huo,Xiaohong Sun,Chunming Zheng
Aqueous zinc-ion batteries (AZIBs) suffer from dendrite growth and side reactions, which severely limit their stability and commercialization. To address these issues, we developed a novel self-regulating hybrid interfacial layer composed of sodium alginate (SA) and in-situ formed zinc phosphate (ZP), which effectively regulates Zn 2+ flux and promotes uniform deposition. Specifically, SA coordinates with Zn 2+ through carboxyl groups to buffer local ion accumulation, while ZP improves ionic conductivity to facilitate rapid and uniform Zn 2+ transport. The synergistic interface mitigates interfacial ion concentration gradients and promotes homogeneous nucleation and lateral Zn growth, resulting in preferential (002)-oriented deposition and effective dendrite suppression. Therefore, the modified Zn anode demonstrates exceptional cycling stability, operating stably for >3000 h at 1 mA cm −2 and 1 mAh cm −2 , and maintains stable performance exceeding 3050 h at 5 mA cm −2 . This work proposes a scalable and eco-friendly interfacial strategy for stabilizing Zn anodes and highlights the potential of Zn 2+ flux modulation in advancing practical AZIBs.
✓ 已验证
产品关联
DOI
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2024
·
IF 6.9
Qin Lihao,Liu Tingting,Zhang Jiawei,Bai Yifei,Tang Zheyu,Li Jingyan,Xue Tongqing,Jia Zhongzhi
In patients with diabetic wounds, wound healing is impaired due to the presence of persistent oxidative stress, an altered inflammatory response, and impaired angiogenesis and epithelization. Salvianolic acid B (SAB), which is derived from the Chinese medicinal plant Salvia miltiorrhiza , has been found to exhibit antioxidant, anti-inflammatory, and proangiogenic effects. Previous studies have used 3D bioprinting technology incorporating sodium alginate (SA) and gelatin (Gel) as basic biomaterials to successfully produce artificial skin. In the current study, 3D bioprinting technology was used to incorporate SAB into SA-Gel to form a novel SAB-SA-Gel composite porous scaffold. The morphological characteristics, physicochemical characteristics, biocompatibility, and SAB release profile of the SAB-SA-Gel scaffolds were evaluated in vitro. In addition, the antioxidant, anti-inflammatory, and proangiogenic abilities of the SAB-SA-Gel scaffolds were evaluated in cells and in a rat model. Analysis demonstrated that 1.0 wt% (the percentage of SAB in the total weight of the solution containing SA and Gel) SAB-SA-Gel scaffolds had strong antioxidant, anti-inflammatory, and proangiogenic properties both in cells and in the rat model. The 1.0% SAB-SA-Gel scaffold reduced the expression of tumor necrosis factor-α, interleukin-6, and interluekin-1β and increased the expression of transforming growth factor-β. In addition, this scaffold removed excessive reactive oxygen species by increasing the expression of superoxide dismutase, thereby protecting fibroblasts from injury. The scaffold increased the expression of vascular endothelial growth factor and platelet/endothelial cell adhesion molecule-1, accelerated granulation tissue regeneration and collagen deposition, and promoted wound healing. These findings suggest that this innovative scaffold may have promise as a simple and efficient approach to managing diabetic wound repair.
✓ 已验证
DOI
PubMed
高影响因子
ChemistrySelect
·
2024
·Vol. 9
·期 14
·e202400566
·
IF 1.9
Zicheng Yang,Rongyu Li,Ruonan Wang,Senhe Qian
Graphical An SA/SS/GI/PSP@AgNP composite film was developed, and its physicochemical properties, cytocompatibility, antioxidant activity, and antibacterial properties were investigated. The composite film released PSP@AgNPs in a sustained way, and the film demonstrated favorable mechanical properties, excellent cytocompatibility, and high antioxidant and antibacterial activities in both in vitro and in vivo models. As a result, we conclude that this composite film has potential for application as a medical material. A sodium alginate/silk sericin (SA/SS) film was modified with glycerin (GI) and Polygonatum sibiricum polysaccharide@silver nanoparticles (PSP@AgNPs) to create a SA/SS/GI/PSP@AgNP composite film with antibacterial and antioxidant properties. The physicochemical properties of the SA/SS/GI/PSP@AgNP composite film were analyzed, and its cytocompatibility, antioxidant activity, and antibacterial properties were investigated. The optimum conditions for the preparation of the SA/SS/GI/PSP@AgNP composite film were 2 % SA, 2 % SS, 20 % GI, and 40 μg/mL of PSP@AgNPs. The addition of GI improved the surface smoothness of the composite films, while the presence of PSP@AgNPs did not significantly alter it. Spectroscopic characterization demonstrated that GI and PSP@AgNPs were physically bound to SA/SS. Approximately 53 % of the PSP@AgNP was released from the SA/SS/GI/PSP@AgNP composite film over 24 h of soaking in aqueous solution. The resulting leaching solution did not cause hemolysis or cytotoxicity, indicating its biocompatibility. Additionally, the SA/SS/GI/PSP@AgNP composite film exhibited strong antioxidant and antibacterial properties, and it promoted healing of mouse wounds infected with Staphylococcus aureus .
