JOURNAL OF MOLECULAR LIQUIDS
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2023
·
IF 6
Zhixia Wang
The enrichment and separation of trace compounds, as well as the preparation of nanomaterials, are all greatly facilitated by responsive micro-emulsion. A multi stimuli-responsive ionic liquids-based micro-emulsion system was established with alkyl-N-Tropine (trans) P-methoxycinnamate ([C n Tr][PMCA], TILS) as a surfactant. The factors affecting the phase behavior of micro-emulsion, such as the structure of the TILS, cosurfactant, oil, temperature, pH, and salinity, were investigated by multiple research methods. Five zones were identified inside the micro-emulsion phase region as O/W, B.C., liquid crystal (L.C.), L.C.+B.C., and W/O. The TILS-based micro-emulsion displayed high stability at measured temperatures. High salinity contributed to a higher water solubilization capacity of the micro-emulsion. For the potential applications of the micro-emulsion, with sizes ranging from 20 to 70 nm, nanoscale silica particles showed persistent stability. High levels of drug loading rate (about 8.6 mg·g −1 ) and encapsulation efficiency (about 99%) of the micro-emulsion loaded with curcumin were attained.
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高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Hua-Bin Yuan,Jin Cheng,Desheng Sha,ManMan Zhao,Tieling Xing,Guoqiang Chen
Multifunctional superhydrophobic materials demonstrate remarkable performance and promising application prospects in various fields. However, there is still considerable interest in developing milder superhydrophobic modification techniques for materials. In this study, we aimed to improve the surface roughness of cotton fabric by utilizing an in-situ growth method to incorporate zeolitic imidazolate framework-8 (ZIF-8). The fabric underwent a subsequent treatment with curcumin at room temperature, which served as a bridge for connection and provided multifunction to form a core–shell structure (curcumin/ZIF-8). Eventually, by implementing a mild thiol-ene click chemistry reaction, specifically by grafting octadecanethiol onto the C = C bond within the curcumin structure, we successfully prepared superhydrophobic modified cotton fabric known as SHCZC. The contact angle of the SHCZC material reached 168.7°, accompanied by a sliding angle of just 1°. Furthermore, SHCZC exhibited exceptional stability in harsh environments, enduring exposure to strong acids, alkalis, organic solvents, high and low temperatures, repeated washing, and abrasion. The material also demonstrated excellent thermal stability and remarkable breathability. Additionally, SHCZC possessed self-cleaning, UV-blocking, anti-fouling, antibacterial, anti-icing, and oil/water separation characteristics. The presence of these characteristics expands the potential of SHCZC beyond the field of superhydrophobic materials, positioning it as a highly advanced and versatile multifunctional material.
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JOURNAL OF FOOD ENGINEERING
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2023
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IF 5.5
Jinyu Miao,Xinyu Zuo,David Julian McClements,Liqiang Zou,Ruihong Liang,Lu Zhang,Wei Liu
Water-in-oil high internal phase emulsions (HIPE W/O ) are promising as fat substitutes and nutrient carriers in food systems. A method was developed to replace the water phase of HIPE W/O with natural deep eutectic solvents (NDES) to enhance the loading and stability of nutraceuticals. NDESs, comprising varying ratios of d -glucose, sucrose , and water, were used. Higher sucrose ratios resulted in larger crystals in NDES-based HIPE W/O . Glucose-to-sucrose molar ratios below 1 generated gel-like HIPEs with excellent thermal, centrifugal, freeze-thaw, and storage stability. Increased sucrose proportion in NDES promoted crystal formation, thus improving emulsion stability. NDES-HIPEs demonstrated high curcumin loading with high encapsulation efficiency. Crystal-containing NDES-HIPEs exhibited improved ultraviolet and gastrointestinal stability. This study presents a novel method for HIPE W/O preparation. Using NDES as the internal phase regulates crystal morphology, enhances emulsion stability, and protects nutrients. These unique emulsions hold potential as carriers for bioactive components in food, nutraceutical, and pharmaceutical applications.