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Zewen Shi,Fang Yang,Qian Pang,Yiwei Hu,Haijian Wu,Xueqiang Yu,Xianjun Chen,Lin Shi,Bowen Wen,Rui Xu,Ruixia Hou,Dan Liu,Qingjiang Pang,Yabin Zhu
With the development of minimally invasive orthopedics, injectable materials for bone repair are attracted more attention, especially for those wound with a small external mouth and sizeable internal cavity. In this work, the hydrogel with features of thermo-responsiveness, degradability and injectability was designed and fabricated. The hydrogel, named as FHCS, is composed of Pluronic F-127 (F127) loaded with carboxymethyl chitosan/sodium alginate nanoparticles (nCS) and nanohydroxyapatite (nHA). The hydrogel FHCS was non-toxic and good hemocompatible. It can enhance the ALP activity and extracellular matrix calcification of MC3T3-E1 due to the chitosan-based nanoparticle components (nCS). Moreover, FHCS-5 (containing 5 mg/mL nCS) showed relative high expression of osteogenic genes and protein markers. Osteal regeneration was observed treated by FHCS-5 hydrogel in a critical-size rat calvarial bone defect model. CT scanning showed that the whole defect was basically covered by new bone after FHCS-5 hydrogel. The results of H&E staining and Masson's trichrome staining on histological sections further confirmed that FHCS-5 hydrogel promoted new osteal formation and maturation, which up regulated the osteogenic related genes and proteins of ALP, OCN, OPN through BMP/Smad signaling pathway. Hence, this study suggests that FHCS-5 hydrogels have a promising application for non-loading bone regeneration.
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Nutrition
·
2025
·
IF 5.1
Jinpeng Gong,Boya Liu,Tao Huang,Lu Wei,Yupeng Ma,Hao Chen,Jing Gan,Junbo Ge
Osteoporosis, a prevalent metabolic bone disease, poses a significant challenge for bone repair in aged populations. Soy-derived osteogenic peptide (SOP) holds promise but its clinical translation is hampered by rapid enzymatic degradation and poor oral bioavailability, representing a major challenge that necessitates the development of a protective delivery system. To address this, we developed a novel composite hydrogel based on fish gelatin and sodium alginate (SA/FG) as an oral delivery vehicle to overcome these limitations. Systematic characterization revealed that the SA/FG formulation offers distinct advantages: the incorporation of an optimal amount of SA significantly enhanced the mechanical strength and stability of the hydrogel, addressing the common weakness of single-network gelatin hydrogels, while maintaining a high water content (~90%) and a superior rehydration capacity (83.65% in distilled water). In a glucocorticoid-induced zebrafish osteoporosis model, the SOP-loaded SA/FG hydrogel significantly increased skull bone mass by 120.17% and improved larval swimming behavior, markedly outperforming the free SOP group. This study presents the first report of an SA/FG composite hydrogel for effective oral delivery of an osteogenic peptide. The system demonstrates great potential as a functional food or supplement for preventing and treating osteoporosis, offering an innovative strategy to enhance peptide stability and bioavailability through a biocompatible, double-network carrier.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Shiyao Fang,Kang Liu,Xin Zhou,Xin Jin,Chaozhe Feng,Qiang Zhu,Hongjiang Jiang,Peng Zhang
Extrusion-based 3D printing technology enables the precise design and fabrication of hydrogel scaffolds, demonstrating great potential for tissue repair applications. However, the addition of rheological modifiers or adjustment of the printing environment is often required to achieve successful scaffold formation. In this study, we developed a high-viscosity gelatin/acrylamide/sodium alginate (Gel/AM/SA) hydrogel ink that allows direct high-precision printing of triple-network hydrogel scaffolds. Our results show that the addition of SA significantly increased ink viscosity and yield stress, thereby reducing deposition