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FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Fuyun Ji,Huihui Liu,Chuyan Wang,Na Guo,Yizhong Shen,Shuizhong Luo,Shaotong Jiang,Zhi Zheng
Curcumin (Cur) and (−)-Epigallocatechin gallate (EGCG) have synergistic bioactivity in several terms, but their polar differences and environmental sensitivity make co-utilization challenging. Soy protein fibrils (UF) have sparked broad attention as outstanding carriers for bioactive substances. In this study, EGCG was applied to remodel the structure of Cur-loaded UF complex (UFC) to form novel UF-based hydrogels co-encapsulated Cur and EGCG (UFCE). The fluorescence spectroscopy, ITC , and FTIR analysis demonstrated that EGCG absorbed and deposited on the surface of UFC through hydrophobic and electrostatic interactions. The binding of EGCG led to the formation of UFCE, which constructed a stable and uniform gel network during heat treatment. UFCE gels formed with varying EGCG/protein concentration ([E]/[F]) ratios showed different structural properties with different encapsulation effects. At 2.5% protein concentration, UFCE gels formed at [E]/[F] ratio of 0.08 (UFCE 0.08 ) exhibited better gelling properties. The encapsulation efficiency of Cur and EGCG in UFCE 0.08 gel was up to 97.71% and 91.02%, respectively. Moreover, UFCE 0.08 gel exhibited significantly enhanced stability of Cur (95.27%) and EGCG (70.27%) than that of free Cur (53.13%) and free EGCG (13.32%) after thermal treatment at 85 °C for 120 min. UFCE 0.08 gel was also effective in improving the UV light stability of Cur (88.70%) and EGCG (72.96%). Furthermore, the binding of EGCG had pronouncedly boosted the anticancer activity of Cur in the UFCE 0.08 gel against Caco-2 cells. This study provides new perspectives into the fibril-polyphenol hydrogel systems for the co-encapsulation of EGCG and Cur, which has substantial potential for health-promoting applications.
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JOURNAL OF NANOBIOTECHNOLOGY
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2023
·Vol. 21
·期 1
·1-21
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IF 10.2
Han Xiaoqin,Luo Ruifeng,Qi Shanshan,Wang Yanli,Dai Linxin,Nie Wenbiao,Lin Meisi,He Haoqi,Ye Naijing,Fu Chaomei,You Yu,Fu Shu,Gao Fei
Ulcerative colitis (UC) faces some barriers in oral therapy, such as how to safely deliver drugs to the colon and accumulate in the colon lesions. Hence, we report an advanced yeast particles system loaded with supramolecular nanoparticles with ROS scavenger (curcumin) to treat UC by reducing oxidative stress state and inflammatory response and accelerating the reprogramming of macrophages. In this study, the dual-sensitive materials are bonded on β-cyclodextrin (β-CD), the D-mannose (Man) is modified to adamantane (ADA), and then loaded with curcumin (CUR), to form a functional supramolecular nano-delivery system (Man-CUR NPs) through the host-guest interaction. To improve gastrointestinal stability and colonic accumulation of Man-CUR NPs, yeast cell wall microparticles (YPs) encapsulated Man-CUR NPs to form Man-CUR NYPs via electrostatic adsorption and vacuum extrusion technologies. As expected, the YPs showed the strong stability in complex gastrointestinal environment. In addition, the Man modified supramolecular nanoparticles demonstrated excellent targeting ability to macrophages in the in vitro cellular uptake study and the pH/ROS sensitive effect of Man-CUR NPs was confirmed by the pH/ROS-dual stimulation evaluation. They also enhanced lipopolysaccharide (LPS)-induced inflammatory model in macrophages through downregulation of pro-inflammatory factors, upregulation of anti-inflammatory factors, M2 macrophage polarization, and scavenging the excess ROS. Notably, in DSS-induced mice colitis model, Man-CUR NYPs can reduce the inflammatory responses by modulating TLR4/NF-κB signaling pathways, alleviate oxidative stress by Nrf2/HO-1 signaling pathway, promote macrophages reprogramming and improve the favorable recovery of the damaged colonic tissue. Taken together, this study not only provides strategy for “supramolecular curcumin nanoparticles with pH/ROS sensitive and multistage therapeutic effects” in “advanced yeast particles”, but also provided strong theoretical support multi-effect therapy for UC.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2021
·Vol. 19
·期 1
·1-18
·
IF 10.435
Chen Yi,Jiang Zhaohui,Xu Jinzhuan,Zhang Jiyuan,Sun Runbin,Zhou Jia,Lu Yuan,Gong Zipeng,Huang Jing,Shen Xiangchun,Du Qianming,Peng Jianqing
Background The combination of berberine (BER) and curcumin (CUR) has been verified with ameliorative effects on non-alcohol fatty liver disease (NAFLD). However, discrepant bioavailability and biodistribution of BER and CUR remained an obstacle to achieve synergistic effects. Multilayer nanovesicles have great potential for the protection and oral delivery of drug combinations. Therein lies bile salts inserted liposomes, named as bilosomes, that possesses long residence time in the gastrointestinal tract (GIT) and permeability across the small intestine. Diethylaminoethyl dextran (DEAE-DEX) is generally used as an outside layer on the nanovesicles to increase the mucinous stability and promote oral absorption. Herein, we developed a DEAE-DEX-coated bilosome with BER and CUR encapsulated (DEAE-DEX@LSDBC) for the treatment of NAFLD.Results DEAE-DEX@LSDBC with 150 nm size exhibited enhanced permeation across mucus and Caco-2 monolayer. In vivo pharmacokinetics study demonstrated that DEAE-DEX@LSDBC profoundly prolonged the circulation time and improved the oral absorption of both BER and CUR. Intriguingly, synchronized biodistribution of BER and CUR and highest biodistribution at liver was achieved by DEAE-DEX@LSDBC, which contributed to the optimal ameliorative effects on NAFLD. It was further verified to be mainly mediated by anti-oxidation and anti-inflammation related pathwaysConclusion DEAE-DEX coated bilosome displayed promoted oral absorption, prolonged circulation and synchronized biodistribution of BER and CUR, leading to improved ameliorative effects on NAFLD in mice, which provided a promising strategy for oral administration of drug combinations.Graphic abstract
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高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 19
·6403-6415
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IF 6.843
Li-Jun Zhang,Rui Huang,Yi-Wen Shen,Jie Liu,Ye Wu,Jin-Mei Jin,Hong Zhang,Yun Sun,Hong-Zhuan Chen,Xin Luan
Tumor hypoxic stress after photodynamic therapy (PDT) will be inevitably exacerbated by the vascular blocking effects and oxygen consumption in the tumor microenvironment (TME) which usually leads to compromised efficacy and clinical performance. Increasing evidence links the hypoxia induced up-regulation of hypoxia inducible factor 1α (HIF-1α) with immunosuppressive TME, including the polarization of M2 phenotype tumor associated macrophages (TAMs), which promote the recurrence and metastasis. Here, we reported NIR-triggered core-satellite upconverting nanoparticles (CSNPs) with curcumin (Cur) embedded as a difunctional photosensitizer, which could realize PDT in deep tumors with long excitation wavelength (980 nm) and reverse the immunosuppressive TME induced by up-regulated HIF-1α at the same time. This Cur-loaded CSNPs (Cur–CSNPs)-mediated PDT could successfully induce the immunogenic cell death (ICD) of triple negative breast cancer (TNBC) cell lines (4T1 and MDA-MB-231) in vitro and repolarize the 4T1 cells co-cultured TAMs from pro-tumor M2 to the anti-tumor M1 phenotype. Furthermore, Cur–CSNPs-mediated PDT could suppress the 4T1 tumor growth in primary and distant sites through the synergistic immunotherapeutic effects in vivo by priming M1 type TAMs and CD4+/CD8+ T cells’ infiltration. Our data highlight the novel application of CSNPs-embedded Cur as a difunctional photosensitizer to enhance the anti-tumor efficacy of PDT.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2020
·
IF 3.721
Lingfei Liu,Qin Hu,Huijuan Sun,Jie Han,Yangni Pan,Zhen-quan Yang
This work reports the development of a new analytical method for the rapid detection of curcumin in food samples by using bluish green emissive fluorescence carbon quantum dots (BG-CQDs) as nanoprobe. The sensing mechanism behind the detection work is the quenching effect of curcumin on the fluorescence intensity of BG-CQDs, where curcumin and BG-CQDs interact via a combined effect of inner filter effect (IFE) and dynamic interaction process. After optimisation of the experimental parameters, the developed analytical method is capable of detecting curcumin with good selectivity and high sensitivity, achieving good linearity in the concentration range of 0.01–25.0 μM. A limit of detection (LOD) of 28.7 nM was obtained, which is lower than that of any of the previously reported CQDs-based fluorescence methods. The developed analytical method was applied to the analyses of food samples with a high degree of accuracy and precision. This work highlights a robust BG-CQDs-based analytical platform of rapid response, low cost, great simplicity, high selectivity and favourable sensitivity, which exhibits immense potential for the accurate monitoring of the curcumin content in dietary food samples.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Chong Chen,Lin-Lin Yang,A-Ling Tang,Pei-Yi Wang,Rong Dong,Zhi-Bing Wu,Zhong Li,Song Yang
Salicylic acid (SA), a crucial, plant-derived signal molecule, is capable of launching global transcriptional reprogramming to assist plants in obtaining the systemic acquired resistance (SAR) mechanism. Thus, the accurate detection of SA will not only significantly contribute to the understanding of the plant SAR but also contribute to crop protection and to the security of the agricultural production and food supply. However, detection of SA using fluorescent probes is a great challenge for scientists, because SA analogues can significantly interfere with the detection results. Herein, we first reported using a simple, natural curcumin–Cu2+ ensemble to selectively and sensitively monitor SA in situ and in vivo, directed by a fluorescence “turn-on” mode. A binary combination curcumin–Cu2+ was first fabricated with a fluorescence “turn-off” pattern caused by the paramagnetic nature of Cu2+. Subsequently, a fluorescence “turn-on” response was performed for detecting SA accompanied by the formation of the ternary complex curcumin–Cu2+–SA due to the high affinity of SA toward Cu2+, which reduced the fluorescent impact caused by the paramagnetism of Cu2+. Further study revealed that the rationally designed hybrid probe could monitor SA in living cell lines. We anticipate that this finding can inspire the discovery of a high-performance SA probe.