deformation and improving printing accuracy. Our fabricated gelatin/polyacrylamide/sodium alginate (Gel/PAM/SA) scaffolds exhibited excellent mechanical properties, with a compressive strength of 3.69 MPa and a compressive modulus of 496 kPa. Moreover, the Gel/PAM/SA scaffold demonstrated long-term stability in the biological environment, with a weight loss rate of only 41.79 % after 28 days of degradation. The scaffold showed good cell compatibility and the cell adhesion rate on the scaffold reached 88.3 % after 1 day of culture. This study underscores the ability of Gel/AM/SA ink to fabricate scaffolds with complex shapes and structures at high fidelity, offering new avenues for biomedical applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Bioresources and Bioprocessing
·
2021
·Vol. 8
·期 1
·1-17
·
IF 4.578
Wang Jianfei,Guo Huanyu,Huang Jiaqi,Jiang Shaoming,Hou Shibo,Chen Xingyu,Lv Hujie,Bi Xudong,Hou Maolin,Lin Hebei,Lu Yuming,Qiao Jinyue,Yang Ruiyi,Liu Shijie
Under the optimal conditions of immobilization and fermentation, the highest LA yield of 0.966 ± 0.006 g/g fructose and production rate of 2.426 ± 0.018 g/(L × h) with an error of -0.5% and -0.2% to the predicted results were obtained from batch fermentation by the CS film-coated SA-PVA immobilized L. pentosus cells. The LA yield and production rate of these immobilized cells were 2.7% and 10.1% higher than that of normal SA-PVA immobilized cells respectively, and they were 5.7% and 48.4% higher than that of free cells, respectively. The effect of temperature on different types of immobilized cells and free cells was significantly different, but the effect of pH on different types of cells was not much different. The kinetic models could effectively describe the different fermentation performances of three types of cells. The immobilized cells have excellent reusability to conduct 9 runs of repeated batch fermentation.
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2015
·
IF 4.504
Yan Li,Defa Huang,Wenjiang Shen
Supercapacitors based on MnO 2 /CB/C nanocomposites films are prepared by direct electrophoretic deposition (EPD) process on nickel plates in an aqueous solution containing of MnO 2 nanoparticles , carbon black (CB) and sodium alginate (SA), followed by carbonization of SA to carbon layer . The nanocomposites of MnO 2 /CB/C films are prepared from different electrolytic solutions with mass ratios of MnO 2 nanoparticles, CB and SA from 8: 1: 1 to 6: 2: 2. Same mass ratios of nanocomposites are prepared by traditional Doctoral Blade (DB) process for morphologies and performances comparisons, in which mixtures of MnO 2 nanoparticles, carbon black with polyvinylidene fluoride (PVDF) are used. From scanning electron microscopy (SEM) and high resolution transmission electron microscopy (HRTEM) images, the MnO 2 /CB/C shows a uniform aggregation of MnO 2 and carbon nanoparticles covered with carbon layers. In the case of the MnO 2 /CB/PVDF from DB process, the MnO 2 nanoparticles are separately clustered, and the clusters are adhered to CB together with PVDF. More uniform film and better contact of MnO 2 with CB by carbon layer can be obtained from EPD/Carbonization process. The electrochemical performances of MnO 2 /CB/C and MnO 2 /CB/PVDF nanocomposites in different mass ratios are compared by areal specific capacitances (C a ), charge transfer resistance of films and retention of capacitance after 1500 cycles of charge/discharge to test stability respectively. The nanocomposites of MnO 2 /CB/C show better areal specific capacitances and smaller charge transfer resistances at each ratio. The carbon layer coating on surface of MnO 2 nanoparticles can effectively delay the capacitance loss, which leads to 98% of capacitance after charge/discharge cycles, much better than retention of those from DB process (50%). The EPD/Carbonization is an easy way to make carbon layer on pseudo capacitive materials from sodium alginates , and the carbon layer can effectively improve the charge/discharge stability of supercapacitors.