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高影响因子
FOOD HYDROCOLLOIDS
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2020
·
IF 7.053
Yu Hu,Chengxin He,Chengjia Jiang,Yang Liao,Hua Xiong,Qiang Zhao
Whey protein fibrils (WPF) formed at 6, 12, 18, and 24 h (80 °C, pH 2) and chitosan were utilized as vehicles to enhance curcumin dispersion stability at pH 3.5. Their antioxidant activity and release behavior in vitro were investigated. Compared with whey protein isolates (WPI), WPF possessed higher surface hydrophobicity and ζ-potential without reducing solubility. The solubility of curcumin was improved to 297.8 ± 3.3 μg/mL (400 μg/mL added) via complexation with chitosan and WPF-18 (WPF formed at 18 h). The hydrophobic groups of fibrils, rather than those exposed due to the hydrolyzed peptides, accounted for major binding sites of curcumin. Chitosan and fibrils combined with curcumin formed a bicontinuous polymer through electrostatic interaction and increased the repulsive force between fibrils, resulting in a delivery system with increased stability. Compared with curcumin alone, the complexes showed significantly improved antioxidant activity (DPPH radical scavenging activity and reducing power). Moreover, the delivery systems further provided opportunities for curcumin to release in the intestine. This potential vehicle may contribute further to introduce curcumin into fat-free acidic functional beverages.
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高影响因子
Food & Function
·
2021
·Vol. 12
·期 16
·7469-7479
·
IF 5.396
Kai Chen,Shengrong Yuan,Dan Wang,Dongming Qi,Fengfeng Chen,Xueqing Qiu
Bacterial infections and multidrug resistance can seriously endanger the health and lives of humans, therefore the development of novel and efficient antibacterial strategies and drugs is urgently needed. Herein, a series of highly biocompatible lysine modified enzymatic hydrolysis lignins (EHL-Lys-x) were synthesized using the Mannich reaction. The sterilizing efficiency of EHL-Lys-2.0 against S. aureus and E. coli at 20 mg mL−1 is 93% and 50%, respectively, which is 26% higher than pure EHL. Quartz crystal microbalance with dissipation monitoring (QCM-D) and atomic force microscopy (AFM) analysis showed that the adsorption and adhesive force between EHL-Lys-x and bacteria increase with the increased amount of grafting of Lys on EHL owing to the increase of the electrostatic interaction between the EHL-Lys-x and bacteria, which results in an improvement in the antimicrobial activity of EHL-Lys-x. Subsequently, EHL-Lys-x combined with alkyl polyglucoside (APG) was used to stabilize the high internal phase emulsion containing curcumin (HIPEs-cur). The dispersed phase fraction of HIPE-cur is 87 vol%, which is the highest internal phase reported to date in the medical research area. The highest residual levels of curcumin in HIPEs are 60-fold, 3-fold and 5-fold compared to that in bulk oil after treatment with UV radiation, thermal emittance and after storage, respectively. The minimum inhibitory concentrations of HIPEs-cur against S. aureus and E. coli were found to be 1.56 and 6.25 mg mL−1, respectively, which are far higher than that of pure EHL-Lys-x. This strategy not only increases the chemical stability and bioavailability of curcumin, but also provides a novel method for the application of lignin in biomedical science.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Weinan Huang,Lihong Wang,Yuqing Wei,Mengna Cao,Hujun Xie,Di Wu
In this manuscript, lysozyme/κ-carrageenan (LYS-CRG) complexes were prepared and used to encapsulate curcumin. The LYS-CRG complexes demonstrate good encapsulation of curcumin (CUR), and the encapsulation efficiency ( EE ) and loading capacity ( LC ) reach 96.2% and 2.31%, respectively. The encapsulated CUR has high antioxidant activity , while the thermal stability and photostability of CUR are also increased. The LYS-CRG complexes could effectively improve the storage stability of CUR and increase its retention rate. In simulated gastric fluid, only 17.91% CUR in the CUR-LYS-CRG complex nanoparticles is released in 3 h, while in the simulated intestinal fluid, the CUR release rate quickly reaches 62.56% in 1.5 h. The release rate tends to be stable within 1.5 h to 3 h and the final release rate reaches 67.23%, suggesting that the formation of CUR-LYS-CRG complex nanoparticles does not affect CUR release in the simulated intestinal fluid.
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高影响因子
危险品化学品经营许可证（带存储）