✓ 已验证
DOI
高影响因子
Food Chemistry-X
·
2026
·
IF 9.2
Miao Chen,Panyao Ruan,Sinuo Wu,Shanshan Li,Changjun Xin,Dongmeng Zhang,Zhihan Wang,Yongsheng Wang,Xiao Liu
This study reported a multifunctional sodium alginate (SA) film enhanced with silver nanoparticles (AgNPs) for pork preservation and freshness monitoring. Spectroscopic analyses confirmed that thesinic acid (CBDA-11) served as a dual bio-reductant and capping ligand, facilitating the green synthesis of stable AgNPs. Those nanoparticles established a dense cross-linked network with the SA matrix, achieving an extraordinary tensile strength of 101 MPa while enhancing water vapor barriers and UV–vis shielding (>99.86% at 200–280 nm). The films exhibited potent antibacterial efficacy and robust antioxidant activity (84.54% ABTS scavenging). In practical applications, SA-CBDA-11-Ag films effectively retarded myoglobin oxidation, delayed protein degradation, and significantly inhibited volatile basic nitrogen accumulation and microbial proliferation, extending pork shelf life to 8 days. Furthermore, the film functioned as a colorimetric sensor, showing a pH-dependent visual transition for freshness monitoring. This work highlighted the potential of AgNPs-based films as advanced active-intelligent systems for sustainable food preservation.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Zhihang Xu,Hong He,Jian Du,Peng Shan,Chenglong Fu,Jinwen Hu,Yehan Tao,Chao Li,Yanna Lv,Haisong Wang
Anthocyanin-based pH-responsive indicators are promising for food freshness monitoring, but UV exposure during transportation and retail display causes chromophore degradation and fading. Herein, core–shell sodium alginate/cinnamaldehyde/zein/anthocyanin nanoparticles (SCZC) were fabricated via a multiscale protection strategy. Anthocyanins were confined in a hydrophobic zein core through hydrophobic and π–π interactions, while cinnamaldehyde-assisted interfacial densification and a sodium alginate shell provided diffusion barriers against external stresses. After incorporation into a carboxymethyl cellulose (CMC) matrix, the CMC film containing 0.4 g SCZC nanoparticles (C/SCZC-0.4) exhibited improved UV and visible-light stability, with ΔEab values of only 5.21 after 4 h of UV irradiation and 5.22 after 8 days of visible-light exposure. Compared with the free-anthocyanin CMC film (C/C), C/SCZC-0.4 reduced anthocyanin migration in water from 84.34% to 35.65%, while improving oxygen barrier performance and tensile strength to 2.32 cm 3 ·μm·m −2 ·day −1 ·kPa −1 and 30.0 MPa. The label retained pH/ammonia responsiveness and visually distinguished seafood freshness. Download: Download high-res image (208KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Gongke Hu,DongJing Jiang,Hao Yangliuma,Jingting Cheng,Guangmei Liang,Lu Ni,Chao Lei,Shasha Li,Xiangyang Yuan,Wei Wang,Yuntao Liu,Hejun Wu
Bioactive films based on polysaccharides incorporated with theabrownin were developed. • Theabrownin improved UV barrier and antioxidant activity of films. • The addition of theabrownin significantly enhanced the mechanical properties of films. • The films can effectively extend the shelf life of fresh Auricularia auricula-judae . In this study, theabrownin (TB) was extracted from Tibetan tea and characterized using active functional groups including hydroxyl and carboxyl groups, exhibits a porous and wrinkled surface morphology, displays a characteristic absorption peak around 200 nm, and demonstrates significant antioxidant capacity. Based on these findings, composite films of potato starch (PS)/ sodium alginate (SA) with varying TB content were prepared by solution casting. When the TB content was 7.5%, the composite film exhibited optimal overall performance: the water vapor transmission rate decreased to 173.87 g/(m 2 ·24 h), the oxygen transmission rate was as low as 0.33 cm 3 /(m 2 ·24 h·0.1 MPa), the tensile strength increased to 16.89 MPa, and the specimen demonstrated substantial radical-scavenging capacity, DPPH and ABTS radical scavenging rate recorded at 61.26% and 64.38%, respectively. Furthermore, when applied to the preservation of fresh Auricularia auricula-judae , the composite film effectively inhibited weight loss, enzymatic browning, and overall quality deterioration after 13 days preserved at 4 °C, demonstrating favorable preservation effects. This study provides an effective strategy for the design of high-performance polysaccharide-based packaging materials, and broadens the approaches for the high-value utilization of tea extracts in the field of green packaging.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Ying Li,Xiaoyu Yang,Liang Li
To address the technical challenge of balancing the stability and bioavailability of conventional iron supplements, this study developed a plant-based composite gel system in which Fe(II) served as both a nutritional factor and an ionic crosslinker. The results showed that the three-dimensional gel network was primarily maintained by hydrophobic interactions. Two-dimensional correlation analysis further indicated that Fe(II) may coordinate with the carboxyl groups of sodium alginate (SA) to form ionic bridges, triggering the dissociation and reconstruction of the hydrogen-bonding network, subsequently inducing soy protein isolate (SPI) conformational unfolding, thereby regulating gel network formation. At an Fe(II) concentration of 0.25%, the in-situ ionic crosslinking degree reached the optimum level, yielding a gel with a hardness of 55.72 ± 0.27 g, the highest storage modulus, and the most uniform pore distribution. The β-sheet content in the SPI secondary structure reached its maximum (38.40%), effectively retarding Fe(II) diffusion and gastrointestinal loss. Overall, this study elucidated the mechanism of Fe(II)-mediated in-situ ionic crosslinking and established the structure–function relationship among crosslinking degree, gel structure and Fe(II) controlled-release behavior. These findings provide a novel food-grade iron supplement for alleviating iron-deficiency anemia and expanding the application of plant protein-based composite gels in active mineral delivery.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）